ReSolute Project’s Post

C–N bond formation still stands as one of the most extensively employed transformations in both the Pharmaceutical and Fine chemicals industry. I am pleased to present two articles highlighting a sustainable alternative to Palladium-catalyzed Buchwald–Hartwig aminations of aryl halides with both aromatic and aliphatic amines. These articles showcase methodologies that utilize parts per million levels of Palladium, in a completely biodegradable and recyclable aqueous medium. Further applications like Late-stage functionalization and Pharmaceutical diversification have also been demonstrated. I would like to thank all of my co-authors: Dr. Rahul Kavthe, Dr. Yuting Hu, Robert Lammert Jr., and Jordan Yirak for their contributions. Links for publications: 1. Aminations with aliphatic amines https://lnkd.in/dGPQUsAx 2. Aminations with Aromatic amines https://lnkd.in/d_JHkM69

🌱Excited to share our latest publication in Sustainable Chemistry and Pharmacy (Elsevier): "Sustainable synthesis of 2-ethyl hexyl oleate via lipase-catalyzed esterification: A holistic simulation and cost analysis study". ✅ Our study highlights the economic and environmental benefits of lipase-catalyzed synthesis, achieving a 91% conversion rate under optimized conditions. A detailed cost analysis shows production at $2109 per ton with a 28% profit margin, supported by a projected NPV of $14.7M, ROI of 583.91%, payback period of 6 years, and IRR of 23%. These findings underscore the potential of this cleaner and profitable approach in fatty acid ester synthesis. Read more using the personalized URL that provides 50 days of free access to the article: https://lnkd.in/eUaXuW5c #Sustainability #GreenChemistry #Biocatalysis #EconomicAnalysis #Research #Innovation

🚀 Case Study Spotlight: Advancing Sustainable Nicotine Production 🌿 At Enzymicals, we're thrilled to share a breakthrough in sustainable chemistry! Back in 2017, we embarked on an exciting journey with Zanoprima Lifesciences Ltd, UK, to develop an innovative imine reductase (IRED) catalyzed process for producing (S)-Nicotine. Our team: ✅ Developed a highly efficient biocatalyst ✅ Optimized the biocatalytic process for chiral intermediate production ✅ Supported scale-up to commercial production The result? Synthetic nicotine is now on the market, offering significant environmental benefits. Compared to tobacco-derived nicotine, synthetic nicotine: 🌍 Emits up to 12 times fewer greenhouse gases 💧 Uses significantly less water More info on the Carbon and Water Footprints of Tobacco-Based vs. Synthetic Nicotine: https://lnkd.in/deCVYRQF Interested in how Enzymicals can support your innovative projects? Reach out to us to learn more about this case study and explore how our expertise can bring your ideas to life. Come and visit us at our stand J50 at the Chemspec Europe - Int. Exhibition for Fine & Speciality Chemicals. We look forward to seeing you! #SustainableChemistry #Biocatalysis #Innovation #GreenTech #CaseStudy #SyntheticNicotine #EnvironmentalImpact #Biotechnology #GreenCheistry

I am excited to share the recent publication of our paper titled "Clean Production of Isopropyl Myristate: A Cutting-Edge Enzymatic Approach with a Holistic Techno-Economic Evaluation" in the journal Sustainable Energy Technologies and Assessments (IF=8). This collaborative effort, co-authored with Ahmad Mustafa, N.A. Mostafa, Luigi di Bitonto, and Carlo Pastore, represents a significant advancement in green chemistry and sustainable industrial processes. Our research introduces a novel, environmentally friendly method for synthesizing isopropyl myristate (IPM) using an enzymatic process catalyzed by immobilized Candida Antarctica lipase. This method stands out for its simplicity, energy efficiency, and reduced environmental impact. Utilizing Response Surface Methodology (RSM), we optimized the reaction conditions to achieve a high yield of IPM, with experimental and predicted conversions reaching 92.4% and 92.0%, respectively. One of the highlights of our study is the comprehensive techno-economic analysis, which demonstrates the economic viability of this green synthesis route. The projected net present value (NPV) of $44.8 million, a return on investment (ROI) of 716.17%, and an internal rate of return (IRR) of 110% underscore the profitability of adopting this innovative approach. Additionally, the levelized cost of production (LCOP) was calculated at $1,777 per ton over a 14-year project lifespan, further supporting the economic benefits. Environmental sustainability is a crucial aspect of our work. The enzymatic process significantly reduces CO2 emissions, with only 0.25 tons of CO2 equivalent generated per ton of IPM produced, highlighting the environmental advantages over traditional chemical methods. This research not only offers a greener alternative for IPM production but also provides valuable insights into the potential for sustainable practices in the chemical manufacturing industry. We are proud to contribute to the advancement of green chemistry and look forward to the positive impact this work may have on both industry and the environment. For more details, you can access the full paper here: https://lnkd.in/grfzcyQq #GreenChemistry #Sustainability #TechnoEconomicAnalysis #EnzymaticSynthesis #EnvironmentalImpact #Innovation #Research #ChemicalEngineering #CleanProduction #IPM #SustainableProcesses #ChemicalManufacturing #GreenTechnology #RenewableEnergy

