https://lnkd.in/gqGC3ESu Article Title: Physicochemical characterization and biological activity of polysaccharides from the seeds of the turnip Brassica rapa Author(s): Yuliya I Oshchepkova*, Мunojat J Oripova, Zulfizar N Kuzieva, Barno B Koraboeva, Dilnoza G Abdugafurova, Dilfuza A Amanlikova and Shavkat I Salikhov Journal: International Journal of Pharmaceutical Sciences and Developmental Research Journal ISSN: 2640-7760 Abstract: Analysis of the monosaccharide composition showed that the composition of the neutral polysaccharide BSP-1-1 is represented by monosaccharides in the following composition: ribose – 5.05%, arabinose – 56.38%, mannose – 5.87%, glucose – 8.63% and galactose – 24.05%. The composition of the anionic polysaccharide BSP-2-1 is represented by monosaccharides: ribose – 6.35%, arabinose – 60.15%, mannose – 7.19%, glucose – 4.12% and galactose – 22.16%. It was determined that the isolated polysaccharides consist mainly of arabinose (BSP-1-1 – 56.3%, BSP-2-1 – 60%) and galactose (BSP-1-1 – 24%, BSP-2-1 – 22%). #Brassicarapa #Polysaccharides #Monosaccharidecomposition #IRspectroscopy #Diabetesmellitus #Alloxan #MedicinalChemistry #DrugDevelopment #Pharmacokinetics #Pharmacodynamics #Pharmacogenomics #Toxicology #Pharmaceutics #Biopharmaceutics #Pharmacognosy #PharmaceuticalChemistry #PharmacyPractice #CommunityPharmacy #HospitalPharmacy #IndustrialPharmacy #RegulatoryAffairs #DrugFormulation#DrugDelivery #PharmacyManagement #PharmaceuticalTechnology #PharmacyEducation #ClinicalTrials
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https://lnkd.in/gAmYqQHS Article Title: In-silico analysis of tenidap and its derivative as a novel 5-lipoxygenase inhibitor Author(s): Asma Noor*, Ardas Masood, Jawaria Khan, Tanveer Abbas and Muhammad Imran Qadir Journal: International Journal of Pharmaceutical Sciences and Developmental Research Journal ISSN: 2640-7760 Abstract: Tenidap is a derivative of Flavonoids which are actually plant derivatives, it shows inhibition activity of 5-lipoxygenase. Molecular models were directed to discover molecular docking mode, also to help explain molecular tool behind its inhibitory action. Molecular relations of tenidap with the catalytic trio (His523, His518, Ile875) inside active or dynamic position of 5-lipoxygenase through hydrogen bonding, appears to the major reason elaborate in its substantial 5-lipoxygenase activity of inhibition. #Tenidap #5lipoxygenase #Antiinflammatoryeffect #Pharmacy #Pharmacology #PharmaceuticalSciences #ClinicalPharmacy #MedicinalChemistry #DrugDevelopment #Pharmacokinetics #Pharmacodynamics #Pharmacogenomics #Toxicology #Pharmaceutics #Biopharmaceutics #Pharmacognosy #PharmaceuticalChemistry #PharmacyPractice #CommunityPharmacy #HospitalPharmacy #IndustrialPharmacy #RegulatoryAffairs #DrugFormulation #DrugDelivery #PharmacyManagement #PharmaceuticalTechnology #PharmacyEducation #ClinicalTrials
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https://lnkd.in/gWts95Ra Article Title: Synergistic antifungal effectiveness of essential oils from andean plants combined with commercial drugss Author(s): Beatriz Lima, Maximiliano Sortino, Alejandro Tapia and Gabriela E Feresin* Journal: International Journal of Pharmaceutical Sciences and Developmental Research Journal ISSN: 2640-7760 Abstract The appearance of antifungal resistance promotes the investigation of therapeutic options. There are few studies on the combined effect of antifungal drugs and essential oils (EOs). In the present work, regarding the association of eight EOs Andean plants with antifungal agents against a panel of fungi strains. Combinatorial effects were determined using the Fractional Inhibitory Concentration Index (FICI) and Dose Reduction Index (DRI). A combination of A. cryptantha-B EO with fluconazole showed a synergistic effect against C. Albicans (FIC = 0.31 and DRI = 16.25). EOs from A. cryptantha-A and L. integrifolia showed an additive effect (FICI = 0.75) against C. neoformans. A combination of EOs from A. seriphioides and A. cryptantha-A with terbinafine showed an additive effect on T. rubrum (FIC = 0.56; DRI = 16) and M. gypseum (FICI = 1.03; DRI = 32). In conclusion, combinations between EOs of species from Andean plants and commercial antifungal drugs yielded some interesting findings, as potential antifungal strategies used for treating infections associated with C. Albicans and T. rubrum . #Antifungal #Essentialoil #Synergism #Azorellacryptantha #Candidaalbicans #MedicinalChemistry #DrugDevelopment #Pharmacokinetics #Pharmacodynamics #Pharmacogenomics #Toxicology #Pharmaceutics #Biopharmaceutics #Pharmacognosy #PharmaceuticalChemistry #PharmacyPractice #CommunityPharmacy #HospitalPharmacy #IndustrialPharmacy #RegulatoryAffairs #DrugFormulation#DrugDelivery #PharmacyManagement #PharmaceuticalTechnology #PharmacyEducation #ClinicalTrials
