SYNTHELIS’ Post

📢 Dev Crease, Partner in Keltie's Life Sciences team, will speak at SynbiTECH 2024 on 3rd December. Keltie is proud to sponsor this important event bringing together leaders in engineering biology. If you’re attending, come and say hello to Dev and the Keltie team, including Laura Kehoe and Matt Aldridge. Discover more about SynbiTECH here: synbitech.com. #SynbiTECH2024 #SyntheticBiology #LifeSciences #KeltieLLP SynbiCITE

Follow CityU iGEM and stay tuned for the latest updates on iGEM 2024! 🙌

Achieving the structure of a desired membrane protein is the holy grail for many structural biologists. But it’s not just about choosing the right solubilization method—whether it’s detergents or leveraging our 𝗡𝗮𝘁𝗶𝘃𝗲𝗠𝗣™ platform, which preserves the protein's native environment. It’s also about the 𝗽𝗮𝗿𝘁𝗻𝗲𝗿𝘀𝗵𝗶𝗽𝘀 and 𝗰𝗼𝗹𝗹𝗮𝗯𝗼𝗿𝗮𝘁𝗶𝗼𝗻𝘀 that help drive research forward. Science is a team effort. At Cube Biotech, we collaborate with incredible partners like Momentum Biotechnologies and NanoTemper Technologies to tackle the complex challenges of drug discovery. Pioneering together, we're solving some of the most challenging protein research problems. Are you in the Greater Boston area and want to learn more about our combined capabilities? ➡️ My colleagues Jan Kubicek (CSO) and Barbara Maertens (COO) will visit Boston from 𝗗𝗲𝗰𝗲𝗺𝗯𝗲𝗿 𝟮𝗻𝗱 𝘁𝗼 𝟲𝘁𝗵—they’d love to meet and explore opportunities together! #membraneproteins #NativeMP #structuralbiology #drugdiscovery

I was on a very interesting panel about the democratization of science, about communicating science to the people, about synthetic biology, and all sorts of cool, interrelated concepts. It was also filmed at a really neat studio space at Concordia University. If you have any interest in these topics, go watch the video now! #scicomm #syntheticbiology #synbio #sciencejournalism #trust #biology #sciencemuseum #scienceeducation https://lnkd.in/eQDmcduh

#DoNotMissThis: ProteiNext 2024: Extracellular Vesicles Symposium The free online event will take place on June 12, 2024 - Europe live sessions 3:00 PM – 5:05 PM CET - Asia live sessions 12:00 PM - 1:35 PM SGT - Americas live sessions 12:00 PM - 2:55 PM PDT About The Event Welcome to ProteiNext Symposium, proudly brought to you by Bio-Techne. With a focus on #proteinanalysis, ProteiNext is an annual symposium that offers a platform for sharing insights, overcoming challenges, and driving meaningful progress in the field. This year, we shine a spotlight on #ExtracellularVesicles (#EVs), inviting over 10 esteemed scientists to join us in tackling crucial aspects related to #EVs, ranging from #samplepreparation and #isolationprotocols to #proteincharacterization, #quantification, and #datanormalization. Together, we'll navigate the challenges inherent in unraveling the mysteries of #EVs, paving the way for transformative discoveries and advancements. Join us as we embark on a journey of exploration, innovation, and discovery at ProteiNext. Together, let's push the boundaries of possibility and shape the future of protein science. Please register here: https://lnkd.in/eER9SbTB #EVresearch #proteinscience #biotechne #researchneverstops

🚀 Discover the next generation of multiomics with AVITI24™. 🧬An integrated biology platform, #AVITI24 empowers sequencing and in situ #multiomic analysis providing deep insights. With multiple read-outs, flexible experimental design, and compatibility with diverse analyses, the possibilities are limitless. 🌟 Download our #infographic and learn how AVITI24 can transform your research and unlock complex biological insights https://bit.ly/4g7024e

