SciLifeLab’s Post

🔬 Dive into the World of Life Sciences & Biotechnology with AFM! 🌱 We’re thrilled to share our newly curated resource page dedicated to Atomic Force Microscopy (AFM) applications in Life Sciences & Biotechnology. Explore how AFM is pushing the boundaries of biological research and helping scientists uncover nanoscale insights. 💡 What’s included? 📄 Application Notes: Practical guides to solving specific research challenges. 🎥 Webinars: Learn from industry experts and dive deep into advanced AFM techniques. 🛠️ How-To Guides: Step-by-step instructions for optimizing your experiments. 📚 Publications: Research-driven content to inspire your next breakthrough. 👉 Why spend time searching when you can find everything you need in one place? 🔗 Explore our resource pages and find solutions tailored to your research focus: https://hubs.la/Q030vqk60 Have questions or looking for a specific resource? Let us know in the comments or reach out directly!

In June this HALRIC pilot project kicked off their first activities towards tackling the global challenge of multidrug-resistant bacteria, responsible for 1.27 million deaths annually. By 2050, this number could rise to 10 million worldwide unless new antibiotic solutions are developed. The cross-border research team focuses on colistin, a potent antibiotic effective against various gram-negative bacteria, but also known for its kidney toxicity. The research approach is to encapsulate colistin in nanoparticles and an aim of the pilot project is to uncover the intricate internal structure of these nanoparticles and their molecular dynamics, which are crucial for improving their pharmacological profiles. The collaboration is between Reidar Lund, Thomas Vogelaar, The Faculty of Mathematics and Natural Sciences, University of Oslo and Jan Skov Pedersen, Department of Chemistry - Aarhus University and they will employ three scattering techniques: ✳️ Large-scale Neutron Scattering #SANS at the Institute Laue-Langevin (ILL) in France. ✳️ Small-Angle X-ray Scattering #SAXS and Dynamic Light Scattering at AU and UiO, Norwegian Centre for X-ray Diffraction, Scattering and Imaging (REXS). This joint effort not only underlines the importance of cross-border collaboration in scientific research, but also brings us a step closer to new, safer antibiotic formulations to combat MDR bacteria. Find out more about this HALRIC Pilot Project including references: https://lnkd.in/dNHsZaXp Interdisciplinary Nanoscience Center - Aarhus University #Science #Innovation #Collaboration #Research #Antibiotics #Nanotechnology #GlobalHealth #HALRIC #overgransen

Only 11 days left until the DRAGON Symposium! If you are passionate about drug discovery, save the date and register now https://lnkd.in/ggWm_cUD   Some scientific highlights attendees can look forward to include: ➡️ recent results on the assembly of a new generation of #radiopharmaceuticals with #supramolecular #theranostics ➡️ the 3D-printing of metal organic frameworks (MOFs) for biomedical applications ➡️ bioinspired supramolecular materials as drug delivery systems ➡️ machine learning applied to the understanding of noncovalent interactions via the acceleration of atomistic simulations.    “The presentations will feature senior scientists but also early career postdoctoral researchers who bring all their out-of-the-box ideas, energy and enthusiasm to the event,” says Prof Casini, host for the event and leading expert in medicinal and bioinorganic chemistry.   Find out how Prof Casini's expertise in supramolecular approaches at Technical University of Munich directly connects to the DRAGON Symposium: https://lnkd.in/gY5sywGM   #DRAGONSymposium #PrecisionMedicine #MedicinalChemistry #BioinorganicChemistry

On the 5th of December, I was fortunate enough to get a chance to present my poster at the Molecular Biosciences Research Thrust (MBRT) Research Symposium held at the University of the Witwatersrand. There were plenty of interesting talks as well as many familiar faces and even a few new ones. The aim of my research is to develop a Nextflow workflow that integrates multiple CNV callers for improved CNV calling from exome sequencing data. The workflow will include a VCF conversion step, a merging step, a feature annotation step and finally random forest prediction and validation steps.

🎉 Excited to have attended the Third Edition of North American Supramolecular Chemistry (NASC 2024)! I had the honor of presenting our recent work on synthesizing a new family of coumarin derivatives. These molecules show great potential in applications such as: 🔬 Cell imaging 🧪 Biosensing ⚡ Electrogenerated chemiluminescent (ECL) luminophores 🔍 Chemodosimeters for detecting toxic analytes 🌐 Aggregation-induced emission studies It was inspiring to exchange ideas and connect with leading researchers in supramolecular chemistry. Excited to see how these discoveries advance the field! #SupramolecularChemistry #NASC2024 #CoumarinDerivatives #ScientificResearch #Innovation #OrganicSynthesis

