PolyPeptide Group’s Post

See how #MassPhotometry can be used for epitope binning in #antibody characterization in a recent paper from Ben Spiller's lab at Vanderbilt University School of Medicine. The authors created a library of #nanobodies against Streptococcus pyogenes Cas9 (SpCas9). After screening, three nanobody variants were found that tightly bound different epitopes in SpCas9 without interfering with its enzymatic activity or each other – a helpful toolbox for attaching genome-modifying enzymes or fluorescent tags to Cas9. We note that the anti SpCas9 nanobodies were provided by Flower Blossom the alpaca. Read the full story here! 👉 https://lnkd.in/diWar5Uw #MassPhotometryStories

Here it is - out just in time for the holidays! 🎄 We are pleased (and somewhat relieved) to finally announce the publication of our seminal review on the octadecanoids. For those of you not familiar with octadecanoids, they are the little studied C18-carbon cousins of the more well-known #eicosanoids. These lipid mediators exert potent functions in multiple biological processes. Within these 90 pages, you will find our best attempt to summarize as much of the octadecanoid literature as possible. We provide a detailed review of the field, including nomenclature, formation and biological activity of these important #lipid mediators. We hope that this work will help spur interest in our favorite molecules! Amazing effort led by Johanna Revol-Cavalier and Alessandro Quaranta with John Newman, Alan Brash and Mats Hamberg. Here is a link to the paper - which is freely available open access 👇 https://lnkd.in/dKxz9VpA Grateful for the support from Karolinska Institutet, Hjärt-Lungfonden, Vetenskapsrådet / Swedish Research Council as well as Larodan AB.

The Silver Medal for Ambry's Best Blogs explores the results of a 2023 study that examined variants of uncertain significance (VUS) in multi-gene panels. Ambry is dedicated to furthering our scientific knowledge and continuously improving our tests. #Bestof #Ambry https://hubs.ly/Q02_jgtb0

The last paper of 2024 is out! An excellent team effort with Petri Kursula, Hauke Werner, and Brad Zuchero lab. We characterized a set of 🦙 #nanobodies binding CNPase, a highly abundant protein on myelin-sheets. Check the paper published in the Journal of Neurochemistry. Here is the link: https://lnkd.in/eUTpPWnP

#mdpicompounds #openaccess 🌟 Glad to share excellent work published in Compounds MDPI. 📍 Title: Rheology of Cellulosic Microfiber Suspensions Under Oscillatory and Rotational Shear for Biocomposite Applications 💡 Authors: Helena Cristina Vasconcelos, Henrique Carrêlo, Telmo Eleutério, Maria Gabriela Meirelles, Reşit Özmenteş and Roberto Amorim 👉 More information about the paper can be found here: https://lnkd.in/gws9c9XV

I'm excited to announce that my first author paper from my graduate school career is officially published in eLife (second draft on the way in January with only fairly minor revisions/reanalysis and no added experiments)! My colleagues and I show that FHOD3L's elongation ability is most important for sarcomere formation in cardiomyocytes, and not its nucleation, capping, or bundling ability. This provides significant insights that further our understanding for the mechanism of sarcomere formation in cardiomyocytes.

🔬 If you are attending the CAR-TCR Summit Series in Boston. You will want to stop by and visit our booth#103. RJ Lee Eliona Kola will also be presenting the critical importance of Leukopak quality and how Cryopreserving Leukopaks and primary cells offers several advantages: 1. Flexibility: Easier scheduling of experiments. 2. Cost-effectiveness: Reduced research and development expenses. 3. Accessibility: Easier access to samples for future studies. #CARTCR #CGT #CellandGeneTherapy

I am delighted to share that our paper, titled "The Molecular Insights of Cyanobacterial Bioremediations of Heavy Metals: The Current and Future Challenges", has been published in Frontiers in Microbiology (Scopus, Q1, SCIE, Impact Factor: 4.0). The paper explores critical molecular mechanisms behind cyanobacterial bioremediation of heavy metals and addresses both present challenges and future opportunities in the field. Authored by Jinita Lourembam, Banaraj Haobam, Kshetrimayum Birla Singh, Savita Verma, and Jay Prakash Rajan. It is available online at: DOI link: https://lnkd.in/g_F9zsZ2

We are attending the Boulder Peptide Symposium. Check out our poster (P-14) and say hi to Tina Boville, Wendy Hartsock, and Jimmy Mann! Boulder Peptide Foundation Aralez Bio #peptidetherapeutics #peptidesforever #benoncanonical #aminoaciddiversity

The SelectBIO Conferences - Extracellular Vesicles Asia 2025 will take place February, 7. - 8., 2025 in Hong Kong. We are very pleased to be part of it. Dr. Sven Kreutel will be at the Particle Metrix GmbH booth together with our local distributor A&P Instrument Co., Ltd. to demonstrate the ZetaView® product family. In addition, he will explain the #characterization of #ExtracellularVesicles and other #biological #nanoparticles using NTA in a talk. Come and join us. 👉 https://lnkd.in/epKeN5b2 📍 ALVA HOTEL BY ROYAL, Shatin, Hong Kong 📅 Friday, February 7, 2025 - Saturday, February 8, 2025 📢 February 7, 2025 - 14:00 - Characterization of Extracellular Vesicles and other Biological Nanoparticles using #NTA with Sven Kreutel #SelectBIO2025 #EVs #EVcharacterization #NanoparticleTrackingAnalysis #Size #Concentration #ZetaPotential #Colocalization #Fluorescence #Subpopulations #ZetaView #particlemetrix