Rainer Böckmann’s Post

Excited to see the alignment of cutting-edge research with foundational insights from Michael Buschmann's 2021 work (DOI: 10.21203/rs.3.rs-798453/v1) on lipid pKa and its critical role in LNP design. The recent study by Trollmann and Böckmann (DOI: 10.1101/2024.11.27.625717) takes this further by providing mechanistic insights into pH-driven phase transitions in LNPs. Together, these studies highlight how understanding pKa differences and phase behavior at a microscopic level can revolutionize therapeutic design, reducing trial-and-error approaches and saving millions in development costs. It’s inspiring to see how precision-driven research is shaping the future of mRNA and nucleic acid delivery technologies! #LNPDesign #Therapeutics #Innovation #Formulation #mRNA #Vaccines

Our LNP Encapsulation Kits simplify the preparation of lipid nanoparticles for different biomedical uses. Key Features: - Complete Kit: Contains ionizable lipids, base lipids, long-circulating lipids, and cholesterol. - Multifunctional: Suitable for encapsulating RNAs, proteins, and drugs. - Performance: Ensures biocompatibility and efficient encapsulation. - Wide Applicability: Ideal for cell transfection and animal studies. https://lnkd.in/gZ8ERAt5

#Webinar now available on demand! Pure and simple: understanding #LNPanalytics for better #mRNA-based drugs #Ionizablelipids, the enabling technology of #lipidnanoparticles (#LNPs), are susceptible to impurities that cause loss of mRNA potency. Careful assessment of ionizable lipid purity throughout the #LNPmanufacturing process is vital. Adam Crowe (Senior Manager Analytical Development, Precision NanoSystems ULC (part of Cytiva)) will explore how #lipidpurity is carefully characterized using high resolution #massspectrometry coupled with a novel #fragmentationtechnology to both detect harmful N-oxide impurities at very low abundance, and distinguish them from other oxidated impurities. Watch this webinar at your convenience below:

Macrocyclic peptides, known for their enhanced specificity, stability, and bioavailability, are gaining prominence in peptide drug discovery. Automating head-to-tail cyclization on-resin, a traditionally challenging step, has the potential to boost recovery and minimize manual intervention in peptide synthesis. Take a closer look at our poster and learn more about automated peptide synthesis: https://hubs.ly/Q02Rsygl0 #peptidesynthesis #automation #biotage

R&D and Manufacturing of GGFG linker and exatecan faced two challenging issues in the ADC drug production, which should produce irreversible effects on the preclinical study and clinical study. First issue is racemization of the F amino acid during the peptide coupling significantly impacting on the release efficiency of payload. Another problem is the dr value of Exatecan coming from the chemical suppliers or CROs, which shall reduce the efficacy of ADC drug in the clinical study. Synmolecules CO.,LTD focuses on the ADC drug R&D and successfully solves those problems. Please feel free to contact us if you have any questions. synmolecules@163.com

Very nice work by Carmine D'Amico and colleagues, now out on ChemRxiv as a preprint! We are introducing poly(2-oxazoline) based microneedles for transdermal drug delivery. The patch itself is an amorphous solid dispersion with mechanical properties suitable for effective skin penetration. The amphiphilic triblock copolymer used dissolves directly into drug loaded micelles with high drug loading, we tested here up to 40 wt.%. The drug loading also effects the dissolution rate, potentially enabling slow and controlled drug release. Collaboration with Hélder A. Santos Anna-Lena Ziegler, Marianna Kemell and Giuseppina Molinaro at University of Helsinki and UMCG research. Can we take this forward, DelAQUA Pharmaceuticals? #nanomedicine #transdermal #nanoformulations #biomaterials

Unlock the potential of RNA-LNP vaccines at the #WVCEU. Discover how our scalable technologies and pre-optimized lipid compositions simplify LNP formulation and accelerate drug development, so that anyone can step into the world of nanomedicines. Join us on October 29 to learn how to streamline your process, from payload screening to lead candidate selection, with high quality, stable LNPs.

Unlock the potential of RNA-LNP vaccines at the #WVCEU. Discover how our scalable technologies and pre-optimized lipid compositions simplify LNP formulation and accelerate drug development, so that anyone can step into the world of nanomedicines. Join us on October 29 to learn how to streamline your process, from payload screening to lead candidate selection, with high quality, stable LNPs.

Unlock the potential of RNA-LNP vaccines at the #WVCEU. Discover how our scalable technologies and pre-optimized lipid compositions simplify LNP formulation and accelerate drug development, so that anyone can step into the world of nanomedicines. Join us on October 29 to learn how to streamline your process, from payload screening to lead candidate selection, with high quality, stable LNPs.

Unlock the potential of RNA-LNP vaccines at the #WVCEU. Discover how our scalable technologies and pre-optimized lipid compositions simplify LNP formulation and accelerate drug development, so that anyone can step into the world of nanomedicines. Join us on October 29 to learn how to streamline your process, from payload screening to lead candidate selection, with high quality, stable LNPs.