Thomas Scientific’s Post

#NewType of #catalyst containing #magnesium oxide modified with various modifiers ranging from bromine and iodine, to interhalogen compounds, hydrohalogenic acids, and alkyl halides have been #prepared using chemical vapor deposition (#CVD) and wet impregnation methods. New #publication in #Molecules 2024, 29(13), 3180; titled: "MgO Modified by X2, HX, or Alkyl Halide (X = Cl, Br, or I) Catalytic Systems and Their Activity in Chemoselective Transfer Hydrogenation of Acrolein into Allyl Alcohol" with Dariusz Łomot at Institute of Physical Chemistry, Polish Academy of Sciences. #OpenAccess and more information: https://lnkd.in/dqRVK8wa

Selective pyrazole N-methylation using commercially available, bench-stable α-halomethylsilanes as masked methylating reagents. https://bit.ly/4akBjpX https://bit.ly/49R5FAm #synthesis #chemistry

Automated capsule chemistry with Synple Chem for faster access to 1,4-disubstituted 1,2,3-triazole following copper-mediated click reaction of alkynes and azides. The reaction and product isolation steps are fully automated with no further user involvement, resulting in the triazole products in high purity. The publication also describes the effectiveness of capsule-based automated organic synthesis by sequencing the automated synthesis of organic azides, followed by a second capsule for CuAAC with no intermediate purification. The method utilizes prepacked capsules that contain all necessary reagents and materials for the reaction and purification processes. https://lnkd.in/gWes8VSk

My best friend and roommate in college, Austin, would always joke about "heavy water" (political science guy). Well, here you go - how we use that heavy water to create more potent drugs and how this method of deuteration "offers a sustainable and versatile alternative to traditional metal-catalyzed H/D exchange techniques, addressing challenges such as the use of expensive metals, impurity formation, and the necessity for residual metal removal from the final products." #smallmolecule #CMO #synthesis #D2O

✅ 🆕Long awaited publication from us, is available! 🎉 🎊 Crystallise! AG (single crystal and SCXRD), TeraCrystal (CRO, solid state characterization) and ELDICO Scientific AG (Electron Diffraction) joint efforts have been recently published. The link to the publication (in case you are interested in the details), see comments. Kudos to the co-authors. Don't hesitate to contact the main authors (Gustavo Santiso-Quinones and Mihaela Pop) if you are interested to know more about our work and capabilities. Our expertise in #solidstate characterization, #crystallization, #SCXRD, #ElectronDiffraction (#3DED, #microED) could be beneficial for your field of research, especially for the #pharma, #chemical, and #agrochemical industries.

In the latest video from Vapourtec, they highlight their Variable Bed Flow Reactor (VBFR) and advanced automation software to synthesize a 28-mer GLP-1 peptide at 0.2 mmol scale. Using only 3 equivalents of amino acid the process achieves a crude purity of 77% in only 3.5 hours synthesis time. The total solvent and reagent consumption is remarkably low at just 795 ml. Click here to find out more: https://bit.ly/40rzFka #Vapourtec #PeptideSynthesis

Dear Connections, Only a Few Chapters are left. You can Submit the abstract@ drabhishekiftm@gmail.com on or before 04/10/2024. Chapter 2: Synthetic Strategies for Bioactive Polyphenols Chapter 5: Synthesis of Lignans and Lignan Glycosides Chapter 6: Chemical Modification of Polyphenols Chapter 10: Future Directions in Polyphenol Synthesis Chapter 13: Sustainable Synthesis of Bioactive Polyphenols

(Hetero)aryl C–O bonds are a critical motif in small molecules and are favourite with Medicinal Chemists. Dominated by copper and palladium catalysis, forging C-O linkage in the drug like molecules is often a times plagued by the use of strong, insoluble inorganic bases needing activated (pseudo)electrophiles which limits the functional group tolerance and compatibility. A new thermal Nickel-Catalyzed Carbon–Oxygen Cross-Coupling of (Hetero)aryl Halides with alcohols enabled by the use of a silane reductant, commercial ligand and a amine base represents an efficient cross-coupling of alcohols and (hetero)aryl halides across a number of functionalized arenes, even those containing electron-donating substituents. The transformation is complementary to current strategies, as it tolerates motifs typically prone to side reactions in photochemical methods, such as olefins. The thermal conditions makes it cost-effective and simple, requiring no tedious setup, and can be applied to late-stage drug molecules, including gram-scale synthesis. https://lnkd.in/gzd5Vhq6

Jump start your click reaction with optimized FastClick™ Click Reagents FastClick™ reagents have been developed by our scientists for enhancing the yield and reaction speed of copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction. They contain a copper-chelating ligand that significantly stabilizes the Cu(I) oxidation state and thus accelerates the click reaction. They do not require the use of an external copper-chelator (such as the common THPTA or BTTAA). Under extremely mild conditions the FastClick™ azides and alkynes react much faster in high yield compared to the corresponding conventional CuAAC reactions. https://lnkd.in/gm-ZcNeK #clickchemistry #chemisty #drugdiscovery