Oxford Biomedica’s Post

🚀 Exciting News from A4Cell! 🚀 We are thrilled to introduce our latest innovation in cell-based assays: the OHrad ROS SPAchip® Single-Detection Kit! This groundbreaking technology is designed to revolutionize your drug discovery process by offering: 🌟 Key Features: Stability: Active only when processed by intracellular cytosolic esterases, ensuring precise and reliable results. Specificity: Selectively detects hydroxyl radicals (•OH), providing targeted insights into reactive oxygen species (ROS) activity. Robustness: pH-insensitive, guaranteeing consistent performance across various conditions. Product Highlights: 🔬 Novelty & Innovation: A cutting-edge silicon chip covalently functionalized with a fluorogenic chemical probe reactive to ROS, bringing together the best of nanotechnology and cell biology. 🎯 Selective Detection: Accurately detects •OH radicals, whether generated as primary ROS or secondary species downstream of other ROS. ⏱️ Real-Time Monitoring: Enables real-time monitoring of intracellular ROS over long periods via fluorescence intensity within living cells. At A4Cell, we are committed to advancing the field of drug discovery with innovative solutions that enhance efficiency, accuracy, and reliability. The OHrad ROS SPAchip® is designed to meet the highest standards of selectivity, robustness, and stability, ensuring you get the most reliable data for your research. Join us in revolutionizing the future of biotechnology! For more information on SPAchip technology and how it can benefit your drug discovery efforts, please contact us! #A4Cell #SPAchip #DrugDiscovery #Biotechnology #Innovation #ResearchAndDevelopment #ROSDetection #CellBiology

🔬 **Unlocking the Power of Microfluidic Reactors** Microfluidic reactors, or microreactors, are revolutionizing chemical and biological processing by allowing for precise control at the microscale. These advancements not only streamline reactions but also enhance efficiency and reduce waste compared to traditional methods. 🧠 **Applications in Science** Microfluidic reactors represent a significant advancement in chemical and biological processing, offering precise control, enhanced efficiency, and versatility. Their applications in pharmaceuticals, biotechnology, analytical chemistry, and neuroscience are transforming research and industry. 🚀 **Looking Ahead** The future of microfluidic technology is bright, with potential applications expanding across various fields. From drug development to personalized medicine, the possibilities are endless as we harness the power of these innovative devices. 💡 Curious to learn more? Check out ALine's latest blog post where we delve deeper into the principles, applications, and future of microfluidic reactors: https://lnkd.in/g3XbDKHy #Neuroscience #Biotechnology #ChemicalEngineering #InnovativeTech #EngineeringExcellence #FutureOfScience #DigitalMicrofluidics #Innovation #MedicalDiagnostics #FutureTech #Microfluidics #ScienceInnovation #ALineInc #ALine #MicrofluidicTechnology #MicrofluidicDevices

Our latest work on the #cryopreservation and #biobanking of spheroids has been published in Biomaterials Science and Engineering Manchester Institute of Biotechnology . We explore how inducing ice nucleation at higher temperatures protects spheroids. We show the nucleation prevents the solvent-exposed cells from shedding, using GFP-expressing cells for resolution. This is helping us to design methods and tools to bank 3D cell models. Why? 3D #cellmodels are more predictive of human outcomes in drug screening than common 2D cell culture, but not everyone has the resources/skills to make them. If we can freeze them better, they can be used 'off the shelf'. Our longer term vision is to freeze primary-cell spheroids/organoids to replace #animaltesting with more predictive, cheaper and accessible models. Read the work here: https://lnkd.in/eP5cNNR3

An interesting read on how biotechnology and bioengineering of systems and screening platform technologies enabled the discovery and design of molecular glues. https://lnkd.in/gDhKHidi

