Nicholas Hunt’s Post

Our Genmab colleague Cristine Steen-Louws, is presenting at the EBF Open Symposium in Barcelona during the Patient-Centric Trials (PCT) & DBS Technology session. Cristine will share insights into applying microsampling in non-clinical studies in combination with Ligand Binding Assays, discussing what it takes to develop sustainable solutions while upholding high-quality standards in the bioanalytical lab.

I got 27th place/ 1946 and won a silver medal in a kaggle competition!!! This competition on Kaggle invited participants to forecast the efficacy of potential new medicines. This competition aimed to accelerate drug discovery by enabling more precise predictions of drug outcomes based on chemical data. For our solution, we prepared 2 models, one for which the structure of the molecule is shared in the training set, and another for molecules with unseen structures.  For the shared data, we enhanced accuracy by using a 1D CNN that treats SMILES as strings, incorporating residual connections and attention mechanisms. we used ChemBERTa, capable of transfer learning, and preserved generalization performance by freezing the first three layers during training to retain information from pre-trained molecules. This competition had a huge gap in molecular structure between the Public and Private leaderboards, making it a very "shaky" competition. Despite this, our team managed to create a highly robust model, achieved 8th on the Public and 27th on the private as well. Here is our solution. Any comments or questions are welcome! https://lnkd.in/gjhM5yBj

“The most crucial step in scaling up your chromatographic methods is always the R&D phase.” Join Matthias Käseborn and our team of experts at CPHI, Milan this October to discuss your drug discovery and scale-up challenges! Learn more about our presence at CPHI and book a meeting with our experts here: https://hubs.ly/Q02PQ8wQ0

“Almac Discovery warmly welcomes today’s launch of the Future Medicines Institute (FMI). We are excited to start the journey on this five-year UKRI project and look forward to developing sector-relevant skills, enhancing access to cutting edge equipment and expertise, driving business opportunity and growth and ultimately to seeing direct benefits to patients in NI and beyond.” Dr Stephen Barr, President and Managing Director of Almac Discovery. Read more: https://hubs.li/Q02-nYyD0

✨ It was a pleasure to hear Miki Giffin summarize her recaps from SOT 2024, as well as others takeaways and thoughts at the April Biocompatibility Coffee Break. Thank you for sharing!   In short from the discussion: ✅ Medical device poster session were well attended, even more people than previous years ✅ Use of AI for TRAs were discussed in presentation and in a poster. AI can be a great tool in the future if used properly.  ✅ If you work with absorbable/degradable devices, a tricky group of devices to test, look at the quite new ISO 37137:2021 for guidance ✅ Identifications confidence in chemical characterization – can be impacted by sample preparation, databases and laboratory methods ✅ Interesting Round Robin study highlighted issues with reproducibility between laboratories for chemical testing. ✅ There are some confusions in the use of scaling factor in part 17 and also how to use TSL for specific compounds and patient groups ✅ Comparison between in vitro and in vivo results for skin irritation presented by FDA. ✅ James Morrison gave a tip that David Saylor and Joshua Yong from US FDA, CDRH,OSEL Regulatory Science regular have meetings where they share information about their work within chemical testing. We have attended several meetings with interesting discussions and can recommend you to register. ✅ Several of the participants kindly offered to share their posters from SOT2024 if you send them an email. Please add the topic in a comment to this post if you are one of them who are happy to share yours.    Next SOT meeting will be in Orlanda, FL, USA, March 16-20, 2025. The deadline for session proposals sent to MDCPSS is May 1.   To everyone who got stuck in the lobby, we're really sorry we couldn't let more people in. It seems we reached a limit on the number of people, which we have not experienced before even with more participants. We are looking into this to get it fixed before the next session in May.   👋 Registration for Biocompatibility Insights 2024, Copenhagen, Denmark during October 15 (training day) and October 16-17 main conference days is now open. Hope to see you! Carl-Johan Zettervall, Jonathan Kelly, Lina Burman, Monica Grekula, and Rose-Marie Jenvert The Biocompatibility & Toxicology team at Veranex Sweden AB #iso10993 #biocompatbilityInsights2024 #veranex

This is clinical mass spectrometry technology that has the potential to revolutionise paraprotein detection, monitoring and classification. It’s an exciting time!

Fuel Your Clinical #RFP with #SuperNOVA at #BIOAsia24 Do you have an upcoming #clinicaltrial or #clinicaltrialsimaging needs?Would you like to explore different options for clinical trials and imaging needs? If so, please reach out to us to discuss your #RFP needs. We will also be exhibiting at #BIOAsia24 at the end of July 24. Elevate your clinical research journey with the SuperNOVA 40 oz thermal cup—the ultimate companion for busy professionals navigating the industry's demands. This high-performance insulated cup keeps your hot beverages piping hot for up to 12 hours and your cold drinks refreshingly chilled for up to 24 hours, ensuring you stay energized and focused throughout the conference and beyond. As a special offer, SuperNOVA Clinical Research is giving away a limited number of these coveted cups to the first 8-12 organizations that engage with us during the upcoming BIO Asia 24 conference and initiate RFP discussions. This is your chance to not only secure a practical and stylish accessory but also to explore the transformative clinical solutions that SuperNOVA has to offer. Don't miss out on this exclusive opportunity to fuel your clinical breakthrough. Schedule a meeting with our team at the conference and let's discuss how SuperNOVA's innovative technologies, patient-centric approaches, and global expertise can propel your clinical trials to new heights of success. Secure your free SuperNOVA 40 oz cup and start your path to clinical innovation today. #ClinicalResearch #CRO #PharmaceuticalIndustry #BiotechIndustry #ClinicalTrials #PatientCentricity #ThermalCup #FreeGiveaway #ConferenceOffer #InnovativeSolutions #GlobalExpertise #RegulatoryCompliance #ImagingServices #RFPDiscussions

Paroxysmal Nocturnal Hemoglobinuria (PNH) diagnostics and monitoring on ESCCA 2024

Important milestone for our company as we announced early completion of enrollment in LunAIRo, Apnimed’s Phase 3 #OSA #clinicaltrial examining the efficacy and safety of AD109 compared to placebo at six-months and one-year. We believe AD109 has the potential to be the first nighttime oral pharmacologic treatment for people with obstructive #sleepapnea who are either intolerant of, or refuse to use, positive airway pressure therapy. We want to thank the patients who volunteered to participate in this study, extend our gratitude to the investigators for their support and give a shout out to our amazing clinical and medical colleagues who made this important step possible. Topline data expected mid-2025. Learn more about the study design and its presentation at #ATS2024: https://bit.ly/4draxhP #biotech #innovation

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