𝟯️⃣ [ 𝗧𝗛𝗘 𝗩𝗛𝗛 𝗧𝗢𝗢𝗟𝗕𝗢𝗫 ] 𝗨𝗻𝗹𝗼𝗰𝗸𝗶𝗻𝗴 𝗻𝗲𝘄 𝗶𝗻𝘀𝗶𝗴𝗵𝘁𝘀 𝗶𝗻 𝗧𝗮𝘂 𝗳𝗼𝗹𝗱𝗶𝗻𝗴 𝗮𝗻𝗱 𝘀𝘁𝗿𝘂𝗰𝘁𝘂𝗿𝗮𝗹 𝗱𝘆𝗻𝗮𝗺𝗶𝗰𝘀 𝘄𝗶𝘁𝗵 𝗼𝘂𝗿 𝗡𝗮𝗻𝗼𝗯𝗼𝗱𝗶𝗲𝘀®🔬    Our 𝗩𝗛𝗛 𝗧𝗼𝗼𝗹𝗯𝗼𝘅 continues to push boundaries in the field of Tau research! This spring, our synthetic nanobodies were highlighted in the Journal of Biological Chemistry (April 2024). The study from Isabelle Landrieu’s lab and collaborators explores how these nanobodies provide crucial insights into Tau folding, structural dynamics, and activity relationships. ➡️ 𝗪𝗵𝗮𝘁’𝘀 𝗡𝗲𝘅𝘁? We’re excited to share that more VHHs are in development! Clément DANIS and Elian Dupre, with the support of our PhD network European Network TauImmune, are working on new anti-Tau nanobodies that will further expand the capabilities of our toolbox.  𝗘𝘅𝗽𝗹𝗼𝗿𝗲 𝗼𝘂𝗿 𝗶𝗻𝗻𝗼𝘃𝗮𝘁𝗶𝗼𝗻𝘀 𝗮𝗻𝗱 𝘀𝗲𝗲 𝗵𝗼𝘄 𝗼𝘂𝗿 𝗰𝘂𝘁𝘁𝗶𝗻𝗴-𝗲𝗱𝗴𝗲 𝗻𝗮𝗻𝗼𝗯𝗼𝗱𝗶𝗲𝘀 𝗰𝗮𝗻 𝗯𝗼𝗼𝘀𝘁 𝘆𝗼𝘂𝗿 𝗽𝗿𝗼𝗷𝗲𝗰𝘁 ! 🔗 https://lnkd.in/eKYNXnDv #Innovation #Biotechnology #Nanobodies #Tau #ScientificResearch #HybrigenicsServices #SyntheticNanobodies #TauResearch 

EMBO Workshop "Autophagy Across Scales" We are excited to announce the EMBO Workshop on Autophagy Across Scales, taking place from September 23-27, 2024, in the beautiful setting of Sorrento, Italy. This event is co-organized by Antonella De Matteis from TIGEM, Italy, Helene Knævelsrud from the University of Oslo, Norway, and Sascha Martens from the University of Vienna, Austria. Autophagy, a fundamental cellular quality control process, has witnessed remarkable progress since the identification of Autophagy-related genes (ATGs) in the 1990s. These breakthroughs have given us a deeper understanding of how these genes orchestrate the encapsulation of cellular materials within autophagosomes, leading to their lysosomal degradation. Recent advances have shifted the focus towards understanding how ATGs interact with membrane trafficking and lipid transfer machinery at molecular and cellular levels. The ability to manipulate autophagy with precision is becoming increasingly critical for exploring its role as a stress-response pathway across various tissues and organisms. This workshop offers a unique opportunity to dive deep into the latest mechanistic insights and scalable tools, while emphasizing the need for interdisciplinary collaboration to keep pace with the rapidly evolving field. Autophagy Across Scales is dedicated to bridging these vital developments, providing a platform for autophagy researchers to share knowledge and foster new ideas. #Autophagy #EMBO #Tigem #ScientificWorkshop

This week during the BREAKthrough_DN 2nd Annual Meeting in Bled, Slovenia, I had the opportunity to speak about my thesis work on the structure/function of L,D-transpeptidases catalyzing attachment of Lpp to peptidoglycan in Gram-negative bacteria. We believe that understanding Ldts molecular mechanism is the beginning of a novel strategy to overcome bacterial resistance based on using Ldts inhibitors to trigger outer membrane destabilisation. Being part of BREAKthrough_DN and being able to share my research with brilliant scientists makes me feel incredibly fortunate. Excited to see what comes next! #AMR #AntibioticResistance #BREAKthrough #Biochemistry

📢 Incredible new application of the #FluidFM OMNIUM platform 🚨 🌟🔬 Meet Spirostomum (or Spiro), a one-celled organism that contracts 14x faster than freefall. After triggering these little creatures a few times, scientists noticed something unusual: Spiros “remember” and stop reacting - a single-cell organism with memory! 🤯 🪂⚡. Researchers at the Georgia Institute of Technology want to understand how, so they turned to FluidFM OMNIUM for single-cell biopsies.   We successfully took biopsies of living Spiros, which are up to 100-400 times larger than an average mammalian cell, and guess what? Success! 🎉  Two amazing outcomes:  ✅ Our work demonstrated that the OMNIUM platform can handle these challenging, large-dimension cells.  ✅ Spiros tolerate the biopsy procedure without harm. 🧫✨   Learn more about FluidFM technology👉 https://lnkd.in/gT8Fchi4   Stay tuned for more exciting updates from the world of single-cell science! 🌍🧫   #SingleCell #Biotech #BiotechInnovation #CellularBiopsy #Spirostomum #ScientificDiscovery #TeamworkWins #ResearchBreakthrough #BiotechJourney #GameChanger #CellMemory #FutureOfResearch #transcriptomics #NGS #Spiro #RNAseq #scRNASeq