TowardPi’s Post

Do you know the pattern of vortex vein drainage is adhered to the ST–SN–IT–IN order of descending perfusion? Read the research published in TVST and learn the characteristics of choroid vessels. Publication of TowardPi comes one after another, especially in the field of UWF-OCTA and choroid. If they are not validation of clinical and academic position of TowardPi OCT/OCTA, what eles can be?

🌟 Celebrating the End of Our First Year! 🌟 As we close this chapter, we’re proud to showcase highlights from the latest issue, covering diverse and impactful topics in ophthalmology: - Corneal and conjunctival abnormalities in Ebola survivors 🦠 : Comprehensive analysis of long-term ocular changes in survivor populations.  - Visual prognosis in retinoblastoma 👦 : Real-world insights into preserving vision through multimodal therapies.  - Real-world data on Intravitreal faricimab 💉 : Promising early results in treating retinal vascular diseases.  - Ocular neuropathic pain 👁️ : Challenges and opportunities in diagnosing and managing this complex condition.  - Telehealth and eye care 🔭 : Evidence that telehealth leads to earlier diagnosis and treatment.  - AI for facial recognition 🤖 : A novel tool with potential for advancing ocular diagnostics.  - Iridex MP3 vs. P3 probes 💧 : A comparative look at glaucoma treatment outcomes.  - Dexamethasone in cataract surgery in RP patients 💊 : Examining its role in inflammation control.  - Therapies for cicatrizing conjunctivitis 🔬 : Evaluating mycophenolate mofetil for challenging cases.  - AI in ophthalmology 🌐: Assessing large language models in clinical practice. Additional topics include gender differences in EMR use, evolving practice patterns among young specialists, and innovative approaches to managing keratoconus, glaucoma, and rare infections like Candida keratitis. 🙏 Thank you to all contributors for making this year a success. Here’s to another impactful year with new editorial ventures on the horizon! #Ophthalmology #Ajointernational #YearInReview #Elsevier  https://lnkd.in/d-q6NY7m

The LONGROP study comparing time-limited vs time-unlimited viewing of images in #ROP is available today at the American Journal of Ophthalmology. Topline results–expert graders are ignoring 90% of the data when making assessments on ROP tempo. There was a 10x difference between ability to detect change on an Eye level (all images) compared to a Component level (features within an image view, e.g. zone, stage, plus etc.) and a 7x difference between a View level (e.g. right eye, temporal vs right eye, temporal), favoring telemedicine (time-unlimited viewing with longitudinal comparison). This is the first study to demonstrate both that 1) expert graders integrate features of ROP in different ways and that 2) this integration varies by technique. Thank you to my awesome collaborators for making this study happen –Tatiana Rosenblatt, Hashem Ghoraba, Marco H. Ji, Caroline Baumal, MD, Nina Berrocal, Cagri G. Besirli, MD, PhD, Kimberly Drenser, Anna Ells, MD, FRCS (C), Armie Harper, Baker Hubbard, Eric Nudleman, Polly Quiram, Irena Tsui, Yoshihiro Yonekawa, Edward Wood, and Jochen Kumm! https://lnkd.in/gq5gzQ_f

Corneal and anterior segment parameters in patients with clinically unilateral pseudoexfoliation syndrome Efthymios Karmiris, Genovefa Machairoudia, Aikaterini Roussou, Anastasia Tsiogka, Evangelia Chalkiadaki 🥇 New issue with great papers from #Greece, #King_Saudi_Arabia, #Portugal, #Türkiye, #United_States, etc. Background: Pseudoexfoliation syndrome (PES) is an age-related systemic condition that predominantly affects ocular structures and is characterized by the deposition of material on the lens, ciliary body, zonules, corneal endothelium, iris, and pupillary margin. We compared the corneal endothelial morphology, anterior segment parameters, corneal densitometry, and corneal topographic characteristics between the clinically affected and apparently normal fellow eyes of patients with clinically unilateral PES. Methods: This was a comparative, cross-sectional study of 34 patients with clinically unilateral PES. The anterior segment was examined using a Scheimpflug imaging system, and the corneal endothelium was assessed using a noncontact specular microscope. Corneal endothelial cell density, polymegathism, and pleomorphism were assessed using the specular microscope. Furthermore, the Scheimpflug camera was used to measure the corneal power of the flat and steep axis, mean corneal power, maximum keratometry, anterior chamber angle, anterior chamber depth, anterior chamber volume, corneal volume, and the corneal thickness at the apex point, center of the pupil, and the thinnest point. Corneal densitometry was evaluated at two concentric zones (0–2 mm and 0–12 mm). Results: In total, 68 eyes from 34 patients were ultimately included in the study. The mean (standard deviation) age of the patients was 73.38 (8.75) years (range: 50–87 years). Among the included patients, 17 (50%) were male and 17 (50%) were female. The anterior segment parameters did not significantly differ between eyes with PES and their clinically unaffected fellow eyes (all P > 0.05). Similarly, no statistically significant difference was observed in corneal endothelial morphology (all P > 0.05). Conclusions: Our measured parameters do not differ between the clinically affected eye and the clinically unaffected fellow eye. This supports the theory that PES is a bilateral disorder. Considering the variety of complications associated with PES, bilateral involvement should be assumed in the clinical and surgical management of patients with clinically unilateral PES. In the future, new research could increase our understanding of this syndrome.

