Stanford Department of Medicine’s Post

Stanford researchers are leading the INTERCEPT project, a major international initiative aimed at studying cancer development in blood. This study will examine both traditional and novel risk factors, including biomarkers, across multiple countries: the U.S., Ghana, Israel, Japan, and Taiwan. Key features of the project include a large participant pool of 3,840 individuals, a focus on various cancer types, a diverse multi-ethnic demographic, and the exploration of biological, psychological, and environmental influences on cancer risk. The project aims to create an international biobank with up to 140,000 specimens and a comprehensive database to support future cancer prevention research.

🌟 Advancing the Fight Against Brain Metastases in Lung Cancer Recent research highlights the pivotal role of cancer-driver genes and non-coding RNAs (ncRNAs) as biomarkers for brain metastases in lung cancer. These discoveries open new doors for early detection and targeted therapies in one of the most aggressive forms of cancer. 🔑 Key Insights: Cancer Driver Genes (e.g., EGFR, KRAS, ALK): These genetic mutations significantly contribute to tumour progression and metastasis. Identifying these mutations enables more personalized and effective treatments. Non-Coding RNAs (e.g., miR-423, MALAT1): Previously underestimated, these RNAs regulate cancer cell invasion and play a critical role in metastasis development. They now serve as promising diagnostic and prognostic tools. 🎯 Why It Matters: Understanding the molecular mechanisms behind brain metastases is critical for improving survival and quality of life for lung cancer patients. These biomarkers provide a foundation for precision medicine, allowing healthcare professionals to predict metastases and tailor treatments to individual genetic profiles. Let’s continue the discussion! How do you think these breakthroughs could reshape cancer care? Share your thoughts below! 💡 Interested in learning more? Read the full article here: https://lnkd.in/djwusGpe #CancerResearch #LungCancer #BrainMetastasis #PrecisionMedicine #GeneticBiomarkers #Oncology #MedicalInnovation

🌟 Revolutionary Cancer Treatment: Forcing Cancer Cells to Self-Destruct! 🌟 I'm excited to share a groundbreaking advancement in cancer research that could change the way we approach cancer treatment. Scientists have developed a novel method that forces cancer cells to kill themselves using a simple yet ingenious trick involving two proteins. Here's how it works: 🔬 The Science Behind It: 1. Harnessing Apoptosis: The method leverages the body's natural process of programmed cell death, known as apoptosis. 2. Molecular "Glue": Researchers created a molecular "glue" that forces the interaction of two specific proteins, BCL6 and CDK9. 3. Flipping the Script: Mutations in BCL6 can prevent cell death, leading to cancer. However, when BCL6 is bound to CDK9, it triggers a cascade of cell death signals, causing lymphoma cells to self-destruct. 💡 Why It Matters: - Targeted Approach: Unlike traditional treatments like chemotherapy and radiation, which can harm healthy cells, this method selectively targets cancer cells. - Promising Results: Laboratory tests have shown that this compound selectively kills diffuse large B-cell lymphoma cells while sparing other cancer cell types and showing no significant toxicity in mice. 🌱 The Future of Cancer Treatment: While further research is needed, including tests on mice with lymphoma and eventual clinical trials, this innovative approach offers hope for a more targeted and effective cancer treatment with potentially fewer side effects. Let's celebrate this remarkable achievement and the hope it brings to millions worldwide! 🌍✨ #CancerResearch #MedicalBreakthrough #Apoptosis #HealthcareInnovation #CancerTreatment #MedicalLaboratoryTechnology #Microbiology #Phlebotomy #LaboratoryTesting #DiagnosticTesting #HealthcareProfessional #MedicalTesting #ClinicalLaboratory #BiomedicaScience #HealthcareIndustry #MedicalScience #LaboratoryMedicine #ClinicalMicrobiology #InfectionControl #PhlebotomyTechnician #MedicalLabTechnician #MicrobiologyLab #ClinicalLab #HealthcareCareer #MedicalCareer #ScienceCareer #COVID19Testing #Virology #Bacteriology #Parasitology #MolecularDiagnosis #GeneticTesting #Cytology #Histopathology

