🧬 Quinten Health 𝗷𝗼𝗶𝗻𝘀 𝘁𝗵𝗲 𝗣𝗜𝗣𝗘𝗟𝗜𝗡𝗘-𝗥𝗦𝗩 𝗽𝗿𝗼𝗷𝗲𝗰𝘁 𝘁𝗼 𝗽𝗿𝗲𝘃𝗲𝗻𝘁 𝗿𝗲𝘀𝗽𝗶𝗿𝗮𝘁𝗼𝗿𝘆 𝗶𝗻𝗳𝗲𝗰𝘁𝗶𝗼𝗻𝘀 𝗶𝗻 𝗻𝗲𝗼𝗻𝗮𝘁𝗲𝘀 🧬 We are glad to support this public health research, initiated by the CENTRE HOSPITALIER ANNECY GENEVOIS, to improve the prevention of respiratory syncytial virus (RSV) infections in infants and reduce the related mortality. Quinten Health will serve as a methodological expert using Bayesian modeling to strengthen the statistical analysis of this large clinical program, in collaboration with experts in pediatrics, virology and immunology. This project will combine trials and Real-World Data to evaluate and compare prevention strategies combining vaccination with antibody injections to provide maximum protection to newborns from their first weeks of life. 🌐 This project is part of the European PIPELINE platform, designed to prevent pandemics among the most vulnerable populations. We are delighted to put our expertise in support of this major public health unmet needs and to partner with top-tier academics in public health and clinical research. 👇 Read the Press Release 👇 #BillyAmzal #BayesianModeling #PublicHealth #RSV #Prevention #PediatricResearch
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FDA expands indication for Nerivio® as the first-and-only REN wearable for migraine treatment for children aged 8 and above! We are thrilled to announce that the FDA has expanded the indication for the Nerivio REN wearable for use in children as young as 8 years old. This is a significant step forward in providing a safe, drug-free migraine treatment for the pediatric population. Migraine is a debilitating neurological disease that affects 1 billion people worldwide, including 1 in 10 children.[1,2] Treatment options for children 8 and above are extremely limited and often not well tolerated. The REN wearable, a non-drug, non-disruptive option, fills a crucial gap in care and is the only preventive option that is FDA indicated for this patient age group. “For children and adolescents, uncontrolled migraine disease can negatively impact life trajectory and potentially lead to other disabilities. Early and effective intervention is critical, however more options for effective treatment are needed, specifically in patients younger than 12 years old,” said Dr. Trevor Gerson, MD, associate professor of pediatrics with the University of Missouri-Kansas City School of Medicine and associate program director of the Headache Medicine Fellowship. This expanded indication is not just a win for families, but a transformative step in redefining migraine care for younger patients. Learn more here: https://lnkd.in/g7RQ4smm —--------------------------------------------------- 1. Amiri et al, “Migraine, A Review on Its History, Global Epidemiology, Risk Factors, and Comorbidities”, 2022. 2. Khalil et al, “Migraine Headache in Childhood”, 2023.