Lowered contrast sensitivity (CS), gauged using quantitative contrast sensitivity function (qCSF) appears to be strongly associated with structural change in eyes with intermediate age-related macular degeneration (iAMD) — in fact, decreased CS in low spatial frequencies can predict advancing disease, particularly geographic atrophy (GA), reports a study in American Journal of Ophthalmology. Because photopic visual acuity may not decline until late AMD, mesopic qCSF that challenges both rods and cones presents time-effective data. Read more: https://bit.ly/3W4uu6U #ContrastSensitivity #QuantitativeContrastSensitivity #qCSF #GeographicAtrophy #IntermediateAgeRelatedMacularDegeneration #iAMD #Ophthalmology #EyeCare

The November issue is out for Ophthalmology and Therapy! I would recommend taking a look especially if you are interested in AMD, glaucoma or dry eye, as the issue has a number of articles in these areas: https://lnkd.in/efhDWsjE Some of my personal highlights include:   📣 A commentary on adopting interventional #glaucoma via sustained-release therapies from Arkadiy Yadgarov et al   🔮 Authors investigate the predictors of disease activity after anti-VEGF treatment for nAMD using real-world data from the PROOF study 🔦 Authors add to the evidence pool for the safety, tolerability, and short-term efficacy of low-level light therapy for dry AMD - Enrico Borrelli et al 📖 Utilising Narrative Medicine to Identify Key Factors Affecting Quality of Life in Dry Eye Disease: An Italian Multicentre Study - Pasquale Aragona, Stefano Barabino et al 👁️ Posterior Vitreous Detachment and Risk of Neovascular Glaucoma in Eyes with Prior Retinal Vascular Occlusions - from Section Editor Sanjay Asrani and colleagues ❓ A survey study asks patients with diabetic macular edema what factors influence their treatment preference

ICYMI: Cornea Update: Clinical Outcomes in Patients With Traumatic Dehiscence of Penetrating Keratoplasty Grafts: Purpose: The purpose of this study was to report clinical characteristics and outcomes of surgical repair for patients with traumatic dehiscence of penetrating keratoplasty (PKP) grafts. Methods: Retrospective, consecutive chart review of patients evaluated at Bascom Palmer Eye Institute between 2015 and 2020 with traumatic dehiscence of penetrating keratoplasty grafts. Results: The study cohort consisted of 65 eyes of 65 patients. The mean age at presentation was 72 years (SD 18), with a male predominance (65%). The most common indications for PKP included keratoconus (42%), corneal scar (31%), and Fuchs corneal dystrophy (8%). Dehiscence occurred as a result of blunt trauma in 94% of cases, and the mean wound length was 6.4 clock hours (SD 2.4), with a predominance of inferior dehiscence. The mean presenting visual acuity (VA) was 2.45 logMAR (SD 0.41), and the mean final VA was 2.17 logMAR (SD 0.99). Graft failure occurred in 64% of patients, and 22% underwent repeat PKP. When stratified by indication for corneal transplantation (keratoconus vs. other), there was no significant difference in graft age at the time of rupture, final VA, rate of graft failure, or rate of repeat PKP. Conclusions: Traumatic dehiscence of corneal grafts remains a rare but serious subtype of ocular trauma with generally poor visual prognoses. Presenting VA along with severity of trauma and posterior segment involvement tend to be the worst prognostic factors in final visual outcome. http://dlvr.it/T4tyk6 #Cornea #Ophthalmology #Ophthotwitter

https://lnkd.in/ePYz-tQA Article title: Role of Radiation Therapy for Choroidal Hemangioma: A Brief Review   Author(s): Kiran Turaka; Aruna Turaka*; Bobby N Koneru   Journal: Journal of Clinical Research and Ophthalmology   Journal ISSN: 2455-1414 Abstract: Choroidal hemangioma is an uncommon benign vascular hamartoma. Depending on the extent of the involved choroid, it can be subtyped into circumscribed form that occurs sporadically as an isolated tumor or a diffuse form that occurs in association with Sturge-Weber syndrome. It appears as an orange-red mass, located commonly posterior to the equator and is mostly asymptomatic. Poor vision is attributed to exudative retinal detachment, cystoid macular edema, foveal distortion and refractive errors. Diagnosis is crucial and is aided by ancillary tests such as ophthalmic ultrasonography, fundus fluorescein angiogram and Indocyanine green angiogram. The aim of treatment is to induce tumor atrophy, resolve the exudates, improve the vision, preserve the overlying retinal function and salvage the globe. #Choroid #GammaKnifeRadiosurgery #Hemangioma #PhotodynamicTherapy #Radiotherapy #SturgeWeberSyndrome #OphthalmologySubspecialties #Optometry #VisualScience #PharmacologyInEyeDiseases #BasicSciences #PrimaryEyeCare #SecondaryEyeCare #PatientSafety #QualityImprovements #NeuroOphthalmology #MedicalEyeCare #SurgicalEyeCare #GlaucomaFilteringProcedure #OcularDrugDesign #ClinicalPsychophysics #DiabeticRetinopathy #CataractSurgery #RefractiveSurgery #PVRStudies #LowVision #PterygiaStudies #PupilLightReflex #Peertechz #PeertechzPublications #SecondaryCataractStudies #RetinalDiseases #RetinalSurgery #SubstancePStudies #Cornea #ExternalEyeDisease #DefensinsForCorneaTransplants #CraniofacialClinic #OptometryClinic #OphthalmicGeneticsClinic #NeuroOphthalmologyClinic #Oculoplastics #TearingDisordersClinic #PediatricRetinaClinic #CornealNeovascularization #ImmunologicalMechanisms #MolecularMechanisms #LaserTherapyInOphthalmology #ImagingInOphthalmology #OcularImmunology #VisionAndOphthalmology #NeuroOphthalmology

Moderate aortic stenosis: Navigating the uncharted 🛥️🗺️ 🔗https://lnkd.in/dDzdFSY4 Lay summary There is growing attention on when and how to intervene in patients with moderate #aortic #stenosis (AS), due to its association with increased risks of death and heart damage. Current guidelines suggest earlier assessments and potential interventions, but the benefits of early valve treatment remain debated. This debate centers on whether preemptive #surgery or #transcatheter #treatment can prevent severe complications and improve survival, against the backdrop of unclear evidence and diagnostic challenges. The review centers on the complexities of diagnosing and managing moderate AS. It highlights the issues with inconsistent grading of AS, and the benefits of using #multimodality #cardiovascular #imaging to assess associated cardiac damage and heart failure, which aids in better risk stratification. The review also anticipates the impact of ongoing clinical trials suggesting that forthcoming results could significantly influence treatment approaches for moderate AS.

Explore the effect of long-term hemodialysis on DR by UWF full range SS-OCTA! New research recently published on <BMC Ophthalmology> explored the immediate effect of single hemodialysis (HD) session on retinal and choroidal thickness in DR patients with end-stage kidney disease (ESKD) and the features of DR and the prevalence of DME in these patients who have received long-term HD by using UWF full range SS-OCTA. The results showed that the incidence of DME in patients undergoing HD was only 20% which was lower than epidemiological research, and the choroidal thickness changed significantly before and after single HD session, which may be related to short-term effects such as reduced blood volume and plasma osmotic pressure caused by single HD session. The results also showed that there was no significant change in the average central retinal thickness (CRT) or central retinal volume (CRV) before and after single HD session and no statistically significant difference in the CRT, CRV, subfoveal choroidal thickness (SFCT) or subfoveal choroidal volume (SFCV) before the two single HD sessions. These findings might be the fact that the renal function of patients with ESKD tended to fail, thus the SFCT and SFCV increased again before the next single HD session and long-term HD led to the stabilization of the macular anatomical structure of the retina. All these findings indicated that HD can not only effectively improve the renal function of diabetes patients with ESKD but also promote the stability of DR in such patients.  A 400KHz speed full range swept source OCTA (#BMizar, TowardPi Medical) was used in this study to visualize all the features of DR. Measurements of retinal and choroidal thickness and volume and quantifications of vessels are automatically achieved on the device. This study was authored by Dr. Ke He, team of Prof. Peng Zhang, from department of ophthalmology, Xi’an No. 3 Hospital, the Affiliated Hospital of Northwest University, and Dr. Suijun Liu from department of hemodialysis, Xi’an No. 3 Hospital, the Affiliated Hospital of Northwest University. Link to original text: https://lnkd.in/giQjhYAq #ophthalmology #SSOCT #medicaldevices