Sci.STEPS’ Post

The Jean-Pierre Lab (FJP Lab) is looking for a PhD student to join our dynamic research group located in the Department of Biology at the Université de Sherbrooke, Canada.   The lab studies the molecular underpinnings whereby microbes show emerging phenotypes when grown as polymicrobial biofilm-like communities that would not readily be seen by using bacterial monocultures.   More specifically, the lab uses cystic fibrosis (CF)- a multiorgan genetic disease that primarily affects the airways of these individuals- as an infection model to understand how interspecies interactions among abundant and prevalent microbes impact changes in antimicrobial susceptibility when grown in CF-like conditions.   The project will focus specifically on identifying genes and signals that are impacting streptococci physiology and mechanisms of recalcitrance when grown in a polymicrobial system that we have recently developed. Candidates should contact the PI (Fabrice Jean-Pierre – fabrice.jean-pierre@usherbrooke.ca) with the following documents: ·        A one-page max cover letter describing the reasons for (i) completing graduate studies and (ii) joining the FJP Lab. ·        C.V. ·        Unofficial transcripts. ·        Contact information for at least two references (with at least one from the most recent supervisor).   The expected starting date is January 2025 or May 2025. More details here: https://lnkd.in/gZcA95Rw #scholarshipopportunities #graduateschool #gradschool #phd #phdposition #microbiology #funding #research #university #theqayersgroup and #keepyourdreamsalive

🌟 Innovative Breakthrough in Synthetic Biology! 🌟 I'm excited to share a groundbreaking development in the field of synthetic biology: cyborg cells that combine the features of living cells with synthetic materials! 🧬✨ Researchers at the University of California, Davis have created these semi-living cells, which are designed to maintain essential cellular activities while being more resistant to stressors like high pH and antibiotics. 🔬 Key Highlights: - Hybrid Nature: These cyborg cells blend the engineering simplicity of synthetic materials with the complex functionalities of natural cells. - Enhanced Durability: They are more resistant to environmental stressors that would typically kill normal cells. - Potential Applications: These cells could revolutionize fields such as medicine (targeted drug delivery and cancer therapy) and environmental cleanup. This innovative approach opens up new possibilities for creating cells that can perform specific tasks without the risk of uncontrolled replication. It's a fascinating step forward in synthetic biology and could lead to significant advancements in both healthcare and environmental science. Let's celebrate this incredible achievement and look forward to the future possibilities it brings. 🚀🔍 #SyntheticBiology #Innovation #Research #CyborgCells #MedicalAdvancements #EnvironmentalScience #MedicalLaboratoryTechnology #Microbiology #Phlebotomy #LaboratoryTesting #DiagnosticTesting #HealthcareProfessional #MedicalTesting #ClinicalLaboratory #BiomedicalScience #HealthcareIndustry #MedicalScience #LaboratorMedicine #ClinicalMicrobiology #InfectionControl #PhlebotomyTechnician #MedicalLabTechnician #MicrobiologyLab #ClinicalLab #HealthcareCareer #MedicalCareer #ScienceCareer #COVID19Testing #Virology #Bacteriology #Parasitology #MolecularDiagnosis #GeneticTesting #Cytology #Histopathology #Immunology #Serology

🌟 Excited About My Journey in Biochemistry and Molecular Biology! 🌿🧬 I’m thrilled to share that I’ve embarked on my journey as a Biochemistry and Molecular Biology (BMB) student at JKUAT. My passion lies in cancer biology, bioinformatics, and exploring the frontiers of precision medicine. Currently, I’m focused on building skills in: 🔬 Molecular biology research 💻 Bioinformatics tools and data analysis 📊 Cancer biomarker discovery and precision medicine Though bioinformatics isn’t part of my course structure, I’m committed to self-learning through online courses and practical projects. My long-term goal is to contribute to cancer research, particularly in lung cancer biomarker discovery. I’m excited about future collaborations, research opportunities, and connecting with like-minded professionals. Let's innovate together for a healthier future! #CancerBiology #Bioinformatics #PrecisionMedicine #BMBStudent #Research #Biotechnology #MolecularBiology #LungCancerResearch #StudentJourney #JKUAT #STEM