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The Seattle STRIDE study 🔬, a groundbreaking collaboration between Seattle Children's and the Allen Institute for Immunology, is poised to revolutionize the treatment of pediatric IBD. By harnessing the power of deep immune profiling, researchers are gaining an unprecedented understanding of the complex molecular mechanisms underlying this disease. 🦠 This innovative approach allows scientists to analyze individual immune cells and molecules within tissues collected during routine hospital visits. By tracking changes over time, they can identify specific patterns associated with disease progression and treatment response. This wealth of data is providing researchers with a roadmap to develop targeted therapies that address the root causes of IBD, offering hope for improved outcomes and a brighter future for children affected by this debilitating condition. #SeattleChildrens #AllenInstituteforImmunology #IBD #pediatricIBD #clinicaltrials #research #deepimmuneprofiling #immunology
ICYMI - Together with Seattle Children's Research Institute, we're launching the Seattle STRIDE study, an initiative to unravel the molecular mysteries of pediatric IBD through deep immune profiling. More about the study: https://lnkd.in/gEpEd-UG #pediatricIBD
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On February 29, we will observe World Rare Disease Day, a day dedicated to raising awareness about rare diseases and the individuals and families affected by them. Rare diseases—despite their individual rarity—collectively impact millions of people worldwide, often leading to significant challenges in diagnosis, treatment and support. Clinical research is crucial for developing effective treatments for these diseases and we help make a difference through our support of complex and novel clinical trials. To achieve true equity, it's necessary to acknowledge the unique circumstances of each participant and allocate resources accordingly. In partnership with drug developers, and our Rare Diseases, Advanced Therapies and Pediatrics Team (RAPT)—must consider how we conduct clinical trials and the requirements placed on rare disease participants. #rarediseaseday #showyourrare #fortrea
Rare Disease Day: Celebrating progress and hope for the future
fortrea.com
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Neonatal neutropenia is a condition where newborns fail to produce enough neutrophils, leaving them vulnerable to infection. Recent studies from Columbia University suggest that this condition may originate from a natural maternal mechanism that protects the placenta from inflammation but leaves newborns susceptible to infection if not turned off after birth. Using mouse studies, researchers found that fetal blood-forming stem cells are suppressed by maternal anti-inflammatory factors, primarily interleukin-10 (IL-10), which limits the newborn's ability to produce myeloid cells and activate emergency myelopoiesis (EM) pathways. The loss of maternal IL-10 restores EM activation in fetal stem cells, but at a cost to the fetus. This research highlights an evolutionary trade-off inherent in maternal anti-inflammatory responses that maintain pregnancy but render the fetus unresponsive to EM activation signals. #neonatalneutropenia#stemcells#inflammation#EMpathways#maternalhealth#childhealth
Exploring why some newborns develop severe infections
medicalxpress.com
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This recent study highlights the urgent need for research into pediatric post-acute sequelae of SARS-CoV-2 (PASC), or long COVID. While most studies have focused on adults, we know even less about how this complex condition affects children. We aim to change that by investigating which symptoms correlate with specific activated ancestral genes in long COVID cases. Our upcoming IRB study will focus on uncovering the underlying mechanisms of long COVID, including its overlap with neurodegenerative diseases like the Parkinsonian diseases. We’re using social media to reach out to those already working in this space and welcome anyone who is interested in collaborating or sharing insights. If you or someone in your network is studying long COVID or related fields, please connect with us via LinkedIn or through our website at FBBBio.com. #dementia #alzheimers #venturecapital #angelinvestor #cancer #hivaids #bioOS #biotechnology #diagnostics #innovation #technology #management #startups #liquidbiopsy #neurodegenerativediseases #multiplesclerosis #parkinsonsdisease #alzheimersdisease #longhaulers #longcovid #humangenome #onetestonelife #longevity #artificialintelligence #rna #rnaseq #personalizedprevention #PersonalizedMedicine #ClinicalResearch #COVID19 #Parkinsons https://lnkd.in/ePWbVwhW
Characterizing Long COVID in Children and Adolescents
jamanetwork.com
