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Chemotherapy switch for localized #PancreaticCancer: a systematic review and meta-analysis ➡️ https://lnkd.in/gQE4e6d5 This #systematicreview and #metaanalysis of five studies identified that one in five patients with localized pancreatic ductal adenocarcinoma underwent chemotherapy switch after an inadequate response or toxicity to first-line chemotherapy The pooled resection rate after chemotherapy switch was 42% Postoperative survival of patients who underwent chemotherapy switch was similar to that of patients treated without a switch in systemic therapy The findings suggest that chemotherapy switch may improve biochemical and radiological response, increase the chance of surgical resection, and improve survival Work by Esther N Dekker, Raja R Narayan, Mohamed A Ahmami, Anis Meddouch, Eva M M Verkolf, Anne M Gehrels, Marc G H Besselink, Casper H J van Eijck, Marjolein Y V Homs, Bianca Mostert, Grainne M O’Kane, Roeland F de Wilde, Johanna W Wilmink, Eileen M O’Reilly, Motaz Qadan, Bas Groot Koerkamp #SoMe4Surgery #MedTwitter #SurgEd #Surgery @RCPSGTrainees @aecirujanos @SEIQuirurgica @iss_sic #MedicalTechniques @BJSAcademy @young_bjs @BJSOpen @des_winter @evanscolorectal @robhinchliffe1 @bplwijn @MalinASund @nfmkok @TejedorPat @paulo_sutt @PVaughanShaw @JJEarnshaw @juliomayol @ksoreide #some4hpb #some4tpl @DPCG_official @pancreatitis_nl @PancreasClub #PancreasClub2023 #PancreaticCancer #Pancreatitis #HCC @PanCAN #PanCANawareness @EurPancClub @P_C_E_ @dice_europe #PancreaticCancer #cholangiocarcinoma

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