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https://lnkd.in/g8bExAEP Article Title: Developing analytical parameters and evaluation of thermo fisher urinary creatinine enzymatic method to implement in open system chemistry analyzers Author(s): Ashraf Mina*, Leah McNeice, Shanmugam Banukumar and Santiago Vazquez Journal: International Journal of Pharmaceutical Sciences and Developmental Research Journal ISSN: 2640-7760 Abstract: Creatinine assay is used mainly to monitor kidney function and for sample validity when testing for drugs of abuse. Creatinine alkaline picrate method based on Jaffe’s reaction calls for extra cleaning procedures to minimize interference from picric acid and sodium hydroxide. Thermo Fisher enzymatic method is more sensitive and specific when compared to alkaline picrate method, but there were no available analytical parameters to setup this enzymatic method on open chemistry analyses platform such as Beckman-Coulter AU5800 analyser. Specific analytical parameters were developed and the assay performance is evaluated against the alkaline picrate method. We successfully set up analytical parameters on Beckman-Coulter AU5800, as an example of open system analyser, and evaluated its performance against Thermo Fisher Jaffe’s reaction method. The weighted Deming regression analysis for 408 samples showed a good correlation at a 95% confidence interval. Slope is 1.065 to 1.091, Y-intercept when X=0.0 is -0.9377 to -0.5443 and correlation coefficient (r) is 0.993. The alkaline picrate method Mean and SD for tested samples are 13.2877 and 7.414 respectively and for the enzymatic method are 13.5823 and 7.987 respectively. Many interferences from drugs and other substances are eliminated when using the enzymatic method and the stability of other reagents on-board improved because the reagents used in the enzymatic method are less invasive. #Creatinine #Enzymaticcreatinine #Samplevaliditytesting #Urinarycreatinine #MedicinalChemistry #DrugDevelopment #Pharmacokinetics #Pharmacodynamics #Pharmacogenomics #Toxicology #Pharmaceutics #Biopharmaceutics #Pharmacognosy #PharmaceuticalChemistry #PharmacyPractice #CommunityPharmacy #HospitalPharmacy #IndustrialPharmacy #RegulatoryAffairs #DrugFormulation#DrugDelivery #PharmacyManagement #PharmaceuticalTechnology #PharmacyEducation #ClinicalTrials
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The European Medicines Agency (#EMA) has recently released a draft guideline on the development and manufacture of synthetic #oligonucleotides. This comprehensive guideline covers crucial aspects to ensure the quality, safety, and efficacy of these advanced therapeutic agents. 🔍 Key Points of the Guideline: ➡ Manufacturing Process: Detailed guidance on the synthesis of oligonucleotides, including solid-phase and alternative methods, ensuring high-quality production standards. ➡ Characterization and Specifications: Requirements for structural elucidation, impurity profiling, and analytical methods to guarantee the consistency and purity of the active substance. ➡ Conjugation and Active Substance in Solution: Standards for the conjugation of oligonucleotides and the stability and characterization of the active substance when in solution. ➡ Medicinal Product Development: Comprehensive instructions for the development of oligonucleotide-based medicinal products, including personalized medicine approaches. ➡ Clinical Trial Applications: Specific requirements for the quality documentation needed for clinical trial applications, ensuring thorough evaluation of safety and efficacy. ➡ Generics Development: Guidelines for the development of generic oligonucleotide products, promoting innovation and accessibility in the pharmaceutical market. 📅 Consultation Period: The public consultation period starts on July 22, 2024, and will run until January 31, 2025. Follow us for regulatory updates and scientific insights! 💻www.toxhub-consulting.com 📩 info@toxhub-consulting.com #ToxHub #Consultancy #Consulenza #Tossicologia #Toxicology #Pharma
