System Biosciences’ Post

The combination peptide, CagriSema might be more effective in achieving significant weight loss in a shorter period compared to Tirzepatide, even at its highest dose. This could indicate a potential advantage for CagriSema in terms of efficiency and speed of weight reduction. Here is the CagriSema trial result: According to a Phase II trial of CagriSema, the combination therapy caused a decrease in bodyweight at Week 32 of treatment by 15.6% from baseline. On the other hand, in the SURMOUNT-1 Phase III trial, Tirzepatide caused a bodyweight decrease at 72 weeks of 15% from baseline at the lowest dose, and 20.9% at the highest dose (15mg). These results suggest that CagriSema is likely to cause a bigger change in body weight from baseline than even the highest dose of Tirzepatide, in a fixed amount of time. CagriSema is available in phcoker in lyophilized powder form as a research peptides only. #Cagrisema #peptides #researchpeptides #tirzepatide

Geo Greenhealth is very exiting with the new method of DEIONIZED/ THERMAL extraction of RGLV (Red Grape Leaf Vines). Poly Pheols are the active ingredients, where Quercitin are the main ingredient. This typical extract is used for Lower Leg blood flow support; Liver booster/ Cancer; Anti-aging; Alzheimer’s and so much more. It will soon be put into API formulations. It is up to 20 times stronger than std. powder form pills. #pharmaceuticalindustry;#pharmakorea,#pharmaceuticalmanufacturing;#pharmaceuticalcompanies;#pharmadistribution;Wholesalepharmaceutical

Using patch clamp to screen compound action on ion channel or ligand/receptor achieved great progress in validating the pharmacological efficacy and pathophysiological mechanism among the candidates. For example, I have evaluated a series of therapeutic compounds including Trailpeg, Li2193, Li633, GABAZIN, Butyrate, fragments of synbiotics, short chain fatty acids, TGFb1, etc. in concerning about their ionic conductance, permeability, EC50, receptor activation signal pathway, and modulatory mechanisms.

New: Sensitive MS-assay for detection of polysorbate-degrading HCPs in mAb products. Polysorbate surfactants are crucial to the stability and efficacy of monoclonal antibody (mAb) products, and polysorbate degradants may form particles which pose a risk to patient safety. Consequently, polysorbate stability is a major concern in mAb development and may cause delays, often in the late stages of project development. For this reason, we have collaborated with our clients to develop a highly sensitive mass spectrometry (MS)-based assay for detecting polysorbate-degrading host cell proteins (HCPs) in mAb products. 🖼 For more information, download our newest poster on the MS assay by Victor Chrone, Vasileios Tsiamis, Cecilie Hovitz Lautrup-Larsen, Ejvind Mørtz, and Thomas Kofoed – presented by Thomas at the 2024 BEBPA HCP Conference.

Did you know that our new products ReadyShield™ Protease Inhibitor Cocktail have a special non-freezing formula so they are ready when you are! Containing inhibitors with a broad specificity for serine, cysteine, acid proteases and aminopeptidases, they are optimized for various cell types and tissue extracts for instant inhibition. Click to learn more! #ProteaseInhibitor #CellBiology #proteinstabilization

Have you heard of BPC-157? This is a synthetic peptide derived from a naturally occurring protein in the human stomach. It is known for its potential regenerative and healing properties. Each bottle is packed with 60 capsules, each containing 500 mcg of BPC-157 in its most effective oral form—arginate salt—and enhanced with 3 mg of SNAC for superior absorption. Here are several positive effects of using: - Healing and Tissue Regeneration - Increases Blood Flow - Reduces Inflammation - Superior Absorption Recommended Usage is to take 1-2 capsules daily, with or without food. If you have questions about if this would be a good fit for you, contact us today or ask your provider! #healthiswealth #familymedicine #peptidetherapy #peptides #functionalmedicine #functionalpractice #rootcause #directapproach #indianapolis #nursepractitioners #nps #healthyliving #liveyourbestlife #feelyourbest #bpc157 #peptide

⭕️ KNOGLINA Nasal Spray - Calcitonin (Salmon) Nasal Solution USP Treat and prevent Diminished bone strength, Most Ideal Solution for Osteoporosis. Inhibits Osteoclast and Increase Bone Mass. Calcitonin is an amino acid linear polypeptide hormone that is produced in humans primarily by parafollicular cell of thyroid it act to reduce blood calcium opposing the effect of parathyroid hormone. ️✉ : info@progresspharma.com 🌐 : https://progresspharma.in/ #knoglina #nasalspray #bonehealth #bonestrength #painfree #pharmaceuticalsales #painmanagementsolutions #progresspharma #makingyouhealthy #calcitonin #pharmaceuticalindustry #pharmaceuticalcompanies #PharmaceuticalCompany

We continue to spotlight another popular excellent article published in our journal, Antibody Therapeutics (2022 CiteScore: 6.4). The diversity of protein structures has led to an increased complexity of product- and process-related impurities. The article by the authors at GenScript ProBio summarizes the primary challenges encountered during the downstream processing of proteins, and presents effective solutions and case studies to tackle each major challenge.   Antibody Therapeutics (2022 CiteScore: 6.4) is the official journal of Chinese Antibody Society (CAS), published by Oxford University Press. CAS’s 2024 Annual Conference will take place in Cambridge, MA, USA, on Saturday, May 11, 2024. The agenda of this conference was just released this Monday. You are welcome to register for the conference right NOW via the following link. https://lnkd.in/ecmFPA4v #antibodies #antibody #antibodytherapeutics #mabs #mab #antibodydiscovery #cmc #proteinpurification #bioprocessing #annualmeeting #annualconference 

Apixaban is a highly selective, direct, and reversible inhibitor of factor Xa, a key component in the blood coagulation cascade. It works by blocking the activity of factor Xa, which catalyzes the conversion of prothrombin to thrombin. Thrombin is the final enzyme responsible for the formation of fibrin clots. By inhibiting factor Xa, apixaban indirectly reduces thrombin formation and subsequent clot development. Pharmacokinetics (Adult Data Unless Noted) #Onset: 3 to 4 hours #Distribution: Vss: ~21 L #Protein binding: ~87% #Metabolism: Hepatic predominantly via CYP3A4/5 and to a lesser extent via CYP1A2, 2C8, 2C9, 2C19, and 2J2 to inactive metabolites. #Half-life elimination: ~12 hours (8 to 15 hours) (AHA [Raval 2017]) #Time to peak: 3 to 4 hours #Excretion: Urine (~27% as parent drug); feces (biliary and direct intestinal excretion)

#ICYMI, our CEO and Co-Founder Ira Spector, Ph.D., spoke to Ira Pastor of Progress, Potential, And Possibilities about his background, co-founding SFA Therapeutics, and our unique approach using endogenous short-chain fatty acids to develop potentially safer and more effective therapeutics for chronic inflammatory conditions. Check it out here: https://lnkd.in/eGFatpXg #ChronicDisease