TAmiRNA GmbH’s Post

As a researcher in the field of microRNAs for many years now, I cannot be more than thrilled that the 2024 Nobel Prize in Physiology or Medicine has been awarded to two giants in the field of microRNA science, Prof. Victor Ambros and Prof. Gary Ruvkun who discovered "microRNA, a new class of tiny RNA molecules that play a crucial role in gene regulation"!!! Thanks to their discoveries, my laboratory and others around the world are studying these molecules that are crucial in the progression of lung cancer and offer unprecedented opportunities to predict response to cancer immunotherapies and new therapeutic strategies! #microRNA #NobelPrize2024 #LungCancer https://lnkd.in/dGHdNMB7

🚀 Excited to share that my research article, titled "Design, Synthesis, Evaluation, and Molecular Docking Study of Novel Quinoline Hydrazone Analogues as Anti-Tubercular Agents," has been published in the Journal of Computational Biophysics and Chemistry! 🌟 This work, derived from my MS thesis at NIPER Raebareli, explores novel approaches to combating drug-resistant tuberculosis through innovative molecular design and synthesis. I would like to thank my mentor Dr. Gopal Khatik sir, and other co-authors for their constant support and motivation.! 🙌 DOI: https://lnkd.in/gf6eUaaf #Research #PharmaceuticalSciences #DrugDiscovery #Tuberculosis #NIPER

The Nobel Prize It’s quite amazing that the 𝟐𝟎𝟐𝟒 𝐍𝐨𝐛𝐞𝐥 𝐏𝐫𝐢𝐳𝐞𝐬 in 𝐏𝐡𝐲𝐬𝐢𝐜𝐬, 𝐂𝐡𝐞𝐦𝐢𝐬𝐭𝐫𝐲, and of course, 𝐏𝐡𝐲𝐬𝐢𝐨𝐥𝐨𝐠𝐲 𝐨𝐫 𝐌𝐞𝐝𝐢𝐜𝐢𝐧𝐞, were awarded to researchers whose discoveries have revolutionized the life sciences. Their discoveries have impact elsewhere, too, but their main applications from artificial intelligence to protein structure and micro-RNAs are all mainly in life sciences. It is like all 3 Nobels are for biology and medicine innovation! #NobelPrize #Nobel2024

New image from Ella Maru Studio! Conformational Changes of Choline and Ethanolamine Transporters 🌀 Dr. Schara Safarian, @Di Wu and colleagues from Max Planck Institute of Biophysics, Fraunhofer ITMP, Goethe University Frankfurt, Fraunhofer Gesundheit, National University of Singapore deciphered the 3D structure and cellular function of #FLVCR proteins paving the path to understanding the pathogenesis of rare diseases and developing new therapies. This findings clarify the mechanisms of choline and ethanolamine transport by FLVCR1 and FLVCR2, enhance our comprehension of disease-associated mutations that interfere with these vital processes and shed light on the conformational dynamics of these major facilitator superfamily proteins during the transport cycle. Learn more 👉 https://lnkd.in/eMdNkRD6 #biophysics #cryoEM #MDsimulations #ella_maru_studio #journalcover #phdlife #phd #sciencegirl #scicomm #womaninscience #medicalartist #sciencegirl #biology  Max Planck Society

Our cells contain huge amounts of information about the inner workings of our body. Lysosomes, for example, exist within our cells and are a big part of our immune defence. But they can also be a major factor in neurodegenerative diseases. Sofía Fajardo Callejón is a PhD student and DAAD scholarship holder at the Rheinische Friedrich-Wilhelms-Universität Bonn, where she works at the Institute of Biochemistry and Molecular Biology. For 'Science in a Nutshell', Sofía gave us an insight into her research of identifying subpopulations of lysosomes in our cells and how the identification of these subpopulations might lead to new therapeutic approaches towards diseases like Niemann-Pick Type A, Alzheimer's, and more. Watch all episodes of Science in a Nutshell here: ➡️ https://lnkd.in/dQ3KpGPh #DAADScienceInANutshell #NeurodegenerativeDiseases #CellBiology #Research #Biochemistry #MolecularBiology #DAAD #ChangeByExchange

