Quentin Monchicourt’s Post

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Anesthesiologist & Intensivist

Researchers at Dalhousie University, led by Nelofar Kureshi, have explored the connection between traumatic brain injury (TBI) and the development of new-onset psychiatric disorders (NPDs). Using a dataset of 3,453 TBI patients and 13,112 controls from a provincial trauma registry, they applied latent class analysis to uncover distinct phenotypes within the TBI population. The results showed that TBI patients are significantly more likely to develop NPDs compared to non-TBI individuals, with odds ratios of 2.78 for those without pre-injury psychiatric history and 2.36 for those with prior psychiatric conditions. Eight different phenotypes were identified, each showing varying risks for NPD development, influenced by factors like age, injury severity, length of hospital stay, and discharge destination. For example, older adults requiring extended recovery and supportive care showed a 53% higher risk of developing NPDs compared to younger individuals with shorter recovery times. This research emphasizes the need for tailored psychiatric care, particularly early intervention based on individual risk profiles. By identifying specific patient clusters, this study offers a framework for improving mental health outcomes in TBI patients through targeted, phenotype-driven care strategies. The findings highlight the importance of integrating psychiatric risk assessments into TBI patient care, particularly at discharge, to better manage long-term psychiatric effects and improve patient recovery. #TBI #Psychiatry #Neuroscience #MentalHealth #HealthcareInnovation #PublicHealth #TraumaCare

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