Sterne, Kessler, Goldstein & Fox’s Post

Recently, I conducted a preliminary patent search focused on VHH (Variable Heavy-chain of Heavy-chain) antibodies, using specific keywords and classification codes. In this brief analysis, I identified approximately 2,700 patent families, with nearly 50% filed by Chinese applicants—highlighting the dominant role Chinese applicants play in patent filings within this field. These patent families encompass around 9,000 individual patents, of which roughly 2,600 have been granted. The top three entities with the most granted patents are Ablynx (now part of Sanofi), Flanders Interuniversity Institute for Biotechnology (FIB), and Centre National de la Recherche Scientifique (CNRS). These patent assignees continue to actively pursue patents for their VHH-based products, with a focus on protecting critical functional sequences, such as CDR regions. For those interested in VHH, examining the patent strategies and areas of focus of these key players may be a good start for deeper insights.

Check out Director Jorge Goldstein's article, "Solutions to the Problem of Therapeutic Antibody Genus Claims," featured in the latest edition of American Intellectual Property Law Association (AIPLA)'s Quarterly Journal. https://lnkd.in/e-kdmdV9 Jorge, after analyzing decades of enablement and written description case law, proposes creative claim-drafting solutions to one of the most controversial problems in modern biotechnology patents: How to obtain enforceable claims to a genus of antibodies or their uses. Biopharma patent practitioners will find valuable insights on strategies to prosecute, assert, and defend such genus claims. #Biotech #TherapeuticAntibodies

Kilpatrick attorneys Yifan Mao and Stuart Eric Pollack, Ph.D. recently attended the 20th annual KTIPS (Kilpatrick Townsend Intellectual Property Seminar) to discuss the “The Federal Circuit’s New § 112 Attack on Biotechnology: Diagnosis and Prescription.” The recent rulings from the Federal Circuit have emphasized the importance of the written description and enablement defenses in patent litigation and prosecution, particularly in the field of biotechnology. This new case law now requires that inventors provide a detailed process for identifying new antibodies, peptides, proteins, and nucleic acids that may be discovered in the future and providing structural information for these bioproducts. This session described the new law, discussed the implications and suggested effective approaches to counter these defenses during patent prosecution. Read their 7 Key Takeaways here: https://lnkd.in/d7YP_uKx

Worth a stop and chat on how Synple can make your research program efficient!

Our group work on the photocatalytic synthesis of an unsymmetrical bis-N-heterocycles hybrid molecule that links indole and quinoline/isoquinoline through a methylene linker is online now. This protocol is a green tool for integrating drug molecules to generate a unique chemical space for further exploration in drug discovery. Indomethacin and ibuprofen-based biologically important motifs were coupled with isoquinolines to generate a unique chemical space. Detailed experimental and theoretical mechanistic studies have been conducted to understand the reaction pathway.

💡"The modularity of the #peptoid structure allows combinatorial exploration and gives us the opportunity to develop a correlation between sequence and structure and function", says Dr. Ronald Zuckermann. Read the full interview here... 👉We are talking about peptoids, a very promising modality for novel pharmaceutical and material developments. 🚀And as we gear up for the 12th Peptoid Summit, a pivotal event in the field, we invite you to a sneak peek into the stimulating discussions with a short interview with peptoid pioneer Dr. Ronald Zuckermann, Researcher Emeritus, Biological Nanostructures at The Molecular Foundry, Lawrence Berkeley National Laboratory. ⭐Gain more insights and read the full interview here: https://lnkd.in/edmzdEDn #peptoids #purepep #synthesis

Happy to share a new Knowledge: Characterization of Nanoparticles from AAPS COMMUNITY PLATFORM! In Brief Nanoparticle characterization in drug delivery refers to the process of assessing and evaluating the physical, chemical, and biological properties of nanoparticles that are used as carriers for drugs. These properties are critical for determining the effectiveness, safety, and stability of nanoparticle-based drug delivery systems (DDS). Effective characterization ensures that the nanoparticles can achieve their intended therapeutic goals, such as targeted delivery, controlled release, and improved bioavailability of drugs.

We are excited to share our latest paper on "Characterization of Anticancer Drug Protomers Using Electrospray Ionization and Ion Mobility Spectrometry–Mass Spectrometry" just published on #JASMS https://lnkd.in/eq58i-nN We used electrospray ionization and ion mobility spectrometry–mass spectrometry to detect and characterize the three anticancer drugs palbociclib, copanlisib, and olaparib. Ion mobility–mass spectrometry and density functional theory revealed that these compounds generate isomers during ionization (protomers) due to the presence of multiple protonation sites within their chemical structures. #AcceptedArticle #ChargeEffect #MassSpectrometry #ElecetrosprayIonization #IonMobilitySpectrometry Thanks to the entire team, without whom this would not have been possible @Marc Safferthal, Borislav Kovacevic, Pascal Schorr, @Jerome Riedel, Kevin Pagel, and @Dietrich A. Volmer. #HUBerlin #FUBerlin

Many of the active compounds in pharmaceutical drugs have poor solubility in water, and given that water accounts for a large percent of the human body’s composition, this hinders their ability to perform to their full potential. Physics Professor and CEPS Research Chair in Novel Sustainable Nanomaterials Dr. John Dutcher, alongside PhD candidate Nicholas van Heijst, are developing a solution using a safe and natural nanomaterial, Phytoglycogen (PG) that can improve the solubility of hydrophobic compounds to improve the effectiveness of pharmaceutical treatments. Read more here: https://lnkd.in/en2W7jXi