Biosurfactants, which are environmentally friendly and versatile microbial molecules with unique amphiphilic properties, have numerous applications across various industries, particularly in the petroleum sector, where they offer sustainable alternatives to synthetic surfactants for processes such as hydrocarbon recovery, product formulation, and innovative uses, making them a promising focus for future research and development in the oil industry. Link: https://lnkd.in/gaZ2Zxf Link: https://lnkd.in/dayUe8HZ Keywords: #Biosurfactants #Biodegradability #Hydrocarbon #Sustainable

"With a growing consumer emphasis on sustainability, the live resin market may see a shift towards more environmentally friendly production methods. Techniques that reduce energy consumption, solvent use, and waste in extraction could become major selling points for these products.Producers who prioritize green practices might not only reduce their environmental impact but also appeal to eco-conscious consumers." Read More: https://lnkd.in/eeA_XKu8 Learn about Geomat: geomat.com/cannabis #cannabis #cannabisindustry

#Sophorolipids—they're not just eco-friendly #biosurfactants; they're powerful, versatile ingredients. From coalescing agents to solubilizers, they redefine green chemistry by proving that #sustainability and exceptional performance can go hand in hand. Check out our latest blog to learn more: https://bit.ly/3v3IMda #greenchemistry #sustainableinnovation #greenformulations #locusingredients

Did you see our 'top 100 cited bioactive small molecules' analysis? 📈 As part of our series on the most used research products in publications from 2023, we recently dived into the bioactive market. Here's some key takeaways: 🔹Ten different companies featured in the top 100 list 🔹Cocktail products were popular 🔹MilliporeSigma and Selleck Chemicals led You can download the top 100 bioactive dataset over on the CiteAb blog for your own analysis of the market! #bioactives #marketinsights

🔬✨ Explore the world of #enzymes with DC Fine Chemicals ! With over 15 years of expertise, we're your trusted partner in enzyme solutions for various industries. Enzymes are nature's catalysts, driving important processes. From aiding in drug development to improving food production, enzymes play a crucial role in advancing innovation across sectors. Keen to learn more about the versatile applications of enzymes? Dive into our selection of enzyme products and uncover their potential for your industry!: https://bit.ly/3z6Iqo8 Questions or need more information? Feel free to reach out to us at info@dcfinechemicals.com. #Enzymes #Innovation #DCFineChemicals #Adifferentkindofchemistry

𝑷𝒐𝒍𝒚𝒆𝒕𝒉𝒚𝒍𝒆𝒏𝒆 𝑭𝒖𝒓𝒂𝒏𝒐𝒂𝒕𝒆 (𝑷𝑬𝑭) 𝑴𝒂𝒓𝒌𝒆𝒕 𝒔𝒊𝒛𝒆 𝒘𝒂𝒔 𝒗𝒂𝒍𝒖𝒆𝒅 𝒂𝒕 𝑼𝑺𝑫 𝟐𝟎.𝟑𝟑 𝒎𝒊𝒍𝒍𝒊𝒐𝒏 𝒊𝒏 𝟐𝟎𝟐𝟑. 𝑻𝒉𝒆 𝒎𝒂𝒓𝒌𝒆𝒕 𝒊𝒔 𝒂𝒏𝒕𝒊𝒄𝒊𝒑𝒂𝒕𝒆𝒅 𝒕𝒐 𝒈𝒓𝒐𝒘 𝒇𝒓𝒐𝒎 𝑼𝑺𝑫 𝟐𝟏.𝟖𝟓 𝒎𝒊𝒍𝒍𝒊𝒐𝒏 𝒊𝒏 𝟐𝟎𝟐𝟒 𝒕𝒐 𝑼𝑺𝑫 𝟑𝟗.𝟕𝟔 𝒎𝒊𝒍𝒍𝒊𝒐𝒏 𝒃𝒚 𝟐𝟎𝟑𝟐, 𝒆𝒙𝒉𝒊𝒃𝒊𝒕𝒊𝒏𝒈 𝒂 𝒈𝒍𝒐𝒃𝒂𝒍 𝑪𝑨𝑮𝑹 𝒐𝒇 𝟕.𝟖% 𝒅𝒖𝒓𝒊𝒏𝒈 𝒕𝒉𝒆 𝒇𝒐𝒓𝒆𝒄𝒂𝒔𝒕 𝒑𝒆𝒓𝒊𝒐𝒅. 𝙈𝙤𝙧𝙚 𝙍𝙚𝙥𝙤𝙧𝙩 𝘿𝙚𝙩𝙖𝙞𝙡𝙨: https://lnkd.in/gdtb6-P8 #polyethylenefuranoate #pefmarket #sustainableplastics #bioplastics #greenpackaging #eco-friendlymaterials #renewableresources #biodegradableplastics #plasticinnovation #pefmaterials #polymertechnology #sustainablepackaging #environmentallyfriendly #biopolymer #pefapplications #packagingindustry #greenchemistry #circulareconomy #futurematerials #polaris Polaris Market Research & Consulting