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🧬A new study by Karvas et al. (2023) introduces a powerful model of the human placenta using stem-cell-derived trophoblast organoids (SC-TOs). These 3D organoids provide critical insights into placental development and its susceptibility to viral infections like SARS-CoV-2 and Zika virus. 🔍 Why this matters: Realistic Modeling: SC-TOs accurately replicate the villous architecture and hormone secretion patterns of early pregnancy, addressing the limitations of prior 2D models. * Disease Susceptibility: They reveal that while SARS-CoV-2 shows limited infectivity, Zika virus readily invades these early placental cells, shedding light on potential risks for fetal development. *Research Potential: With single-cell transcriptomics, the organoids highlight key pathways of cell differentiation and X-chromosome inactivation during placental development. This cutting-edge research offers a patient-specific platform to study maternal-fetal interactions, promising to accelerate breakthroughs in reproductive health and infectious disease research. 🚀 If you want to know more: https://lnkd.in/eq2X_Qfm
Stem-cell-derived trophoblast organoids model human placental development and susceptibility to emerging pathogens
ncbi.nlm.nih.gov
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Thrilled to announce our latest research work "SelfTuberXray: Self-Supervised Learning for Zero-Shot Pediatric Tuberculosis Detection in Chest X-Rays" now available on SSRN. Paper: https://lnkd.in/dVEAPyce Code: https://lnkd.in/dY2FH5sx The study presents a novel approach using self-supervised learning to detect pediatric tuberculosis in chest X-rays. This innovative method uses zero-shot learning to achieve accurate TB detection in unseen cases, addressing the scarcity of annotated medical datasets. The model is tailored to meet the specific needs of pediatric patients, who are often more vulnerable to TB. This groundbreaking innovation aims to improve diagnostic accuracy, especially in resource-limited settings, and potentially significantly impact pediatric health. #Research #MachineLearning #Healthcare #PediatricHealth #Tuberculosis #MedicalImaging #SelfSupervisedLearning #ZeroShotLearning
SelfTuberXray: Self-Supervised Learning for Zero-Shot Pediatric Tuberculosis Detection in Chest X-Rays
papers.ssrn.com
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Explore the June issue of Kidney360! Discover recent investigations in clinical research, review thought-provoking editorials, read global perspective pieces, and more. Learn from this month’s articles: 🔸 Epidemiology, Risk Factors, and Clinical Outcomes of AKI in Pediatric Hematopoietic Stem Cell Transplant Patients: https://bit.ly/3L095pA 🔸 Tubular Injury Biomarkers to Predict CKD and Hypertension at 3 Months Post-Cisplatin in Children: https://bit.ly/3L1yAa3 🔸 Association of Changes in Vector Length with Changes in Left Ventricular Mass among Patients on Maintenance Hemodialysis: A Secondary Analysis of the Frequent Hemodialysis Network Daily Trial: https://bit.ly/4eFPnNo 🔸 Global Perspective on Kidney Transplantation: Bosnia and Herzegovina: https://bit.ly/3zk4HPJ 🔸 Cardiac Surgery–Associated Acute Kidney Injury: https://bit.ly/3VMh7ai Check out this selection and more: https://bit.ly/3Ued87h
Epidemiology, Risk Factors, and Clinical Outcomes of AKI in ... : Kidney360
journals.lww.com
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While the survival of children with cancer has improved over time, infection remains a major morbidity and mortality risk. The Karius team together with Nicole Coufal, Samuel R. Dominguez, Kevin Messacar, and Frederick D. Goldman published a review of the state of our understanding of the value of the infectious disease diagnostic procedures currently in use in this population. The review highlights the lack of published data on infectious disease testing in pediatric oncology patients, and the need for well-designed clinical impact and cost-effectiveness studies of both existing and novel diagnostic platforms. Such studies are necessary to optimize diagnostic and antimicrobial stewardship, leading to improvement in patient outcomes. https://hubs.li/Q02v26DV0 #pediatrics #infection #infections #diagnostics #microbiology #oncology #immunocompromised #clinicalimpact #costeffectivness #antimicrobialstewardship
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“Systems immunology approach to long COVID” Systems immunology is a compilation of strategies for measuring a broad range of immunological assays as a powerful way of making the human immune systems more interpretable and understandable as a whole by discovering the relationships between the phenomena, factors, or mechanisms involved in diseases. This is vital for diagnosing and treating long COVID, which, like myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), is a multifactorial disease that cannot be diagnosed by a single laboratory test nor treated with a single medication. Long COVID is now recognized as a separate disorder that follows soon after an initial infection with SARS-CoV-2 and may last for an indefinite period, with a wide range of persisting, returning or even new but related symptoms that involve different tissues and organs, including respiratory, cardiac, vascular, gastrointestinal, musculoskeletal, neurological, endocrine and systemic. Along with this multiplicity of symptoms, there are also several mechanisms that work together to bring about this disease. For more on this abstract or to register for our Fall Conference, visit the link below: https://lnkd.in/dgpPHZRy #LongCovid #MAPS #Immunology #CME #pediatrics #specialneeds #medical
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