Oriental Journal of Chemistry’s Post

The wide-energy programmable microwave plasma-ionization mass spectrometry (WPMPI-MS) system offers a single-ion source technique for all analyte types, enabling high coverage of substances and rapid detection of biomolecules, heavy metals, and non-polar molecules. It performs well in real samples, detecting soil extracts, solid pharmaceuticals, and landfill leachate, and is expected to become a viable alternative to commercially available ion sources. Read more: https://lnkd.in/eAgrUqAM Advance Your Research with #Spectrus 👩🏽🔬 spectruscorp.com #AnalyticalChemistry #MassSpectrometry #LiquidChromatography #Proteomics #Metabolomics #Glycomics #Lipidomics #Epigenetics #FragmentScreening #PolymerAnalysis

🔜 #Visible-Light-Mediated Vicinal Dihalogenation of Unsaturated C–C Bonds Using Dual-Functional Group Transfer Reagents ▶ The growing demand for chemical production continues to drive the development of sustainable and efficient methods for introducing molecular complexity. In this context, the exploration of unconventional functional group transfer reagents (FGTRs) has led to significant advancements in practical and atom-efficient synthetic protocols. Aiming to advance the field of valuable organic synthesis, herein we report the successful development of carbon-based, bench-stable, modular, and inexpensive reagents implemented in dual halogen transfer to unsaturated hydrocarbons via photocatalytic activation of reagents based on a radical-polar crossover mechanism. This method beneficially enables vicinal dichlorination, dibromination, and bromo-chlorination reactions of olefins, offering practical alternatives to the use of toxic binary halogens. Detailed mechanistic studies, combining experimental, spectroscopic, and theoretical investigations, revealed a distinctive photocatalytic single-electron transfer reduction of FGTR. This process triggers mesolytic carbon–halogen bond cleavage, followed by a radical 1,2-halide rearrangement, leading to the continuous generation of dihalogen species in the reaction medium. The wide applicability of the developed protocol is demonstrated through an extensive scope of unsaturated molecules, including additional operations on strain-release dihalogenation.

Need an alternative to poly(ethylene glycol)? Try making block copolymers with N-vinylpyrrolidone 🧪 Poly(ethylene glycol) is a commonly used plastic in biomedical applications. Think IBS management or oral drug capsules. The catch? It exhibits unwanted immune responses. Alongside Lauren Ball (first author), Bert Klumperman and Rueben Pfukwa, we looked at the RAFT mediated synthesis of poly(styrene-co-maleic anhydride)-block-poly(N-vinylpyrrolidone) to form double hydrophilic block copolymers. Read all about it in ACS Macromolecules 👉 https://lnkd.in/dyGFJyGA #Macromolecules #ACS #StellenboschUniversity #copolymer #RAFT

Early detection of 4-ethylphenyl sulfate (4-EPS), a gut microbial metabolite, in bodily fluids has huge implication in neurological and developmental disorders such as autism spectrum disorder (ASD). https://lnkd.in/g4xuc6ZF Our latest paper about the new method to detect 4‑ethylphenyl sulfate with enhanced sensitivity. #science #biotechnology #bioscience #microbiome #microbiology #metabolite #gutmicrobiome #gut #microbiota #biology #csir #drdo #dbt #dst #pharmaceutical #microbial #drugdiscovery #drugdevelopment #Biochemistry #biotech #biology #chemistry #college

Scientists are striving to make peptide synthesis more environmentally friendly. Although green conditions for all chemical syntheses remain a distant goal, researchers continue to develop greener alternatives. An article titled "Solid Phase Peptide Synthesis Using Side-Chain Unprotected Arginine and Histidine with Oxyma Pure/TBEC in Green Solvents" highlights one such green approach, encouraging further progress in sustainable synthetic methods. Here is the link: https://lnkd.in/epTsjk6Q #PeptideSynthesis #GreenChemistry #Synthesis #MedicinalChemistry #DrugHunting #AminoAcids

With its roles in bioisosterism, prodrug strategies, hydrogen sulfide (H₂S) donation, metal chelation, and the development of thioamide-based metal complexes, thioamide group continues to gain a considerable attention due to its unique physical and chemical properties and versatile roles in medicinal chemistry. An excellent, open access review that unlocks the potential of the thioamide group in drug design and development. https://lnkd.in/g7bkUh4s

A new paper is a great way to end the year! Check out my debut (co)first author publication in Accounts of Chemical Research. Reactivity of Anomalous Aziridines for Versatile Access to High Fsp3 Amine Chemical Space. https://lnkd.in/gNb9AqXe

Streamline heterocycle synthesis pathway masterfully with allenyl thianthrenium (ATT) hexafluorophosphate! ↗️ ATT hexafluorophosphate is a bench-stable, non-hygroscopic electrophilic reagent used in cross-coupling reactions (https://lnkd.in/dVjYcv76). It is capable of the formation of C(sp²)-C(sp²) and C(sp³)-C(sp²) bonds via Suzuki and reductive coupling reactions. ATT⁺ PF₆⁻ provides a straightforward and efficient approach to introducing allenyl functionality into aromatic and aliphatic systems. It avoids isomerization typical of propargylating reagents, ensuring cleaner reaction profiles. Applications span from the synthesis of biologically relevant compounds to advanced material precursors. 🛒 This reagent is available in our stock! https://lnkd.in/d-fy8Syn 💡 Enamine offers a broad range of reagents and product subsets for organic synthesis that facilitate a wide variety of transformations. Explore all them here https://lnkd.in/gFMXnPKj #reagents #organicchemistry #molecule #drugsynthesis #drugdesign #research #chemicals #JACS #orgchem #chemicalbuildingblocks #Enamine

Microwave Assisted Synthesis and Characterization of 4-Aminothiophenol with Two Mixed Ligands Chelates of Cobalt, Nickel and Mercury Read the Article here: https://bit.ly/4cweFfa #4Aminothiophenol #Benzoateion #Biopotential #Metalchelates #Nitriteion #XRD #chemistry #biochemistry #nanomaterial #analyticalchemistry #chemicalengineering #Phytochemicals #ChemicalSciences #ChemicalTechnology

N-aziridinyl radicals as novel reactive intermediates that enable transfer of intact aziridines to olefinic substrates. Generated under mild photochemical conditions, transient N-Aziridinyl radicals enable the strained fragment to engage in intermolecular addition chemistry without an appreciable ring opening The results establish aziridinyl radicals as new reactive intermediates in synthetic chemistry and demonstrate aziridine group transfer as a viable synthetic disconnection. https://lnkd.in/gJUuJeZq