Dr. Sargol Aminnezhad’s Post

Check out the most recent UDN publication! ⭐️Key takeaway: Biallelic #UQCRFS1 variants cause a rare mitochondrial complex III deficiency with lactic acidosis and scalp alopecia, with recent findings confirming complex III dysfunction and expanding the understanding of this and #GJA8-related cataracts. Undiagnosed Diseases Network (UDN) Undiagnosed Diseases Network Foundation (UDNF)

Profile antibody responses against 10 different neglected tropical diseases! The PEPperCHIP® Neglected Tropical Diseases Peptide Microarray covers 3,390 different epitopes & can be used for antibody biomarker discovery, patient monitoring, antibody characterization, and high-throughput antibody profiling. Ready to discuss your project about neglected tropical diseases? Talk to one of our scientists: https://buff.ly/3Y7cXea #NeglectedTropicalDiseases #peptidearrays #antibodyprofiling

Although there are regions in Africa in which the effect of neglected tropical diseases is comparable to that of malaria and tuberculosis, most funding goes to research on the "big three" infectious diseases HIV/AIDS, tuberculosis, and malaria. The novel PEPperCHIP® Neglected Tropical Diseases Peptide Microarray enables cost-effective research on antibody responses against the corresponding pathogens on the epitope level. https://lnkd.in/e8csmSus

#Diarrhea #Syndromic PCR What if syndromic PCR testing was used at the beginning? In a case from northern Spain, a 76-year-old patient with diffuse large B cell lymphoma and immunocompromised status suffered from severe diarrhea attributed to Cyclospora cayetanensis infection. Initial bacterial cultures (Salmonella spp., Shigella spp., Yersinia spp., and Campylobacter spp.) yielded negative results. Despite this, diarrhea persisted for one month. Following admission to the intensive care unit, syndromic PCR testing with the Allplex Gastrointestinal panel assays covering a spectrum of viral, bacterial, and protozoa was expeditiously employed and promptly identified the etiological agent, facilitating the subsequent administration of targeted therapy with azithromycin and trimethoprim-sulfamethoxazole (TMP-STX). Over time, the patient alleviated symptoms, underscoring the efficacy of syndromic PCR testing followed by tailored therapeutic intervention for vulnerable patients.

Lyme tests checking genetics and immune markers are worthless, the CD57 is the most accurate test available. This study describes why this is true, and how Lyme is able to hide and spread. It also demonstrates why Low Dose Immunotherapy (LDI) is the most effective treatment available, as it affects the adaptive immune system. Go here for the full description: https://lnkd.in/eM-tbUBm Lyme disease is found in a large percentage of people, most of whom are unaware that they are infected. If you are unable to find answers to your symptoms, it is strongly recommended that you get tested. If positive, LDI is the single best therapy available. Hastey CJ, et. al. Borrelia burgdorferi Infection-Induced Persistent IgM Secretion Controls Bacteremia, but Not Bacterial Dissemination or Tissue Burden. J Immunol. 2023 Nov 15;211(10):1540-1549. doi: 10.4049/jimmunol.2300384. PMID: 37782044.

See my latest co-authored publication: Identification of GTF2I Polymorphisms as Potential Biomarkers for Chronic Kidney Disease in the Han Chinese Population. Excited about my new Kudos profile and sharing my publication

Aggressive TB screening and advanced molecular technology for early detection are crucial in combating tuberculosis effectively. Early identification through rigorous screening can prevent the spread of TB, particularly in high-risk communities. Advanced molecular techniques enhance the accuracy and speed of diagnosis, allowing for timely treatment initiation. This proactive approach not only reduces the transmission rates but also improves patient outcomes, ultimately contributing to better public health and a significant decrease in TB-related mortality and morbidity globally https://lnkd.in/gQX3ZQFy

Happy to share some work from my PhD :) In this preprint, we investigated the role of genes related to 52 aging-related diseases using data from the UK Biobank and a network approach. We found that genes directly associated with multiple aging-related diseases (i.e., pleiotropic genes) are often linked to immunological disorders, but do not overlap with aging-related genes. Instead, aging-related genes tend to connect with multiple aging-related diseases through indirect interactions. We then analyzed the differences between these two groups of disease-connecting genes (direct and indirect). We found a polarizing effect: genes directly connecting multiple aging-related diseases exhibit high tissue-specific expression but low coexpression with disease-related genes. Conversely, indirectly-connecting genes show low tissue-specificity but high coexpression with disease-related genes. Lastly, we used machine learning to predict potentially novel aging-related genes based on the network connections. This work paints a deeper picture of the multiple types of interactions between ageing-related processes and ageing-related diseases. 

We are thrilled to announce positive results from Part 1 of our two-part Phase 2 ELIMINATE trial were published today in The Lancet Infectious Diseases. This Phase 2 trial is evaluating LBP-EC01, a CRISPR-Cas3 genetically engineered bacteriophage therapy, designed to treat patients with urinary tract infections (#UTIs) caused by antimicrobial-resistant (#AMR) and multi-drug-resistant (#MDR) E. coli.   Additionally, we are excited to share that dosing has begun in the randomized, controlled, and blinded Part 2 portion of this Phase 2 study. This clinical trial is supported by the Biomedical Advanced Research and Development Authority (BARDA).   With an estimated 150 million people worldwide affected by UTIs annually, the CDC and the World Health Organization have identified antibiotic-resistant E. coli as an urgent and serious public health threat requiring the development of new treatments.   Stay tuned for more updates as we continue our mission to combat these challenging infections! https://lnkd.in/eZDuCx9Y

Nationwide study of patients with #diarrheal disease in Bangladesh studying #bacteria-phage #coevolution indicates that the phage-to-bacteria ratio may serve as a biomarker of disease severity in #cholera patients #microbiome #microbiota #diarrhea #phage #vibrio https://lnkd.in/ecTjGvN9 (behind paywall)