Rhianna-lily Smith’s Post

What is neurogenesis and neuritogenesis and how might this process impact Alzheimer's disease progression? #Neurogenesis is the production of new neurons and #neuritogenesis is the growth and extension of the branches or neurites of a neuron. Both the neurogenesis and neuritogenesis process slows down or altered as we age and, particularly in patients with dementia. The neurite extension enables neuronal communication, important for healthy memory and cognitive functions. Restoring the neuritogenesis process presents an opportunity to reverse the loss of neuronal function caused by Alzheimer’s disease. INM-901 has demonstrated an ability to extend neurite outgrowth, a promising effect in the treatment of Alzheimer's disease. Learn more: https://ow.ly/x2Ge50Rcikz $INM #Alzheimers #Research #cannabinoids

We are entering an era in medicine when new diagnostics can help change the management of #neurodegenerative diseases from “sick care” to #proactive preventative care. In an engaging and open piece about his quest to assess his own risk for dementia, Dr. Sanjay Gupta describes the potential of new, multimodal diagnostic approaches in assessing brain health and providing an action plan to optimizing it through personalized lifestyle changes and therapeutic interventions. While Dr. Gupta’s concerns are shared by most people over 50, his access to many of the types of tests used in his diagnostic journey is not. New technologies are needed to both expand access to personalized assessments of #brain health and provide ways of measuring key #biomarkers of neurodegenerative disease that are not currently measurable.   Amydis, Inc. is the leader in leveraging the #eye as a window to the brain with first-in-class ocular tracers that enable the detection of disease-related biomarkers in the retina. We are in human clinical trials exploring the eye to detect Alzheimer’s disease, Parkinson’s disease, ALS, and other diseases. We envision a future where people can turn to the Amydis #eyetest in their quest to assess their brain health and form an action plan for a healthier future. #Alzheimers #Parkinsons #ALS #patientsfirst CNN https://lnkd.in/ghh9jGSU

New in the main journal, Rahimi et al explore neuroimaging changes in patients with mild Wilson disease. Imaging changes can be seen before neuropsychiatric symptoms; myelin or white matter in general seems vulnerable to low-level copper toxicity, with white matter volume loss showing promise as a marker for assessing brain involvement in early WD stages. Brain morphometry in hepatic Wilson disease patients Parya Rahimi, Stanislav Mareček, Radan Brůha, Dezortova Monika, Petr Sojka, Milan Hájek, Marta Skowrońska, Łukasz Smoliński, Petr Urbánek, Tomasz Litwin, Petr Dušek https://lnkd.in/g2NirhAv #wilsondisease #neuroimaging

We all agree that Alzheimer's is a scary disease. With hundreds of billions of dollars invested in ALZ and PD research, we are not getting even close to finding the treatment. The absence of disease-modifying treatments for Alzheimer’s disease has led to the emergence of new pathogenic mechanisms to target - the brain's glymphatic system, the system responsible for the movement of cerebrospinal fluid and clearance of metabolic waste. Glymphatic system should be the main therapeutic focus. Early diagnosis and understanding of core causes are very important. MRI methods for monitoring glymphatic system activity in the CNS can potentially uncover the relationship between glymphatic system activity and pathological alterations. The review “Noninvasive Magnetic Resonance Imaging Measures of Glymphatic System Activity” by Kamagata et al. is a good review of where we stand with noninvasive MRI measures of glymphatic system activity.  Source: https://lnkd.in/gR4PR9RB #EndAlz #AlzheimersDisease #Dementia #MotoGlymphatic

I recently had the opportunity to join Integrative Practitioner to explore groundbreaking research on a topic that's shaping the future of brain health: the role of microglial cells in neurodegenerative disorders. These specialized brain cells are central to how our brains age and adapt. Emerging evidence suggests that when microglial cells become dysfunctional, they contribute to the progression of conditions like Alzheimer’s and Parkinson’s. Targeting and reprogramming these cells could pave the way for innovative treatments that address neurodegeneration at its root. This research is not just fascinating—it holds incredible potential for reshaping how we protect and restore cognitive function. You can tune into the full discussion here: https://lnkd.in/eqNxDB7d #BrainHealth #Science #Alzheimers #Parkinsons

Novel mechanism in brain blood flow regulation offers insights into treating stroke and dementia https://lnkd.in/eXCeWkY3

Novel mechanism in brain blood flow regulation offers insights into treating stroke and dementia https://lnkd.in/eXCeWkY3

1. Alzheimer's disease causes brain damage before any symptoms appear, indicating a "silent" early stage of progression. 2. Approximately 5.8 million Americans are affected by Alzheimer's, making it the most common form of dementia. 3. The disease involves a buildup of abnormal proteins in and around brain cells, which may occur later in the disease timeline than previously believed. 4. Researchers analyzed the brains of 84 deceased donors to identify two distinct phases of Alzheimer's progression. 5. The first phase is characterized by increased inflammation and loss of three key brain cell types. 6. The second phase shows the typical accumulation of abnormal proteins and further brain cell loss. 7. Early detection of these changes could enhance diagnosis and treatment strategies for Alzheimer's. 8. The findings may fundamentally change the understanding of how Alzheimer's damages the brain and inform future treatment developments.

Novel mechanism in brain blood flow regulation offers insights into treating stroke and dementia https://lnkd.in/eXCeWkY3

🔬 𝗥𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝗶𝗻 𝘁𝗵𝗲 𝗦𝗽𝗼𝘁𝗹𝗶𝗴𝗵𝘁 🔍 Researchers at the Keck School of Medicine of USC tested a biomarker linked to vascular dementia and propose an explanation for how cognitive impairment arises. Link to full manuscript: https://lnkd.in/e3F7ZAkC #ResearchInTheSpotlight #Innovation #Science #Technology #dementia #brain #alzheimers #alzheimersdisease