Singleron Biotechnologies’ Post

Ahead of print Identification of a pyroptosis-related long noncoding RNA signature for determining the prognosis and immune status of hepatocellular carcinoma patients Despite improvements in cancer screening and diagnosis, hepatocellular carcinoma (HCC) is still diagnosed at an advanced stage, and the prognosis is worse than that of early HCC patients. Therefore, better molecular markers and therapeutic targets in HCC are required. We investigated the predictive value of pyroptosis-related long noncoding RNAs (lncRNAs) in HCC and the effects of these lncRNAs on the immune microenvironment of HCC. https://lnkd.in/dkBKXF-9

Kirstin Spencer is the METUPUK lead for SMC drug appraisals. She explains in her blog about treatment resistance, especially in ER+ disease. This topic was covered at the UK Interdisciplinary Breast Cancer Symposium in Birmingham which METUPUK attended and had a stall. Kirstin explains that tumours can accumulate new mutations over time, and that some of these, in particular variants of the ESR1 mutation, are associated with resistance to commonly used treatments. However, there are new treatments which are currently being appraised by NICE which are targeted to the ESR1 mutation. If recommended, these will increase the use of genomic profiling on the NHS as well as increasing treatments available to patients. https://buff.ly/3UvHYH9 #MetastaticMay #costofliving #severitymodifier #METUPUK #DarkerPink #BusyLivingWithMets #IAmThe31 #waitingroomfeet #BCAM #BreastCancer #BreastCancerCommunity #BreastCancerJourney #BreastCancerSupport #DyingForACure #EarlyDetectionSavesLives #MetastaticBreastCancerAwareness #SecondaryBreastCancer #SecondarySisters #Stage4NeedsMore #StageIVNeedsMore

Where are we with gastric cancer screening in Europe in 2024? The leading gastroenterology journal GUT has published a review by M.Leja on the status and perspective of gastric cancer screening in Europe. Although the Council of the European Union has recommended implementation of gastric cancer screening, the guidelines on how to manage implementation still have to be developed. Screen and treat strategy for Helicobacter pylori, i.e. active search for the presence of the infection with the aim to eradicate it if found to be positive is the most promising strategy for Europe. Brief insight in the ongoing implementation studies in Europe: GISTAR, Eurohelican, TOGAS, EUCanScreen is provided. The access to the paper is available via the following link: https://lnkd.in/dgxi_q2d #GastricCancerScreening #Gastroenterology #GISTAR #Eurohelican #TOGAS #EUCanScreen #HelicobacterPylori #health #medicine #HaDEA

Lynch syndrome is characterised by a predisposition to early onset colorectal cancer and several extra-colonic malignancies related to pathogenic germline mutations in one allele of the mismatch repair (MMR) genes MLH1, MSH2, MSH6 or PMS2. Identifying Lynch Syndrome’s related UTUCs has important clinical implications for both the patient and their relatives given the high risk of developing subsequent multiple different malignancies in the carrier and the strong hereditary predisposition of this condition. The Amsterdam II criteria can be used to identify families that are at increased risk of Lynch syndrome. Perform germline DNA sequencing in patients with clinical suspicion of hereditary UTUC. This recommendation comes from the EAU Guidelines on Upper Urinary Tract Urothelial Cell Carcinoma, Edition 2024. #UTUC #EAUguidelines Recommendations are posted daily on 'X' and weekly on LinkedIn. For more recommendations visit our website: https://lnkd.in/eXciu-Sg

Prior studies have shown that myeloproliferative neoplasm (MPN) with JAK2-V617F mutation has an increased expression of programmed death-ligand 1 (PD-L1) in megakaryocytes leading to cancer immune evasion by inhibiting T-lymphocytes. Recently, Ibrahim et al. compared PD-L1 expression in bone marrow (BM) of patients with JAK2-mutant & JAK2-negative MPN, with normal controls. Results suggest that patients with JAK2 mutation have a higher PD-L1 expression in megakaryocytes than that in normal controls. A combination of checkpoint and JAK2 inhibitors may be an active treatment option. Full text: https://lnkd.in/dQbFHQjg #CancerReports #Wiley #OpenAccess #MyeloproliferativeNeoplasm #JanusKinase2 #PD_L1