With wishes for a great day to everyone involved in ⭐#EMMP, I am sending to the air a 🔵SECOND CALL TO MY FUTURE #EMMP STUDENTS by a 🔵#TeachingTriad (3 articles) on 🔵#singlecell analysis #technologies (SCTs). Just to remind you: we’ll meet in the Module 10 (New Technological Developments 🧡), on a topic dedicated to #RNA. I was told you’ll have (only!) 5h to learn about these technologies, on which we have (almost!) 5x5 new papers every 5h! So, better to start earlier, and give ourselves more time => remove the pressure... ✅Why a Triad? ‘cus many students have told me they best remembered groups of 3 (terms, numbers, letters, items, phases, paragraphs etc). ✅Why on SCTs? ‘cus, from the ‘traditional’ point of view, they are more #cellbiology than #pathology technologies but we must never forget that, in fact, #cellbiology is The Basis of Pathology and the entire #medicine! And the SCTs have been shedding an unprecedent light on #cellbiology and our understanding of health and disease! ✅SCTs show us 3 MAIN THINGS: 🔵WHO IS THERE? (cellular identity) 🔵WHO IS AROUND? (intercellular relationships) 🔵WHO IS ABNORMAL? (cellular states) 🔔SCTs are not only those analyzing RNA! There are many SC #omics (#proteomics, #epigenomics, #metabolomics etc) and the combinations of them (such as #proteogenomics). 🔺SCTs are not always #spatial! They are spatial only if they are #insitu, otherwise the #tissue must be dissociated for a SC analysis - the spatial information is lost. 🔵🔵🔵 WHY should a #pathologist know about SCTs nowadays??? For 3 MAIN REASONS: 🔵BIOMARKERS (of diseases) 🔵MECHANISMS (of tissue/organism/disease development), 🔵CONSEQUENCES (of pathogen/therapy action). ⭐Convinced, interested to learn more? If yes, start with these 3 papers, all #openaccess: 1) PMID: 37280296, https://lnkd.in/dDSwCRKA 2) PMID: 37002403, https://lnkd.in/djJKPUdU 3) PMID: 37117846, https://lnkd.in/dU5s6MB4 And - #NoPressure, learn 'cus you want, not 'cus you must! Plus, 📣 DO NOT HESITATE TO #gotoyourpathologist (me) if you have questions. I know, modern technologies are not always easy to understand, that’s why we started early! #EMMP #MolecularPathology #StartEarly #Module10 #HowDoYouLearn 🌞 #TeachersWithoutBorders

Dr Frank Sainsbury's research group in the Institute for Biomedicine and Glycomics, Griffith University is currently looking for a PhD candidate to research structural plasticity in #viruses. The primary focus of this role is to investigate the ability of both native and engineered viral proteins to assemble into capsids with varying geometry. His research group is primarily interested in #virus capsids, pushing the boundaries of how they assemble and what can be learned from using them as biochemical reaction vessels and delivery vehicles. This project will involve #structuralbiology using state-of-the-art techniques including cryo-electron microscopy and charge detection mass spectrometry, recombinant protein expression in both prokaryotic and eukaryotic expression systems, and the development of purification processes and analytics for biological macromolecules. For more details: https://lnkd.in/egdctNZW #virology #scholarshipopportunities #graduateschool #gradschool #phd #phdposition #funding #research #university #theqayersgroup and #keepyourdreamsalive

I am thrilled to announce that I have achieved a First Class Honours (81.6) for my Final Year dissertation titled "Investigating the Role of H4K16 Acetylation in the Regulation of LINE-1 Expression During Neuronal Differentiation." In this research, I delved into the epigenetic modifications of histone proteins, specifically focusing on the acetylation of histone H4 at lysine 16 (H4K16). This post-translational modification is known to play a crucial role in chromatin structure and function. My study aimed to elucidate how H4K16 acetylation influences the expression of Long Interspersed Nuclear Elements-1 (LINE-1), a type of retrotransposon, during the process of neuronal differentiation. LINE-1 elements constitute a significant portion of the mammalian genome and are typically repressed in somatic cells. However, their expression can be reactivated during specific developmental stages or in certain diseases. Understanding the regulatory mechanisms controlling LINE-1 expression is essential for comprehending their impact on genomic stability and cellular function. Throughout my research, I employed a combination of molecular biology techniques, including immunostaining and immunofluorescence of cerebral organoids to investigate the interplay between H4K16 acetylation and LINE-1 expression in neural progenitor cells and mature neurons. My findings revealed novel insights into the epigenetic regulation of LINE-1 and highlighted the potential implications for research in neurodegenerative diseases such as Alzheimer’s. Achieving this First Class Honours is a significant milestone in my academic journey, and I am grateful for the support and guidance of my supervisor and peers throughout this research.

