St George & Sutherland Medical Research Foundation’s Post

🏋♂️ 𝗜𝗦 𝗘𝗫𝗘𝗥𝗖𝗜𝗦𝗘 𝗕𝗘𝗧𝗧𝗘𝗥 𝗧𝗛𝗔𝗡 𝗗𝗥𝗨𝗚𝗦? 💊 A team of Virginia Tech biologists, led by Professor Zhen Yan, says yes! Their recent findings, published in the journal Nature, explore the molecular mechanisms underlying the benefits of regular exercise. These advances promise crucial implications for health and medicine, challenging the traditional approach to treating disease. ✔ 𝗞𝗲𝘆 𝗽𝗼𝗶𝗻𝘁𝘀 𝗼𝗳 𝘁𝗵𝗲 𝘀𝘁𝘂𝗱𝘆: In mouse models, endurance exercise over 8 weeks revealed thousands of molecular changes in various tissues and organs. ✅ 𝗨𝗻𝗽𝗮𝗿𝗮𝗹𝗹𝗲𝗹𝗲𝗱 𝘀𝘆𝘀𝘁𝗲𝗺𝗶𝗰 𝗶𝗺𝗽𝗮𝗰𝘁𝘀: Data show regulation of immune, metabolic and stress responses, as well as disruption of mitochondrial pathways. ✅ 𝗚𝗲𝗻𝗱𝗲𝗿 𝗱𝗶𝗳𝗳𝗲𝗿𝗲𝗻𝗰𝗲𝘀: Unique changes were observed between male and female mice in several tissues. “𝗡𝗼 𝘀𝗶𝗻𝗴𝗹𝗲 𝗱𝗿𝘂𝗴 𝗰𝗼𝘂𝗹𝗱 𝗵𝗮𝘃𝗲 𝘀𝘂𝗰𝗵 𝗽𝗼𝘀𝗶𝘁𝗶𝘃𝗲 𝘀𝘆𝘀𝘁𝗲𝗺-𝘄𝗶𝗱𝗲 𝗶𝗺𝗽𝗮𝗰𝘁𝘀 𝗮𝗻𝗱 𝗯𝗲 𝘀𝗼 𝗹𝗼𝗻𝗴-𝗹𝗮𝘀𝘁𝗶𝗻𝗴” 𝘄𝗿𝗶𝘁𝗲 𝘁𝗵𝗲 𝗮𝘂𝘁𝗵𝗼𝗿𝘀. Exercise influences our bodies more broadly and sustainably than any available drug. These findings suggest that, for many clinical conditions, an exercise prescription should be considered as a first option. The benefits cover conditions ranging from non-alcoholic fatty liver to inflammatory bowel diseases. 🔬 𝗡𝗲𝘄 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝗵𝗼𝗿𝗶𝘇𝗼𝗻𝘀 This outlines new avenues of research, including the effects of resistance training and the analysis of protein factors released into the bloodstream by organs and tissues in response to a single session of exercise. Do you think adopting an exercise routine could be the most powerful prescription? #Excercise #Health #Fitness #ResistanceTraining

The significance of vitamin A in human health cannot be overstated. Given that it is linked to several physiological processes. Our last study on how vitamin A homeostasis is controlled by the brain, specifically the hypothalamus is well covered in this write up alongside other recent studies on the topic. A good read. I will recommend you have a read to understand the significance of this all important biomolecule of life. #vitaminA #brain #neuroscience.

#HighlyCitedPapers   📝 In Vitro Models of Bone Marrow Remodelling and Immune Dysfunction in Space: Present State and Future Directions — Sarkar and Pampaloni.   In this paper, the authors aimed to review the effects of microgravity on the bone marrow niche and cells of the innate immune system.    Full text is available 👇 https://lnkd.in/dPBifUsY   #medicine #health #research #science

Retinitis pigmentosa (RP), defined more properly as cone–rod dystrophy, is a paradigm of inherited diffuse retinal dystrophies, one of the rare diseases with the highest prevalence in the worldwide population and one of the main causes of low vision in the pediatric and elderly age groups. In this paper, the authors focus on the pathomolecular mechanisms underlying RP better to understand the prospects of its treatment using innovative approaches. 📝 The New Era of Therapeutic Strategies for the Treatment of Retinitis Pigmentosa: A Narrative Review of Pathomolecular Mechanisms for the Development of Cell-Based Therapies — Becherucci, et al. Full text is available 👇 https://lnkd.in/dNHZceVz #medicine #health #research #science 

