Pharmacy Group Journals’ Post

Novel Drug Approval by FDA in 2024 2) REZDIFFRA (resmetirom) Introduction REZDIFFRA, a thyroid hormone receptor-beta (THR-β) agonist, treats adults with noncirrhotic NASH and moderate to advanced liver fibrosis (F2 to F3). Approved under accelerated approval, it represents a breakthrough in managing NASH alongside diet and exercise. Mechanism of Action REZDIFFRA activates the THR-β receptor in the liver, reducing liver fat, which is key in treating NASH. Lab tests show that REZDIFFRA almost matches the activity of natural thyroid hormone (T3) on THR-β, while having minimal effects on THR-α, which is more active in the heart and bones. This selective action targets the liver effectively without causing unwanted side effects. Dose REZDIFFRA dosage depends on body weight:<100 kg: 80 mg orally, once daily ≥100 kg: 100 mg orally, once dailyIt can be taken with or without food. Adverse Effects Common side effects include diarrhea, nausea, constipation, pruritus, dizziness, and abdominal pain. Regular monitoring helps manage these effects. Contraindications Avoid REZDIFFRA in patients with decompensated cirrhosis or moderate to severe hepatic impairment (Child-Pugh Class B or C). Use caution when combining it with drugs affecting CYP2C8. Uses REZDIFFRA is indicated for adults with noncirrhotic NASH and moderate to advanced liver fibrosis, aiming to halt liver damage progression. #Hepatology #LiverHealth #PharmaUpdate #medicine #pharma #pharmacy #drchakradharwadhekar

Interesting I just had a conversation with a group of dietitians at dinner about MASH in kids (hello high fructose corn syrup).. and open up my computer to see the headline. What do we think? New drug therapy option for MASH, metabolic dysfunction–associated steatohepatitis (New name NAFLD). Nerdy pharmacist over here looking at MOA and it's interesting! (it's an oral thyroid hormone receptor-beta selective agonist..nerdy pharmacist also now is going to research this more) Certainly there are a lot of #lifestylemedicine interventions that can help MASH and improving overall insulin resistance, but it is nice to see an option because the overall healthcare system is burdened by this. The cost of MASH is enormous across the system and likely it will reduce cost, but can we ban HFCS, get people proper choline and address their microbiome too? #nafld #mash #diabetes #obesity #liverfailure #cirrhosis #integrativemedicine #pharmacists #pharmacist https://lnkd.in/gzzPvPJF

Paracetamol (acetaminophen) toxicity occurs when the liver is overwhelmed by a toxic metabolite called N-acetyl-p-benzoquinone imine (NAPQI), which is normally detoxified by glutathione. In overdose, glutathione is depleted, and NAPQI accumulates, leading to liver damage. Symptoms of paracetamol toxicity develop in stages: Stage 1 (0-24 hours): Nausea, vomiting, sweating, and pallor. • Stage 2 (24-72 hours): Liver damage becomes evident with right upper abdominal pain, elevated liver enzymes, and signs of hepatotoxicity. Stage 3 (72-96 hours): Fulminant hepatic failure, jaundice, confusion, and potential multi-organ failure. Stage 4 (4-14 days): Recovery or death from liver failure. Drug treatment of paracetamol overdose: Activated charcoal (if within 1-4 hours of ingestion): Adsorbs paracetamol in the stomach, reducing absorption. V N-acetylcysteine (NAC): Main antidote, replenishes glutathione stores, preventing NAPQI buildup. It is most effective within 8 hours of overdose. v Liver transplant: In cases of severe liver failure where medical treatment is ineffective. Early treatment with NAC can prevent significant hepatotoxicity and improve outcomes. #paracetamol #acetaminophen #paracetamoltoxicity #acetaminophentoxicity #nacetylcysteine #activatedcharcoal #clinicalpharmacology #pharmacology #medicine #medstudent #pharmacystudent #pharmd #copied

Tomorrow I will have the pleasure to co-chair the session "Drug transporters and their impact on drug metabolism and disposition" with Sybille Neuhoff #MDO2024 in Prague! Will also be the opportunity to present some unpublished data on our latest study on virtual twinning using PBPK for direct oral anticoagulant, one of the largest in the field alongside very exciting talks from Matúš Soták Dirk Theile Matthew Harwood and Sibylle Neuhoff. #pharmacology #health #medicine #pharmacy #metabolism

