Pharmacy Group Journals’ Post

FAKE PILLS! HOW CAN YOU TELL YOUR PROVIDERS? Recently, we tested a urine specimen from a patient that was on #oxycodone for #chronicpain. The #confirmatorydrugtesting came positive for fentanyl and its metabolite nor fentanyl. The prescribing clinician was a primary care physician. He called the lab and said, “the patient denies consuming fentanyl and the patient is 65 years old female that has been my patient for several years and I trust her”. We looked at #chromatographypeaks on the #LCMS and everything showed that there was no mistake. When we contacted the prescribing physician and told him that we think there is no mistake and the patient most likely consumed fentanyl, he was not happy with our answer. There is a possibility of laboratory error with urine drug testing using confirmatory method. However, we think there are other explanations for this event. Recent reports from CDC (1) and DEA (2) indicate that fake pills consumption is growing in the United Sates at a fast pace. We think it is possible that the patient used a fake pill that was laced with fentanyl. When we searched to see if there is any scientific report discussing the effects of fake pills on laboratory results of drug testing, unfortunately, NONE was found. We were wondering if other laboratories had the same experience regarding the impact of fake pills on results of #drugtesting. https://lnkd.in/gfjgph32 https://lnkd.in/gPTqiHdj Mehran Haidari PhD, DABCC (CC, CT) Contact us at: info@avicennalabconsulting.com for clinical supports on #Moleculardiagnostics and #Toxicology

https://lnkd.in/giQPPbCR Article Title: Edaravone Protects against Vascular Oxidative Damage Induced by AAPH in Chick Embryo Author(s): Xin Wan, Meng-Xun Luo, Chong Jie, Tong Wu, Gui-Yuan Yu, Yi-Fang Li, Rong-Rong He and Hiroshi Kurihara* Journal: International Journal of Pharmaceutical Sciences and Developmental Research Journal ISSN: 2640-7760 Abstract Background: Edaravone (Eda) is a free-radical scavenger which is used in treating stroke, cerebral hemorrhage and some other diseases in clinic. However, it’s antioxygenation during development is still unknown. #Edaravone #AAPH #Growthretardation #Angiogenesis #Oxidativedamage #Pharmacy #Pharmacology #PharmaceuticalSciences #ClinicalPharmacy #MedicinalChemistry #DrugDevelopment #Pharmacokinetics #Pharmacodynamics #Pharmacogenomics #Toxicology #Pharmaceutics #Biopharmaceutics #Pharmacognosy #PharmaceuticalChemistry #PharmacyPractice #CommunityPharmacy #HospitalPharmacy #IndustrialPharmacy #RegulatoryAffairs #DrugFormulation #DrugDelivery #PharmacyManagement #PharmaceuticalTechnology #PharmacyEducation #ClinicalTrials

A lesson from Toxicology Drug Testing!

https://lnkd.in/gsH5eS6n Article Title: Diabesity Increases Inflammation and Oxidative Stress Author(s): Dayre A, Pouvreau C, Butkowski EG, de Jong B and Jelinek HF* Journal: International Journal of Pharmaceutical Sciences and Developmental Research Journal ISSN: 2640-7760 Abstract Background: Inflammation and oxidative stress are two pathophysiological mechanisms that link obesity, type 2 diabetes mellitus (T2DM) and diabesity. However how levels of inflammatory and oxidative stress markers differ between patients with obesity, T2DM and diabesity has not been completely elucidated. #Diabesity #Inflammation #Oxidativestress #Biomarkers #Pharmacy #Pharmacology #PharmaceuticalSciences #ClinicalPharmacy #MedicinalChemistry #DrugDevelopment #Pharmacokinetics #Pharmacodynamics #Pharmacogenomics #Toxicology #Pharmaceutics #Biopharmaceutics #Pharmacognosy #PharmaceuticalChemistry #PharmacyPractice #CommunityPharmacy #HospitalPharmacy #IndustrialPharmacy #RegulatoryAffairs #DrugFormulation #DrugDelivery #PharmacyManagement #PharmaceuticalTechnology #PharmacyEducation #ClinicalTrials

https://lnkd.in/gwUAFkiA Article Title: Antidiabetic, Antihypertensive and Statin Medication Use in Metabolic Syndrome Author(s): Ie Butkowski E, Brix L, Al-Aubaidy HA, Kiat H and Jelinek HF* Journal: International Journal of Pharmaceutical Sciences and Developmental Research Journal ISSN: 2640-7760 Abstract Background: Metabolic syndrome (MetS) is characterised by a cluster of metabolic risk factors, which eventually increases the risk of diabetes and cardiovascular disease (CVD). The aim of the current study was to investigate medication use in outpatient communities with respect to the occurrence of these metabolic risk factors as defined by ATPIII. #Pharmacy #Pharmacology #PharmaceuticalSciences #ClinicalPharmacy #MedicinalChemistry #DrugDevelopment #Pharmacokinetics #Pharmacodynamics #Pharmacogenomics #Toxicology #Pharmaceutics #Biopharmaceutics #Pharmacognosy #PharmaceuticalChemistry #PharmacyPractice #CommunityPharmacy #HospitalPharmacy #IndustrialPharmacy #RegulatoryAffairs #DrugFormulation #DrugDelivery #PharmacyManagement #PharmaceuticalTechnology #PharmacyEducation #ClinicalTrials

