PUXANO’s Post

🔬 Celebrating Research Innovation: Dolomite Telos 3D Flow Focus Chip in the Spotlight This publication in 'Colloids and Surfaces A' has put a spotlight on the capabilities of the Telos 3D Flow Focus Chip, part of Dolomite Microfluidics’ suite of instruments. Researchers Tymèle Deydier, Guido Bolognesi and Dr Goran Vladisavljevic at Loughborough University used our cutting-edge technology to push the boundaries of droplet generation to new heights. Highlights from the Paper: - Successful high-throughput production of monodisperse droplets with less than 3% variation. - Extended stable droplet generation in a rigorous 6-hour run. - Enhanced throughput with lower viscosity dispersed phases, ideal for creating drug microcarriers. This independent research not only demonstrates the Dolomite Telos System’s precision and robustness but also opens avenues for advancements in drug encapsulation and delivery. We are thrilled to see Dolomite Microfluidics’ technology play a pivotal role in advancing microfluidic applications. Explore the paper to see our instruments in action: https://lnkd.in/ebXMD9aZ #Microfluidics #HighThroughputProduction #Innovation #ScientificResearch #DrugDelivery #PharmaceuticalEngineering #MicrofluidicTechnology #Encapsulation

Advances in human biology continues to identify novel druggable targets. These new targets create fundamental challenges for medicinal chemists. Many of these new molecules are insoluble in water and have limited permeability in the small intestine. Serán BioScience specializes in a variety of drug delivery and formulation approaches that are ideally suited to optimizing bioavailability. Our PPS and risk-assessment based approach balances selection of the drug product intermediate technology with the highest possible exposure with other considerations such as stability, pill burden, material availability, timelines and patient experience giving our client's programs the strongest probability of success. Discover more about Serán and how our team can help you find the solutions your product needs. https://hubs.li/Q02pG-RN0 #CDMO #drugformulation #drugdevelopment #solubilityenhancement

Serán BioScience has decades of experience in particle engineering, including spray drying. Our technology enables delivery of drugs to a wide variety of biological targets, including the small intestine to enhance bioavailability, colonic, and pulmonary delivery. Whether considering enabling technologies (amorphous solid dispersions, lipid formulations, particle size reduction techniques) or conventional approaches, we comprehensively assess technology options to consider bio-performance, stability, manufacturability, and drug product design – aiming to deliver you the simplest approach that meets your program’s needs. Contact us to see how Serán's technical experience can give your drug the competitive edge. https://hubs.li/Q02vs3Rl0 #drugdevelopment #spraydrying #amorphousdispersion #ASD #CDMO

📘 Just Released: Dolomite’s Application Note on Advanced Droplet Generation for Drug Discovery and Molecule Encapsulation We're proud to publish an Application Note that epitomizes the capabilities of the Dolomite Mitos System. This detailed guide provides invaluable insights into the precision engineering of water droplets in FluoSurf carrier phases, showcasing our system's proficiency in creating a wide array of droplet sizes. ✨ Whether creating monodisperse droplets or encapsulating delicate biomolecules or microparticle generation, the Dolomite Mitos System is synonymous with unparalleled precision and control for academic and industry labs alike. Elevate your research precision today by exploring the full application note. Discover how Dolomite is driving forward the boundaries of scientific exploration and innovation. 🔗 https://lnkd.in/eCbUYgqm #Microfluidics #PrecisionEngineering #ResearchAndDevelopment #Science #microparticles #DrugDiscovery #Diagnostics #Pharmaceuticals #Biotech #Microencapsulation #Droplets

🚀 Boost Your Lab's Efficiency with the Formulatrix Mantis! 🧪 The Formulatrix Mantis is a game-changing liquid handler designed for precise, reliable microvolume dispensing—perfect for molecular biology, drug discovery, and high-throughput screening. 🌟 Key Highlights: ✅ Microfluidic Technology: Non-contact dispensing with unmatched accuracy. ✅ Flexible Volume Range: Handles from 0.1 µL to larger volumes. ✅ User-Friendly: Intuitive touchscreen for quick setup and seamless operation. ✅ Multi-Reagent Capability: Switch easily between reagents without contamination. ✅ Compact Design: Saves precious bench space. ✅ Broad Compatibility: Works with various plate formats (96-well, 384-well, and more). 🔬 Trusted for Critical Applications: ✔ PCR & qPCR Setup: Ensure precision and consistency. ✔ Assay Development: Biochemical and cell-based assays made easy. ✔ Protein Crystallization: Optimized workflows for crystallography. ✔ Drug Discovery: High-throughput compound screening with efficiency. 💡 Why Choose Mantis? It minimizes reagent waste, ensures reproducibility, and simplifies workflows, making it the go-to tool for scientists. 🌐 Ready to transform your lab? Contact sales@medlabdia.com to learn more! #LabAutomation #LiquidHandling #PrecisionScience #DrugDiscovery #MolecularBiology #Innovation All trademarks and registered trademarks appearing are property of the corresponding companies and are fully recognized by us!