🌟 𝐄𝐬𝐦𝐨𝐥𝐨𝐥 𝐇𝐲𝐝𝐫𝐨𝐜𝐡𝐥𝐨𝐫𝐢𝐝𝐞 𝐌𝐚𝐫𝐤𝐞𝐭: 𝐓𝐫𝐞𝐧𝐝𝐬, 𝐈𝐧𝐧𝐨𝐯𝐚𝐭𝐢𝐨𝐧𝐬, 𝐚𝐧𝐝 𝐅𝐮𝐭𝐮𝐫𝐞 𝐏𝐫𝐨𝐬𝐩𝐞𝐜𝐭𝐬 📈💊🌍 𝐂𝐥𝐢𝐜𝐤 𝐇𝐞𝐫𝐞, 𝐓𝐨 𝐆𝐞𝐭 𝐅𝐫𝐞𝐞 𝐒𝐚𝐦𝐩𝐥𝐞 𝐑𝐞𝐩𝐨𝐫𝐭 https://lnkd.in/gbZgaZDX 📊 Market Overview: The Esmolol Hydrochloride Market is experiencing steady growth driven by the increasing prevalence of cardiovascular diseases, advancements in drug formulations, and rising demand for emergency cardiovascular care. Esmolol hydrochloride's rapid onset and short duration of action make it ideal for acute management in clinical settings. 🌟 Key Trends and Insights: Increasing Cardiovascular Diseases: The global rise in cardiovascular conditions, such as arrhythmias and hypertension, is driving the demand for effective treatments like esmolol hydrochloride. Emergency Medicine: Esmolol hydrochloride is widely used in emergency departments and intensive care units, highlighting its importance in acute cardiovascular management. Innovative Formulations: Ongoing research and development are leading to improved formulations that enhance the drug's efficacy and patient compliance. Aging Population: The growing elderly population, which is more susceptible to cardiovascular diseases, is contributing to market growth. Regulatory Approvals: Favorable regulatory policies and approvals for new esmolol hydrochloride formulations are facilitating market expansion. #Company Abraxis BioScience Hikma Pharmaceuticals Baxter International General Injectables and Vaccines, Inc. Bayer Bioniche Pharma USA LLC Qilu Pharmaceuticals #Type 1ml:0.1g 2ml:0.2g #Application Hospitals Clinics Others #EsmololHydrochloride #CardiovascularCare #EmergencyMedicine #Pharmaceuticals #HealthcareInnovation #PersonalizedMedicine #R&D

''Unlocking the Unique Benefits of Rosuvastatin: A Game-Changer in Cholesterol Management'' ➢➢Considering these parameters, rosuvastatin ➔has several advantages ➔not shared with several other statins (eg, atorvastatin). ➢➢ When some statins are metabolized in the liver, the common enzyme cytochrome ➔P4503A4 is activated but may also be simultaneously➔ functioning to metabolize other ➔drugs. ➢ ➢P4503A4 catalyzes more than 50% of clinically used drugs. ➢➢Rosuvastatin has the advantage that it is 90% excreted metabolically unchanged ➔ (primarily in the bile) so that minimal ➔drug−drug interactions occur. ➢➢In addition rosuvastatin is the most potent of ➔available statins such that 10 mg/d provides the same LDL reduction as ➔40 mg/d of atorvastatin. ➢➢When rosuvastatin was directly compared with atorvastatin, simvastatin, and pravastatin at all available dosages in a randomized controlled trial ➔rosuvastatin was superior to all other statins in lowering LDL➔ cholesterol. ➢➢Because rosuvastatin is a very potent statin in➔ lowering LDL cholesterol,➔ it is possible to utilize a low dose ➔of this drug (10 mg/d) to achieve a➔ very significant reduction in LDL cholesterol (approximately 40%). ➢➢In addition, rosuvastatin at a dose of 10 mg/d does➔ not increase the risk of diabetes. References:- (1)https://lnkd.in/dSmEcBCk) (2)https://lnkd.in/dGdn5QMX (3)https://lnkd.in/dGdn5QMX #pharmacology #pharmacotherapeutics #pharmd #clinical #hyperlipidemia #discussion #hearthealth #statins #rosuvastatin #LDL #healthcare

📚 Day 13 of the 30-Day Continuous Learning Challenge: Quiz and Reflection It’s Day 13! Today, let’s test your knowledge with a quiz on pharmacodynamic interactions. This will help reinforce the concepts we’ve covered over the past week. Take your time and think through each question. Quiz 1. Which of the following drug pairs is an example of an antagonistic interaction? • A. Warfarin and Vitamin K • B. Lisinopril and Hydrochlorothiazide • C. Metformin and Insulin • D. NSAIDs and Anticoagulants 2. A patient taking both digoxin and verapamil may experience increased risk of: • A. Hypertension • B. Hyperglycemia • C. Bradycardia • D. Hypokalemia 3. Which of the following drug pairs could potentially cause serotonin syndrome? • A. Sertraline and Sumatriptan • B. Atenolol and Amlodipine • C. Warfarin and Aspirin • D. Metformin and Glipizide 4. Combining benzodiazepines with opioids can lead to: • A. Increased anticoagulant effect • B. Severe respiratory depression • C. Decreased blood glucose levels • D. Enhanced diuretic effect 5. Which of the following drug interactions involves an antagonistic effect? • A. Naloxone and Morphine • B. Lisinopril and Hydrochlorothiazide • C. Metformin and Insulin • D. Clopidogrel and Aspirin Tomorrow, we’ll start with Drug-Food interactions. Keep up the great work and stay engaged! #Pharmacy #DrugInteractions #MedicationSafety #Pharmacology #HealthcareProfessionals

