STALICLA’s Post

Let's meet and discuss the latest developments in Neuro diseases. Me and my colleague Prof. Xanthopoulos shall introduce you to the extended capabilities and the reliable network that Accelsiors CRO offers. #ADPD2024 #clinicalresearch #alzheimers #parkinsons #neuroscience

Accelsiors is continuing to support #ADPD with our attendance in Lisbon, this March 2024.   Meet our colleague Thani Pavlidou, Business Development Director to gain insights into our trusted network of neurology sites and investigators.   She will be happy to share with you the outcomes of the most recent feasibility data in #Alzheimer’s and #Parkinson’s diseases and all the key methods to achieve success in your clinical trials.   #ADPD2024  #clinicalresearch #clinicaltrials #biomarkers #neurology #neuroscience

🔬 N9 Microglial Cells at 20x Magnification! 🧠 These cells are a key model for studying neuroinflammation and neurodegenerative diseases. Microglia, the brain's resident immune cells, play a crucial role in maintaining brain homeostasis and responding to injury or disease. By observing and analyzing N9 cells, Jugal Kishore and I hope to gain deeper insights into the molecular mechanisms of neuroinflammation, helping to unlock new therapeutic targets for conditions like Alzheimer's, Parkinson's, and other neurological disorders. #Neuroscience #Microglia #Research #Neuroinflammation #CellBiology #BrainHealth

Our international neurophysiology research consortium has published a summary of the most recent evidence suggesting a contribution of parvalbumin-positive (PV+) interneuron dysfunction to the pathophysiology of a spectrum of brain proteinopathies and primary neurodegenerative diseases, such as Alzheimer's disease, Frontotemporal Dementia (FTD), and Dementia with Lewy bodies (DLB). Specifically, we focused on the interplay between misfolded protein accumulation and this specific subtype of inhibitory interneurons whose functional alteration leads to network hypersynchrony, cortical hyperexcitability, and gamma rhythm disruption, with the aim of integrating these findings into a coherent pathophysiological framework for each disease. Highlights: • Parvalbumin-positive interneurons regulate cortical excitation/inhibition balance. • Their dysfunction results in cortical hyperexcitability and gamma rhythm disruption. • PV+ interneurons are impaired in AD; their restoration improved patients’ cognition. • Albeit with some differences, PV+ cells are also impaired in FTD and DLB mouse models. • Their dysfunction represents a common pathophysiological aspect across etiologies. Learn more: https://lnkd.in/er5gp3q6 Elsevier #neuroscience #neurology #precisionmedicine #neurophysiology #EEG #neuroimaging #systemstheory #systemsthinking #brainfunction #brainhealth #neurodegeneration #neurodegenerativediseases #neurologicaldisorders #dementia #cognitivedecline #alzheimer #alzheimersdisease #FTD #FrontotemporalDementia #DLB #DementiawithLewybodies #cortex #neurons #interneuron #neuron #parvalbumin #biomarkers Figure legend: The pathophysiological framework of PV+ interneuron dysfunction in Alzheimer’s Disease.

My colleagues and I have published a new article in the Cell Press journal MED featuring fluid biomarkers findings across twelve anti-amyloid-beta clinical trials. Emerging biomarker data provide evidence on the impact of new therapies on the underlying pathophysiological processes of Alzheimer’s disease, supporting the presence of a disease-modifying effect. Read more here: https://lnkd.in/eS58QTRJ Cell Press Med by Cell Press Suzanne Hendrix Jeffrey Dage Oskar Hansson #neurology #neuroscience #alzheimer #AlzheimersDisease #biomarkers #clinicaltrials #precisionmedicine #neurodegeneration #neurodegenerativediseases #neurologicaldisorders #cognitivedecline #dementia #diseasemodification #liquidbiopsy #medicalaffairs #drugdevelopment #pathophysiology #amyloid #blood #plasma #bloodbiomarkers #CSF #therapy #alzheimertherapy #outcomes #outcomesresearch #brain #brainhealth #trialdesign