🚀 Exciting Advances in Cancer Treatment! 🚀 A new breakthrough from Stanford Medicine researchers is transforming the fight against cancer. The team developed a molecule that brings together two proteins to trigger self-destruction in cancer cells—a novel approach with promising applications in treating diffuse large cell B-cell lymphoma. Unlike traditional therapies that kill healthy cells along with cancerous ones, this method precisely targets lymphoma cells, activating natural cell death pathways. This “molecular glue” could potentially revolutionize oncology by reprogramming cancer’s survival mechanisms to become self-destructive. Tested in lab conditions, the compound showed potent results against cancer cells, with no observed toxicity in healthy mice. Co-founders of Shenandoah Therapeutics, Professors Gerald Crabtree and Nathanael Gray, along with their team, are committed to advancing this research and hope to soon begin clinical trials to make this life-saving therapy accessible to patients. Kudos to Stanford for this innovative step toward safer, targeted cancer treatments! #CancerResearch #Biotech #Innovation #Healthcare #CancerTreatment #Lymphoma #StanfordMedicine #Oncology https://lnkd.in/d8CeZCj5

Join us for a series of insightful presentations and discussions at this year’s National Conference on Cancer Medicine (NCCM).: 📍 𝐅𝐢𝐧𝐝 𝐮𝐬 𝐚𝐭 𝐄𝐱𝐡𝐢𝐛𝐢𝐭𝐢𝐨𝐧 𝐁𝐨𝐨𝐭𝐡 𝐁09 𝐇𝐢𝐠𝐡𝐥𝐢𝐠𝐡𝐭𝐬 𝐈𝐧𝐜𝐥𝐮𝐝𝐞: 𝐏𝐥𝐞𝐧𝐚𝐫𝐲 𝐒𝐞𝐬𝐬𝐢𝐨𝐧: Join Professor Dr. Chee-Onn Leong, our CEO, on June 22nd at 9:00 AM for a groundbreaking discussion on "𝘛𝘩𝘦 𝘙𝘰𝘭𝘦 𝘰𝘧 𝘓𝘪𝘲𝘶𝘪𝘥 𝘉𝘪𝘰𝘱𝘴𝘺 𝘢𝘯𝘥 𝘊𝘪𝘳𝘤𝘶𝘭𝘢𝘵𝘪𝘯𝘨 𝘛𝘶𝘮𝘰𝘳 𝘋𝘕𝘈 𝘪𝘯 𝘗𝘳𝘦𝘤𝘪𝘴𝘪𝘰𝘯 𝘖𝘯𝘤𝘰𝘭𝘰𝘨𝘺." This session is crucial for medical professionals interested in the latest advancements in cancer screening and diagnosis. 𝐑𝐚𝐩𝐢𝐝 𝐅𝐢𝐫𝐞 𝐏𝐫𝐞𝐬𝐞𝐧𝐭𝐚𝐭𝐢𝐨𝐧𝐬: 📌Validation of a Multi-Cancer Early Detection Test Among the Asian Population Using Circulating Tumor DNA 📌Enhanced Detection of Actionable Mutations through Concurrent Tissue and Circulating Tumor DNA Profiling in Lung Cancer 📌Characterization of Cancer-Driving Genetic Variants in the Malaysian Population These presentations will showcase our latest research and developments in the field of genomic medicine, emphasizing our commitment to innovation and precision in cancer diagnosis and treatment.

Happy to announce that my lab has been awarded an American Cancer Society Yosemite grant to use #AI to improve diagnostics for myelodysplastic syndromes. Unexplained cytopenia is a common finding and a frequent source of morbidity especially in older people. The differential diagnosis of cytopenia is broad and often requires a bone marrow biopsy to evaluate which adds costs and complexity to the diagnostic evaluation. The true incidence of #MDS is estimated to be three fold higher than indicated by SEER data, and many patients with MDS go undiagnosed and untreated. AI-based analysis of blood and marrow has the potential to streamline the evaluation of cytopenia. In this grant we will use machine learning methods to evaluate blood blood/bone marrow smears and flow cytometry data to improve the detection of MDS. Looking forward to working with Dr. Chenyang Lu and his lab at Washington University in St. Louis. Washington University School of Medicine in St. Louis https://lnkd.in/gePhuCCE

