Sling Therapeutics’ Post

Providing novel insights on its development and management, a recent study from the Technical University of Munich clarifies how mitochondrial malfunction could contribute to Crohn's disease. Here, we talk about this study and our Crohn's disease Diagnosis. #marbella

Here's a link to our physician webinar on screening for liver disease using whole-body MRI - detecting and managing fatty liver disease, hemochromatosis, fibrosis/cirrhosis/cancer are now more accessible than ever, and Prenuvo is leading the way towards early diagnosis. https://lnkd.in/eAfWatZU

#NewBlogPost Explore our #newblog post about the Autoimmune Disease Diagnostics.💊 Learn about future #markettrends, important key drivers, and the #topcompanies in this field. This market is expected to reach $17.9 billion by 2028. Click the link to read the #blog now!👇 https://bit.ly/4aLtIRB

It was almost 6 years ago that these pair of identical twin sisters walked into my clinic. Back then, they had been "diagnosed" with enlarged lymph nodes and severe anemia of unknown cause following a health screen, and decided to seek further help at the National Cancer Centre Singapore. It was clear to us back then that we were all in a common "zone of the unknown". We did not know what was going on and I did not know how to treat them. The room was silent as I told them frankly that I did not know what was going on. What happened afterwards, rather magically - was a handshake of trust (with each twin), and a promise of close patient-physician collaboration. I told them that we will form a team and we will find out the answer together one day. Fast forward to September 2021, we officially announced the #starlightinitiative for rare cancer research. We formed a team with a national mandate to steer rare cancer research into the light. Fast forward to 2024, we finally solved "The Mystery of the Castleman" and got international expert approval of our diagnosis. We uncovered gene mutations that possibly cause this disease and identified the culprit cells that produces a key protein, IL-6, that leads to the many symptoms of this disease. Today, we present the world's first description of multicentric Castleman disease in identical twins, gracing the cover page of Blood as the issue highlight and we are humbled to read the commentary by Castleman disease hero David Fajgenbaum, MD, MBA, MSc. This work would not have been possible without research funding and close support from industry partners BGI · Research NovogeneAIT Genomics Mirxes 10x Genomics. Jui Wan Loh Jing Quan Lim Herty Liany Elizabeth Chun Yong Lee Jing Yi Lee Bavani Kannan Lim Boon Yee (Bonnie) Alun Guo Cedric Ng Tun Kiat Ko HUANG DACHUAN Chee Leong Cheng Sock Hoai Chan Joanne Ngeow Bin Tean Teh Soon Thye LIM Choon Kiat Ong Kerry Lim Jeslin Ha Dominique Seow Cancer Discovery Hub #starlightinitiative #rarecancersg #lymphoma #castlemandisease #singlecellsequencing #stereoseq #spatialtranscriptomics

Many medical roads lead to lung failure. And though some of the conditions, at some point in their progress, may be treatable - if the lungs become involved, the person’s chances of survival plummet. Why? Because lungs are a frontier of medicine that is still in the dark ages in many ways. In a disease category called interstitial lung disease (ILD), the condition is almost invariably fatal. And in a few sad, short years for most. Just like the man in the story linked below. How can ILD and lung failure be solved? It desperately needs to become a national (and international) priority. FDA, NIH, CDC and other key agencies are needed in this fight - to prioritize this deadly condition that has no life-saving treatment (sans Lung transplant which is available for a relative lucky few). And not even a way of improving most symptoms - eapecially shortness of breath when people are gasping for air. This story is heart wrenching. And though this man’s diagnostic path was long and complicated - it isn’t much different than what we see in this space every day. When the fatal aspect of diseases of many kinds happen when they affect the lungs (like COVID, pneumonia, acute respiratory exposures), you would think it would be a national priority to pull out all of the stops to solve it. And yet, if you have heard and read about the early days of cancer therapy (I recommend reading “The Emperor of All Maladies” when most everyone died) — we are there now in interstitial lung disease (ILD). Patients suffering from ILD are sufffering horribly. Please for goodness sakes, America, make this a priority.

Neuroinflammation brings to focus the optimal activity of GLIA as an essential component as commanalities reported among Parkinsons Disease, Batten Disease and Gauchers Disease ; https://lnkd.in/gww8hf7h; Will a safe and beneficial modification of Neutrophil-to-Lymphocyte Ratio (NLR) be of help?

Policy | In the First Catalogue of Rare Diseases, which was jointly developed by the National Health Commission of the PRC and five other departments in 2018, there is a rare disease called IgG4-Related Disease (IgG4-RD). As of now, clinical diagnosis of IgG4-RD relies on the following 3 aspects: https://lnkd.in/g4kD4G_v #IVD #diagnostics #raredisease #bloodtest #tumor #immunedisease #organ #tissue

It is so often that we hear 'the drug will sell itself', and the surprise when great efficacy or data don't result in rapid adoption. By uncovering and addressing the hidden barriers, the things that market research don't tell you, the habits and beliefs of your audience, you can accelerate adoption and be sure that the story you are telling is the story that is needed to achieve positive change.

Researchers at Karolinska Institutet have developed scDrugPrio, a computational model for creating a "digital twin" of autoimmune diseases. This model enables personalized medication choices by analyzing cellular interactions and drug effects. This innovative approach, validated in studies on mice and patients with inflammatory bowel disease, promises to enhance treatment efficacy and reduce healthcare costs by selecting the most effective drugs for individual patients based on the disease's genetic and cellular complexities. #DigitalTwins #ComputationalModels

Systematic Review and Meta-Analysis of Extracorporeal Photopheresis for the Treatment of Steroid-Refractory Chronic Graft-Versus-Host Disease.. Good to re-confirm effectiveness of ECP as therapy for refractory #cGVHD since last systematic review in 2014.. still needs more work in harmonisation of diagnostic and treatment outcome measures. https://lnkd.in/eEh_kFkU