Elucidate The Chemical Structure of Your Compounds 🔍 Whether it's a drug metabolite, an impurity from stability testing, or an extracted compound—do you know its exact structure? We activate for you the power of Liquid Chromatography - High Resolution Mass Spectrometry (LC-HRMS) to reveal the structure of your compounds. #LCMS #HighResolutionMassSpectrometry #DrugMetabolites #ChemicalAnalysis #Metabolomics
Starlight’s Post
More Relevant Posts
-
AOD 9604 CAS:221231-10-3 Custom Peptide Synthesis Name: AOD 9604 CAS No.:221231-10-3 Sequence: SALLRSIPAPAGASRLLLLTGEIDLP Molecular formula: C78H123N23O23S2 Molecular weight:1815.1 Purity: >95.0% Source: synthetic MSDS and COA: available Note: For research use only #peptide #AOD9604 #custompeptide #peptidesynthesis
-
-
Overcome #metabolite synthesis and identification challenges with @rtMolecule. More than 20 years' experience in the custom chemical synthesis with innovative solutions in stable isotopes, metabolites and impurities.
-
Understanding critical quality attributes (CQAs) of biologic drugs is essential. The new Agilent AdvanceBio Peptide Plus columns provide excellent and reproducible peak shapes for peptides and impurities using formic acid (FA) mobile phase additive, simplifying processes and enhancing transferability across platforms. Unlike traditional C18 columns, these columns offer superior performance under the MS-friendly FA additive, providing better peak shape, selectivity, and resolution. Compatible with both HPLC and UHPLC systems, they deliver high-speed, sensitivity, and efficiency for peptide mapping and characterization, reducing operating costs while ensuring high-quality, accurate characterization. Achieve 91% of the peak capacity of sub-two micron particles at less than half the backpressure. Elevate your lab's efficiency and reduce costs with Agilent AdvanceBio Peptide Plus columns. https://bit.ly/4cp16OS #Peptide #Biomolecules #Biotherapeutics #Chromatography #AgilentIndia
-
-
Spiro-containing systems have greater three-dimensionalitythan flat aromatic compounds and in combination with the incorporation of one or more fluorine atoms can lead to promising results for biological and pharmacological activity of target molecule. Enamine LTD chemists have synthesised this new outstanding 1-(trifluoromethyl)-2-azaspiro[3.3]heptane. For more details https://lnkd.in/dB94zFu5 Enamine – Your Partner in Drug Development! Andrii K.
-
-
𝐏𝐞𝐩𝐭𝐢𝐝𝐞 𝐒𝐲𝐧𝐭𝐡𝐞𝐬𝐢𝐬 𝐑𝐞𝐚𝐠𝐞𝐧𝐭𝐬 𝐟𝐫𝐨𝐦 𝐓𝐂𝐈: TCI offers different protected & unprotected amino acids and peptide synthesis reagents that includes Oligopeptides, Resins, Fmoc-Amino Acids, condensing agents, activating agents, cleavage and work-up agents, Protecting and de-protecting agents, readily available to serve you better & faster. 𝐏𝐥𝐞𝐚𝐬𝐞 𝐜𝐨𝐧𝐭𝐚𝐜𝐭 𝐓𝐂𝐈 𝐒𝐚𝐥𝐞𝐬: Sales-UK@TCIchemicals.com for all your peptide synthesis needs. 𝐋𝐞𝐚𝐫𝐧 𝐌𝐨𝐫𝐞: https://lnkd.in/gwcbSRh4 #aminoacids #peptidesynthesis #oligopeptides #reagents #protectingagents #tcichemicals #lifescience #researchchemicals #molecules #cell #tissue #peptides #peptidechain #antibacterial #coupling #pharmaceuticalindustry #qualityreagents.
