Pharmacy Group Journals’ Post

https://lnkd.in/gWts95Ra Article Title: Synergistic antifungal effectiveness of essential oils from andean plants combined with commercial drugss Author(s): Beatriz Lima, Maximiliano Sortino, Alejandro Tapia and Gabriela E Feresin* Journal: International Journal of Pharmaceutical Sciences and Developmental Research Journal ISSN: 2640-7760 Abstract The appearance of antifungal resistance promotes the investigation of therapeutic options. There are few studies on the combined effect of antifungal drugs and essential oils (EOs). In the present work, regarding the association of eight EOs Andean plants with antifungal agents against a panel of fungi strains. Combinatorial effects were determined using the Fractional Inhibitory Concentration Index (FICI) and Dose Reduction Index (DRI). A combination of A. cryptantha-B EO with fluconazole showed a synergistic effect against C. Albicans (FIC = 0.31 and DRI = 16.25). EOs from A. cryptantha-A and L. integrifolia showed an additive effect (FICI = 0.75) against C. neoformans. A combination of EOs from A. seriphioides and A. cryptantha-A with terbinafine showed an additive effect on T. rubrum (FIC = 0.56; DRI = 16) and M. gypseum (FICI = 1.03; DRI = 32). In conclusion, combinations between EOs of species from Andean plants and commercial antifungal drugs yielded some interesting findings, as potential antifungal strategies used for treating infections associated with C. Albicans and T. rubrum . #Antifungal #Essentialoil #Synergism #Azorellacryptantha #Candidaalbicans #MedicinalChemistry #DrugDevelopment #Pharmacokinetics #Pharmacodynamics #Pharmacogenomics #Toxicology #Pharmaceutics #Biopharmaceutics #Pharmacognosy #PharmaceuticalChemistry #PharmacyPractice #CommunityPharmacy #HospitalPharmacy #IndustrialPharmacy #RegulatoryAffairs #DrugFormulation#DrugDelivery #PharmacyManagement #PharmaceuticalTechnology #PharmacyEducation #ClinicalTrials

https://lnkd.in/gAmYqQHS Article Title: In-silico analysis of tenidap and its derivative as a novel 5-lipoxygenase inhibitor Author(s): Asma Noor*, Ardas Masood, Jawaria Khan, Tanveer Abbas and Muhammad Imran Qadir Journal: International Journal of Pharmaceutical Sciences and Developmental Research Journal ISSN: 2640-7760 Abstract: Tenidap is a derivative of Flavonoids which are actually plant derivatives, it shows inhibition activity of 5-lipoxygenase. Molecular models were directed to discover molecular docking mode, also to help explain molecular tool behind its inhibitory action. Molecular relations of tenidap with the catalytic trio (His523, His518, Ile875) inside active or dynamic position of 5-lipoxygenase through hydrogen bonding, appears to the major reason elaborate in its substantial 5-lipoxygenase activity of inhibition. #Tenidap #5lipoxygenase #Antiinflammatoryeffect #Pharmacy #Pharmacology #PharmaceuticalSciences #ClinicalPharmacy #MedicinalChemistry #DrugDevelopment #Pharmacokinetics #Pharmacodynamics #Pharmacogenomics #Toxicology #Pharmaceutics #Biopharmaceutics #Pharmacognosy #PharmaceuticalChemistry #PharmacyPractice #CommunityPharmacy #HospitalPharmacy #IndustrialPharmacy #RegulatoryAffairs #DrugFormulation #DrugDelivery #PharmacyManagement #PharmaceuticalTechnology #PharmacyEducation #ClinicalTrials

