Slavov Lab’s Post

AD | Unlock the power of proximity #biotinylation for your research with Protein A-Turbo.  Key Features:  -Enzymatically biotinylate all proteins near your protein of interest.  -Simple: Just combine your antibody, biotin, ATP, and Protein A-Turbo.  -Use the biotin to pull-down for #MassSpec proteomics, or for #fluorescentmicroscopy.  You can also streamline proximity labeling studies, uncover protein-protein interactions, and investigate protein localization. Get your hands on Protein A-Turbo today! -> https://bit.ly/4dpzqdH

Trypsin is the protease most frequently used in mass spectrometry, but most existing Proteomics and Mass Spec grade trypsin contains detectable non-specific cleavage and autoproteolytic activity, which can impact the specificity of your protein analysis. Watch this webinar to learn how Trypsin Platinum helps keep protein characterisation clean, accurate and conclusive. https://bit.ly/3x6mb0H #MassSpec #MassSpectrometry #Proteomics

Trypsin is the protease most frequently used in mass spectrometry, but most existing Proteomics and Mass Spec grade trypsin contains detectable non-specific cleavage and autoproteolytic activity, which can impact the specificity of your protein analysis. Watch this webinar to learn how Trypsin Platinum helps keep protein characterisation clean, accurate and conclusive. https://bit.ly/4fkEW1s #MassSpec #MassSpectrometry #Proteomics

𝗣𝗲𝗽𝘁𝗶𝗱𝗲 𝗮𝗻𝗱 𝗣𝗿𝗼𝘁𝗲𝗶𝗻 𝗔𝗻𝗻𝗼𝘁𝗮𝘁𝗶𝗼𝗻 – 𝗗𝗮𝘁𝗮 𝗔𝗻𝗮𝗹𝘆𝘀𝗶𝘀 📊 Did you know Biogenity can process raw files from most proteomics and peptidomics studies? Processing mass spectrometry-derived data can be complex. Different approaches deliver diverse insight, e.g., proteins can be missing in proteome analysis, yet if we look at the peptide level, we may discover peptides that are fragments of the proteins. These may be relevant, and therefore the fragmentation spectra of the peptides need to be validated. Whether you want us to confirm the finding, search the data using new databases, perform denovo sequencing, or validate MS/MS spectra, we got you covered.

Imagine analyzing both #metabolites and #proteins from a single sample, with enhanced sensitivity and resolution. That's the promise of PANAMA (proteomic and nanoflow metabolomic analysis), a novel workflow described in a recent publication. By combining solid-phase micro-extraction with nanoflow LC-MS, PANAMA delivers comprehensive, high-quality data, opening new doors for research in various fields. Here’s the full article: https://lnkd.in/ewcUjNDh A big shoutout to the authors for their work! Weiwei Lin, Fatemeh Mousavi, Ph.D., Benjamin B., Christian F Heckendorf, Matthew Lawton, Noah Lampl, Ryan Hekman, Hongbo Guo, Mark McComb, Andrew Emili. #metabolomics #proteomics #LCMS #nanoflow #research #LC #liquidchromatography #nLC #analyticalchemistry

Powerful combination of two robust technologies ( Mass Spec and PEA) to get the maximal read outs from a protein sample. #Proteomics #Olink Proteomics https://lnkd.in/g7vU3d9Q

Imagine all you can achieve with ~11,000 total protein measurements, spanning every major biological pathway, without sacrificing reproducibility, sensitivity, or specificity. Download the SomaScan® 11K Assay v5.0 Technical Note for more information about the new proteomics platform and its performance metrics: https://bit.ly/431t5P1 #HALFtheHumanProteome #proteomics #biomarkers #drugdiscovery #drugdevelopment

I am pretty sure that everyone puts weight on considering the actual weight as a relevant factor, but sometimes with advances in technology and approaches, we can lose the traditional tools of evaluation, together with some reachable information. For example, in proteomics, we can lose track of the direct measure of the molecular weight of proteins, traditionally provided by gel-assisted proteomics. A newly developed approach can be used as a tool for high-throughput MW analysis simultaneously with the conventional expression analysis: the gel-assisted proteome position integral shift (GAPPIS) assay. GAPPIS can be, for example, used to study a broad range of biological processes involving proteolytic events. https://lnkd.in/dWtK4MAf Congrats and thanks to all the team, especially Zhaowei Meng and Roman Zubarev #proteomics #MassSpectrometry #Gels #MW

AD | Unleash the power of proteomics in your lab! Speak to an expert now to learn how the Platinum® Next-Generation Protein Sequencer™ can help you achieve your current research goals! Our latest V2 Sequencing Kits bring together enhanced proteome coverage and improved sequencing output seamlessly, offering unparalleled simplicity and exciting opportunities for your research. The new Platinum system offers application capabilities, such as: • Protein Barcoding: Utilize peptide barcodes to directly sequence proteins with single amino acid resolution.  • Protein Variants: Rapid and accurate distinction of variants based on differences in the amino acid sequences.  • Post-Translational Modifications (PTMs): Discover the power of using Kinetic Signatures to sequence proteins and detect changes in the proteome, including PTM analysis. Contact Us: https://bit.ly/4aFyOP4

DNA carries genetic makeup inherited from both parents, providing the foundational blueprint for our biology. However, our unique protein profile is shaped by more than just our genes. The choices we make every day—what we eat, how much we exercise, and our overall lifestyle, play a crucial role in influencing our protein expression. These factors contribute to the individuality of our biological makeup, highlighting the interplay between genetics and lifestyle in determining our health and well-being. Precision health is meeting the individual needs of one’s biological profile.