Sayad Doobary-Vobora’s Post

Check out our recent paper: “Generation of multimillion chemical space based on the parallel Groebke–Blackburn–Bienaymé reaction”, co-authored by Evgen Govor, Vasyl Naumchyk, Ihor Nestorak, Dmytro Radchenko, Dmytro Dudenko, Yurii Moroz, and Oleksandr Grygorenko. This study evaluated the parallel Groebke–Blackburn–Bienaymé reaction, highlighting Sc(OTf)3 as the superior catalyst. A model 790-member library was obtained with 85% synthesis success rate, generating a 271-Mln. readily accessible (REAL) heterocyclic chemical space mostly containing unique chemotypes, with 432 compounds showing biological activity according to the ChEMBL database. Read more: https://lnkd.in/dqJgQHiK Browse and purchase our products at EnamineStore: https://lnkd.in/diy7GrH5

Congratulations to our senior researcher Mikhail Elyashberg and his co-authors for reaching the milestone of 2000 views of their paper on the #structural reassignment of polyenol natural products. Published in 2023 in the European Journal of Organic Chemistry, the paper examines how two unusual polyenols categorized as defying chemical principles were subsequently reassigned as the well-known nucleosides, adenosine and uridine, following reanalysis of the original data. By applying chemical intuition, computer-assisted structure elucidation (CASE), using the ACD/Labs’ Structure Elucidator Suite, and DFT methods, the team was able to unravel the complexity of determining the chemical identity of natural products, where the extensive demands on interpreting spectroscopic information can often lead to misassignment. CASE can help in combating potential errors caused by subjective interpretation using classical elucidation methods. Read more in the full paper: https://buff.ly/3YRabLW The paper is authored by Prof. Andrei Kutateladze, Prof. Roderick W. Bates, Prof. Mikhail Elyashberg, and Prof. Craig Williams.

The versatile reactivity of diaminoacetylenes allowed the preparation of 2,3-diaminocyclopentadienones by the cycloaddition with diarylcyclopropenones. We used this new pro-chiral ligand class to prepare iron carbonyl complexes for the application in reductive amination catalysis. I'm proud to have finally published the results in Catalysis Science & Technology! https://lnkd.in/eq_DZSDV

I am excited to share our latest work that has been accepted for publication in Chemistry–A European Journal! A fresh approach to 2-quinolone synthesis! This study presents an innovative organocatalytic electrophilic arene amination strategy, enabling the efficient synthesis of a diverse array of 2-quinolones—a critical scaffold with extensive industrial applications. By circumventing traditional metal-based catalysts, this approach paves the way for advancements in multiple sectors, offering a sustainable and versatile alternative. You can access the full article here: https://lnkd.in/gnCFUyBq Thanks to all authors for your valuable contributions. László Kürti, ARGHYA GHOSH, Muhammed Yousufuddin

Our latest paper on halogen bonds of coumarins, published in Zeitschrift für Physikalische Chemie (International Journal of Physical Chemistry), is available online. Congratulations, Mebin Varghese. https://lnkd.in/g2NN2h36

The synthesis technique for clusters is crucial for advancing cluster science. Integrating diverse methods from various chemical fields will facilitate material exploration across the periodic table. This review by Takamasa Tsukamoto focuses on all substances that are regarded as cluster materials and makes a new attempt to provide a comprehensive understanding through categorizing and summarizing clusters based on their constituent elements in the periodic table. Find out more in the full article at https://lnkd.in/errT37Wg

In the dynamic field of material science, reticular chemistry and Metal-Organic Frameworks (MOFs) are currently at the forefront, heralding a new era of innovation and application. The concept, popularized by the pioneering work of chemists like Omar Yaghi, has transformed how we approach the design and synthesis of complex materials. For those who are interested in this hot topic; these are some lectures illustrated by Omar Yaghi talking about MOFs as the backbone of reticular chemistry, it's key characteristics, and applications of MOFs like gas storage and separation, catalysis, drug delivery, environmental remediation, and sensing. To download it , https://lnkd.in/dWvDWFtA

For those in the chemistry and related fields. (and do tell Nessa Carson if you find / know of other conferences so she can add to this super database!)

Secrets of Chemistry will never end!!! 🔬 Single-electron carbon-carbon bond identified!!! Elusive bond isolated after almost 100-year wait by Victoria Atkinson, special to C&EN Scientists at Hokkaido University have experimentally confirmed the existence of a single-electron carbon-carbon bond for the first time (Nature 2024, DOI: 10.1038/s41586-024-07965-1).  Unbelievable result, but it happens!, I think it will make a great change in chemistry in the near future. I have called it "The Confused Electron" (الألكترون الحائر) See the chemical compound below (source: Nature 2024, DOI: 10.1038/s41586-024-07965-1)

Jingru Fu, Ying Wang, Teng Ben and colleagues efficiently extracted high-purity D2 from an isotopic mixture under ambient conditions by spatial confinement between ultrasmall Pd nanoparticles and a crystalline porous organic framework (CPOF-1) skeleton. The D2/H2 separation performance of Pd was enhanced by the confined effect. This study provides a novel concept for deuterium separation with low energy consumption, low cost, and high efficiency, and demonstrates great significance for practical applications. #Matter https://lnkd.in/dS88DpZj