My review article, "Integration of Molybdenum Disulfide and Phosphorene into Polymeric-Based Nanocomposite Hydrogels for Various Biomedical Applications: Recent Advances and Future Prospects," is accepted in the #European_Polymer_Journal. #Research #Nanocomposites #2DMaterials #MolybdenumDisulfide #Phosphorene #PolymericHydrogels #BiomedicalApplications #Tissue_engineering #Photothermal_Therapy #Drug_Delivery #Wound_healing #FutureProspects #ScientificPublication #EuropeanPolymerJournal #Innovation

🤔 What if we could revolutionise drug delivery by taking inspiration from an unlikely source: caterpillars? 🐛 Associate Professor Jing Yu and his interdisciplinary team at Nanyang Technological University Singapore, comprising Dr Haopeng Li and Dr Xuliang Qian, have developed a versatile drug delivery system by mimicking the self-assembling proteins within the cuticles of the Asian corn borer moth caterpillars (Ostinia furnacalis). 🧬 In collaboration with Xinghua University Professor Huajian Gao of Tsinghua University, Professor Tian Liu of Dalian University, and Professor Qing Yang of the Chinese Academy of Agricultural Sciences, the team created versatile nanocapsules capable of delivering a wide range of therapeutic agents, including small-molecule drugs, nucleic acids, and mRNA. 💊 The research, published in Springer Nature Group’s Nature Nanotechnology journal, introduces a simple, template-free method for generating hollow peptide nanocapsules that can efficiently encapsulate various cargoes. This one-step mixing method leverages concentration gradient as the driving force, allowing nanocapsules to form spontaneously without additional steps. For more about the research, visit: https://lnkd.in/gNhZ-fyb #NTUsgResearch #NTUsgMSE #NTUsgMaterialsScience #MaterialsScience #DrugDelivery #Biomimicry #BiomimeticMaterials #Nanotherapeutics #NTUsg2025 #RIE2025

📢 New Publication! 🌟 Our latest article titled "Biosynthesis of Copper Based Nanomaterials for Biosensor and Drug Delivery Applications" has just been published in BME Horizon! 🌟 📜 In this review, we delve into the remarkable potential of copper-based nanomaterials in the biomedical field. With unique physicochemical properties, these nanomaterials, synthesized using plant biomolecules, offer promising solutions for biosensors and drug delivery systems. Discover how these biocompatible and less-toxic innovations are paving the way for the future of healthcare. 👉 Read the full article here: https://lnkd.in/gwNWjw9b #Nanotechnology #Biosensors #DrugDelivery #MedicalInnovation #CopperNanomaterials #BiomedicalScience #Research

We are delighted to share that our review article titled "Integration of Two-Dimensional MXene into Polymeric-Based Nanocomposite Hydrogels for Various Biomedical Applications: Recent Advances and Future Prospects" has been accepted for publication in the prestigious #European_Polymer_Journal Stay tuned for more updates! 🙌 #MXene #Hydrogels #BiomedicalResearch #EuropeanPolymerJournal #Innovation #Nanotechnology #FutureProspects #Research

🇩🇪 🏴󠁧󠁢󠁳󠁣󠁴󠁿INTERNATIONAL CONFERENCE🇩🇪 🏴󠁧󠁢󠁳󠁣󠁴󠁿 Still time to register for the 2nd Scotland - Rheinland-Pfalz Life Sci and Biotech Conference on May 14th (online) Co-hosted by RPTU Kaiserslautern We will have a plenary talk from BASF, a panel discussion on funding and scientific presentations on the following topics: - Sustainability in Biotechnology - Neurodegeneration and Healthy Ageing - Biotechnology for Advanced Therapies - Engineering Biology - AI and Data in Healthcare https://buff.ly/47U4xd6

The discovery, published in the journal Nature, uses a novel technique using a type of interlocked molecule known as rotaxane. Under the influence of mechanical force - such as that observed at an injured or damaged site - this component triggers the release of functional molecules, like medicines or healing agents, to precisely target the area in need. For example, the site of a tumour. #nanotechnology #biotechnology #medicine #lifesciences #technology #oncology #innovation