Research Lake International Inc.’s Post

📃Scientific paper: Unraveling the microRNAs, key players in folliculogenesis and ovarian diseases Abstract: Background Folliculogenesis is an intricate process that involves the development and maturation of ovarian follicles in females. During folliculogenesis, multiple factors including hormones, growth factors, and signaling pathways regulate the growth and maturation of follicles. In recent years, microRNA, short non-coding RNA molecules, has gained attention due to its roles in the physiology and pathophysiology of various diseases in humans. It is known to have an important part in ovarian health and illness and its functions extend to several cellular processes. Main body In this overview, we look at the importance of microRNAs in ovarian illnesses and how they function during follicle growth in the ovaries. Short RNA molecules (22 nucleotides) called microRNAs may influence several mRNA targets in different biological processes. The expression patterns of these small non-coding RNAs undergo dynamic changes during the several phases of follicular development; they play a function in post-transcriptional gene regulation. Follicle development, follicular atresia (regression of the follicles), and ovulation are all intricately regulated by the dynamic expression of distinct miRNAs throughout the various phases of folliculogenesis. The role of microRNAs (miRNAs), which are known to regulate gene expression, has recently come to light as crucial in the development and advancement of a number of ovarian diseases. Abnormalities of the human ovary, such as ovarian cancer,... Continued on ES/IODE ➡️ https://etcse.fr/uLQlJ ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

🔬✨ New Protocol Alert! Protocol to establish an accelerated murine model for Helicobacter-induced gastric cancer by Bali et al. from Marygorret Obonyo’s lab from UC San Diego   Summary: Learn how to establish an accelerated murine model for Helicobacter-induced gastric cancer, featuring rapid disease progression with precancerous lesions developing within 6 months post-infection. Protocol Highlights: Explore the accelerated model for Helicobacter-induced gastric cancer, covering infection procedures, disease severity assessment, and gene expression analysis techniques for studying disease progression. Read the full protocol here: https://lnkd.in/e2gn5xkD #STARProtocols #GastricCancerModel #HelicobacterInfection #ResearchMethods #Protocols #CellPress

🌟 The article, titled "Relationship between vaginal and oral microbiome in patients of human papillomavirus (HPV) infection and cervical cancer", was published in Journal of Translational Medicine. The aim of this study was to assess the microbial variations and biomarkers in the vaginal and oral environments of patients with human papillomavirus (HPV) and cervical cancer (CC) and to develop novel prediction models. 🔍 Microbiota analysis was conducted using full-length 16S rDNA gene sequencing with the PacBio platform. HPV infection and CC impact both the vaginal and oral microenvironments, affecting systemic metabolism and the synergy between bacteria. This suggests that the use of oral flora markers is a potential screening tool for the diagnosis of CC. 🔬 #BMKGENE provided sequencing and analysis services of full-length 16S rDNA gene for this study. #FullLength16S #Microbiome #HumanPapillomavirus #CervicalCancer

Thank you, Kathy Baker, for spearheading the #FamilyGeneShare video series. This important initiative will save lives with genetic testing. When you know, you know, and then you can do something about it. Knowing I have the CHEK2 mutation has literally saved my life. While I'm not loving the goofy look on my face in the still frame (lol!), this information is too important not to share. Watch the video to see my story, and if you want to learn even more, visit my website at www.jennervin.com. More inspiring videos can be found at www.familygeneshare.org. #genetictesting #chek2 #breastcancer #knowyourrisk

We're excited to spotlight a groundbreaking research tool from our team at the National Centre of Asbestos Related Diseases (NCARD) – our MexTAg mouse model. 🐭 These genetically engineered mice are a game-changer in the study of #mesothelioma, a rare but aggressive #cancer caused by #asbestos exposure. By modifying the mice's mesothelial cells (the cells that turn into mesothelioma) to be susceptible to cancer, we've created a model that faithfully mimics the human disease. 🧫 The true power of the MexTAg model lies in its reliability. All MexTAg mice exposed to asbestos develop mesothelioma, providing a consistent and accurate platform for research. This allows us to investigate the mechanisms behind asbestos-induced cancer and test new treatment approaches in a living system that closely resembles the complexities of the human body. 🔬 Our MexTAg mice have already been used in several studies, including those examining the effects of vitamin supplementation and exercise on mesothelioma. 💪 We believe that this innovative model will continue to play a crucial role in advancing our understanding of asbestos-related diseases and bringing us closer to finding effective treatments and, ultimately, a cure. 🎗️ Stay tuned for more updates on how our MexTAg mice are contributing to the fight against mesothelioma. #NCARD #asbestosawareness #medicalresearch #innovativescience

