Thomas Scientific’s Post

#NewType of #catalyst containing #magnesium oxide modified with various modifiers ranging from bromine and iodine, to interhalogen compounds, hydrohalogenic acids, and alkyl halides have been #prepared using chemical vapor deposition (#CVD) and wet impregnation methods. New #publication in #Molecules 2024, 29(13), 3180; titled: "MgO Modified by X2, HX, or Alkyl Halide (X = Cl, Br, or I) Catalytic Systems and Their Activity in Chemoselective Transfer Hydrogenation of Acrolein into Allyl Alcohol" with Dariusz Łomot at Institute of Physical Chemistry, Polish Academy of Sciences. #OpenAccess and more information: https://lnkd.in/dqRVK8wa

Need an alternative to poly(ethylene glycol)? Try making block copolymers with N-vinylpyrrolidone 🧪 Poly(ethylene glycol) is a commonly used plastic in biomedical applications. Think IBS management or oral drug capsules. The catch? It exhibits unwanted immune responses. Alongside Lauren Ball (first author), Bert Klumperman and Rueben Pfukwa, we looked at the RAFT mediated synthesis of poly(styrene-co-maleic anhydride)-block-poly(N-vinylpyrrolidone) to form double hydrophilic block copolymers. Read all about it in ACS Macromolecules 👉 https://lnkd.in/dyGFJyGA #Macromolecules #ACS #StellenboschUniversity #copolymer #RAFT

My best friend and roommate in college, Austin, would always joke about "heavy water" (political science guy). Well, here you go - how we use that heavy water to create more potent drugs and how this method of deuteration "offers a sustainable and versatile alternative to traditional metal-catalyzed H/D exchange techniques, addressing challenges such as the use of expensive metals, impurity formation, and the necessity for residual metal removal from the final products." #smallmolecule #CMO #synthesis #D2O

Automated capsule chemistry with Synple Chem for faster access to 1,4-disubstituted 1,2,3-triazole following copper-mediated click reaction of alkynes and azides. The reaction and product isolation steps are fully automated with no further user involvement, resulting in the triazole products in high purity. The publication also describes the effectiveness of capsule-based automated organic synthesis by sequencing the automated synthesis of organic azides, followed by a second capsule for CuAAC with no intermediate purification. The method utilizes prepacked capsules that contain all necessary reagents and materials for the reaction and purification processes. https://lnkd.in/gWes8VSk

Streamline heterocycle synthesis pathway masterfully with allenyl thianthrenium (ATT) hexafluorophosphate! ↗️ ATT hexafluorophosphate is a bench-stable, non-hygroscopic electrophilic reagent used in cross-coupling reactions (https://lnkd.in/dVjYcv76). It is capable of the formation of C(sp²)-C(sp²) and C(sp³)-C(sp²) bonds via Suzuki and reductive coupling reactions. ATT⁺ PF₆⁻ provides a straightforward and efficient approach to introducing allenyl functionality into aromatic and aliphatic systems. It avoids isomerization typical of propargylating reagents, ensuring cleaner reaction profiles. Applications span from the synthesis of biologically relevant compounds to advanced material precursors. 🛒 This reagent is available in our stock! https://lnkd.in/d-fy8Syn 💡 Enamine offers a broad range of reagents and product subsets for organic synthesis that facilitate a wide variety of transformations. Explore all them here https://lnkd.in/gFMXnPKj #reagents #organicchemistry #molecule #drugsynthesis #drugdesign #research #chemicals #JACS #orgchem #chemicalbuildingblocks #Enamine

GL Sciences InertSustain C30 InertSustain C30 is an HPLC column in which triacontyl groups are chemically bonded to silica gel. This column has high stereoselectivity and excellent separation ability for isomers and structurally similar compounds with high lipophilicity. #lcgc #manufacturing #quality #bio #glsciences #lcgcbioanalytical #lcgcbio #glscience #columns #fyp #page #networking #business #marketing #linkedin #linkedinlearning #linkedinmarketing #linkedinpost

Dear Connections, Only a Few Chapters are left. You can Submit the abstract@ drabhishekiftm@gmail.com on or before 04/10/2024. Chapter 2: Synthetic Strategies for Bioactive Polyphenols Chapter 5: Synthesis of Lignans and Lignan Glycosides Chapter 6: Chemical Modification of Polyphenols Chapter 10: Future Directions in Polyphenol Synthesis Chapter 13: Sustainable Synthesis of Bioactive Polyphenols

(Hetero)aryl C–O bonds are a critical motif in small molecules and are favourite with Medicinal Chemists. Dominated by copper and palladium catalysis, forging C-O linkage in the drug like molecules is often a times plagued by the use of strong, insoluble inorganic bases needing activated (pseudo)electrophiles which limits the functional group tolerance and compatibility. A new thermal Nickel-Catalyzed Carbon–Oxygen Cross-Coupling of (Hetero)aryl Halides with alcohols enabled by the use of a silane reductant, commercial ligand and a amine base represents an efficient cross-coupling of alcohols and (hetero)aryl halides across a number of functionalized arenes, even those containing electron-donating substituents. The transformation is complementary to current strategies, as it tolerates motifs typically prone to side reactions in photochemical methods, such as olefins. The thermal conditions makes it cost-effective and simple, requiring no tedious setup, and can be applied to late-stage drug molecules, including gram-scale synthesis. https://lnkd.in/gzd5Vhq6

With its roles in bioisosterism, prodrug strategies, hydrogen sulfide (H₂S) donation, metal chelation, and the development of thioamide-based metal complexes, thioamide group continues to gain a considerable attention due to its unique physical and chemical properties and versatile roles in medicinal chemistry. An excellent, open access review that unlocks the potential of the thioamide group in drug design and development. https://lnkd.in/g7bkUh4s

In the latest video from Vapourtec, they highlight their Variable Bed Flow Reactor (VBFR) and advanced automation software to synthesize a 28-mer GLP-1 peptide at 0.2 mmol scale. Using only 3 equivalents of amino acid the process achieves a crude purity of 77% in only 3.5 hours synthesis time. The total solvent and reagent consumption is remarkably low at just 795 ml. Click here to find out more: https://bit.ly/40rzFka #Vapourtec #PeptideSynthesis