Suhao Wang’s Post

New animated cover! Have you seen the latest work of Simon Blakey's team on a novel carbon-directed C-H annulation strategy for the synthesis dihydroquinoline heterocycles? I did, and it inspired this cover about making a ring! (the triple bond in gold, the nitrogen atom as a sapphire and the boron complex as a light green gem!) The key innovation in their work is the use of a commercially available single-carbon 'linchpin' reagent that can be easily attached to simple aniline starting materials, installing an alkylboron group. This positioning group then enables a rhodium-catalysed reaction sequence! Highlights: ⏣ Modular synthesis of dihydroquinolines from simple anilines and alkynes ⏣ One-step transformations provide access to other valuable heterocycles ⏣ Mechanistic studies suggest irreversible, non-rate-limiting C-H activation This novel 'one-carbon linchpin' strategy provides a powerful new platform for carbon-directed C-H annulation reactions towards medicinally relevant heterocycles. I look forward to seeing how this chemistry will enable further advances! Co-authors: Michael R. Hollerbach, Eleda Plouch and Samantha Velazquez #sciart ⌬ #research ⌬ #chemistry

Fluorescent Molecules to Illuminate Life: Simplified Synthesis with Formaldehyde A research team led by Professor Young-Tae Chang from the Department of Chemistry at POSTECH and Dr. Sun Hyeok Lee from the Basic Science Research Institute of POSTECH has recently made a breakthrough in synthesizing organic fluorophores more cost-effectively and atom-efficiently than ever before by using formaldehyde, the simplest carbon molecule. Professor Young-Tae Chang who led the research remarked, "This marks the first successful synthesis of Cy3 molecules using formaldehyde." He continued, "Our method is not only cost-effective and highly atom-efficient, but it can also be utilized in vivo, expanding the potential applications of organic fluorophores in life sciences research and diagnostics."  📌Read more: https://lnkd.in/edwBA3fP 📌DOI: https://lnkd.in/erd3Nwxc

Time to unveil my latest cover design, inspired by an article by Helen Hailes and Tom Sheppard on biocatalytic fluorination in organic synthesis! In this paper, they explore an innovative approach to creating enantio-enriched sp3 fluorides using biocatalysis. The team has developed an ingenious method that harnesses the power of ene reductases (EREDs) to perform stereoselective reduction of α-fluoroenones and α-fluoroenoates, resulting in the formation of valuable fluorine-containing compounds. Here are some of the highlights of this research: ⏣ A series of functionalised chiral fluorinated compounds were synthesised with remarkable yields and stereoselectivities. ⏣ The biocatalytic process was successfully scaled up, demonstrating its potential for industrial applications. ⏣ Computational docking studies were carried out, shedding light on the mechanism of stereoselectivity in the enzymatic reduction process. This approach represents a significant leap forward in the field of organofluorine chemistry, offering a sustainable and efficient alternative to traditional synthetic methods for the preparation of chiral fluorine-containing molecules! Co-Authors: Helen Allan, Yu Wang, Bethan Winterson, Alex King, Abil Aliev , Rachel Szpara, PhD, Victor La-serna, Charlotte Coomber, John M. Ward, Jack Jeffries #sciart ⌬ #research ⌬ #chemistry ⌬ #biochemistry

🔬 In response to growing concerns about the health, environmental and #ethical impacts of #nanosciences and #nanotechnologies (N&N), the European Commission has presented a comprehensive Code of Conduct for Responsible Nanosciences and Nanotechnologies. 💼 📚The e-CODUCT consortium is committed to responsible N&N by implementing the Code of Conduct. To improve communication and ensure clarity in our project activites, we are adopting standardised N&N terminology and using the latest #EU glossary with the European Commission's definition of #nanoparticles https://lnkd.in/dcXdfPjk ⭐ Nanomaterials are characterised by their extremely small size — no larger than a hundred nanometres, about a thousand times smaller than a human hair. These materials can consist of various substances, including metals, ceramics, polymers and biological materials. Due to their tiny size, nanomaterials have unique properties that differ from those of their solid counterparts. These properties can include altered mechanical, electrical, magnetic, optical and chemical characteristics. Some nanomaterials exhibit higher strength, conductivity or reactivity compared to larger materials, making them valuable for a wide range of applications in industries such as electronics, medicine, energy and environmental remediation ♻ Due to their special properties, nanomaterials are subject to specific regulatory oversight, which includes general chemicals legislation (REACH) and sectoral regulations for their use in specific products such as biocides, cosmetics or food.📝 #Responsibletech #eCODUCT #Nanoscience #Nanotechnology #EUCommission #Innovation #CO2Reduction #HorizonEurope UGent TotalEnergies Kemijski inštitut - National Institute of Chemistry Process Design Center CNRS Saint-Gobain DECHEMA Benkei @CO NOT Slovenia

Meet Manolis Doxastakis, an associate professor of chemical and biomolecular engineering. Doxastakis’ research uses computational methods as applied to a broad spectrum of soft matter that covers polymer melts, blends, and copolymers, as well as lipid membranes and protein assemblies. Check out the video to learn more!

