Ramón Bouza Deaño’s Post

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Laboratory Manager at AGQ Labs Spain. PhD in Analytical Chemistry. eMBA.

#analyticalchemistry news In a fascinating leap in #chemistry and diagnostics, a newly published study in Analytical Methods reveals an innovative approach to detecting **Mycobacterium bovis**, the bacterium responsible for bovine tuberculosis. The team of researchers has ingeniously combined a colourimetric tandem method with CRISPR/Cas12a technology and a dual-functional hybridisation chain reaction, achieving ultra-sensitive detection capabilities. The significance of this research cannot be overstated. By utilising the CRISPR/Cas12a system, the method exhibits a high level of specificity due to its ability to target specific DNA sequences. This is complemented by the hybridisation chain reaction, which amplifies the signal, rendering even minute quantities of the bacterium detectable. The use of a colourimetric readout further simplifies the process, allowing results to be easily interpreted without the need for complex equipment. For those unfamiliar with these terms, CRISPR/Cas12a acts like molecular scissors that can cut and modify DNA, while hybridisation chain reactions amplify the target signals to make them more detectable. Combining these two cutting-edge technologies results in an unprecedented level of sensitivity, which is crucial for early detection and control of infections. This breakthrough has practical implications beyond the laboratory. The method's simplicity and ultra-sensitivity make it particularly suitable for field use, potentially transforming how we monitor and control bovine tuberculosis in livestock. This could lead to significant improvements in animal health management, reducing economic losses associated with livestock diseases. The fusion of CRISPR technology with advanced amplification techniques marks a pivotal advancement in #analyticalmethods, bringing us one step closer to rapid and precise diagnosis of infectious diseases in various settings. Discover more about this promising research and its implications in the full article linked above. #CRISPR #biotechnology #infectiousdiseases #mycobacterium #analyticalchemistry #innovation #diagnostics, If you want to know more about #analyticalchemistry news, follow me: https://lnkd.in/d29pbjb9

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This is truly groundbreaking! The integration of CRISPR/Cas12a with hybridisation chain reaction for detecting Mycobacterium bovis is a remarkable advancement. The potential for field application is particularly exciting, as it could revolutionize livestock health management. I'm eager to see how this technology will be implemented in real-world scenarios.

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