Interesting post and link to a journal article including blood based biomarkers in clinical trials for Alzheimer's disease therapies from Harald Hampel, MD, PhD, MSc. University of Otago researchers had Harald's biomarker shopping list from an earlier Alzheimer's conference presentation on their mind when they started looking for new blood based Alzheimer's biomarkers. #OtagoInnovation #ADdx Check this out Jo Williams, Warren Tate, Wickliffe Abraham and Diane Guevremont

𝐂𝐨𝐦𝐩𝐫𝐞𝐡𝐞𝐧𝐬𝐢𝐯𝐞 𝐏𝐃𝐅 𝐆𝐮𝐢𝐝𝐞 𝐭𝐨 #Brain Biomarkers 𝐂𝐥𝐢𝐜𝐤 𝐇𝐞𝐫𝐞 𝐅𝐨𝐫 𝐏𝐃𝐅: @ https://lnkd.in/dxPH9Uw7 Brain biomarkers are measurable biological and physiological indicators of brain function and activity. These markers can evaluate the presence, severity, or progression of various brain-related conditions such as neurological disorders, psychiatric disorders, or even traumatic brain injury. The use of brain biomarkers provides several advantages over traditional methods of diagnosis and treatment monitoring. These include increased accuracy, objective measurement, and improved ability to predict treatment response. The end-user industries for brain biomarkers include the pharmaceutical and biotech industries, medical research institutions, and healthcare providers. #BrainBiomarkers #NeuroScience #NeuroTech #BrainHealth #NeurodegenerativeDiseases #MentalHealthTech #BiomarkerResearch #Neurobiomarkers #CognitiveHealth #AlzheimersResearch #ParkinsonsResearch #Neurology #BrainResearch #HealthInnovation #DiagnosticBiomarkers

📢 #Publication alert 🩸Vascular #dementia (VaD), the second most common form of #dementia (after #Alzheimers disease), is associated with cerebrovascular dysfunction, often as a consequence of chronic vascular damage and reduced blood flow in the #brain. 🐁Dr Latha Diwakar's lab developed a mouse model of VaD. This was done using the vasoconstricting peptide Endothelin-1 (ET-1) to mimic recurrent transient ischemic attacks. The findings show that ET-1 disrupts the blood-brain barrier, leading to neuronal loss and memory impairment. However, co-administering pleiotrophin helps restore barrier integrity and memory function! 🧠This model will aid in exploring the underlying mechanisms of VaD and may provide insights for the development of promising therapies. 📑Please read the full story on Experimental Neurology @Elsevier here: https://lnkd.in/dG6VPyg7 Mayank . | Ankita Talukdar | Shobha Anilkumar ,PhD | Thomas Issac | Latha Diwakar #Aging #Neuroscience #Neurodegeneration #VascularHealth #BrainHealthMatters

𝐁𝐫𝐚𝐢𝐧 𝐁𝐢𝐨𝐦𝐚𝐫𝐤𝐞𝐫𝐬 - 𝐂𝐨𝐦𝐩𝐥𝐞𝐭𝐞 𝐏𝐃𝐅 𝐆𝐮𝐢𝐝𝐞 𝐃𝐨𝐰𝐧𝐥𝐨𝐚𝐝 𝐅𝐫𝐞𝐞 𝐏𝐃𝐅 𝐁𝐫𝐨𝐜𝐡𝐮𝐫𝐞: https://lnkd.in/d7PXzM8D The report also includes the profiles of key brain biomarkers market companies along with their SWOT analysis and market strategies. In addition, the report focuses on leading industry players with information such as company profiles, components and services offered, financial information of last 3 years, key development in past five years. 𝐌𝐀𝐑𝐊𝐄𝐓 𝐏𝐋𝐀𝐘𝐄𝐑𝐒 : • Advanced Brain Monitoring • Electrical Geodesics, Inc. • F. Hoffmann-La Roche Ltd • Johnson & Johnson • Siemens Healthineers • BrainScope • Quest Diagnostics • QIAGEN N.V • Natus Medical • Myriad Genetics #BrainBiomarkers #NeurodegenerativeDiseases #Neurology #BrainHealth #ParkinsonsDisease #Neuroimaging #NeuroScience #PrecisionMedicine #ClinicalBiomarkers #EarlyDetection #CognitiveHealth #BrainDisorders #Neurotherapeutics #BiomarkerDevelopment #HealthcareInnovation #NeurologicalDisorders