𝗕𝗶𝗼𝗺𝗶𝗺𝗲𝘁𝗶𝗰 𝗺𝗲𝗺𝗯𝗿𝗮𝗻𝗲 𝗳𝗼𝗿 𝗲𝗹𝗲𝗰𝘁𝗿𝗼𝗰𝗵𝗲𝗺𝗶𝗰𝗮𝗹 𝘀𝗲𝗻𝘀𝗶𝗻𝗴 𝗼𝗳 𝗮𝗻𝘁𝗶𝗼𝘅𝗶𝗱𝗮𝗻𝘁𝘀 The strategical design of bioinspired membranes (BMs), i.e. membranes that contain non-biological and biological molecules, to provide enhanced ions transport rates or mediated molecules separations has proved applied applications in several fields. Inspired by the latest advancements in biomaterial technology, this paper presents the development and performance evaluation of a synthetic nanomembrane made from a biodegradable and biocompatible PLA matrix with PEG-cholesterol building blocks. The membrane is designed to detect L-ascorbic acid (vitamin C) and Trolox® (a vitamin E derivative). The membrane resistance and the sensor sensibility towards the antioxidants molecules were evaluated by electrochemical techniques with Autolab302N potentiostat/galvanostat. Authors: Ahammed Hussain Madhani Mohammed Sadhakathullah, Sofia Paulo Mirasol, Brenda G. Molina, PhD , Juan Torras & Elaine Armelin Full paper: https://lnkd.in/ee-ZwW_W #Sensor #Antioxidants #Bioengineering #Biomaterials #Nanomembranes #Electrochemistry #Metrohm #Autolab

I’m thrilled to announce that some of research work from my PhD studies has been published (it has been a minute!) 🎉🎉🎉 The research deals with Dithiadiazolyls (DTDA) compounds, a class of sulfur-nitrogen heterocycles, where the core unit consists of a five-membered ring containing one carbon, two sulfur atoms and two nitrogen atoms. These compounds have attracted interest in materials science due to their unique electronic and magnetic properties. The interesting part? There are no metals in these compounds, so they might be cheaper and greener alternatives to existing products by forming organic magnets and/or conducting materials. This particular publication deals with one interesting DTDA molecule, namely (4-(2′,3′,5′,6′-tetrafluoro-4′-nitrophenyl)-1,2,3,5-dithiadiazolyl, which I (together with my co-authors) synthesized and analyzed with various analytical instruments and computational analysis techniques. Our efforts yielded some interesting results that help to explain some of its properties. Not going to lie, I do miss the wet lab sometimes! Maybe one day I'll come across a patent filed for this technology 😁 #PhD #Research #Publication #ProudMoment #Innovation #Science

We cordially invite you to read our new article🖋️📖  Rapid industrial growth is associated with an increase in the production of environmentally harmful waste. A potential solution to significantly reduce pollution is to replace current synthetic materials with readily biodegradable plastics. Moreover, to meet the demands of technological advancements, it is essential to develop materials with unprecedented properties to enhance their functionality. Polysaccharide composites demonstrate significant potential in this regard. Polysaccharides possess exceptional film-forming abilities and are safe for human use, biodegradable, widely available, and easily modifiable. Unfortunately, polysaccharide-based films fall short of meeting all expectations. To address this issue, the current study focused on incorporating carbon quantum dots (CQDs), which are approximately 10 nm in size, into the structure of a starch/chitosan biocomposite at varying concentrations. This modification has improved the mechanical properties of the resulting nanocomposites. The inclusion of nanoparticles led to a slight reduction in solubility and an increase in the swelling degree. The optical characteristics of the obtained films were influenced by the presence of CQDs, and the fluorescence intensity of the nanocomposites changed due to the specific heavy metal ions and amino acids used. Consequently, these nanocomposites show great potential for detecting these compounds. Cellular viability assessments and comet assays confirm that the resulting nanocomposites do not exhibit any cytotoxic properties based on this specific analytic method. The tested nanocomposites with the addition of carbon quantum dots (NC/CD II and NC/CD III) were characterised by greater genotoxicity compared to the negative control. The positive control, the starch/chitosan composite alone, was also characterised by a greater induction of chromatin damage in mouse cells compared to a pure mouse blood sample.Keywords: carbon dots; nanocomposites; cytotoxicity; starch; chitosan; biocomposite filmshttps://lnkd.in/dnhdy3WW #nanocomposites  #carbondots #cytotoxicity Magdalena Krystyjan Marcel KrzanMaterials MDPI

Today my essay 'The Green Industrial Revolution and the Future of Steel Production: Using the Innovative Sheffield Cell' has gone live in the Essex Student Journal at the University of Essex. If you are interested in all aspects of biochemistry, bioremediation, innovation and steel then please have a read. DOI: https://lnkd.in/eFhpgSEx

Nice collaborative paper with Samarendra Maji  Gomathi Sivakumar and ANASHWARA BABU on temperature controlled catalysis with PNIPAMcoated MnO2 nanoparticles, as part of the 15th anniversary special issue of RSC Polymer Chemistry