PUXANO’s Post

Join us for the first SACCMA Virtual Workshop Series 2024 event presented by ZEISS Microscopy!!! Come and learn more about your microscopy options when using Advanced Cell Modelling in your research. #organoid #3Dcellculture #bioimaging #spheroid #iPSC #cellmodelling

I am pleased to share that I presented my recent research at The Vital Nature Sign conference today. Moreover - the publication ,,Mitochondrial Depolarization and ATP Loss During High Frequency Nanosecond and Microsecond Electroporation'' has been accepted for publication in #Bioelectrochemistry journal! 📝 I look forward to presenting the results at the forthcoming World Congress on Electroporation in #Rome! #VNS2024 #WCE2024 #InnovativeMedicineCentre #electroporation #nsPEF #mitochondria

From June 23-26, the 44th Annual Congress of the European Society of Mycobacteriology will be held in Bruges, Belgium. ZytoVision will be present with a booth at the conference, presenting the VisionArray MYCO Chip 2.0 (and other exciting products). The VisionArray MYCO Chip was designed to detect several different types of clinically relevant mycobacterial species. The VisionArray MYCO Chip 2.0 is used with the corresponding VisionArray MYCO PreCise MasterMix 2.0 and a VisionArray Analysis Software for a fast and reliable detection. For further information on the VisionArray system, visit our booth at the conference or our website. #zytovision #visionarray #mycobacteriology #pathogendetection

Excited to share that our study on the cell origin of IPMN is now published! This work would not have been possible without the dedications of my postdoc, Dr. Kiyoshi Saeki, and my collaborator, Dr. Janel Kopp. In our studies, we found that Acvr1b loss, likely through abrogation of Activin signaling, is one of the few pathways identified to date that promotes precancerous lesion formation from both acinar and ductal cells expressing Kras G12D. https://lnkd.in/ei6HcgF5

In our new #Big4BioPodcast episode, we spoke with Tim O'Bryan, director of discovery partnerships and commercial integration at Charles River Laboratories, and Dr. Karl Bertram, co-founder and managing director for ATEM Structural Discovery. We explore ATEM’s cryo electron microscopy technology, or Cryo-EM, its incorporation of machine learning, and how it fits in with Charles Rivers’ broader #drugdiscovery offerings. Cryo-EM enables high-resolution screening for small molecules and biological ligands, particularly for targets that are challenging to crystallize. 🎙 Listen to the episode here: https://lnkd.in/eMmTgX8s #biotech #biotechnology #machinelearning

In our latest publication, the result of a collaboration between Elettra Sincrotrone Trieste, Area Science Park, Università Politecnica delle Marche, and Istituto Italiano di Tecnologia, we show how infrared and plasmonic can be used to support the development of SARS-CoV-2 antivirals. Check out the full paper at the link: https://lnkd.in/dmQXnaNS #SARSCoV2 #Infrared #PandemicResearch

🔥 VDURA is driving innovation in Life Sciences! We’re proud to sponsor the inaugural Texas CryoEM Symposium hosted by UT Southwestern Medical System and lead the charge in cryo-electron microscopy (Cryo-EM) data management. Our platform is built to handle the most complex life science workloads, ensuring unmatched data durability and performance for researchers pushing the boundaries of discovery. 🧬🔬 "VDURA’s sponsorship of the Texas CryoEM Symposium underscores our commitment to advancing data-driven breakthroughs in life sciences research," said Matt Swalley, Senior Director of Marketing at VDURA. "Our platform’s unmatched performance, scalability, and data durability make it the ideal solution for cryo-EM researchers, ensuring they can process and analyze vast datasets without bottlenecks." Read more here: https://lnkd.in/eCjN3Uss Learn more about the Texas CryoEm Symposium here: https://lnkd.in/eY2fiuuf VDURA is where data durability meets scientific breakthroughs! #CryoEM #LifeSciences #DataDurability #ScientificInnovation #VDURAStrong #TexasCryo #TexasCryoEm #Symposium #Cryogenics

Crémant and smiles to farewell my PhD student Candy L. Steffen Steffen! Good luck and all the best for your future. This event also marked the acceptance of our STAR Protocol paper of applying BRET to measure protein interactions in cells, with lead authors Carla J. Duval and Candy L. Steffen. Here is the link to "Protocol to measure and analyze protein interactions in mammalian cells using bioluminescence resonance energy transfer": https://lnkd.in/eskypw8q hashtag #cancerresearch, hashtag #Luxembourg

Same Same But Different: Check Out Our New Surface Atlas of the Alternative Animal Model Manduca sexta 🐛 🦋 🐭 https://lnkd.in/ei4NgUTC https://wix.to/Dkj4c8P Big Thanks to the team! Leonie Graser Fraunhofer-Institut für Molekularbiologie und Angewandte Oekologie IME Justus-Liebig-Universität Giessen Manduca is a valuable model for studying gut inflammation but currently lacks a physiological reference standard. This is why we created a surface atlas using scanning electron microscopy and nano-computed tomography. This atlas aids in identifying abnormal gut phenotypes and estimating the resorptive midgut surface area, facilitating dose conversion in preclinical research according to the 3R principle.

I am proud to present the preprint of our work “GōMartini 3: From large conformational changes in proteins to environmental bias corrections”. Take a look in the BioRxiv preprint here: https://lnkd.in/dJ9m7hSX This work started many years ago, when Sebastian Thallmair and I still shared an office as postdocs in the group of Siewert J. Marrink in Groningen. Inspired by the work of Adolfo Poma and co-workers published in 2017, the enhanced #Gō-like model combined with #Martini3 – coined #GōMartini3 - was released together with Martini 3 in 2021. After many extensive tests of community, only now we present in detail this approach and also the current Martini 3 protein model. The #GōMartini3 better captures conformation changes in proteins in relation to elastic network models, being able to capture subtle differences caused by interactions with #membranes, #smallmolecule #binding and single point #mutations. It also demonstrated capability to capture large conformational changes in #nanomechanics studies. Additionally, the model can be used to implement an environmental bias to correct recently described inaccuracies of the Martini 3 protein model, such as underestimated dimensions of #IDPs and low hydrophobicity of certain amphiphilic small #peptides. A big collaborative effort involving Sebastian Thallmair, Adolfo Poma, Siewert J. Marrink, Luís Borges Araújo, Manuel Melo, Hafez RAZMAZMA, Fabian Grunewald and many others. The Martini 3 Protein task force is only starting and many new developments should be coming this year. From my side, thanks for the support of #LBMC (Laboratory of Biology and Modeling of the Cell), #CBPsmn (Centre Blaise Pascal de Simulation et de Modélisation Numérique), #ENS de Lyon (École normale supérieure de Lyon), CNRS and CNRS Délégation Rhône Auvergne.