I'm excited to share with you a game-changing technology that's transforming the field of biotherapeutic development. The Sartorius Octet system is a cutting-edge platform that's revolutionizing the way we conduct label-free detection for protein quantitation and kinetic characterization. What makes the Octet system so special? Here are a few reasons: ✅ Real-time analysis: The Octet system allows for the monitoring of biomolecular interactions in real-time, providing immediate insights into binding kinetics, affinity, and specificity. ✅ Versatility: Whether you're working with small molecules or large proteins, the Octet system is designed to handle a wide range of samples, making it a versatile tool for any lab. ✅ Efficiency: With the ability to analyze up to 96 samples simultaneously, the Octet system significantly increases throughput, saving valuable time and resources. The Sartorius Octet system is more than just a piece of equipment; it's a gateway to faster, more accurate discoveries that can lead to life-changing therapies. If you're interested in learning more about the capabilities of the Octet system, check out the link below: https://lnkd.in/gGCHC7P5 #Biotechnology #ProteinAnalysis #SartoriusOctet #Innovation #LabTech #ScienceAndTechnology

🤔Curious about the latest in #biotech #innovation? 🔬Don’t miss Dr. Richard Hailin Huang, Ph.D. from RedShiftBio on Aug 20th as he dives into #microfluidic #modulation #spectroscopy! Learn how #MMS is revolutionizing research in ligand binding, stability/aggregation, formulation screening, and biosimilarity. Join us in person or online to see how this tech can advance your work. 🌟🧪 👉Details here: https://ow.ly/nAoW50SXTy0 #UBC #BioProducts #IndustryCollaboration #Proteomics #DrugDevelopment #SustainableMaterials

Happy to share the first paper of this very nice and productive collaboration with the lab of Cees Dekker, a specific co-production between Xiuqi Chen 陈修齐, Jasper van de Sande, and Justas Ritmejeris. They accepted the challenge to use nanopore reading to distinguish sulfotyrosie (sY) from phosphotyrosine (pY). These two PTMs have virtually the same molecular weight, which makes them difficult to distinguish by mass spectrometry (MS). Even more, work-up procedures that are used to prepare biological samples for MS analysis are heavily biased towards the isolation and detection of phosphorylated amino acids (most notably Ser, Thr and Tyr), which often leads to overlooking of sulfated amino acids. This is particularly problematic for samples that have low quantities of sulfated amino acids, as is the case for plant peptide hormones (usually active in low nanomolar range). Surprisingly, these PTMs can readily be distinguished using nanopore reading, even when both sY and pY are placed in very close to each other (at position i and i+2). We also found that incorporation of such an anionic PTM in the reading sequence leads to an unexpected bump in the ionic current, providing important cues for next generation developments, especially when anionic PTMs need to be considered. It's been a great first development in this fresh collaboration, showing how nanopore reading can be used to assign PTMs that empower peptide phytohormones.

Perfusion Bioreactor and Related Methods of Use A U.S. Patent for a "Perfusion Bioreactor and Related Methods of Use" was awarded to Regeneron on April 23rd, 2024. The present invention is a method of controlling a bioreactor system includes providing a cell culture in a bioreactor, wherein conditions in the bioreactor enable the cell culture to produce a protein of interest (POI), measuring process parameters (PPs) of the culture within the bioreactor by RAMAN, wherein the process parameters are selected from the group consisting of nutrient concentration, viable cell concentration, and protein attributes, measuring a predetermined weight of the bioreactor with the cell culture... https://lnkd.in/dMuT_hFB #aspenalert #biotech #bioprocess

🚀 Accelerate your medicinal chemistry analysis and #membraneprotein research. 👨🔬 NanoImaging Services is thrilled to announce a collaboration with Cube Biotech to enable a streamlined #genetostructure #cryoem workflow. Begin the #structuredetermination process with Cube’s #proteinproduction and #constructdesign expertise to give your cryo-EM high-resolution structural enablement projects the best chance of success. 🚧 Overcome roadblocks in structure determination such as misfolding or incorrect structures with Cube’s advanced polymer technology, and quickly receive 3D maps from NanoImaging to streamline your pipeline. 📖 Learn more: