Magstim’s Post

Alzheimer's disease impacts a person's memory, thinking skills, and ability to live independently. I am excited to share this new TMS research and video: Targeted Magnetic Stimulation Slows Alzheimer's Progression in Phase II Study— Neuro-navigated repetitive TMS in the precuneus slowed progression in mild-to-moderate disease Thank you to MedPage Today for featuring this important research. Article states,"A personalized transcranial magnetic stimulation (TMS) protocol, designed to stimulate the precuneus within the default mode network, was well tolerated and significantly slowed clinical decline in patients with mild-to-moderate Alzheimer's disease, according to data presented at the Clinical Trials on Alzheimer's Disease (CTAD) annual meeting in Madrid."   Honored that researchers used Magstim TMS technology for this important work. #TMS #Alzheimers #brain https://lnkd.in/gvbwyYC5

🧠 Alzheimer's disease is the most common type of dementia. The symptoms are due to the widespread death of neurons in the brain. The mechanism by which cell death is triggered remains unknown. Alzheimer’s disease research requires a great diversity of life science products to investigate new methods for diagnosis and treatment. More about the pathological hallmarks, other dysregulated pathways and research tools in our blog: https://lnkd.in/ehvqjFJa #Amyloidbeta #Alzheimers #Oligomers #Fibrils #Research #Lifesciences

Unlocking 🔓 the Brain's Barrier for Better Medicine 🧠💊 Exciting news in the fight against neurological diseases! Researchers have developed an innovative approach to safely transport drugs across the blood-brain barrier. By using a "molecular shuttle" system, therapeutic molecules that are normally blocked can now hitch a ride directly into the brain. This brings new hope for treating conditions like Alzheimer's, Parkinson's, and more. While there's still a ways to go, this breakthrough opens the door to getting life-changing medicines where they're needed most. Here's to the power of persistence and ingenuity in science! 🔬🧪 #GoodNews #MedicalBreakthrough #BrainHealth #GoodNewsOnly

1. A study identifies 'superspreader' proteins linked to Alzheimer's, which spread rapidly in the brain. 2. These proteins may explain the increase of amyloid beta protein clumps as Alzheimer's progresses. 3. The research aims to better understand how these proteins spread, despite the challenges of linking them directly to neurological damage. 4. Previous laboratory studies found no direct evidence of amyloid beta proteins damaging brain cells. 5. Other molecules tangled with amyloid beta may be responsible for neuron damage, not the plaques themselves. 6. The study utilized advanced imaging techniques to observe amyloid beta proteins in a salt solution, mimicking the brain's environment. 7. Researchers identified a specific type of amyloid beta protein (amyloid beta 42) that acts as a superspreader, accumulating faster than others. 8. The study highlights the need for further research to understand the structure and chemistry of these superspreader proteins and their role in Alzheimer's.

Studies investigating the effects of mold on the brain have pointed to several concerning findings. Firstly, certain mycotoxins released by molds have been shown to have neurotoxic effects, which means they can harm neurons and interfere with brain function. Additionally, mold exposure has been linked to inflammation in the body and brain, which is increasingly recognized as a contributing factor in the development and progression of Alzheimer's disease. Continue reading: https://lnkd.in/eVhAPudX #householdmold #Alzheimer #mold #usa #america #humidity #fungi #homes #laboratory #moldtest

Alzheimer's Association International Conference 2024 ✅ I am happy to share that i have got 2 abstracts accepted at the prestigious Alzheimer's Association® International Conference 2024 titled "SIMPLE FULLY CONVOLUTIONAL NETWORK TO ESTIMATE BRAIN AGE" and "SIMPLE FULLY CONVOLUTIONAL NETWORK TO DETECT ALZHEIMER'S DISEASE". We through these work propose a minimal pre-processing pipeline to perform regression on brain age and classify between Cognitively Normal (CN) and Alzheimer's Diseased (AD), the proposed modified Simple Fully Convolutional Network (SFCN) attains near SOTA results for both the mentioned task. Poster links: 1. Regression: https://lnkd.in/gUUfA_Qa 2. Classification: https://lnkd.in/gRZPUjXH #AAIC2024

1. Tau proteins, traditionally viewed as harmful in Alzheimer's disease, may actually play a protective role for the brain against degeneration. 2. New research indicates that tau proteins are essential for forming lipid droplets, which help eliminate toxic materials from neurons. 3. A deficiency or mutation of tau proteins leads to the accumulation of reactive oxygen species (ROS) in the brain, causing cellular toxicity and motor defects. 4. Even a 50% reduction in healthy tau can disrupt lipid droplet formation and contribute to neurotoxicity. 5. The study highlights that tau's protective role is significant in both flies and mammals, including humans. 6. Excess ROS is harmful and triggers oxidative stress, complicating the relationship between tau and neurodegeneration. 7. Misfolded tau proteins are early biomarkers of Alzheimer's, but their role as a cause or consequence of the disease remains unclear. 8. Current drug trials targeting tau may be ineffective because they do not distinguish between the beneficial and harmful forms of tau.

Topic: Regenerative therapy for Alzheimer's disease: A journey from neurodegeneration to neuroregeneration

🧠 Did you know? Alzheimer's disease affects more than memory. Here are 3 things you might not know about Alzheimer's: 1) It impacts multiple cognitive functions beyond memory, including language, decision-making, and even personality. 2) Early detection is crucial. Changes in behavior or cognition could be early signs of Alzheimer's, so it's essential to seek medical attention promptly. 3) Research is advancing. From genetic studies to innovative therapies, scientists are making strides in understanding and treating Alzheimer's. At Biosplice, we're dedicated to contributing to the fight against Alzheimer's through cutting-edge research and development.  #Alzheimer #Biosplice

Exploring the Unseen Pathways in Cerebral Amyloid Angiopathy 🧠✨ Cerebral amyloid angiopathy (CAA) is more than just a mysterious layering of amyloid-β in our brain's blood vessels. Especially prevalent in the elderly and those with Alzheimer's, the complexity deepens as new research brings neuroinflammation to the forefront of CAA studies. Unraveling the molecular pathways involved, there's a spotlight on the potential influence of neuroinflammation. Many questions remain about how this inflammation influences cognitive decline and intracerebral hemorrhage. What could targeting matrix metalloproteinases, complement activation, and microglial activation mean for future therapies? As we continue to dig deeper into understanding CAA, could deciphering the riddle of neuroinflammation lead to breakthrough treatments? The journey is just beginning, and the potential rewards for our aging population might be game-changing. Let's watch as science takes this fascinating leap forward! Read Research 👉🏻 https://lnkd.in/dQ-t_YNW #research #pubmed