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Thank you for contacting AK4AQ Always known 4 assuring quality! Please let us know how we can help you. 1 Molecular docking and molecular synthesis 2 Analytical Techniques and it's interpretation 3 Biological study 4 Drug Extraction

GRI Bio Announces European Patent Office Issued a Decision to Grant Notice for Patent Covering GRI-0803 and Its Library of 500+ Proprietary Compounds. https://bit.ly/3ZHTfa0 #AutoimmuneDisease #FibroticDisease #InflammatoryDisease

Bioconjugation is essential in creating stable and effective antibody-drug conjugates (ADCs), enabling the precise attachment of potent payloads to biologically active molecules. Our latest info sheet, "Streamlining Bioconjugation for Antibody-Drug Conjugate Development," dives into how Abzena’s cutting-edge bioconjugation methods enhance the safety, efficacy, and scalability of ADCs.     With support across every phase—from discovery through to manufacturing—our integrated approach and expertise help de-risk your ADC program, guiding it efficiently to IND and beyond.   Access the full info sheet here: https://lnkd.in/eij9SDtb   #ADCDevelopment #Bioconjugation #DrugDevelopment #ThioBridge #CDMO #CRO

Exciting advancements in mRNA-based drug administration rely on synthetic lipids like ALC-0315. The multi-step synthesis of ALC-0315 yields byproducts that require removal via normal-phase flash chromatography, but poor UV absorption makes detection challenging. By integrating an evaporative light scattering detector (ELSD) into your flash chromatography system, you can effectively detect and purify these synthetic lipids. Read the application note to learn more https://hubs.ly/Q02B4g1x0

There is increased interest in the written description and enablement requirements for patent applications claiming antibodies and other biotech inventions due to new decision by USPTO in Ex parte Chamberlin. Read about the recent attempt to capture broad patent coverage for antibodies in a client alert authored by Partner Laura A. Labeots, Ph.D., J.D. Read the full alert here: https://bit.ly/4eIqRve #Antibodies #IntellectualProperty

#ACROHighlights [Featured Product] 🔬 TL1A-DR3 (TR-FRET) Kit: Advancing TL1A Drug Discovery The TL1A-DR3 Inhibition Kit (TR-FRET) by ACROBiosystems is revolutionizing inhibitor screening with its high sensitivity, specificity, and ease of use. Leveraging Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) technology ensures accurate detection of biomolecular interactions by reducing background interference. This kit is a reliable tool for TL1A-DR3 drug discovery, offering repeatable and efficient results. ➡️ Learn more about TL1A products here: https://smpl.is/9v6f9 #TRFRET #TL1A #DrugDiscovery #BiotechInnovation #InhibitorScreening #HighThroughputAssays

How can characterizing thermodynamic profiles of ligand-protein binding facilitate late-stage discovery? Learn how to implement industry-leading analysis in this blog: https://lnkd.in/gf4Typ6V #DrugDiscovery #Biopharma

The spiropentyl substituent has gained traction in recent medicinal chemistry projects, not only for its elegant, bow-tie-like appearance but also for its highly desirable compact 3D structure. Recent studies from Merck demonstrate that this fragment enhances local hydrophobicity while resisting metabolic clearance—favorable traits for improving a drug’s pharmacokinetic profile. In July 2024, Vertex submitted a new drug application to the FDA for vanzacaftor, a molecule featuring a spiropentyl (dispiroheptyl) group, aimed at treating cystic fibrosis. Enamine offers an extensive selection of molecular building blocks with small spiro skeletons, spiropentane and dispiroheptane: https://bit.ly/40v05BT Try our spiropentanes in your research!

PyMOL 3 brings artistry to drug discovery, enabling you to share your research in a more engaging and understandable way. The video below, created in PyMOL 3, illustrates the binding pocket of 1FJS with its inhibitor. #VisualizingScienceWithPyMOL3 #ComputerAidedDrugDiscovery

Honeywell is excited to partner with Pharmaceutical Technology who will be hosting a webinar entitled: Global Considerations for Oligonucleotide Synthesis Solutions. Don't miss out on this informative webinar! Topics include: • Why a global manufacturing footprint is as critical as having batch-to-batch consistency. • Evaluating supplier to produce custom blends of reagents and solvents in varying batch sizes. • What can be gained by transitioning your solvents and reagents from glass to returnable containers? • Challenges are associated with sulfurization reagents for Oligonucleotide Synthesis.