https://lnkd.in/ga4BpCpz Article Title: The use of pentoxifylline in male reproduction abnormalities Author(s): Aamir Jalal Al-Mosawi* Journal: International Journal of Pharmaceutical Sciences and Developmental Research Journal ISSN: 2640-7760 Abstract: Pentoxifylline a derivative of methylxanthine and nonspecific inhibitor of the phosphodiesterase with vasodilatory properties and rheological properties on blood that made it useful in the treatment of intermittent claudication. Pentoxifylline also has an immunomodulatory effect which inhibits inflammatory cytokines including tumor necrosis factor-alpha. The aim of this paper is to review the uses of pentoxifylline in male reproduction abnormalities. #Pentoxifylline #Male #Reproductiveabnormalities #Therapeuticeffects #MedicinalChemistry #DrugDevelopment #Pharmacokinetics #Pharmacodynamics #Pharmacogenomics #Toxicology #Pharmaceutics #Biopharmaceutics #Pharmacognosy #PharmaceuticalChemistry #PharmacyPractice #CommunityPharmacy #HospitalPharmacy #IndustrialPharmacy #RegulatoryAffairs #DrugFormulation#DrugDelivery #PharmacyManagement #PharmaceuticalTechnology #PharmacyEducation #ClinicalTrials

Real-time, preliminary #bioanalysis and biomarker data sets for in vivo general #toxicology and drug metabolism and #pharmacokinetics (DMPK) studies are available in Charles River’s Apollo ™. How will this latest addition expedite your #drugdevelopment? Find our from our bioanalysis expert Iain Love in this Q&A. https://okt.to/Pu5gc6

Real-time, preliminary #bioanalysis and biomarker data sets for in vivo general #toxicology and drug metabolism and #pharmacokinetics (DMPK) studies are available in Charles River’s Apollo ™. How will this latest addition expedite your #drugdevelopment? Find our from our bioanalysis expert Iain Love in this Q&A. https://okt.to/wxhLVf

https://lnkd.in/gViMHaSd Article Title: A cross sectional study of alcohol consumption and risk factors Author(s): R Dinesh Kumar, J Kalaiselvi and Siva S* Journal: International Journal of Pharmaceutical Sciences and Developmental Research Journal ISSN: 2640-7760 Abstract: Introduction: Alcohol consumption is an important contributor to the global burden of different disease such as stroke, sleep apnea, pancreatitis, diabetes mellitus, CAD and so on. Urban populations are having greater risk of getting the alcohol induced disease. #Alcohol #Hypertension #Diabetes #Sleepapnea #Prospectivestudy #MedicinalChemistry #DrugDevelopment #Pharmacokinetics #Pharmacodynamics #Pharmacogenomics #Toxicology #Pharmaceutics #Biopharmaceutics #Pharmacognosy #PharmaceuticalChemistry #PharmacyPractice #CommunityPharmacy #HospitalPharmacy #IndustrialPharmacy #RegulatoryAffairs #DrugFormulation#DrugDelivery #PharmacyManagement #PharmaceuticalTechnology #PharmacyEducation #ClinicalTrials

Evaluating the mutagenicity of nitrosamines is extremely critical, given their potential link to cancer. Our Enhanced Ames Test (EAT) is designed to provide comprehensive, reliable, and precise results, adhering to stringent EMA/409815/2020 and ICH S2 (R1) guidelines. Our multi-faceted approach includes:  ◾ Multiple tester strains (Salmonella, E. coli) to ensure accuracy  ◾ Metabolic activation using rat and hamster liver S9 extracts to simulate real-world biological conditions  ◾ Detailed reporting with in-depth data analysis With a commitment to the highest standards of safety and compliance, our EAT offers critical insights to safeguarding the safety of your pharmaceuticals and consumer products. Results are delivered within six weeks with a reliable, reproducible workflow. Partner with us to ensure your products meet the highest safety standards and uphold public health. Write to us at info@aragen.com or click on the link https://lnkd.in/gMM6aDde to know more about our EAT services. #toxicology #pharmaservices #mutagenic #nitrosamine #impurities #cdmo #cro #endtoendsolutions