-
Phosphoramidites are key building blocks in oligonucleotide synthesis, allowing for the sequential addition of nucleotides to create synthetic DNA or RNA strands. Amine linkers, on the other hand, provide functional groups containing nitrogen atoms, which can be used for further chemical modifications or conjugation to other molecules. we can supply a long series of phosphoramidtes originated from natural nucleotides and modified nucleotides. The nucleotide PMOs can also be prepared according to the customers enquiry. Additionally, we have a long list of phosphoramidite linkers. Please contact us (director.jssiresearch@gmail.com), Ph: 15195721620) if you need any Phosphoramidites, or its amine linkers and other specialty chemicals and non-GMP APIs. Please ask us if you need help in your contract research in drug discovery and development. Also please refer to our website(https://jsiresearch.ca/#) for a list of other innovative materials, like, LNPs, Lipidoids, GalNAc L-96, PS L-96, nucleotides & Phosphoramidites and linkers.
-
Phosphoramidites are key building blocks in oligonucleotide synthesis, allowing for the sequential addition of nucleotides to create synthetic DNA or RNA strands. Amine linkers, on the other hand, provide functional groups containing nitrogen atoms, which can be used for further chemical modifications or conjugation to other molecules. we can supply a long series of phosphoramidtes originated from natural nucleotides and modified nucleotides. The nucleotide PMOs can also be prepared according to the customers enquiry. Additionally, we have a long list of phosphoramidite linkers. Please contact us (director.jssiresearch@gmail.com, Ph: 15195721620) if you need any Phosphoramidites, or its amine linkers and other specialty chemicals and non-GMP APIs. Please ask us if you need help in your contract research in drug discovery and development. Also please refer to our website(https://jsiresearch.ca/#) for a list of other innovative materials, like, LNPs, Lipidoids, GalNAc L-96, PS L-96, nucleotides & Phosphoramidites and linkers.
-
Peptide synthesis: Alloferon-2 CAS: 347884-62-2 Product name: Alloferon-2 CAS: 347884-62-2 Sequence: Gly-Val-Ser-Gly-His-Gly-Gln-His-Gly-Val-His-Gly Molecular formula: C52H76N22O16 Molecular weight: 1265.32 Source: Synthesis Appearance: white powder Purity: >95.0% Shelf life:> 2 years Notice: For research use only #peptide #Alloferon #Alloferon2 #cosmeticpeptide #custompeptide #peptidesynthesis
-
It is nice articale for methylation of pyrazoles at N1 by using bulky silane methyl chloride!
Hands up if you have ever attempted to selectively methylate the N1-position of a substituted pyrazole with methyl iodide. Let me guess, you ended up with a near equimolar mixture of N1 and N2-substituted products? Yeah, me too… It’s therefore no surprise that research in trying to improve this (lack of) selectivity is an active area. Chemists at Genentech have made what looks to be an important contribution to the field: https://lnkd.in/eKVqZT7F. They have shown that doing the ‘methylation’ with (chloromethyl)triisopropoxysilane (CAS: 18162-82-8) which is commercially available – it is – I checked, facilitates greater selectivity for the pyrazole N1 position due to sterics. Protodesilylation can then be achieved in the same pot – just add water and TBAF to furnish the desired methylated species. You will still need to purify your reaction mixture by column chromatography to remove the unwanted N2 isomer but you’ll hopefully achieve a greater yield that if you used good old-fashioned methyl iodide. Bit of advice from me: go and buy some (chloromethyl)triisopropoxysilane while you can! #OrganicSynthesis #MedicinalChemistry #Pharmaceuticals #DrugDiscovery #Methodology
N1-Selective Methylation of Pyrazoles via α-Halomethylsilanes as Masked Methylating Reagents
pubs.acs.org
-
Peptide synthesis: Alloferon-1 CAS: 347884-61-1 Product name: Alloferon-1 CAS: 347884-61-1 Sequence: His-Gly-Val-Ser-Gly-His-Gly-Gln-His-Gly-Val-His-Gly|H-His-Gly-Val-Ser-Gly-His-Gly-Gln-His-Gly-Val-His-Gly-OH Molecular formula: C52H76N22O16 Molecular weight: 1265.32 Source: Synthesis Appearance: white powder Purity: >95.0% Shelf life:> 2 years Notice: For research use only #peptide #Alloferon #Alloferon1 #cosmeticpeptide #custompeptide #peptidesynthesis