🌿 New Research Alert: Early Detection of Drug-Herb Interactions! 💊 A recent study investigates the pharmacokinetics, bioactivity, and potential interactions between green tea catechins and common cardiovascular drugs. With the growing use of herbal remedies like green tea for cardiovascular disease (CVD), the need for rapid screening of drug interactions is crucial. Key Findings: • Drug Interactions: Green tea catechins, particularly Epigallocatechin Gallate (EGCG), Epicatechin Gallate (ECG), Epigallocatechin (ECG), and Epicatechin (EC), show strong affinity for CVD drugs CYPs, such as Metoprolol, Amlodipine, and Atorvastatin, potentially disrupting their metabolism. • CYP2B6 and CYP2C8: The study found potential interactions with metabolic pathways involving CYP2B6 and CYP2C8, affecting drug metabolism and leading to possible complications. • Computational Methods: Web-ligand-based pharmacokinetic screening and molecular docking methods were used for early detection, demonstrating promising predictions of interactions, particularly for CYP2C8. Implications: These computational methods show promise as rapid screening tools for detecting herb-drug interactions, helping to optimize therapeutic management, such as adjusting dosages or spacing out herb intake to avoid adverse effects. Conclusion: Integrated computational methods present a promising tool for therapeutic management, improving patient care and quality of life by enabling more informed and tailored treatment decisions. Let's prioritize safe and informed use of herbal remedies alongside prescription drugs! 🌱💊 #DrugHerbInteractions #GreenTeaResearch #Pharmacokinetics #CVDManagement #MCBPoster24

Latest research publication with Prof. DI Dr. Winfried Neuhaus on the transport of NSAIDs across the oral mucosa Alternative administration routes to the tablet form for non-steroidal anti-inflammatory agents (NSAIDs) are particularly interesting for children and older people. In order to avoid the first-pass effect, the drugs can be administered in a variety of dosage forms, for example sublingually (under the tongue). To test the penetration of four selected active ingredients, a human oral mucosa in vitro model was developed and the permeability order of the active ingredients was determined. It was also shown that the transport of active ingredients through the oral mucosal epithelium is regulated by efflux transporter proteins and changes significantly under inflammatory conditions. To view the research paper published in the Journal Pharmaceutics please visit: https://lnkd.in/dFYwrbGh #medicine #healthcare #research #inflammation #bloodsalivabarrier #nonsteroidalantiphlogisticdrugs #pain #fever #nsaids #oralmucosa #saliva #prescriptiondrugs #medication #pharmaceuticaltechnology #biopharmaceutics #austria #niederosterreich #danubeprivateuniversity

📌 To keep updated 💡 Bempedoic acid is a novel nonstatin drug therapy currently FDA approved as an adjunct to diet and maximally tolerated statin therapy or Ezetimibe for the treatment of hypercholesterolemia and cardiovascular events by inhibiting the cholesterol biosynthesis in the same mechanism as statins, Whereas statins inhibit HMG CoA reductase, bempedoic acid inhibits ATP-citrate lyase (ACL), two steps upstream of HMG CoA reductase. Unlike statins, bempedoic acid is a prodrug and activated *only by liver enzymes and not in muscles. So, the lack of active metabolites in skeletal muscles obviously reduces the rhabdomyolysis and statin-associated muscle symptoms (SAMS).* 🚨Side effects⁉️ 1-bempedoic acid is associated with hyperuricemia and gout symptoms especially in patients with history of gout. 2- also slightly associated with increased risk of tendon rupture, pain in arms and legs and the risk may be higher in patients over 60 years of age. Dose 💊: According to FDA guidelines, bempedoic acid is recommended to be taken orally 180 mg once daily with or without food in combination with maximally tolerated statin therapy. #zetacolest #Nexletol #clinicalpharmacy #pharmacist #clinicalpharmacist #FDA_guidelines #pharmacist_knowledge #American_Heart_Association #American_College_of_cardiology #national_institute_of_health_NIH #statin_therapy