Next Gen Scientists Foundation India’s Post

🔬 Lab Spotlight: Venkatesh Lab 🔬 Today, we’re highlighting the incredible research at the Laboratory of Axon Growth and Regeneration from the CSIR-Centre for Cellular and Molecular Biology (CCMB).🌟 Led by Dr. Ishwariya Venkatesh, the lab works on understanding the molecular pathways, developmental mechanisms and regulation of growth in Axons !✨ 🔬 Key Research Areas:🔬 Axon Growth Regulation: The lab focuses on how is axon regulated during development and regeneration in mammals.🔬📊 Molecular Pathways in Regeneration: The lab works on understanding why few types of neurons regenerate better in the nervous system and the molecular pathways involved in it.🧬🕳️ Regulatory Mechanism in Development: The lab studies about different regulatory mechanisms and modulate the development axon growth during regeneration.🔬📈 Development Independent Pathways for Repair : The studies are conducted using a combinatorial approach which includes Bioinformatics, Functional Genomics, in vitro assays, in vivo mouse models of injury and behavioural assessments.🐹🧬 Explore more of their amazing research, visit 🔗 Lab webpage:- https://lnkd.in/gXph5ujF ✍🏻Credits: 🎨Poster: Abhilaya Makkuva and Smrutimayee Prusty 📝Content: Abhilaya Makkuva #NGSF #LabShowcaseSeries #genomics #research #CCMB #neuroscience

Very happy to share that I have recently officially started my PhD journey in Michael's Sieweke lab at CRTD! 🎉 Inspired by the cellular plasticity of macrophages and their role in regeneration and disease, I will use my background in Regeneration Biology and Bioinformatics/NGS to study new aspects of macrophage cell identity and apply my knowledge to improve current cell therapies! Exciting times ahead :) #Macrophages #RegenerativeBiology #CellTherapy

🌟 Breaking New Ground in Antimatter Research! 🌟 I'm thrilled to share that scientists at CERN's Large Hadron Collider have discovered the heaviest antimatter particle ever observed: antihyperhelium-4! 🚀 This groundbreaking discovery, made through lead-ion collisions, provides valuable insights into the extreme conditions of the early universe and the baryon asymmetry problem. The particle, composed of two antiprotons, an antineutron, and an antilambda particle, was identified using advanced machine learning models. 🧬 While this experiment confirmed that matter and antimatter are created in equal portions, the mystery of why our universe is dominated by matter remains unsolved. With ongoing upgrades to the LHC, we can look forward to more groundbreaking discoveries in antimatter research. 🌌 🔗 [Learn more about this fascinating breakthrough](https://lnkd.in/d_eXCqqZ) #Science #Antimatter #CERN #Physics #Research #Innovation #EarlyUniverse #MedicalLaboratoryTechnology #Microbiology #Phlebotomy #LaboratoryTesting #DiagnosticTesting #HealthcareProfessional #MedicalTesting #ClinicalLaboratory #BiomedicalScience #HealthcareIndustry #MedicalScience #LaboratorMedicine #ClinicalMicrobiology #InfectionControl #PhlebotomyTechnician #MedicalLabTechnician #MicrobiologyLab #ClinicalLab #HealthcareCareer #MedicalCareer #ScienceCareer #COVID19Testing #Virology #Bacteriology #Parasitology #MolecularDiagnosis #GeneticTesting #Cytology #Histopathology #Immunology #Serology

I recently had the opportunity to represent AmberGen and present a poster at the American Society For Mass Spectrometry (ASMS) annual meeting this month. The poster reports a workflow we call 'Cyclic MALDI-IHC’. AmberGen’s Miralys™ MALDI-HiPlex-IHC is used to simultaneously image hundreds of intact proteins on a tissue section, tissue microarray, or single cells. The Cyclic MALDI-IHC workflow consists of reusing the same tissue section for successive imaging: (i) with the same panel of probes resulting in nearly identical images across cycles demonstrating this is a non-destructive workflow; (ii) with the same panel of probes at higher spatial resolution to image specific regions of interest; (iii) or image even with a completely different panel of probes to obtain additional biological information from precious samples. While this poster demonstrates successive cycles of MALDI-IHC, it also opens the doors for other multiomic and multimodal workflows (e.g., lipids, small molecules, drugs, transcripts) on the same tissue section. If you would like to learn more, contact us at AmberGen.com (info@ambergen.com). I am very grateful for the guidance of the scientific team at AmberGen including Prof. Kenneth Rothschild, Dr. Mark Lim, and Dr. Gargey Yagnik as well as our CEO, John Gillespie!   #ASMS #MSI #spatialbiology #neuroscience #multiomic #multimodal #proteomics