https://lnkd.in/gkmsAQhw Article Title: In Silico Estimation of Skin Concentration of Dermally Metabolized Chemicals Author(s): Tomomi Hatanaka, Saki Yamamoto, Mayuko Kamei, Wesam R Kadhum, Hiroaki Todo and Kenji Sugibayashi* Journal: International Journal of Pharmaceutical Sciences and Developmental Research Journal ISSN: 2640-7760 Abstract Background: A great deal of In Silico estimation methods were proposed for skin concentration and permeation of drugs by many researchers including us. The aim of the present study was to expand our In Silico estimation method of skin concentration to dermally metabolized chemicals. #Skinconcentration #Dermallymetabolizedchemical #InSilicoestimation #Skinpermeation #Skinmetabolism #Estercompound #Pharmacy #Pharmacology #PharmaceuticalSciences #ClinicalPharmacy #MedicinalChemistry #DrugDevelopment #Pharmacokinetics #Pharmacodynamics #Pharmacogenomics #Toxicology #Pharmaceutics #Biopharmaceutics #Pharmacognosy #PharmaceuticalChemistry #PharmacyPractice #CommunityPharmacy #HospitalPharmacy #IndustrialPharmacy #RegulatoryAffairs #DrugFormulation #DrugDelivery #PharmacyManagement #PharmaceuticalTechnology #PharmacyEducation #ClinicalTrials

The European Medicines Agency (#EMA) has recently released a draft guideline on the development and manufacture of synthetic #oligonucleotides. This comprehensive guideline covers crucial aspects to ensure the quality, safety, and efficacy of these advanced therapeutic agents. 🔍 Key Points of the Guideline: ➡ Manufacturing Process: Detailed guidance on the synthesis of oligonucleotides, including solid-phase and alternative methods, ensuring high-quality production standards. ➡ Characterization and Specifications: Requirements for structural elucidation, impurity profiling, and analytical methods to guarantee the consistency and purity of the active substance. ➡ Conjugation and Active Substance in Solution: Standards for the conjugation of oligonucleotides and the stability and characterization of the active substance when in solution. ➡ Medicinal Product Development: Comprehensive instructions for the development of oligonucleotide-based medicinal products, including personalized medicine approaches. ➡ Clinical Trial Applications: Specific requirements for the quality documentation needed for clinical trial applications, ensuring thorough evaluation of safety and efficacy. ➡  Generics Development: Guidelines for the development of generic oligonucleotide products, promoting innovation and accessibility in the pharmaceutical market. 📅 Consultation Period: The public consultation period starts on July 22, 2024, and will run until January 31, 2025. Follow us for regulatory updates and scientific insights! 💻www.toxhub-consulting.com 📩 info@toxhub-consulting.com #ToxHub #Consultancy #Consulenza #Tossicologia #Toxicology #Pharma

https://lnkd.in/g8bExAEP Article Title: Developing analytical parameters and evaluation of thermo fisher urinary creatinine enzymatic method to implement in open system chemistry analyzers Author(s): Ashraf Mina*, Leah McNeice, Shanmugam Banukumar and Santiago Vazquez Journal: International Journal of Pharmaceutical Sciences and Developmental Research Journal ISSN: 2640-7760 Abstract: Creatinine assay is used mainly to monitor kidney function and for sample validity when testing for drugs of abuse. Creatinine alkaline picrate method based on Jaffe’s reaction calls for extra cleaning procedures to minimize interference from picric acid and sodium hydroxide. Thermo Fisher enzymatic method is more sensitive and specific when compared to alkaline picrate method, but there were no available analytical parameters to setup this enzymatic method on open chemistry analyses platform such as Beckman-Coulter AU5800 analyser. Specific analytical parameters were developed and the assay performance is evaluated against the alkaline picrate method. We successfully set up analytical parameters on Beckman-Coulter AU5800, as an example of open system analyser, and evaluated its performance against Thermo Fisher Jaffe’s reaction method. The weighted Deming regression analysis for 408 samples showed a good correlation at a 95% confidence interval. Slope is 1.065 to 1.091, Y-intercept when X=0.0 is -0.9377 to -0.5443 and correlation coefficient (r) is 0.993. The alkaline picrate method Mean and SD for tested samples are 13.2877 and 7.414 respectively and for the enzymatic method are 13.5823 and 7.987 respectively. Many interferences from drugs and other substances are eliminated when using the enzymatic method and the stability of other reagents on-board improved because the reagents used in the enzymatic method are less invasive. #Creatinine #Enzymaticcreatinine #Samplevaliditytesting #Urinarycreatinine #MedicinalChemistry #DrugDevelopment #Pharmacokinetics #Pharmacodynamics #Pharmacogenomics #Toxicology #Pharmaceutics #Biopharmaceutics #Pharmacognosy #PharmaceuticalChemistry #PharmacyPractice #CommunityPharmacy #HospitalPharmacy #IndustrialPharmacy #RegulatoryAffairs #DrugFormulation#DrugDelivery #PharmacyManagement #PharmaceuticalTechnology #PharmacyEducation #ClinicalTrials

