Sense Medical Limited’s Post

Adaptive optics imaging (AOI) is a potentially valuable tool in assessing diabetic retinopathy (DR) severity and identifying microscopic retinal alterations associated with the disease, according to a new study. Read the full article here ⤵️ #VisualAcuity #Optics #DiabeticRetinopathy

Ophthopedia Update:Optical coherence tomography angiography in diabetic retinopathy: A major review: Diabetic retinopathy (DR) is characterized by retinal vasculopathy and is a leading cause of visual impairment. Optical coherence tomography angiography (OCTA) is an innovative imaging technology that can detect various pathologies and quantifiable changes in retinal microvasculature. We briefly describe its functional principles and advantages over fluorescein angiography and perform a comprehensive review on its clinical applications in the screening or management of people with prediabetes, diabetes without clinical retinopathy (NDR), nonproliferative DR (NPDR), proliferative DR (PDR), and diabetic macular edema (DME). #Ophthalmology #Eye #Ophthotwitter

Using multiple imaging techniques to detect early microscopic abnormalities in diabetic retinopathy. https://lnkd.in/dxbVT_n5 #retinopathy #ophthalmology #diabeticretinopathy

Monday 7/15/24 Diabetic neovascularization Optos multimodal imaging When Neo Looks “Pretty” This 54YO male with proliferative diabetic retinopathy (PDR) and retinal neovascularization was evaluated with Optos multimodal imaging. Optos color RG imaging shows active neovascularization in the inferotemporal macula. The neovascularization is best seen in the green channel, which isolates the RPE and neurosensory retina. The blood vessels virtually disappear with the red channel, which is best for viewing the choroid. Finally, the vessels profusely leak on fluorescein angiography. Optos RG color images are generated from a red (635nm) and green (532nm) laser. The absence of a blue channel results in their greenish tint which at first many clinicians find somewhat unsettling. However, much information is contained in these images once one understands how they are constructed. As shown in our patient, these images allow for isolating the neurosensory retina/RPE and choroid, and often reveal more information than is visible in a true color image. Red neovascularization viewed on an orange background (color image) is much more difficult to see than when viewing black neovascularization on a grey background (green channel). Recently Optos introduced a blue laser to their California model which in our opinion now gives the best of all worlds, stunning true color images along with the ability to view each channel separately. Go to www.retinarocks.org/cases for more PDR  cases. [This case can be found on www.retinarocks.org in the Image Gallery, DR (Diabetic retinopathy) 08 PDR folder, DR PDR TLM-20210114] Have an interesting case and want to help your peers learn something about the retina? Submit your images at www.retinarocks.org. Retina Rocks and its charitable foundation, "Eye Reach" are supported in part by Optos (@optomap) and Topcon Healthcare (@topconhealthcare). Retina Rocks is the image bank for the Retina World Congress (@RetinaWorldCongress). #pdr #retina #optometry #ophthalmology #cool #odsonfacebook #adarshcharitablefoundation #UWF #optos #optomap #TopconHealthcare #savingsightsavinglives #RetinaWorldCongress

The November issue is out for Ophthalmology and Therapy! I would recommend taking a look especially if you are interested in AMD, glaucoma or dry eye, as the issue has a number of articles in these areas: https://lnkd.in/efhDWsjE Some of my personal highlights include:   📣 A commentary on adopting interventional #glaucoma via sustained-release therapies from Arkadiy Yadgarov et al   🔮 Authors investigate the predictors of disease activity after anti-VEGF treatment for nAMD using real-world data from the PROOF study 🔦 Authors add to the evidence pool for the safety, tolerability, and short-term efficacy of low-level light therapy for dry AMD - Enrico Borrelli et al 📖 Utilising Narrative Medicine to Identify Key Factors Affecting Quality of Life in Dry Eye Disease: An Italian Multicentre Study - Pasquale Aragona, Stefano Barabino et al 👁️ Posterior Vitreous Detachment and Risk of Neovascular Glaucoma in Eyes with Prior Retinal Vascular Occlusions - from Section Editor Sanjay Asrani and colleagues ❓ A survey study asks patients with diabetic macular edema what factors influence their treatment preference

Ophthopedia Update:CENTRAL BOUQUET HEMORRHAGE: Clinical and Multimodal Imaging Features: Purpose: To describe the clinical characteristics, multimodal imaging features, and anatomic basis of a distinctive pattern of deep retinal hemorrhages located in the central fovea, a presentation referred to as “central bouquet hemorrhage.” Methods: Retrospective, observational, multicenter case series of eyes with central bouquet hemorrhage. Multimodal imaging features were reviewed and analyzed. Results: Ten eyes from 10 patients (4 women and 6 men), with a mean age of 55.6 ± 21.7 years (range 25–84 years) were included. Underlying etiologies were neovascular age-related macular degeneration (40%), lacquer cracks in pathological myopia (30%), macular telangiectasia Type 2 (10%), proliferative diabetic retinopathy (10%), and ocular trauma associated with angioid streaks (10%). On ophthalmoscopy, all eyes with central bouquet hemorrhage displayed a deep retinal hemorrhage with round margins in the central fovea and associated with petaloid hemorrhages radiating in the surrounding Henle fiber layer. Cross-sectional optical coherence tomography showed a well-delineated round hyperreflective lesion involving the central foveal Henle fiber layer/outer nuclear layer in all cases. Accompanying hyperreflective hemorrhages tracking along the obliquely oriented Henle fiber layer were present in all eyes. Resolution occurred in all patients, either spontaneously (30%) or after treatment with intravitreal anti-vascular endothelial growth factor injections (70%), and was associated with partial visual acuity improvement (from 20/113 to 20/36). Conclusion: “Central bouquet hemorrhage” is a novel descriptive term describing a characteristic round pattern of intraretinal blood in the fovea associated with Henle fiber layer hemorrhage and encountered in a spectrum of macular disease. #Ophthotwitter #Ophthalmology #Retina

