Saeid Sadeghnejad’s Post

Origin of life is one of the biggest challenges of science, one of most important open issues in astrochemistry and astrobiology. In this respect, the detection in space of the so-called COMs –complex organic molecules– and in particular of those having a strong prebiotic role (i.e., related to the formation of biomolecule building blocks) can provide important pieces of this huge puzzle. While the evidence for molecular complexity in the universe is undisputed, there is still much to be understood about what molecules are present and how they are formed in the typically cold and (largely) collision free environment of the interstellar medium. Because of difficulties in experimentally mimicking the extreme conditions of the interstellar medium (ISM), accurate computational approaches play a fundamental role in analyzing reaction mechanisms. At the low temperatures of the ISM, reaction rates are exquisitely sensitive to energetics and barrier heights, and their accurate evaluations require very advanced calculations of these energies. In a subsequent step, these need to be combined with suitable tools to compute kinetics [1]. However, to understand the chemical evolution of the ISM, the starting point is the knowledge whether a molecule is present in the astronomical environment considered and, if so, its abundance. In this scenario, rotational spectroscopy plays a crucial role since the astronomical observation of spectroscopic signatures provides the unequivocal proof of the presence of chemical species. Molecular species in the gas phase are usually detected via their rotational signatures, with these accurately obtained from laboratory spectroscopy studies that are increasingly assisted by quantum-chemical calculations to guide and support the spectral recording and analysis In this contribution, by means of a few selected examples taken from the work done at the ROT&Comp Lab, I will address: (i) the detection of prebiotic molecules: from the interplay of experiment and theory in the field of rotational spectroscopy to astronomical observations the exploitation of state-of-the-art computational approaches to derive formation pathways able to explain the presence in the ISM of the detected molecules. https://lnkd.in/dpNwkZVE

🌟 Excited to Announce the Publication of My Research Paper! 🌟 I'm thrilled to share that my research paper, "Quantum Genetic Algorithm Based Hybrid QLSTM Model for Soil Moisture Estimation", which had been presented at the prestigious IEEE IGARSS 2024, Athen, Greece is now available on IEEE Xplore! 📚✨ 🔗 Read the paper here: https://lnkd.in/g4rxBvmy In this work, we tackle the issue of soil moisture estimation, which plays a crucial role in agricultural productivity. Some key contributions include: Quantum Long Short-Term Memory (QLSTM): We introduced a QLSTM model, combining quantum computing principles with classical LSTMs, to improve soil moisture prediction accuracy with a smoother exponential decline in the Test loss. Hybrid Quantum Genetic Algorithm (QGA) and Particle Swarm Optimization (PSO): By integrating a hybrid optimization algorithms, we enhanced the precision of hyperparameter tuning, addressing issues like premature local minima convergence with optimal tradeoffs. Experimental Success: Our proposed QGA-PSO QLSTM model outperformed traditional models, with a significantly lower MSE (0.046) compared to LSTM and other variants. This study offers new insights into soil moisture, temperature, and pH predictions with applications extending to agriculture, hydrology, and ecosystem studies. I hope this work contributes to ongoing research and inspires further innovation in the field. Huge thanks to Anuvab Sen and my co-authors. Working with them was an absolute pleasure and a great learning experience! #QuantumComputing #AI #MachineLearning #SoilMoisture #PublishedResearch #IEEE #AgricultureTech

Check out my latest paper from my PhD lab investigating the structure/features of a paramutagenic allele in maize: https://lnkd.in/eeHwuJR6

MSU-DOE Plant Research Laboratory researchers disprove a long-held view on the permeability of carboxysome shells using molecular dynamics. - In between the proteins that assemble the carboxysome shell, minute gaps exist that gas can move through. - Understanding these shells may allow researchers to engineer cyanobacteria or plants to photosynthesize more efficiently. Capturing the molecular choreography of carbon fixation: https://lnkd.in/gmVQEwVW #Research #Science #Cyanobacteria

🧬 Enhancing Spatial Analysis in Biology: Introducing SPIAT and spaSim 🧬 A Nature Communications article presents the tools: SPIAT and spaSim, increasing our toolbox to studying tissue microenvironments. 🟠 SPIAT: An R toolkit for characterizing spatial patterns in multiplex tissue images, platform-agnostic and user-friendly. 🟢 spaSim: A simulator for creating realistic tissue cell spatial patterns, perfect for testing spatial metrics 🟣 Compatible with various spatial technologies, SPIAT can analyze >1 million cells in <30 mins! 🟡 With spaSim, simulate images that mirror real tissue sections' spatial properties 📚 Paper: https://buff.ly/49csvkG 🔗 SPIAT GitHub: https://buff.ly/4a9pXVz 🔗 spaSim GitHub: https://buff.ly/3PFGyrV 🔗 R Packages: https://buff.ly/4asU0aE and https://buff.ly/4csjNBL 💬 Share your thoughts and experiences in #SpatialAnalysis, #Bioinformatics, and #BiotechResearch in the comments 👇 #NatureCommunications #BiologicalResearch #DataScience