Lipedema is a metabolic condition that primarily affects women, and it suffers from a lack of a clear, consensus definition. Such conditions are often neglected within the healthcare system due to the difficulties in making definitive diagnoses for complex issues with no distinct pathognomonic causes. This poses challenges for research and the development of effective treatments for a likely diverse patient population. However, the authors of the just published “Proposed Framework for Research Case Definitions of Lipedema” have made significant contributions with their objective review of the literature and their efforts to construct a framework that could bolster future research (https://lnkd.in/eJQYtXfD). Meanwhile, personalized treatment remains a critical strategy for identifying effective patient care solutions. There is growing evidence that dietary interventions, such as the ketogenic diet, may offer benefits beyond the mere effect of weight loss, including the alleviation of pain and touch sensitivity. SiPhox Health is honored to sponsor the upcoming Lipedema Project Lipedema Simplified LLC Heart to Heart Virtual 3-day Conference: Keto and Beyond (https://bit.ly/49lNfXq). We anticipate that our platform, which allows comprehensive biomarkers to be tested frequently and easily at home, will be a valuable resource for both patients and healthcare providers, guiding decision-making and enhancing patient outcomes. See my conversation with Leslyn Keith, the Director of Reseach and President of the Board of Lipedema Project to learn more about the SiPhox Health platform and recently beta-launched Heart Health Blueprint: https://lnkd.in/ejWpJsts

Important Research Connecting the Gut Microbiome and Childhood Growth! We continue to uncover the complexities of the gut microbiome in a recent study in iScience, led by notable researcher Dr. Eugene Chang (Chang MED), illustrating how the gut microbiome is vital for the normal growth and development of the nerves that govern gut function from birth. https://lnkd.in/erVbk8W3 These findings open new avenues for innovative diagnostics, treatments, and preventive strategies, enriching our understanding of normal physiology. At 32 Biosciences "Three Squared" Biosciences, we continue to harness our expertise in the intricate interactions between the human body and the gut microbiome to develop cutting-edge solutions that propel the field of Microbiome Medicine forward. If you're eager to explore the future of healthcare and innovation, we invite you to follow us on LinkedIn and visit us at 32biosciences.com. A heartfelt thank you to Dr. Chang for his pioneering contributions to this vital research! Chang MED #GutHealth #MicrobiomeMedicine #HealthcareInnovation #32Biosciences #ResearchAndDevelopment #innovation #Microbiome

Important Research Connecting the Gut Microbiome and Childhood Growth! If your eager to explore the future of healthcare and innovation, we invite you to follow us at 32biosciences.com

1. A study from Baylor College of Medicine and the University of Texas Health Science Center reveals the brain circuits and chemical messengers involved in meal initiation and food intake. 2. The findings suggest potential improvements in therapies for managing obesity, a global epidemic. 3. Previous research highlighted serotonin's role in suppressing food intake, leading to the development of related drugs, some of which have undesirable side effects. 4. The study focused on understanding the regulation of serotonin-producing neurons and their influence on balanced food consumption. 5. Serotonin is mainly produced by neurons in the dorsal Raphe nucleus (DRN), which project to various brain regions, including the arcuate hypothalamus (ARH). 6. GABA and dopamine are identified as key neurotransmitters that inhibit serotonin-producing neurons when the body is hungry, facilitating meal initiation. 7. The combined action of GABA and dopamine is more effective in inhibiting serotonin neurons than either neurotransmitter alone. 8. This research enhances understanding of brain regulation of body weight and feeding behaviors, particularly during meal initiation. 9. Future research aims to identify signals regulating other phases of feeding behavior.

📢 Exciting news! I am thrilled to announce that my recent article "Possible Anti-Obesity Role of Flavonoids Through Brown Adipose Tissue" has been published in Clinical and Experimental Health Sciences. Thanks to my mentor, Prof. Dr. Hilal Yıldıran. Check out the article to learn more about the potential benefits of flavonoids in combatting obesity. 📝 #research #healthscience #obesity

As the year draws to a close, we take a look back at three intriguing fucoidan research papers published during 2024. Global research has explored Marinova’s high purity fucoidans in the context of: 🔍 Supporting prostate health Read more: https://lnkd.in/gFNWBxzd 🔍 Enhancing exercise performance and gut microbiome Read more: https://lnkd.in/gvCSvwzK 🔍 Blocking toxicity effects of snake venom Read more: https://lnkd.in/gFp6pgam We look forward to sharing further fucoidan research in 2025. #research #scientificresearch #fucoidan #innovation #futurefocus #science #scientificstudies #2024research #naturalproducts #scientificoutcomes