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https://lnkd.in/gkmsAQhw Article Title: In Silico Estimation of Skin Concentration of Dermally Metabolized Chemicals Author(s): Tomomi Hatanaka, Saki Yamamoto, Mayuko Kamei, Wesam R Kadhum, Hiroaki Todo and Kenji Sugibayashi* Journal: International Journal of Pharmaceutical Sciences and Developmental Research Journal ISSN: 2640-7760 Abstract Background: A great deal of In Silico estimation methods were proposed for skin concentration and permeation of drugs by many researchers including us. The aim of the present study was to expand our In Silico estimation method of skin concentration to dermally metabolized chemicals. #Skinconcentration #Dermallymetabolizedchemical #InSilicoestimation #Skinpermeation #Skinmetabolism #Estercompound #Pharmacy #Pharmacology #PharmaceuticalSciences #ClinicalPharmacy #MedicinalChemistry #DrugDevelopment #Pharmacokinetics #Pharmacodynamics #Pharmacogenomics #Toxicology #Pharmaceutics #Biopharmaceutics #Pharmacognosy #PharmaceuticalChemistry #PharmacyPractice #CommunityPharmacy #HospitalPharmacy #IndustrialPharmacy #RegulatoryAffairs #DrugFormulation #DrugDelivery #PharmacyManagement #PharmaceuticalTechnology #PharmacyEducation #ClinicalTrials
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https://lnkd.in/gYqzuUA4 Article Title: Spray dried self-nanoemulsifying drug delivery systems for sertraline HCl: Pharmacokinetic study in healthy volunteers Author(s): Hussein O. Ammar, Mahmoud M. Ghorab, Dina M. Mostafa, and Amira M. Ghoneim* Journal: International Journal of Pharmaceutical Sciences and Developmental Research Journal ISSN: 2640-7760 Abstract: Purpose: The aim of this study is to improvelow oral bioavailability of sertraline HCl by formulation and characterization ofsolid self-nanoemulsifying drug delivery system [SNEDDS] using spray drying technique. Methods: Solubility of sertraline HCl in different vehicles was determined, and ternary phase diagrams were constructed.Various formulations were prepared and characterized by morphological characterization, differential scanning calorimetry and droplet size analysis. The formulations were evaluated for In vitro release profile in comparison to the marketed product [Lustral® tablets]. The In vivo study was performed on healthy human volunteers for pharmacokinetic analysis of the optimized formulations. #SertralineHCl #Spraydrying #SelfNanoemulsifying #ReleaseBioavailability #Pharmacokinetics #Antidepressives #Pharmacy #Pharmacology #PharmaceuticalSciences #ClinicalPharmacy #MedicinalChemistry #DrugDevelopment #Pharmacokinetics #Pharmacodynamics #Pharmacogenomics #Toxicology #Pharmaceutics #Biopharmaceutics #Pharmacognosy #PharmaceuticalChemistry #PharmacyPractice #CommunityPharmacy #HospitalPharmacy #IndustrialPharmacy #RegulatoryAffairs #DrugFormulation #DrugDelivery #PharmacyManagement #PharmaceuticalTechnology #PharmacyEducation #ClinicalTrials
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https://lnkd.in/gZZpfqdP Article Title: Regarding the measurement of therapeutic adherence Author(s): Sara Malo* Journal: International Journal of Pharmaceutical Sciences and Developmental Research Journal ISSN: 2640-7760 Adherence to chronic therapies among population living in developed countries has been estimated about 50% [1]. This is a matter of concern, since poor adherence is associated with suboptimal clinical outcomes, increased frequency of adverse effects and high healthcare expenses [2]. #MedicinalChemistry #DrugDevelopment #Pharmacokinetics #Pharmacodynamics #Pharmacogenomics #Toxicology #Pharmaceutics #Biopharmaceutics #Pharmacognosy #PharmaceuticalChemistry #PharmacyPractice #CommunityPharmacy #HospitalPharmacy #IndustrialPharmacy #RegulatoryAffairs #DrugFormulation#DrugDelivery #PharmacyManagement #PharmaceuticalTechnology #PharmacyEducation #ClinicalTrials