Delighted to share my latest publication, 'Bessel Polynomials: Application in Finding Optimal Solution of Fractional COVID-19 Model Using Lagrange Multipliers' which contributes new insights into the field of Biomathematics. This work not only reflects my commitment to advancing knowledge but also underscores the collaborative spirit of research. #Research #Biomathematics #Numerical_Analysis #Covid19

How the DNA Double Helix was discovered 🧬 Unlocking the Power of Tangible Thinking💡   In 1953, American biologist James Watson and English physicist Francis Crick made a groundbreaking discovery: the double helix structure of DNA.   What's less known, however, is the hands-on approach that played a crucial role in their success. You would think they figured out the configuration by calculation and critical thinking…   Watson and Crick, inspired by American biochemist Linus Pauling, created physical models of DNA using simple cardboard cutouts.   They manipulated these models like a puzzle, exploring different configurations. But then they go stuck…   Another scientists called Jerry Donohue advised them to revise their cutouts based on the latest findings at the time. And then: it worked!   They identified the iconic double helix structure.   At the heart of one of the most significant scientific discoveries of the 20th century was physically modeling and trying things out …   Sometimes, the key to understanding complex ideas lies in the simplicity of hands-on experimentation!   #Innovation #Science #MolecularBiology #TangibleThinking #Discovery #WatsonAndCrick #STEM #Reserach #MolecularBiology #Biochemistry Ilona Irina Concha-Grabinger Alexandra Newton The IUBMB Alexander Röntgen

The PhylogenetIKES' team is pleased to announce the organisation of an online workshop on "𝑷𝒉𝒚𝒍𝒐𝒈𝒆𝒏𝒆𝒕𝒊𝒄 𝒂𝒏𝒂𝒍𝒚𝒔𝒊𝒔: 𝑨𝒅𝒗𝒂𝒏𝒄𝒆𝒅 𝑳𝒆𝒗𝒆𝒍". The workshop will be held on 𝐎𝐜𝐭𝐨𝐛𝐞𝐫 𝟏𝟖 & 𝟏𝟗, 𝟐𝟎𝟐𝟒. A google meet link will be shared upon confirmation. To register, please fill in the registration form via the link below. https://lnkd.in/d5GgZbFh Program: - Assess Evolutionary models using Partition Finder. - Define various phylogenetic reconstruction methods, outlining their differences, similarities, advantages, and limitations. - Generate phylogenetic trees using different methods. #PhylogenetIKES, #Phylogenetic_Analysis_Advanced_Level

💥 I'd like to thank Organisers and Participants of 20th European Conference on the Spectroscopy of Biological Molecules #ECSBM which was held this week in Łódż, Poland, for your contributions, great presentations, interested conversations and lovely atmosphere 👏. 💥💥We always try to support outstanding Young Scientists, that's why #Renishaw granted special awards for the best oral presentation selected by Renishaw and 3 best oral presentations and posters selected by the scientific jury of 20th #ECSBM. Contratulations to the Winners: 🏆 Pjotr Meyvisch🏆 from Department of Geology, Universiteit Gent, Belgium, awared by Renishaw for presentation ttled: "Monitoring the transformation of resistant biomolecules to geomolecules: a micropaleontological perspective and applications". Pjotr caught the attention with very good introduction to a purpose of his research, the orginality of his work and the way it was presented. and 🏆 Wiktoria Korona🏆 from Chemistry Department Jagiellonian University in Cracow, Poland, awared by scientfic jury for the best oral presentation titled: “Library of Spectral Reporters of Metabolic Pathways: Metabolomics based on Multiplex Cell Labeling”. I would like to congratulate 👏 All the Winners of the I20th #ECSBM conference (pictured in the left). Good luck in your future research and see you in the lab! #Renishaw; #Raman; #bioimaging; #applyinnovations

Glad to be part of this outstanding team! Electron microscopy research at EMSL through limited scope proposals yields a publication in the Journal of Geophysical Research: Biogeosciences. Check out the science below, #EMSLscience Environmental Molecular Sciences Laboratory (EMSL) Siyuan Wang, Yeala Shaked, Rene Boiteau, et al. A marine cyanobacterium (blue-green algae) abundant in warm oceans gathers desert dust for nutrients, which can sometimes cause bacterium sinking due to added weight. Most colonies stay afloat but at these conditions but we found that metal toxicity is rare at the usual ocean dust concentrations. https://lnkd.in/ehkUQcju https://lnkd.in/eUYpgMRX