New research led by Thomas Ciulla, MD, MBA, FASRS from Indiana University School of Medicine, reveals the significant burden of #geographicatrophy in age-related macular degeneration. Over 800,000 patients were analyzed, showing a 2-line vision loss by year 3, with a heightened risk for those with initial visual impairment. Additionally, the study highlights a meaningful risk of GA progression to neovascular #AMD. Dive deeper into these findings in the latest article from Modern Retina by lynda charters #Ophthalmology #HealthcareInnovation #EyeHealth #EyeSurgery #Biotech #Medtech #Lifescience

Ophthopedia Update:ADAPTIVE OPTICS IMAGING IN DIABETIC RETINOPATHY: A Prospective Cohort Study: Purpose: To investigate the correlation between diabetic retinopathy (DR) severity and microscopic retinal and vascular alterations using adaptive optics imaging. Methods: In this single-center, prospective cohort study, adult participants with healthy eyes or DR underwent adaptive optics imaging. Participants were classified into control/mild nonproliferative DR, moderate/severe nonproliferative DR, and proliferative DR. Adaptive optics imaging using the RTX1 camera was obtained from 48 participants (87 eyes) for photoreceptor data and from 36 participants (62 eyes) for vascular data. Results: Photoreceptor parameters significantly differed between DR groups at 2° and 4° of retinal eccentricity. Wall-to-lumen ratio varied significantly at 2° eccentricity, while other vascular parameters remained nonsignificant. Cone density and dispersion were the strongest predictors for DR severity (P < 0.001) in multivariable generalized estimating equation modeling, while other vascular parameters remained nonsignificant between DR severity groups. All photoreceptor parameters showed significant correlations with visual acuity overall and across most DR severity groups. Conclusion: To date, this is one of the largest studies evaluating the use of adaptive optics imaging in DR. Adaptive optics imaging was demonstrated to differentiate between various levels of disease severity in DR. These results support the potential role in diagnostic and therapeutic microstructural evaluation in research and clinical practice. #Ophthotwitter #Ophthalmology #Retina

🚨 Breakthrough in Glaucoma Treatment!  A pivotal five-year study has validated the long-term safety and efficacy of MicroPulse Transscleral Laser Therapy (TLT), offering a non-invasive, repeatable option for managing glaucoma. 🔑 Key Findings: ✅ 32.5% average reduction in intraocular pressure (IOP). ✅ Significant reduction in reliance on IOP-lowering medications. ✅ Low complication rates across various glaucoma types and severities. ✅ Retreatment success without increased risk, avoiding invasive surgeries. This study, the first of its kind, underscores the transformative potential of MicroPulse TLT for long-term glaucoma care, improving outcomes and enhancing patient safety. 🔗 Learn more about this innovation in glaucoma management here: https://lnkd.in/dayr828Y #Glaucoma #ClinicalTrial #Innovation #Treatment #VisionHealth #EyeCare

ICYMI: Cornea Update: Evolving Trends in the Diagnosis and Management of Keratoconus Over 3 Decades: Purpose: To report the trends in the clinical presentation, diagnosis, and management of keratoconus (KC) in patients presenting to a multitier hospital network over 33 years. Methods: This retrospective study included patients with KC presenting from 1987 to 2020. Patients with KC in at least 1 eye were included. The data of 20,576 patients included in this study were retrieved from the electronic medical record database. Data on patient demographics, ocular diagnosis, contact lens usage, and surgical history were collected and exported for analysis. Descriptive statistics and chi square test were used for statistical analysis. Results: A total of 20,576 KC cases were seen from 1987 to 2020. Mean age at diagnosis reduced from 29.3 years (1987–1991) to 22.2 years (2016–2020). Adults (76.64%) were commonly affected with a majority being male (61.25%). Use of contact lenses increased from 4.34% (2002–2006) to 11.23% (2016–2020). Of the total number of surgical interventions, collagen crosslinking (CXL) constituted more than 1/5th (22.28%) between 2007 and 2011, which increased to more than half between 2012 and 2016 (53.61%) and almost 3/4th (72.53%) between 2017 and 2020. Advances in lamellar surgery have led to more patients undergoing deep anterior lamellar keratoplasty (DALK) as compared with penetrating keratoplasty. In the last 8 years, 17.2% patients underwent surgery and the most common was CXL (14.77%) followed by DALK (1.72%) and penetrating keratoplasty (1.04%). Conclusions: We report the trends in the clinical presentation and management of KC over 3 decades. In the last 33 years, advances in diagnostics have helped diagnose KC earlier. Contact lenses and advances in CXL have reduced the number of keratoplasties in KC, DALK being more common. http://dlvr.it/T9rnZz #Cornea #Ophthalmology #Ophthotwitter