SkillCell’s Post

Our latest systematic review on IGF-2 mediated hypoglycemia has been published in “Endocrinology, Diabetes and Metabolism.” It is a rare yet clinically significant entity with considerable morbidity and mortality. The systematic reviews highlights several aspects of its management. https://lnkd.in/dNxzb9jq Fateen Ata

New study in Diabetes, Obesity, and Metabolism compares SGLT2 inhibitors with DPP-4 inhibitors and sulfonylureas in Type 2 diabetes patients with peripheral artery disease. Results show lower risk for lower extremity amputation with SGLT2 inhibitors vs DPP-4 inhibitors and higher risk vs sulfonylureas. Important insights for clinical practice. #diabetes #research #clinicalpractice #SGLT2inhibitors

#metabolism #diabetes #biology #medicine #medicalsciences  https://lnkd.in/gzk569F9 The topic of human #circadian #rhythms is not only attracting the attention of clinical researchers from various fields but also sparking a growing public interest. The circadian system comprises the central clock, located in the suprachiasmatic nucleus of the #hypothalamus, and the peripheral clocks in various tissues that are interconnected; together they coordinate many daily activities, including sleep and wakefulness, physical activity, food intake, glucose sensitivity and cardiovascular functions. Disruption of circadian regulation seems to be associated with #metabolic #disorders (particularly impaired glucose tolerance) and #cardiovascular #disease. Previous clinical trials revealed that disturbance of the circadian system, specifically due to shift work, is associated with an increased risk of type 2 diabetes mellitus. This review is intended to provide clinicians who wish to implement knowledge of circadian disruption in diagnosis and strategies to avoid cardio-metabolic disease with a general overview of this topic.

Our first article on systematic review and meta-analysis is finally available online. Published on the 14th of Feburary and already has 1014 views and 90 downloads. Mazdutide, also known as IBI362 or LY3305677, is a new dual agonist for the glucagon-like peptide 1 receptor (GLP-1R) and the glucagon receptor (GCGR). It has the potential to simultaneously reduce weight, blood sugar, and other comorbidities associated with obesity. Our study concluded that 1) Mazdutide was effective for weight loss in diabetic and nondiabetic patients. 2) The drug effectively reduced blood pressure, total cholesterol, triglycerides, LDL and HDL. 3) Mazdutide was associated with reduced HbA1c and fasting plasma glucose in patients with type 2 diabetes mellitus. However, it was associated with mild or moderate gastrointestinal side effects. With a convenient weekly dose and a favorable safety profile, Mazdutide is a potential drug of choice for weight reduction in people with diabetes (with or without associated comorbidities) and particularly in the non-diabetic population. However, more RCTs from phase III, larger sample sizes are needed to have a definitive answer on the efficacy and safety of Mazdutide on weight reduction among diabetic and non-diabetic individuals. Follow the link to read more https://lnkd.in/df7iREmY

Proteomics International recently announced the PromarkerD test for predicting renal decline has been tested in patients with type 1 diabetes for the first time, with the groundbreaking study demonstrating high accuracy for predicting chronic kidney disease. The results are a significant advancement and highlights the versatility and robustness of the PromarkerD test, which has been validated for predicting renal decline in type 2 diabetes, at a time when global authorities are continuing to sound the alarm about the economic, social and health impact of the condition. The findings were presented at the recent Australasian Diabetes Conference in Perth and have been accepted for publication in the journal of Clinical Diabetes and Endocrinology. You can read the Medical Forum’s interview with lead author, endocrinologist at Fremantle Hospital and UWA Professor of Medicine, Dr Tim Davis - https://lnkd.in/gT8rHZ55 Read the full announcement here - https://lnkd.in/g2JK344n #ASX #PIQ #diabetes #Type1Diabetes #PromarkerD #EarlyDiseaseDetection #prognostics #diagnostics #DiabeticKidneyDisease #ChronicKidneyDisease #24ADC

The following has just been published in Diabetes, Metabolic Syndrome and Obesity: Contribution of Disease-Specific Distress, Social Support, and Self-Efficacy to Diabetes Self-Management Behaviors in Saudi Adults: A Path Analysis Authors: Kerari A https://lnkd.in/dm--rjiX The Relationship Between Computerized Face and Tongue Image Segmentation and Metabolic Parameters in Patients with Type 2 Diabetes Based on Machine Learning Authors: Wen S, Li Y, Xu C, Jin J, Xu Z, Yuan Y, Chen L, Ren Y, Gong M, Wang C, Dong M, Zhou Y, Yuan X, Li F, Zhou L https://lnkd.in/dUeG3s7H Association Between Triglyceride-Glucose Index and Lung Function Parameters in the General Population Undergoing Health Examinations Authors: Yang Y, Wang S, Jia B, Chen S https://lnkd.in/dcAKGhYq The Relationship Between Age at Diabetes Onset and Clinical Outcomes in Newly Diagnosed Type 2 Diabetes: A Real-World Two-Center Study Authors: Chen M, Feng P, Liang Y, Ye X, Wang Y, Liu Q, Lu C, Zheng Q, Wu L https://lnkd.in/d4kY6Axe Physical Activity to Reduce Pain Scale in Diabetic Neuropathy Patients: A Scoping Review Authors: Pebrianti S, Maulana I, Shalahuddin I, Eriyani T, Nugraha BA https://lnkd.in/dmSdqZKd Liraglutide Ameliorates Renal Endothelial Dysfunction in Diabetic Rats Through the Inhibition of the Dll4/Notch2 Pathway Authors: Li Y, Chen Y, Zhang H, Chen W, Pan Y https://lnkd.in/dTryGJ2E