📅 Upcoming Academic Events from EMBL - EMBL Events! We are excited to share some of the upcoming academic events hosted by our media partner EMBL, covering a variety of essential topics in the life sciences. Take a look at the following events and explore opportunities to expand your knowledge and collaborate with experts in your field! 🧬 Wild frontiers of model organisms ▪️ Start Date: 8 - 11 Apr 2025 ▪️ Website: https://lnkd.in/gj76sG7C ▪️ This conference highlights research on how natural, fluctuating environments challenge traditional models, integrating ecology, genomics, and molecular biology to understand biology and evolution across diverse organisms. 🧬 AI in One Health ▪️ Start Date: 31 Mar - 2 Apr 2025 ▪️ Website:  https://lnkd.in/gptZ2GFP ▪️ This event will explore the impact of recent AI advances on health and life sciences featuring three sessions on "molecular medicine and precision health", "genetics and genomics", and "technology and imaging". 🧬 Mechanisms of drug resistance and tolerance in bacteria, fungi, and cancer ▪️ Start Date: 18 - 21 Mar 2025 ▪️ Website: https://lnkd.in/gsPtHMrW ▪️ Join global experts to explore cellular evolution, biochemistry, and metabolism driving drug resistance in antimicrobial and disease therapies, highlighting cutting-edge advancements and cross-species insights. 🧬 The expanding world of RBPs: from post transcriptional control to riboregulation ▪️ Start Date: 11 - 14 Mar 2025 ▪️ Website: https://lnkd.in/giu3vapm ▪️ Join experts to explore the field of RNA-binding proteins and their exciting progress on all fronts. 🧬 In situ structural biology: expanding the toolbox for structural cell biology ▪️ Start Date: 4 - 7 Feb 2025 ▪️ Website: https://lnkd.in/gWKdearE ▪️ This conference explores in situ structural biology advancements to highlight recent methodological developments, provide a discussion platform, and foster cross-disciplinary collaboration and methodological innovation. Don’t miss out on these incredible opportunities to advance your research and network with leading experts in the field! Be sure to check out the links above for more details and to register. ✨ #EMBL #AcademicEvents #LifeSciences #Research #ImagingData #RNABindingProteins #Immunology #TumorMicroenvironment #EnvironmentalStress

Seven #UMassBoston student researchers presented at the 2024 Annual Biomedical Research Conference for Minoritized Scientists (#ABRCMS) in Pittsburgh, PA. Two students received awards in their categories and all seven students won travel awards! The student researchers: Matheus Berbet was a winner in the Computational and Systems Biology category. Presentation: Amplivision: Automated analysis of multiplexed diagnostics to detect diseases Eyitayo Folorunso (Tayo) Presentation: Improving CAR T Cell Persistence; BAK/BAX double knockdown Sharra Lewis Presentation: Analyzing Localization of Sps1 GCKIII STE20 family of Kinase in S. cerevisiae of GFP Envy Gabriela Nicholson (Gabby) Presentation: Role of the Vagus Nerve in Airway Epithelial Regeneration After Naphthalene Damage Erin O'Neil Presentation: Exploring a Potential genetic mechanism in Dehnel’s Phenomenon using Mpf cells Addylene Semedo was a winner in the Cell Biology category.  Presentation: Examining the role of KIP3 during meiosis of S. cerevisiae Gianna Speaks Presentation: Towards the characterization of 5-hydroxymethyldeoxyuridine DNA kinase substrate specificity through crystallography and immobilization assays In the photo (left to right): Leslie McClain (Program Manager, Biology Department), Sharra Lewis, Tayo Folorunso, Gabby Nicholson, Addylene Semedo, Gianna Speaks, Erin O’Neil, Matheus Berbet #UMB #UndergraduateResearch

Defining the Neuronal Function of Poly(ADP-Ribose) Polymerases 📍Dundee, Scotland Apply now: https://lnkd.in/gFUCS8j4 #Phd #Postdocs #Researchhires #Polymerases The University of Dundee offers a BBSRC-funded 4-year PhD studentship to explore the role of poly(ADP-ribosylation) (PARylation) in neuronal function, particularly its impact on RNA biogenesis in aging neurons. This research focuses on understanding how PARylation modifies RNA-binding proteins, such as TDP-43, influencing mRNA splicing and neuronal survival. The PhD student will use advanced proteomics and transcriptomics techniques to investigate neuronal pathways relevant to neurodegenerative diseases and aging, contributing to critical research in these areas.

Adriana Chrenková will be defending her PhD thesis with a talk entitled "Study of the HipL toxin-antitoxin system and its potential role in phage defense" on Tuesday 9 April 2024 at Aarhus University. During her PhD studies, Adriana Chrenková has studied bacterial kinases and their links to toxin-antitoxin systems and phage defence. Toxin-antitoxin systems are genetic elements in bacteria encoding a toxin protein and an antitoxin protein, able to counteract the toxin. Adriana Chrenková studied a bacterial kinase named HipL with an unusual internal translation initiation start site, presenting a novel way of regulating bacterial toxin-antitoxin systems, where both the toxin and the antitoxin are produced from a single gene. The research findings offer new insights into how bacterial toxin-antitoxin systems are regulated, and how they might be related to phage defense. Read more about her PhD defence: https://lnkd.in/dXhsB87T Members of the assessment committee: Professor Maria Selmer, Department of Cell and Molecular Biology, Uppsala University, Sweden Asc. Professor Sine Svenningsen, Department of Biology, University of Copenhagen, Denmark Senior Researcher Jan Trige Rasmussen (chair), Department of Molecular Biology and Genetics, Aarhus University, Denmark Main supervisor: Professor Ditlev Egeskov Brodersen, Department of Molecular Biology and Genetics, Aarhus University, Denmark Faculty of Natural Sciences - Aarhus University Aarhus University #HipL #toxinantitoxinsystem #phagedefence #bacterialkinases #cells #molecularbiology #structuralbiology #cellbiology #phddefence #research #university