The Nobel Prize Daily #Physiology_or_Medicine #year2001 for their discoveries of key regulators of the cell cycle Your Majesties, Your Royal Highnesses, Honoured Nobel Laureates, Ladies and Gentlemen, Cell division is a fundamental process of life. All living organisms on earth are descended from an ancestral cell that appeared about 3 billion years ago, and which has undergone an unbroken series of cell divisions since then. Each human being also began life as one single cell – a cell that divided repeatedly to give rise to all one hundred thousand billion cells that we consist of. Every second millions of cells divide in our body. The cycle of events that a cell completes from one division to the next is called the cell cycle. During the cell cycle the cell grows in size, it duplicates its hereditary material – that is, it copies the DNA molecules in the chromosomes – and it divides into two daughter cells. This year’s Nobel Laureates have discovered the key regulators of the cell cycle, cyclin dependent kinase (CDK) and cyclin. Together these two components form an enzyme, in which CDK is comparable to a “molecular engine” that drives the cell through the cell cycle by altering the structure and function of other proteins in the cell. Cyclin is the main switch that turns the “CDK engine” on and off. This cell cycle engine operates in the same way in such widely disparate organisms as yeast cells, plants, animals and humans. How were the key regulators CDK and cyclin discovered? Lee Hartwell realized the great potential of genetic methods for cell cycle studies. He chose baker’s yeast as a model organism. In the microscope he could identify genetically altered cells – mutated cells – that stopped in the cell cycle when they were cultured at an elevated temperature. Using this method Hartwell discovered, in the early 1970s, dozens of genes specific to the cell division cycle, which he named CDC genes. One of these genes, CDC28, controls the initiation of each cell cycle, the “start” function. Hartwell also formulated the concept of “checkpoints,” which ensure that cell cycle events occur in the correct order. Checkpoints are comparable to the program in a washing machine that checks if one step has been properly completed before the next can start. Checkpoint defects are considered to be one of the reasons behind the transformation of normal cells into cancer cells. Paul Nurse also used the genetic approach in his cell cycle studies, but in a different kind of yeast. In the late 1970s and early 1980s he discovered the gene cdc2, which could be mutated in two different ways. Either the cells did not divide, or they divided too early. From this he correctly concluded that cdc2 controls cell division. He later discovered that cdc2 not only controls cell division, the final event of the cell cycle, but has a key regulatory function for the whole cell cycle, including that described for CDC28 in baker’s yeast. This key function was...

This is really cool! It reminds me of the following scene in the "Amazing Spider-Man" about cross-species genetics 🧬🩺🔬🐁🐟 ! Imagine, a world without #pain. Instead, a world with #self-#healing humans. Simply put, no more #suffering due to #ill-#health! #DreamBig #HelpOthers #AlwaysBeAKid #SuperHeroMoviesDoComeTrue 💭 https://lnkd.in/eTjPcQqG

We are thrilled to introduce the newly published book, "Integrative Omics in Parkinson’s Disease", edited by Joanne Trinh from Institute of Neurogenetics, University of Lübeck, Germany! This comprehensive resource offers insights into the latest advancements in high-throughput technologies and their implications for understanding the etiology of Parkinson's disease and related disorders. The book traces the evolution of omics technologies, starting from the discovery of monogenic forms of Parkinson's, and explores key areas such as genomics, transcriptomics, epigenomics, and artificial intelligence. It also delves into gene-environment interactions and potential therapeutic applications, making it a valuable addition to the field. Whether you are a researcher, clinician, or simply interested in the future of Parkinson’s disease research, this book provides a deep dive into the transformative potential of omics data. Join us in advancing the conversation around Parkinson’s disease and the innovative approaches shaping its understanding and treatment and get your copy today: https://t.ly/mBzcL. #Parkinsons #Omics #Neuroscience #Research #ElsevierBooks #HealthcareInnovation

I am pleased to announce that my latest paper has been published in eNeuro, the Society for Neuroscience (SfN)'s open-access, multidisciplinary journal (https://lnkd.in/geyjac3B). There is no greater feeling than reading a paper, developing an idea, designing an experiment, and then seeing that idea realized as a published paper, making an impact on science. A brief history of this paper: For several years, our lab faced persistent challenges in generating mature, pure motor neurons. Co-culturing motor neurons with astrocytes significantly prolonged their survival and enhanced functionality but posed limitations for biochemical studies due to the heterogeneous cell composition. After reading a paper on drug toxicity evaluation in a cancer cell line, I was inspired to develop an indirect co-culture system. We introduced an innovative culture insert method, physically separating astrocytes and motor neurons, to generate highly pure motor neurons for downstream assays. I appreciate my mentor, Dr. Baojin Ding, our Ph.D. student Masuma Akter here in LSU Health Shreveport, and our collaborator, Dr. Wu Xu at University of Louisiana at Lafayette. Read and Enjoy! https://lnkd.in/gJbhSX3r #neuroscience #molecularbiology #biochemistry #neurodegenerativedisease #ALS #cellbiology #motorneurons #universityoflouisiana

How do we build bridges across our institute? At VIB.AI, we’re exploring new ways of working that span disciplines and research centers. A prime example is the co-affiliation of PIs from other VIB research centers. While their labs are part of a thematic VIB research center, focused around a central life science area such as neurobiology, plant biology, cancer, or microbiology, they also have strong ties to VIB.AI. How does that work? And how does this impact research activities? Learn more in a conversation with three of our co-affiliated PIs: 👉 Anastassia Vorobieva (VIB-VUB center of Structural Biology 👉 Steven Maere (VIB-UGent Center for Plant Systems Biology) 👉 Yvan Saeys (VIB Center for Inflammation Research) "It is really nice to have a new center dedicated to computational biology and with all the recent advances in AI we can be confident that the new center will become an important stronghold in VIB for all data science-related matters.” https://lnkd.in/etz7QK_J 

In the hunt for an ALS cure, scientists need readily accessible, physiologically relevant human cell models for cell-based assays. Charles River Laboratories use bit.bio's opti-ox™-powered human iPSC-derived ALS disease models with genetically matched controls, leveraging Axion BioSystems' Maestro Pro MEA platform to offer their clients robust electrophysiological assays that connect genotype to phenotype. Read this application note to see these cells in action, and learn how using bit․bio’s cells in your own assays could help improve their physiological relevance. https://hubs.ly/Q033GKdp0 If you are at #SLAS2025 next week, make sure you attend our Exhibitor Tutorial. Dr Austin Passaro from AxionBiosystems will present this data and practical tips on applying HT-MEA technology for disease modelling in ALS. Don't miss the opportunity! Date: January 28th Time: 8:30 AM Room: 24B #research #DrugDiscovery #science #neuroscience #neurons #StemCells #iPSCs #optiox #ioCells #DiseaseModeling #ALS #HTS #MEA #electrophysiology