Comprehensive Genomic profiling at Initial Diagnosis can have significant impact on clinical outcomes In patients with previously untreated, unfavourable, non-squamous Cancer of Unknown Primary who reached disease control after induction chemotherapy, Comprehensive Genomic Profiling with subsequent molecularly guided therapy resulted in longer progression-free survival than standard platinum-based chemotherapy. On the basis of these results, we recommend that CGP is performed at initial diagnosis in patients with unfavourable CUP. https://lnkd.in/g6XR2YPa

Inappropriate Ordering of Multitarget Stool DNA Tests for Colon Cancer Screening. - Aaron B. Ahn, BA, Sajal Kulhari, BA, Jasmine Rhee, BS, and Gregory Cooper, MD Mt-sDNA is indicated for asymptomatic individuals between the ages of 45 and 85, but not for those with rectal bleeding, iron deficiency anemia, adenomatous polyps, previous colonoscopy within 10 years, family history of CRC, positive results from CRC screening tests within the past 6 months, or age less than 45 and greater than 85. We suggest that increasing provider education on the appropriate ordering of noninvasive screening may help decrease the rate of inappropriate referrals, save costs, and improve clinical outcomes in patients at higher risk for CRC. Inappropriate Ordering of Multitarget Stool DNA Tests for Colon Cancer Screening. https://lnkd.in/gY5ajdDq https://lnkd.in/gG6YYjKU

🚀 [4/11] ASCO 2024 Conference Series 🚀 Title: The tumor immune microenvironment features and their prognostic value in rectal and sigmoid colon signet-ring cell carcinoma. Conclusion: SRCC of rectum and sigmoid colon exhibits distinct immune profiles compared to conventional AC, characterized by higher infiltration of CD8+ and CD3+ TILs, but lower infiltration of PD-1+CD8+ TILs. The unique immune landscape in SRCC, particularly the level of PD-1+CD8+ TILs infiltration and its positive predictive value for DFS and OS, provides new perspectives for immune-based stratification and therapeutic strategies for this clinically significant cancer subtype. 📅 Date: June 1, 2024 ⏰ Time: 1:30 PM - 4:30 PM 📍 Location: Poster Board #207 🔖 Session Title: Gastrointestinal Cancer—Colorectal and Anal Join us to explore the unique immune landscape of SRCC and its implications for therapeutic strategies. For more details, visit: https://lnkd.in/gak-H3ji #ASCO2024 #CancerResearch #BurningRockDx #SRCC

Cellular redox homeostasis is crucial for maintaining the balance of reducing and oxidizing reactions within cells. Imbalances in active oxygen can lead to oxidative or reductive stress, contributing to cancer pathogenesis. Dynamic changes in redox influence tumor initiation, progression, and metastasis, causing stress within the tumor microenvironment. This review explores the impact of redox regulation on tumorigenesis and suggests therapeutic avenues through redox-related adjustments in cancer cells. More details Wu, K., El Zowalaty, A.E., Sayin, V.I. et al. The pleiotropic functions of reactive oxygen species in cancer. Nat Cancer 5, 384–399 (2024). https://lnkd.in/guvS5qQA

What are the health benefits of Boswellic Extract? 1.Arthritis and Pain Relief the boswellic acid contained in frankincense extract can treat muscle and arthritis pain. The analgesic effect is significantly higher than that of aspirin. It can enhance joint mobility, inhibit the production of arthritis factors, and effectively avoid the occurrence of senile arthritis and ventilation; 2. Fight cancer The triterpenoid compound contained in product is an anti-cancer substance that can inhibit the synthesis of DNA, RNA and protein in leukemia HL-60 cells, inhibit lipoxygenase and cell proliferation, and induce the apoptosis of tumor cells. Studies have shown that it can reduce the size of tumors in cancer patients and reduce the damage of cancer cells to the brain........ https://lnkd.in/gKXa4MGY