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https://lnkd.in/gkVQeqRf Article Title: A Pharmacokinetic Analysis and Pharmacogenomic Study of 6-mercaptopurine Author(s): Vicha A, Katsila T, Giannopoulou E, Leontari H, El Mubarak M, Gravia A, Chondrou V, Symeonidis A, Patrinos GP, Kalofonos HP and Sivolapenko G* Journal: International Journal of Pharmaceutical Sciences and Developmental Research Journal ISSN: 2640-7760 Abstract Background: The efficacy and safety of 6-mercaptopurine (6-MP) therapy rely on the concentration of its metabolites. The aim of the current study is the pharmacokinetic analysis of 6-MP and the detection of its metabolites as well as the role of Thiopurine S-methyl transferase (TPMT), the enzyme associated with 6-MP metabolism, as a pharmacogenomics biomarker. #6Mercaptopurine #Pharmacokineticanalysis #ThiopurineSmethyltransferase #Pharmacy #Pharmacology #PharmaceuticalSciences #ClinicalPharmacy #MedicinalChemistry #DrugDevelopment #Pharmacokinetics #Pharmacodynamics #Pharmacogenomics #Toxicology #Pharmaceutics #Biopharmaceutics #Pharmacognosy #PharmaceuticalChemistry #PharmacyPractice #CommunityPharmacy #HospitalPharmacy #IndustrialPharmacy #RegulatoryAffairs #DrugFormulation #DrugDelivery #PharmacyManagement #PharmaceuticalTechnology #PharmacyEducation #ClinicalTrials
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https://lnkd.in/g5-wtYMy Article Title: Preparation of itraconazole nanoparticles and its topical nanogel: Physicochemical properties and stability studies Author(s): Kamlesh Amrut Wadile, Pradum Pundlikrao Ige* and Raju Onkar Sonawane Journal: International Journal of Pharmaceutical Sciences and Developmental Research Journal ISSN: 2640-7760 Abstract: The need of present study hypothesized due to drug has low bioavailability (55%) because of low aques solubility and first pass effect. Nanoparticles were prepared by solvent diffusion method by using different stabilizers such as Tween80, Pluronic F127, Sodium lauryl sulfate, span 80 and Polyvinyl alcohol. The prepared nanoparticles were characterized through particle size, polydispersity index (PDI), zeta potential, drug content, in vitro drug release study, infra-red spectroscopy, X-ray powder diffractometry and scanning electron microscopy. #Itraconazole #Nanoparticles #Topicalnanogel #Antifungalactivity #Pharmacy #Pharmacology #PharmaceuticalSciences #ClinicalPharmacy #MedicinalChemistry #DrugDevelopment #Pharmacokinetics #Pharmacodynamics #Pharmacogenomics #Toxicology #Pharmaceutics #Biopharmaceutics #Pharmacognosy #PharmaceuticalChemistry #PharmacyPractice #CommunityPharmacy #HospitalPharmacy #IndustrialPharmacy #RegulatoryAffairs #DrugFormulation #DrugDelivery #PharmacyManagement #PharmaceuticalTechnology #PharmacyEducation #ClinicalTrials
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https://lnkd.in/gZ8WiDmA Article Title: Controlled release of 5-Fluorouracil by a novel L-Lysine based polyesterurethane material synthesized from Epoxide and CO2 via a novel dicopper salen catalyst Author(s): Arunangshu Kundu, Gobinda Chandra De* and Sushobhan Ghosh* Journal: Peertechz Journal of Clinical Pharmacology and Clinical Pharmacokinetics Journal ISSN: 2692-4757 Abstract: Controlled release of anticancer drug 5-Fluorouracil by several delivery systems are known including porous polymeric materials. Herein we report a novel L-lysine based porous polyesterurethane material 1 which acts as a controlled release vehicle for 5-Fluorouracil. Polyesterurethane material 1 was synthesized from a green isocyanate and phosgene free synthetic route involving conversion of epoxide 2-(phenoxymethyl)oxirane and co2 to cyclic carbonate 2 followed by ring opening with an amino acid L-Lysine to a bishydroxy compound 3 under green aqueous reaction condition. The bishydroxy compound 3 was subsequently reacted with 0.66 equivalent of trimesyl chloride in presence of triethyl amine to get the polyesterurethane material 1. The polyesterurethane material 1 was characterized via NMR, IR and MALDI analysis. From the SEM image of the polyesterurethane 1 and 5-Fluorouracil encapsulated polyesterurethane 1 it is evident that material 1 remain with porous topology which is filled by 5-Fluorouracil that is further evidenced by EDX spectroscopy with the presence of Fluorine. The controlled release of 5-Fluorouracil from the drug encapsulated 1 was monitored via UV visible spectroscopy at pH 7.4. #Polyesterurethane #Cycliccarbonate #ControlledRelease #5Fluorouracil #Pharmacy #Pharmacology #PharmaceuticalSciences #ClinicalPharmacy #MedicinalChemistry #DrugDevelopment #Pharmacokinetics #Pharmacodynamics #Pharmacogenomics #Toxicology #Pharmaceutics #Biopharmaceutics #Pharmacognosy #PharmaceuticalChemistry #PharmacyPractice #CommunityPharmacy #HospitalPharmacy #IndustrialPharmacy #RegulatoryAffairs #DrugFormulation #DrugDelivery #PharmacyManagement #PharmaceuticalTechnology #PharmacyEducation #ClinicalTrials
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