#Review Analytical Challenges in Diabetes Management: Towards Glycated Albumin Point-of-Care Detection by Andrea Rescalli, Elena Mariani, Francesco Cellesi and Pietro Cerveri https://lnkd.in/gKcPRzUK   #MDPI #Diabetes #Biochemical #enzymes #biosensors #sensors #openaccess   #Abstract Diabetes mellitus is a worldwide-spread chronic metabolic disease that occurs when the pancreas fails to produce enough insulin levels or when the body fails to effectively use the secreted pancreatic insulin, eventually resulting in hyperglycemia. Systematic glycemic control is the only procedure at our disposal to prevent diabetes long-term complications such as cardiovascular disorders, kidney diseases, nephropathy, neuropathy, and retinopathy. Glycated albumin (GA) has recently gained more and more attention as a control biomarker thanks to its shorter lifespan and wider reliability compared to glycated hemoglobin (HbA1c), currently the “gold standard” for diabetes screening and monitoring in clinics. Various techniques such as ion exchange, liquid or affinity-based chromatography and immunoassay can be employed to accurately measure GA levels in serum samples; nevertheless, due to the cost of the lab equipment and complexity of the procedures, these methods are not commonly available at clinical sites and are not suitable to home monitoring. The present review describes the most up-to-date advances in the field of glycemic control biomarkers, exploring in particular the GA with a special focus on the recent experimental analysis techniques, using enzymatic and affinity methods. Finally, analysis steps and fundamental reading technologies are integrated into a processing pipeline, paving the way for future point-of-care testing (POCT). In this view, we highlight how this setup might be employed outside a laboratory environment to reduce the time from measurement to clinical decision, and to provide diabetic patients with a brand-new set of tools for glycemic self-monitoring.

Alternative polyadenylation regulates the translation of metabolic and inflammation-related proteins in adipose tissue of gestational diabetes mellitus. Read the article here: https://lnkd.in/gZVU5d-v

📢 Review paper Sharing-Vol. 29 No. 6 💕 Title: Endothelial Cell Dysfunction: Onset, Progression, and Consequences 🤵 Authors: Hojjat Naderi-Meshkin,*, Wiwit Ananda Wahyu Setyaningsih 🔔 Full Text: https://lnkd.in/gj-pHsxp 🔑 Keywords: cardiovascular diseases metabolic disorders blood vessels disease modelling vascular dysfunction therapeutic interventions 😎Welcome to your reading! #Bioscience #biomedicalscience #biochem #medicalscience #ScienceCommunication #Biochemistry #StemCell #Virology #CancerResearch #immunology #Genetics #MolecularBiology #Microbiology #medicine #health #CellularHealth #CellCancer

📜Case Report : ✍🏻MAGDALENA OTAZÚ #Pancytopenia Caused by #Methimazole in #Women with #GravesBasedow #Disease - Case Report #ABSTRACT Antithyroid drugs constitute one of the main pillars in the treatment of hyperthyroidism. They are associated with a variety of adverse effects, most of which are mild or minor. However, there are other rare but potentially fatal adverse effects, such as pancytopenia, of which only a few cases have been reported worldwide. This paper presents a clinical case of febrile neutropenia, associated with anemia and thrombocytopenia, secondary to treatment with methimazole. #Introduction Hyperthyroidism is characterized by an increase in the synthesis and secretion of thyroid hormones by the thyroid gland. The prevalence of this disease is approximately 1.2%.... #Clinical Case Female patient, 51 years old, with no notable family or personal history, diagnosed with Graves' Disease in March 2023, in the context of symptoms of thyroid hyperfunction (palpitations, distal tremor, weight loss of 12 kg in 3 months) and diffuse goite.... #Discussion ATD such as methimazole, carbimazole and propylthiouracil (PTU) have been widely used for the treatment of hyperthyroidism for several decades. Their main effect is to inhibit synthesis of thyroid hormone by interfering with thyroid peroxidase-mediated iodination of tyrosine residues on thyroglobulin... #Conclusions MMZ is a drug frequently used in the treatment of hyperthyroidism, and its use is associated with different adverse effects, some of which pose a high risk for the patient.... 📰 Get full-length article here: https://lnkd.in/gw7DzSm2 We do accept #PPTs and #Video Articles to be publish within our Journal. You can send us your article to given email #Email: onlinescientificresearch@gmail.com