My Faulty Gene's #FamilyGeneShare video series seeks to not only share stories related to a variety of gene mutations and hereditary cancers, but to also educate about the importance of issues such as when re-testing should be considered. Jennifer's story provides just such an opportunity. Because she had both first and second-degree relatives who had been diagnosed with breast cancer at relatively young ages, Jennifer's gynecologist recognized the family history might be related to a hereditary cancer syndrome and referred her for "BRCA" testing. She was negative. However, by the time Jennifer's sister had a recurrence of breast cancer a few years later, additional genes had been identified and Jennifer's doctor ordered new testing with a larger gene panel. This time, Jennifer learned she was positive for a CHEK2 mutation. In addition to highlighting the importance of having up-to-date testing, Jennifer's story also highlights the importance of medical management and surveillance once a gene mutation is identified. We encourage you to watch her short and informative video to learn the rest of her story! To watch Jennifer's video, click the following link: https://lnkd.in/gFEtcbvY #hereditarycancer #knowyourrisk #genetictesting #germline #chek2 #breastcancer #familyhealthhistory National Society of Genetic Counselors

I highly recommend cancer biologists, especially younger generations, read this article written by Dr. Robert Weinberg. In the era of 1980-2000, Taiwanese scientists made significant contribution to the discovery of oncogenes and tumor suppressor genes (TSGs). They include Dr. Chiaho Shih mentioned by Dr. Weinberg, my Ph.D. advisor Dr. Mien-Chie Hung who was involved in the finding of oncogenic HER2, Dr. Wen-Hwa Lee who discovered Rb and BRCA genes, among many others. Dr. Hung has told the history how the first transfection technology, calcium precipitation, and transformation assay were developed, and how it promoted the discovery of oncogenes and TSGs. He has also pointed out different technologies, like transfection vs. viral transduction, could result in different findings. Nowadays finding a gene won't make a headline in news. However, the idea and concept of scientific investigation and problem-solving are of no difference between now and then. What was achieved before can enlighten our path on searching ahead. https://lnkd.in/eMpPrYsR

Did you know that our breast and gyne cancer gene test goes beyond BRCA testing? In fact, our test covers these: ✅ ATM ✅ BARD1 ✅ BRCA1 ✅ BRCA2 ✅ BRIP1 ✅ CHEK22 ✅ EPCAM ✅ MLH1 ✅ MSH2 ✅ MSH6 ✅ PALB2 ✅ PTEN ✅ RAD51C ✅ RAD51D ✅ STK11 ✅ TP53 To support 💗 Breast Cancer Awareness Month💗, we have knocked £50 off our test, making it just £449 for the whole of October. Why choose our test? ● Fast: results in 20 working days ● Simple: saliva test at home ● NHS recognised ● Quality: testing, analysis and interpretation by UKAS-accredited ISO15189 Genomics Laboratory Service ● Pre and post genetic counselling included via GCRB-registered Genetic Counsellors Knowledge is power Visit our website to learn more and grab our offer before the end of October: https://lnkd.in/epcX_id3 PS: Don't forget that breast cancer can impact ♂️ men and ♀️ women. #BRCA #hereditarycancer #genetics #cancergene #breastcancerawarenessmonth #knowledgeispower

Abnormal processing of the b-globin primary RNA transcript in humans with the disease β-thalassemia ‼️ In the examples shown, the disease (a severe anemia due to aberrant hemoglobin synthesis) is caused by splice-site mutations found in the genomes of affected individuals. The dark blue boxes represent the three normal exon sequences; the red lines connect the 5′ and 3′ splice sites that are used. The light blue boxes depict new nucleotide sequences included in the final mRNA molecule as a result of the mutation denoted by the black arrowhead. Note that when a mutation leaves a normal splice site without a partner, an exon is skipped as in panel B or one or more abnormal cryptic splice sites nearby is used as the partner site as in panel C. #betatalasemi #genome #Cancer #nucleotide #genotype #phenotype #inheriteddisease #mRNA #SNPs #transcription #hemoglobin #cancer #cancerbiology #molecularbiology #mutations #genetics #cancerbiologyresearch #cancerresearch #mutation #protein #genomics #cell #biology #gene #DNA

A new study has found an interesting link between gene mutations in blood #cancer and #arthritis. The publication explains how specific gene mutations in blood cancer can impact autoimmune diseases such as seronegative RA. The study suggests that effective metabolic therapies in treating blood cancer may help arthritis patients.   → Conclusion: • IDH mutant myeloid neoplasms are associated with seronegative rheumatoid arthritis. • High levels of 2-hydroxyglutarate mediate IDH-associated activation of innate immune response.   → Lih En Hong, Mihir D Wechalekar, and Devendra Hiwase led the research team at the Royal Adelaide Hospital in Australia for this study.    → Publication: Hong, Lih En, et al. "IDH Mutant Myeloid Neoplasms are Associated with Seronegative Rheumatoid Arthritis and Innate Immune Activation." Blood (2024).   📖 Read on…https://lnkd.in/egV5am-P   #Inflammation #Immunotherapy #DrugDevelopment