Swiss Nuclear Doctors’ Post

🔬✨DAT PET-to-SPECT Translation with CycleGAN ✨🔬 We’re excited to share a groundbreaking international study led by Leonor Lopes Lopes, Dr. Kuangyu Shi, and collaborators from Insel Gruppe and Fudan University, Shanghai, recently published in the European Journal of Nuclear Medicine and Molecular Imaging. This work introduces a CycleGAN-based AI approach to translate dopaminergic PET images to SPECT, paving the way for multicenter studies and advancing Parkinson’s disease (PD) diagnostics globally. 🧠🤖 🔹 Study Insights and Methodology: • Challenge: PET imaging ([11C]CFT) and SPECT ([123I]FP-CIT) are widely used for diagnosing Parkinson’s disease and atypical parkinsonian syndromes (APS). However, the difference in imaging modalities complicates data comparison and AI model training across centers. • Solution: A CycleGAN model was developed to synthesize SPECT images from PET data, using unpaired datasets from Huashan Hospital in Shanghai and PPMI. This innovative approach ensures modality compatibility without requiring paired imaging data. • Validation: The synthetic SPECT images were assessed for visual fidelity, semi-quantitative accuracy, and AI-based classification performance. 🔹 Key Findings: • High Visual and Statistical Accuracy: Synthetic SPECT images closely mirrored real SPECT images based on Fréchet Inception Distance (FID) and expert visual evaluation. • AI Classification Success: Models trained on synthetic SPECT achieved 97.2% sensitivity and 90.0% specificity for diagnosing Parkinson’s disease from real SPECT images. • Clinical Potential: This cross-modality synthesis preserves disease-specific features, such as striatal binding loss, supporting studies that integrate PET and SPECT for Parkinsonian disorders. 👏 Congratulations to Leonor Lopes, Dr. Kuangyu Shi, and the Swiss-Chinese research team for their innovative contribution to global nuclear medicine and AI-driven diagnostics! 🔗 Read the full study: https://lnkd.in/evPJ52nh 📂 Explore the GitHub Repository: https://lnkd.in/eRfrmJXB #NuclearMedicine #AI #ParkinsonsDisease #MedicalImaging #DeepLearning #PET #SPECT #CycleGAN #SwissResearch #GlobalCollaboration

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