ARTICLE | Our research on a 𝗺𝗶𝗰𝗿𝗼𝗳𝗹𝘂𝗶𝗱𝗶𝗰 𝗱𝗲𝘃𝗶𝗰𝗲 𝗳𝗼𝗿 𝘁𝗵𝗲 𝗮𝘂𝘁𝗼𝗺𝗮𝘁𝗲𝗱 𝗴𝗿𝗼𝘄𝘁𝗵 𝗮𝗻𝗱 𝗱𝗶𝗳𝗳𝗲𝗿𝗲𝗻𝘁𝗶𝗮𝘁𝗶𝗼𝗻 𝗼𝗳 𝗰𝗲𝗿𝗲𝗯𝗿𝗮𝗹 𝗼𝗿𝗴𝗮𝗻𝗼𝗶𝗱𝘀 𝗳𝗿𝗼𝗺 𝘀𝗶𝗻𝗴𝗹𝗲-𝗰𝗲𝗹𝗹 𝘀𝘂𝘀𝗽𝗲𝗻𝘀𝗶𝗼𝗻𝘀 has been published in the 𝗕𝗶𝗼𝘁𝗲𝗰𝗵𝗻𝗼𝗹𝗼𝗴𝘆 𝗝𝗼𝘂𝗿𝗻𝗮𝗹! 👉 Our team leader, Zbynek Prokop, and alumnus Tomas Landolt (Buryska) collaborated with researchers from Faculty of Medicine, Masaryk University, St. Anne's University Hospital Brno, CEITEC - Central European Institute of Technology and Institute of Molecular Genetics of the Czech Academy of Sciences on the development of a microfluidic chip aimed at simplifying and enhancing the formation and differentiation of cerebral organoids - a unique platform for investigating neural diseases. 👉 Our findings emphasize how custom-designed microfluidic technology can increase culture medium efficiency while minimizing maintenance time. 👉 Check it out: https://lnkd.in/g-uBZ4tX #research #biomedicine #biochemistry #biotechnology #nicrofluidics #neuraldisease #technology 

"My research is focused on studying the effects of biochemical and physical differences between the mitochondria in normal endothelial cells and endothelial cells with reduced TRPV4 sensors within tumors. I have discovered these endothelial cells with reduced TRPV4 have bigger mitochondria and produce higher levels of energy that support tumor growth." Kesha K. Dalal, a Ph.D. student in the Molecular Medicine track of our Biomedical Science Program, wrote a column in the Toledo Blade discussing her research on protein sensors that guide the growth of blood vessels. She is conducting her research in the laboratory of Dr. Charles Thodeti in the Department of Physiology and Pharmacology. Read the article: https://buff.ly/4a1zMEc #UToledoMed #research

It’s Metabolism Day at the Københavns Universitet - University of Copenhagen! Anders Elleby Engell-Kofoed and Tynde Sandor attended the conference focusing on energy control and #metabolism. A highlight was a talk by Claudia Langenberg, who discussed her recent population-based metabolism research using multiomic analysis at Queen Mary University of London. The SomaScan® assay provided comprehensive proteomics data for the project, with a mention of how the high-content platform could be used for predictive medicine. This sentiment is reflected in the Science Translational Medicine publication on the use of #proteomics and machine learning to develop a 27-protein model aimed at predicting the 4-year likelihood of myocardial infarction, heart failure, stroke, or death: https://lnkd.in/gxUSs3BZ

My first, first-author paper is now available open-access at Pain Reports! This story would not be possible without the incredible team that worked on this project. Here, we identify microRNA 374 as a new biomarker of chronic pain in 3 different clinical cohorts. We also report white fat cells as a source of miR-374 and the ability of this miRNA to modulate neuron activity. With the discovery of miRNAs earning the 2024 Nobel Prize in Physiology or Medicine, it is great to know my research is contributing to this exciting and growing field! https://lnkd.in/eA2ZvRnj

For the discovery of microRNA and its role in post-transcriptional gene regulation-Victor Ambros and Gary Ruvkun-2024 Nobel Prize winner in Physiology or Medicine Victor Ambros and Gary Ruvkun discovered microRNA, a new class of tiny RNA molecules that play a crucial role in gene regulation. Their groundbreaking discovery in the small worm C. elegans revealed a completely new principle of gene regulation. This turned out to be essential for multicellular organisms, including humans. MicroRNAs are proving to be fundamentally important for how organisms develop and function. https://lnkd.in/gTbgW2TM https://lnkd.in/dJnPExyr #MicroRNA #GeneRegulation #NobelPrize2024 #VictorAmbros #GaryRuvkun #Ceglas #PostTranscriptionalControl #RNAResearch #MolecularBiology #GeneticsRevolution #EssentialForLife #MulticellularOrganisms #kmdbioscience