Great to see our paper featuring the front cover of Macromolecular Rapid Communication from Wiley. The work, titled "Organic Donor–Acceptor–Donor Trimers Nanoparticles Stabilized by Amphiphilic Block Copolymers for Photocatalytic Generation of H₂" focus on the development of a versatile platform for creating functional π-conjugated organic nanoparticles stabilized by amphiphilic block copolymers for green H₂ photocatalytic generation. The donor–acceptor–donor trimers nanoparticles show enhanced photocatalytic activity (≈0.6 mmol g−1 h−1) for H₂ production via water splitting. This was a collaborative work between three laboratories, LCPO - Laboratoire de Chimie des Polymères Organiques, Institut de Chimie de la Matiere Condensee de Bordeaux, ICMCB, CNRS, Univ. de Bordeaux, Bordeaux INP and ICP from Université Paris-Saclay. Thanks Hynd Remita, Alisha Khan, jean-louis bobet and Eric Cloutet for your collaboration in such a interdisciplinary project.

A novel application of #Terbium161 has been published. A form of injectable nanobrachytherapy using radiolabeled nanaparticles 161Tb-nf Au@TADOTAGA proved to be stable carriers of the Auger-emitting radioisotope #161Tb displaying significant retention time. With the opportunity for imaging, using MRI or CT modalities, this #Tb161 nanobrachytherapy agent may open doors to localized treatment of cancer. Our compliments to the research consortium for this amazing work! Université de Franche-Comté Université de Bourgogne NCSR "DEMOKRITOS"

It's always a good time for something novel! I am announcing the formation of a new company that is invested in realizing a disruptive analytical technology. FreeSRF Holdings LLC is on a mission to change how molecular interactions are measured! Have you ever wondered how labeling of analytes, or tethering them, can affect binding of molecules? Does your technology need a detection system that is agnostic to sample type? Compensated interferometry is a way to allow for no restrictions, native-state, nano-scale determinations. We are merging Physics, Biophysics, Chemical Biology and Medicine to address both basic and applied problems. Check out the opportunity: Freesrf.com Free solution response function darryl bornhop #label-free #free-solution #nano-scale #interferometry

Registration is now available for the 13th International Conference on Biomolecular Engineering (ICBE25)! Attend the premier conference that brings together researchers who are using quantitative approaches to advance the understanding and application of molecular biology. Funding is available to help sponsor registration costs. Students/post-docs and early-career professionals are encouraged to apply! Early bird rates are in effect through November 15, 2024: https://lnkd.in/dCwDveAm Apply For Funding: https://lnkd.in/ePPPwegA Keynote Speakers: April Kloxin, Professor, University of Delaware Danielle Tullman-Ercek, Professor, Northwestern University Jonathan Silberg, Professor, Rice University Conference Topics: Biomaterials and Engineered Living Materials Biomolecular Engineering for Human Health Biomolecular Engineering to Advance Fundamental Science Cellular and Tissue Engineering Emerging Technologies in Molecular Engineering Metabolic Engineering Nucleic Acid Engineering Plant and Environmental Engineering Protein Engineering Conference Chairs: Gözde S. Demirer, Caltech Kevin Solomon, University of Delaware Organizing Committee: Aditya Kunjapur, University of Delaware Chelsea Y. Hu, Texas A&M University Jonathan Conway, Princeton University Katie Galloway, MIT Lydia Contreras, University of Texas, Austin Michael Smanski, University of Minnesota Quinton Smith, University of California, Irvine #ICBE #ICBE25 #MolecularBiology #Molecular #Biology

📣 check out this paper! 🤝 Within a collaborative effort by Jan Kretschmer, Ph.D. & Remy Chiaffarelli, Marta Vuozzo, Jonathan Cotton, Jan Ráliš, Martin Dračínský, Stanislava Matějková, Ulrike Seeling, Andreas Schmid, André F. Martins & Miloslav Polasek, authors demonstrate ‘A Macrocyclic Hybrid PET/MRI Probe for Quantitative Perfusion Imaging In Vivo’: 🖇️ https://lnkd.in/dxRQgQSe 📝 With the advent of combined #MRI/#PET systems, the medical #imaging field has been exploring innovative ways to harness the advantages of both techniques. 📍Here, they developed a #macrocyclic bimodal PET/MRI #probe that exhibits kinetic stability comparable to the most stable contrast agents currently used in clinical MRI. The probe allows for convenient direct radiolabeling in the final synthesis step using 18F and works as a hybrid PET/MRI perfusion agent. Werner Siemens Imaging Center IOCB Prague - Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences Universitätsklinikum Tübingen University of Tuebingen Charles University iFIT - Cluster of Excellence