Shan B, DPT’s Post

I am excited to share our recent publication where we investigated the binding affinities of fourteen ligands from BYL719 (a PI3Kα inhibitor previously discovered at Novartis) analogs. PI3Kα is a lipid kinase that is well-known as an oncogenic target in HR+/HER2- advanced breast cancer treatment. Our study employed a variety of in-silico techniques, including AMBER TI, MMPBSA, MMGBSA, docking, and machine learning, to characterize these ligands and predict their binding affinities. The structural insights from our simulations suggest that although the ligand-hinge interaction is the primary driver of ligand stability at the pocket, the R group positioning at C2 or C6 of pyridine/pyrimidine also plays a significant role. Binding affinities predicted via TI were in good agreement with previously reported affinities. However, computationally demanding techniques such as TI might not always be the most efficient approach for affinity prediction, as in our case study fast high-throughput techniques were capable of classifying compounds as active or inactive, and one docking approach showed comparable accuracy to TI. Camilo Velez Vega Cihan Soylu #cancerresearch #drugdiscovery #computationalchemistry #novartis #drugdesign

NEW from #CAR-T Meeting 2024 | Targeting BAFF-R with CAR-Ts to treat #MCL 🎥 🩸 Mike Barnkob, MD, PhD, Odense University Hospital, shares insights into the development of BAFF-receptor (BAFF-R)-specific #CARs, which were investigated for the treatment of #mantlecelllymphoma (MCL) While these CARs were able to kill primary #MCL #cells, relapse did occur, and Dr Barnkob highlights possible escape mechanisms 🔦 Give it a watch to learn more 👉 https://lnkd.in/ehGZhhxc #HemOnc #Lymsm #VJHemOnc

The targeting of WNT5B and WNT10B in osteosarcoma

Social media continues to be one of the most powerful tools in promoting and educating about health, and even more so when you are trying to reach younger generations. Check out our latest Real Chemistry report that uncovers the top trends leading to #cancerscreening conversations on social media, click-worthy content strategies and the leading voices in promoting early cancer screenings. Top-level findings show: 🏥 #Patient and #healthcare #provider (HCPs) influencers are “eventizing” their cancer screenings and documenting their experiences in real-time to demystify fear of going to their healthcare provider or “white coat syndrome.” 🌟 Hollywood is playing a significant role in driving audiences to be more proactive in early cancer screenings, using micro case studies of popular celebrity influencers such as Olivia Munn and Chrissy Teigen. 📱 Micro- and even nano-influencers are making healthcare a part of their daily content routines and leveraging popular beauty and fashion influencer storytelling like the “Getting ready with me (#GRWM)” movement. ✍️ HCP influencers are adopting roles of both patient and educator by documenting their routine personal healthcare screening journeys for audiences on Instagram and TikTok. 🩷 #BreastCancer screening content still outpaces content for other cancers, and what lessons the #healthcare industry can take to raise awareness for other cancer disease states.

Our Social Media Workshop is live! Learn more about the patient caregiver experience and #BTS on the Targeting Cancer Campaign. This workshop discusses leveraging social media for awareness. Learn more about how to access our virtual sessions here: https://ow.ly/vrNs50QAgm6

Doing a skin check? Confidence is key & social media ads may help

At The Variable, we don't just create ads—we create different. Last night, our Serious Foreplay campaign with Fuck Cancer took home the Shorty Impact Award for awareness campaigns, proving that being bold can have a huge impact. Skin cancer is the most common cancer in the U.S., but it's almost 100% curable if caught early. Inspired by a team member who discovered a cancerous mole during an intimate moment, we partnered with Fuck Cancer to turn foreplay into a lifesaving act. To bring the campaign to life, we created cheeky, inclusive guides like "Reverse the Risk Cowgirl" to make skin scans fun and educational; bold videos that taught the ABCDEs of mole-checking in unforgettable ways; strategic media placements with lifestyle and adult-related content; and partnerships with sex-positive influencers and physicians. The results? ✔ Website traffic tripled ✔ Ads saw an 800% higher CTR ✔ And most importantly, lives were saved—including one of our own team members, who caught a potentially dangerous mole thanks to the campaign's message. This campaign isn't just an ad—it's a movement to make partner-aided skin checks a lifesaving routine. Huge thanks to Fuck Cancer for trusting us to help make a real difference. #wearethevariable

When time is of the essence, every moment counts. Mr. Zhang's story is a powerful testament to the critical importance of swift cancer care. Diagnosed with cancer, he found himself racing against time, a challenge far too many face. Thanks to Medix, Mr. Zhang received the urgent support and treatment he needed without delay. The stakes couldn't be higher: research from BMI highlights a shocking truth, for each month cancer treatment is postponed, the risk of mortality leaps by an astonishing 10%. Yet, the journey for many is hindered by delays that can have dire outcomes. Let's not wait until it's too late. Discover how Medix is revolutionising health outcomes and combatting delayed treatment for cancer patients across the globe at https://lnkd.in/eDa8sp69 #CancerSurvivor #Healthcare #Cancer #CancerCare

Enhance visualization and assessment with spectral accuracy! Improved dose calculation, precision and personalized tumor targeting for better treatment planning #ASTRO24 #SpectralCT7500 https://lnkd.in/gKkF6YW4

BDC-4182 is our next-generation Boltbody™ #ISAC program targeting Claudin18.2. Swipe to learn more about how this ISAC works. #ImmunoOncology #CancerResearch