https://lnkd.in/gZZpfqdP Article Title: Regarding the measurement of therapeutic adherence Author(s): Sara Malo* Journal: International Journal of Pharmaceutical Sciences and Developmental Research Journal ISSN: 2640-7760 Adherence to chronic therapies among population living in developed countries has been estimated about 50% [1]. This is a matter of concern, since poor adherence is associated with suboptimal clinical outcomes, increased frequency of adverse effects and high healthcare expenses [2]. #MedicinalChemistry #DrugDevelopment #Pharmacokinetics #Pharmacodynamics #Pharmacogenomics #Toxicology #Pharmaceutics #Biopharmaceutics #Pharmacognosy #PharmaceuticalChemistry #PharmacyPractice #CommunityPharmacy #HospitalPharmacy #IndustrialPharmacy #RegulatoryAffairs #DrugFormulation#DrugDelivery #PharmacyManagement #PharmaceuticalTechnology #PharmacyEducation #ClinicalTrials

https://lnkd.in/g5-wtYMy Article Title: Preparation of itraconazole nanoparticles and its topical nanogel: Physicochemical properties and stability studies Author(s): Kamlesh Amrut Wadile, Pradum Pundlikrao Ige* and Raju Onkar Sonawane Journal: International Journal of Pharmaceutical Sciences and Developmental Research Journal ISSN: 2640-7760 Abstract: The need of present study hypothesized due to drug has low bioavailability (55%) because of low aques solubility and first pass effect. Nanoparticles were prepared by solvent diffusion method by using different stabilizers such as Tween80, Pluronic F127, Sodium lauryl sulfate, span 80 and Polyvinyl alcohol. The prepared nanoparticles were characterized through particle size, polydispersity index (PDI), zeta potential, drug content, in vitro drug release study, infra-red spectroscopy, X-ray powder diffractometry and scanning electron microscopy. #Itraconazole #Nanoparticles #Topicalnanogel #Antifungalactivity #Pharmacy #Pharmacology #PharmaceuticalSciences #ClinicalPharmacy #MedicinalChemistry #DrugDevelopment #Pharmacokinetics #Pharmacodynamics #Pharmacogenomics #Toxicology #Pharmaceutics #Biopharmaceutics #Pharmacognosy #PharmaceuticalChemistry #PharmacyPractice #CommunityPharmacy #HospitalPharmacy #IndustrialPharmacy #RegulatoryAffairs #DrugFormulation #DrugDelivery #PharmacyManagement #PharmaceuticalTechnology #PharmacyEducation #ClinicalTrials

