Psyence Group’s Post

The latest in Quotient Sciences series of blog posts is now available. In this post we look at the complexities and challenges involved in the development of psychedelic APIs. https://bit.ly/3ARqdMf

Thoughts on this? >> J&J trims pipeline, including two mid-stage neuroscience studies >> Comment below! >>> lqventures.com #strategy #competitiveintelligence #marketing #pharmaceutical #pharma #biotech #healthcare #productmarketing

Thoughts on this? >> J&J trims pipeline, including two mid-stage neuroscience studies >> Comment below! >>> lqventures.com #strategy #competitiveintelligence #marketing #pharma #productmarketing #pharmaceutical #biotech #healthcare

The attempt to combat age-related cognitive decline through the use of cannabinoids is gaining more and more momentum. A preclinical study led by German researcher Andreas Zimmer reveals that the administration of low doses of tetrahydrocannabinol (THC), the main psychoactive compound in cannabis, can reverse the long-term aging processes of the brain. Conducted by researchers from University Hospital Bonn, (The University of Bonn) in partnership with the The Hebrew University of Jerusalem, the study demonstrates the potential of THC as an anti-aging therapy. You can listen to or read this article in Portuguese, English, German, French, Italian, Spanish, Dutch, Hebrew, Thai, Japanese, Arabic, Greek, Russian, Hindi, Korean, Turkish or Mandarin at CannaReporter®.eu Follow this link to get the full story: https://lnkd.in/d7cfs3yn

🍄🌿 Curious minds are probing: do psychedelic mushrooms have their own version of the entourage effect, akin to cannabis? The latest study delves into the intriguing similarities between these natural wonders. Mushrooms like cannabis may possess a synergy within their compounds that enhance their therapeutic potential, beyond what a single compound can offer. 🌟 Exploring beyond THC and CBD, magic mushrooms exhibit a complex mix of compounds that could hold the key to more potent health benefits. The entourage effect, initially observed in cannabis, may have a counterpart in the realm of psychedelics, unlocking new possibilities in mental health treatment. 💭 Thoughts and feelings, anyone? The potential for psychedelics to revolutionize psychiatric care is captivating. Share your reflections on this fascinating intersection of science and nature. 🧠 Dive deeper into the entourage effect's role in psychedelics and join the discussion on the future of medicinal mushrooms. Let's unravel the mysteries and possibilities together. https://lnkd.in/g-J5twKC

The attempt to combat age-related cognitive decline through the use of cannabinoids is gaining more and more momentum. A preclinical study led by German researcher Andreas Zimmer reveals that the administration of low doses of tetrahydrocannabinol (THC), the main psychoactive compound in cannabis, can reverse the long-term aging processes of the brain. Conducted by researchers from University Hospital Bonn, (The University of Bonn) in partnership with the The Hebrew University of Jerusalem, the study demonstrates the potential of THC as an anti-aging therapy. You can listen to or read this article in Portuguese, English, German, French, Italian, Spanish, Dutch, Hebrew, Thai, Japanese, Arabic, Greek, Russian, Hindi, Korean, Turkish or Mandarin at CannaReporter®.eu Follow this link to get the full story: https://lnkd.in/dTTNajfq

The attempt to combat age-related cognitive decline through the use of cannabinoids is gaining more and more momentum. A preclinical study led by German researcher Andreas Zimmer reveals that the administration of low doses of tetrahydrocannabinol (THC), the main psychoactive compound in cannabis, can reverse the long-term aging processes of the brain. Conducted by researchers from University Hospital Bonn, (The University of Bonn) in partnership with the The Hebrew University of Jerusalem, the study demonstrates the potential of THC as an anti-aging therapy. You can listen to or read this article in Portuguese, English, German, French, Italian, Spanish, Dutch, Hebrew, Thai, Japanese, Arabic, Greek, Russian, Hindi, Korean, Turkish or Mandarin at CannaReporter®.eu Follow this link to get the full story: https://lnkd.in/dTTNajfq

Exciting news for those interested in the science behind cannabis! Grants will be awarded to Yale School of Medicine researchers investigating the effects of #cannabis and #cannabinoids on neurodevelopment and mental health. This is a significant step forward in understanding the potential benefits and risks of cannabis use. #cannabisresearch #mentalhealth #neurodevelopment Ganjapreneur #SimplifyingCannabisInsurance

NOVEL ANTICANCER DRUG DISCOVERY STRATEGIES TARGETING HIFs Cancer causes approximately 9.6 million deaths annually, ranking it among the top causes of death worldwide. Solid tumors, which account for nearly 90% of all adult cancers, are the most common type of malignancy in the adult population. In solid tumors, the presence of hypoxic regions and acidosis are well-recognized features of the tumor microenvironment. This condition arises because the rapid growth of cancer cells creates a high demand for oxygen, which cannot be met due to the abnormal and inefficient blood vessels within the tumor. As a result, most areas of the tumor suffer from a lack of oxygen, leading to a hypoxic state that sets off a chain reaction of harmful effects. Hypoxia pushes tumor cells to become more aggressive, leading to faster growth, increased invasion, and greater resistance to treatment. It also weakens immune cell function and changes the surrounding stromal environment, creating conditions that further fuel tumor growth. Hypoxia is a key feature of solid tumors, associated with aggressive behaviors such as radiation and chemotherapy resistance, increased metastasis, and poor prognosis. Hypoxia-inducible factors (HIFs) are essential transcription factors that help tumor cells adapt to hypoxic environments by promoting the expression of pro-oncogenic genes. Reducing HIF activity presents a promising strategy for advancing cancer treatment. The functions of HIF-1 and HIF-2 highlight their roles in therapeutic resistance. HIF-1 generally responds to acute hypoxia and is involved in the initial adaptation of cancer cells, whereas HIF-2 is more critical in chronic hypoxia and long-term tumor progression. Elevated levels of both HIF-1 and HIF-2 are linked to increased resistance to treatments like chemotherapy and radiotherapy, which rely on oxygen-dependent mechanisms to produce reactive oxygen species that damage DNA and induce cell death. Several techniques and chemical scaffolds have successfully targeted HIF-1α. However, additional research is required to sustain HIF-1α inhibition while maintaining anticancer activity. The FDA approval of Belzutifan provided researchers with an opportunity to conduct broader HIF-2 studies. https://lnkd.in/dccyV7KS In this paper, open access, the authors present an overview of recent studies on the development of HIF-1/2 inhibitors as potential anticancer drugs. The article offers a comprehensive analysis of the structural characteristics of these inhibitors and explores their relationship with anticancer activity, focusing on research conducted over the past decade, from 2015 to 2024. #HIF #HypoxiaIinducibleFactors #cancer Mustafa, M., et al. Expert Opinion on Drug Discovery, 2024. https://lnkd.in/dWCuvDH3

Find out more about Brain Penetration in our upcoming webinar scheduled for Wednesday, December 11 at 8am PT/11am ET/4pm GMT. We will be discussing the CNS penetration of molecules where the rate of passage into the brain is comparable to the associated clearance processes, key aspects of their bioanalysis, and the importance of complementary pharmacological measurements. By registering once, you will have access to and receive updates for each webinar in the series. Register for the series here: https://lnkd.in/ekf-CUR2 For more information and to watch previous webinars, check out our page: https://lnkd.in/epEVupqE   #DMPK #webinar #CNS #BrainPenetration