Science Magazine’s Post

Dr. Abdullah Khan, senior research fellow at the MRC WIMM, University of Oxford, builds next-generation human models that allow the study health and disease states, focusing on the bone marrow. In this video, Dr. Khan discusses the existing challenges when working with organoids, the key technologies he uses, and his hope to translate treatments on a precision and personalized medicine basis in the future. Watch more videos on The Scientists' Channel here: https://lnkd.in/epeqUbrT #MedicalResearch #Organoids #PersonalizedMedicine #OxfordResearch MRC Weatherall Institute of Molecular Medicine

Explore the dynamic process of #autophagy with our innovative range of chemical products! From autophagy inducers to lysosomal inhibitors, our solutions provide researchers with the tools they need to investigate cellular recycling mechanisms and their implications for health and disease. Whether you're unraveling the mysteries of aging or studying neurodegenerative disorders, our autophagy products offer precise and reliable tools for advancing #scientific discovery. Join us in unlocking the secrets of cellular self-eating and shaping the future of biomedical research! #Autophagy #CellularRecycling #InnovativeResearch 🧬🔬 https://lnkd.in/eGwSP6E9

Researchers from the National Institute of Biological Sciences in Beijing have developed a groundbreaking imaging method to observe rare LepR+ stromal cells in mouse bone marrow. By using a special antibody and advanced imaging techniques, they’ve achieved unprecedented clarity in viewing cell interactions. This innovation provides deeper insights into bone marrow structure, aging, and inflammation-related diseases, and bridges early-stage research with clinical studies. Dr. Bo Shen calls it a major step forward in regenerative medicine and bone health https://lnkd.in/duSEtQQj. Stay informed: https://lnkd.in/ddFy65uK #MedicalResearch #ImagingTech #RegenerativeMedicine #BoneHealth #StemCells #HealthcareInnovation #ResearchBreakthrough #AIinMedicine

News Medical: Researchers seek to develop noninvasive diagnostics for chronic fatigue syndrome "Cheng is part of an international team of researchers who recently received funding from the National Institutes of Health to explore molecular- and cellular-level changes in muscle tissue that could potentially lead to better diagnostic tools and therapeutic options for both CFS and related conditions, such as long COVID." “When it comes to CFS, researchers have focused on a range of different tissues, organs, and mechanisms, but we're one of the first teams to look specifically at changes in skeletal muscle stem cells,” says Cheng. “And we're using a multidisciplinary approach so we can look at those changes from the molecular level, the subcellular organelle level, and the cellular level.” Dr Charles Shepherd, Hon Medical Adviser MEA, comments on the blog: https://lnkd.in/d-j_KJTX #pwME #MECFS #MyalgicE #MyalgicEncephalomyelitis #LongCovid #PostCovid

1. The autonomic nervous system controls internal organ functions and is divided into sympathetic and parasympathetic systems. 2. A new Caltech study reveals diverse neuron populations within the sympathetic nervous system and their organ-specific control. 3. The research, led by Tongtong Wang, focuses on the cooperation between the brain and body for maintaining internal balance. 4. The study challenges the traditional view of the sympathetic system as a uniform network affecting all organ functions. 5. Using single-cell RNA sequencing and spatial transcriptomic analysis, researchers identified at least two distinct neuron populations in sympathetic ganglia. 6. One neuron group targets the gastrointestinal tract, while another affects secretory areas like the pancreas and bile tract. 7. The study discovered how these neurons influence bile secretion and gut motility, allowing for precise control of digestive functions. 8. This research opens new therapeutic possibilities for treating organ-specific dysfunctions and understanding the brain-to-body signaling pathways.

Let's explore the Human Cell Atlas! Today's #interesting read highlights this 𝙛𝙞𝙧𝙨𝙩 𝙙𝙧𝙖𝙛𝙩 atlas, which aims to create a comprehensive map of all human cell types and will provide unprecedented insights into cell functions, tissue organisation, and their roles in health and disease. 💡 𝙍𝙚𝙖𝙙 𝙩𝙝𝙚 𝙛𝙪𝙡𝙡 𝙨𝙩𝙤𝙧𝙮 𝙝𝙚𝙧𝙚: https://lnkd.in/da2Smdqp #HumanCellAtlas #SingleCellBiology #PrecisionMedicine #Innovation

Discover the future of biomedical research with 3D cell culture models like organoids! These pioneering models allow scientists to replicate complex biological functions and tissue properties in a controlled lab environment. However, creating high-quality organoid models comes with its own set of challenges. In an on-demand Technique Talk from The Scientist, sponsored by Sartorius, Aitor Aguirre, Associate Professor at Michigan State University, dives deep into his team's groundbreaking work. Learn how they create cardiac organoids from iPSCs and use these 3D models to unravel the mysteries of human heart development and investigate various heart diseases. Don't miss out on this insightful discussion. Watch now: https://ow.ly/NSeb50To7E1 #organoids #spheroids #3DCellCulture #HeartHealth #StemCells

🧠Released today the first data regarding the implantation of spinal cord neurostimulators in patients with spinal cord injuries. This is the first step toward a new, promising era for motor neurorehabilitation. 🔬The team, comprising doctors and researchers from IRCCS Ospedale San Raffaele and the San Raffaele University (UniSR) in Milan, and from a group of bioengineers from the Scuola Superiore Sant'Anna, coordinated respectively by Pietro Mortini (San Raffaele) and Silvestro Micera (Sant'Anna School of Advanced Studies), obtained promising results in its treatment of spinal cord injuries (SCI) through the use of a new protocol involving high frequency epidural electrical stimulation. 📝The study, published on Science Translational Medicine, shows how this technique significatively reduces muscle spasticity by improving patients’ motor capacities, giving new hope for a future complete recovery to patients with serious cases of SCI. This achievement became possible only through an interdisciplinary and interuniversity approach which involved experts coming from different fields and different institutions, working together toward the same shared goal: greatly improve their patients’ quality of life. Read about their groundbreaking work here 👉https://lnkd.in/dGZQ6q6F Photo credit: Alessandro Gandolfi/ParalleloZero

This week's issue of Science Translational Medicine has arrived! Personalized electric stimulation shows promise in two patients with spinal cord injuries, a study shows that Staph bacteria rapidly evolve resistance to new antibiotic candidates, and more. https://scim.ag/4j5zjXs

Useful protocol for single cell #genomics #researchers. 👇 FixNCut preserves cellular integrity while allowing flexible sample handling, making it suitable for settings where immediate processing isn't possible. It supports single-cell assays like scRNA-seq and ATAC-seq and is compatible with various biological samples, ensuring RNA and DNA integrity. Additionally, FixNCut enables multi-center studies by facilitating sample fixation at collection points, reducing artifacts associated with stress or necrosis, and enhancing the reproducibility of single-cell analyses.