https://lnkd.in/gYqzuUA4 Article Title: Spray dried self-nanoemulsifying drug delivery systems for sertraline HCl: Pharmacokinetic study in healthy volunteers Author(s): Hussein O. Ammar, Mahmoud M. Ghorab, Dina M. Mostafa, and Amira M. Ghoneim* Journal: International Journal of Pharmaceutical Sciences and Developmental Research Journal ISSN: 2640-7760 Abstract: Purpose: The aim of this study is to improvelow oral bioavailability of sertraline HCl by formulation and characterization ofsolid self-nanoemulsifying drug delivery system [SNEDDS] using spray drying technique. Methods: Solubility of sertraline HCl in different vehicles was determined, and ternary phase diagrams were constructed.Various formulations were prepared and characterized by morphological characterization, differential scanning calorimetry and droplet size analysis. The formulations were evaluated for In vitro release profile in comparison to the marketed product [Lustral® tablets]. The In vivo study was performed on healthy human volunteers for pharmacokinetic analysis of the optimized formulations. #SertralineHCl #Spraydrying #SelfNanoemulsifying #ReleaseBioavailability #Pharmacokinetics #Antidepressives #Pharmacy #Pharmacology #PharmaceuticalSciences #ClinicalPharmacy #MedicinalChemistry #DrugDevelopment #Pharmacokinetics #Pharmacodynamics #Pharmacogenomics #Toxicology #Pharmaceutics #Biopharmaceutics #Pharmacognosy #PharmaceuticalChemistry #PharmacyPractice #CommunityPharmacy #HospitalPharmacy #IndustrialPharmacy #RegulatoryAffairs #DrugFormulation #DrugDelivery #PharmacyManagement #PharmaceuticalTechnology #PharmacyEducation #ClinicalTrials

https://lnkd.in/gqJAWgZw Article Title: Is it possible to perform molecular hybridization between acetaminophen and nitric oxide donor molecule? Author(s): João Gabriel Gouvêa-Silva, Leonardo Ribeiro Bernardo, Ygor Jessé Ramos* and Antônio José Calixto de Souza Journal: International Journal of Pharmaceutical Sciences and Developmental Research Journal ISSN: 2640-7760 Opinion Paracetamol (Acetaminophen) belongs to the class of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), having an analgesic, antipyretic and mild anti-inflammatory action due to a weak inhibitory action on cyclooxygenase isoenzymes, COX-1 and COX-2. These isoenzymes are responsible for the synthesis of prostanoids that have several physiological effects, such as: vasodilation; increased renal blood flow; stimulation of gastric protective mucus production; inhibition of gastric acid secretion responsible for reducing acidity in gastric tissue, among other effects. Despite its beneficial effects, the excessive use of NSAIDs is related to several adverse effects, which can alter the homeostasis of the cardiovascular, renal and gastric system [1]. #MedicinalChemistry #DrugDevelopment #Pharmacokinetics #Pharmacodynamics #Pharmacogenomics #Toxicology #Pharmaceutics #Biopharmaceutics #Pharmacognosy #PharmaceuticalChemistry #PharmacyPractice #CommunityPharmacy #HospitalPharmacy #IndustrialPharmacy #RegulatoryAffairs #DrugFormulation#DrugDelivery #PharmacyManagement #PharmaceuticalTechnology #PharmacyEducation #ClinicalTrials

https://lnkd.in/giQPPbCR Article Title: Edaravone Protects against Vascular Oxidative Damage Induced by AAPH in Chick Embryo Author(s): Xin Wan, Meng-Xun Luo, Chong Jie, Tong Wu, Gui-Yuan Yu, Yi-Fang Li, Rong-Rong He and Hiroshi Kurihara* Journal: International Journal of Pharmaceutical Sciences and Developmental Research Journal ISSN: 2640-7760 Abstract Background: Edaravone (Eda) is a free-radical scavenger which is used in treating stroke, cerebral hemorrhage and some other diseases in clinic. However, it’s antioxygenation during development is still unknown. #Edaravone #AAPH #Growthretardation #Angiogenesis #Oxidativedamage #Pharmacy #Pharmacology #PharmaceuticalSciences #ClinicalPharmacy #MedicinalChemistry #DrugDevelopment #Pharmacokinetics #Pharmacodynamics #Pharmacogenomics #Toxicology #Pharmaceutics #Biopharmaceutics #Pharmacognosy #PharmaceuticalChemistry #PharmacyPractice #CommunityPharmacy #HospitalPharmacy #IndustrialPharmacy #RegulatoryAffairs #DrugFormulation #DrugDelivery #PharmacyManagement #PharmaceuticalTechnology #PharmacyEducation #ClinicalTrials