Revolutionizing Cancer Research: Precision Analysis of Cancer Cells Welcome to the cutting edge of cancer research! Discover a revolutionary tool designed to bring unprecedented precision and efficiency to cancer cell analysis. User-Friendly Interface Our intuitive interface allows researchers to effortlessly input nucleotide FASTA sequences and protein sequences. Designed for simplicity, ensuring you spend less time on data entry and more on critical analysis. Nucleotide Sequence Analysis By entering a nucleotide sequence, the tool swiftly calculates the GC content, providing essential genomic insights critical for understanding the characteristics of the tumor. Advanced Protein Sequence Analysis Input a protein sequence to pinpoint the cell cycle phase of the cancer cell. This analysis delivers vital data for targeted cancer research, aiding in the understanding of cancer cell behavior. Comprehensive Results and Dynamic Visualization Instantly view comprehensive results including GC content and cell cycle phase. A dynamic pie chart visualizes the distribution of cell cycle phases, providing a clear and concise summary. These visual aids make it easier to interpret complex data, leading to more informed research decisions. Transformative Impact This tool is a game-changer, offering fast and accurate analysis of cancer cell sequences. It enables researchers to make groundbreaking discoveries with precision and efficiency, reducing analysis time and allowing researchers to focus on interpreting results and developing innovative treatments #CancerResearch #Bioinformatics #Genomics #Proteomics #CancerAnalysis #ResearchTools

#CAR-T #celltherapy pioneer, Carl June was awarded with 2024 #Breakthrough #Prize in life sciences. 💡Catch up with the #captivating and #motivating story of Carl June here from his #earlydays into #research, working on #viruses at US Navy, deciding to use those experiences to #tackle cancer, and finally infusing #firstpatients with CAR-T cells at Penn Medicine, University of Pennsylvania Health System in 2010. Rest is history, as more than 34,000 #patients have now #received #CAR-T cell therapy and 100s of #clinicaltrials are happening globally. He was awarded alongside another #CAR-T cell therapy leader, #Michel #Sadelain from Memorial Sloan Kettering Cancer Center. Breakthrough Prize Foundation https://lnkd.in/gUebpbM2

🧠✨ Exciting breakthrough in glioblastoma research! Dr. Filippo Veglia and his team at The Wistar Institute have unveiled a critical mechanism driving immunosuppression in glioblastoma, paving the way for potential new treatments. 🌟 - https://bit.ly/3UuwaoG 🔍 By targeting the PERK-histone lactylation axis, they discovered a way to inhibit the glucose-induced immunosuppressive function of macrophages, leading to long-lasting immunity against tumor regrowth. 💡 This discovery offers hope for glioblastoma patients and underscores the importance of understanding cellular mechanisms in fighting cancer. Stay tuned for more updates on this groundbreaking research!🚀 #GlioblastomaResearch #Immunosuppression #MedicalBreakthrough #CancerResearch #glioblastoma #meded #eMednews

Scientists from the Johns Hopkins Kimmel Cancer Center have developed an AI blood test that accurately identifies lung cancer. This new blood test could improve screening and reduce death rates by identifying high-risk patients who would benefit from follow-up CT scans, according to the team’s computer modelling. The study’s corresponding author, Victor Velculescu, MD, PhD, explained: “We have a simple blood test that could be done in a doctor’s office that would tell patients whether they have potential signs of lung cancer and should get a follow-up CT scan.” #LungCancer #CancerResearch #AIinHealthcare #HealthcareInnovation #MedicalResearch #EarlyDetection #JohnsHopkins #HealthTech #MedicalTechnology #ArtificialIntelligence #CancerScreening #PrecisionMedicine #Biotechnology #HealthCare #InnovativeTechnology Click the following link to learn more about it.⬇ https://lnkd.in/gdBVvvGd