Upstate Research’s Post

Join us for the inaugural Stanford Cancer Institute Advances in Mass Spectrometry Enabled Drug Discovery symposium. On October 29, 2024, leading experts in academia and industry will come together to explore current challenges and opportunities, as well as recent achievements across diverse applications in drug development. This field has revolutionized ligand and target discovery by enabling the detection of interactions proteome-wide. Chemoproteomic techniques targeting reactive residues have grown and expanded the scope of covalent ligand discovery. Mass spectrometry instrumentation continues to improve, deepening proteomic coverage, accuracy, and sensitivity while becoming more accessible. The symposium is open to Stanford faculty, students, and postgraduates, as well as those outside of Stanford who are interested in diving into the cutting-edge world of proteomics. Join us for this all-day dynamic learning experience to discuss the exciting progress in mass spectrometry-based proteomics. Early bird registration is still available. short.url/aBcXyZ #DrugDiscovery #MassSpectrometry #StanfordCancer #proteomics Stanford University School of Medicine

Liquid–liquid phase separation (LLPS) is shaping our understanding of cellular dynamics in cancer. This new Perspective delves into how LLPS contributes to cancer pathology, offering fresh insights into potential therapeutic approaches. Dive deeper into the research. #AdFeature with Dewpoint Therapeutics

Publication alert!! It's been a long time coming, but I am happy to share my latest equally contributed first-author research article titled "Functionalized Graphitic Carbon Nitride as an Efficient Electro-Analytical Platform for the Label-free Electrochemical Sensing of Interleukin-8 in Saliva Samples (10.1039/D4NR02039A), published in #royalsocietyofchemistry #Nanoscale. This publication is particularly special because I had the pleasure of co-authoring it with my younger brother, Sumit Yadav. In this study, we investigated the use of functionalized graphitic carbon nitride for the label-free electrochemical detection of Interleukin-8 in saliva samples. Our findings highlight the potential of this platform for non-invasive diagnostics and monitoring of oral cancer conditions. I want to express my heartfelt thanks to my Ph.D. supervisor, Pratima Rathee Solanki, and collaborator, Ajeet Kaushik, Ph.D. FICS I MRSC I ECS I ACS for their unwavering support and hard work. https://lnkd.in/gAuEJ4HN #Research #Electrochemistry #Diagnostics #Interleukin8 #FamilyCollaboration #Science

💡 Successful Virtual Mobility Grant of Marco Barreca from Università degli Studi di Milano-Bicocca ⚗ 💻 "During the Virtual Mobility period, a dedicated taskforce and I defined the main principles of dataset searching and curation. We laid the foundations for a larger project aimed at visualizing and analyzing publicly available omics datasets in the immuno-oncology field. These tools will enable researchers to easily access and organize relevant data, contributing to biomarker discovery and translational research." Congratulations Marco 👏 COST Association - European Cooperation in Science and Technology #immunomodel #virtualmobility #immunotherapy

🤝 EU-OPENSCREEN's latest success story showcases a collaboration between Dr. Laia (Eulàlia) de Nadal, from IRB Barcelona, and Päivi Tammela, Sergey Kuznetsov, and Jani Saarela of the FIMM High Throughput Biomedicine Unit (HTB), University of Helsinki, and Aigars Jirgensons, of the Latvian Institute of Organic Synthesis to identify molecules with promising anti-cancer activity👇 Read the full story here ➡ shorturl.at/gtHNR #CancerResearch #Drugdiscovery #IRBScience

2️⃣ Highly-Cited Paper in "2D and Carbon Nanomaterials" A Green Synthesis Route to Derive Carbon Quantum Dots for Bioimaging Cancer Cells By Karthiga Anpalagan, Jimsheena Valiyakath Karakkat, Raz Jelinek, Nila Nandha Kadamannil, Tian Zhang, Ivan Cole, Kulmira Nurgali, Hong Yin and Daniel T. H. Lai This paper presents a green synthesis method for producing carbon quantum dots (CQDs) using a toasting technique, which is simpler, faster, and less energy-intensive compared to conventional hydrothermal methods. These CQDs show promise for #bioimaging cancer cells due to their #biocompatibility, high solubility, chemical stability, and resistance to photobleaching. Access the full paper at: mdpi.com/2394660

#WhatsUpSIgN We are proud to announce that SIgN was featured at last week’s A*STAR - Agency for Science, Technology and Research BioMedical Research Council (BMRC) Townhall! These awards highlight the scientific excellence and impact of our SIgN-tists’ work across all areas of A*STAR’s mission to Create Growth and Improve Lives. BMRC Collaborative Paper Awards (3 out of 3 awards!): 1.      Deterministic reprogramming of neutrophils within tumors (top left) 2.      Single-Cell Atlas of Lineage States, Tumor Microenvironment, and Subtype-Specific Expression Programs in Gastric Cancer (bottom right) 3.      Spatially informed clustering, integration, and deconvolution of spatial transcriptomics with GraphST (top right) BMRC IAF-PP Industry Value Capture Award: 1.      SinGapore ImmuNogrAm for Immuno-OncoLogy (SIGNAL) (bottom left) BMRC Star Mentor Awards: 1.      Wu Wei Congratulations again to all our SIgN-tists and our fellow BMRC colleagues on the fruits of their hard work! For the full list of SIgN awardees and links to the published manuscripts, please see the first comment below. #immunology #SIgNCentreforExcellence #CreatingGrowth #EnhancingLives #ASTARsg Graphics attribution: https://lnkd.in/gfrd3H_u

Join us for the inaugural Stanford Cancer Institute Advances in Mass Spectrometry Enabled Drug Discovery symposium. On October 29, 2024, leading experts in academia and industry will come together to explore current challenges and opportunities, as well as recent achievements across diverse applications in drug development.  This field has revolutionized ligand and target discovery by enabling the detection of interactions proteome-wide. Chemoproteomic techniques targeting reactive residues have grown and expanded the scope of covalent ligand discovery. Mass spectrometry instrumentation continues to improve, deepening proteomic coverage, accuracy, and sensitivity while becoming more accessible. The symposium is open to Stanford faculty, students, and postgraduates, as well as those outside of Stanford who are interested in diving into the cutting-edge world of proteomics. Join us for this all-day dynamic learning experience to discuss the exciting progress in mass spectrometry-based proteomics. Early bird registration is available now. https://stan.md/3WYqJRP #DrugDiscovery #MassSpectrometry #StanfordCancer #proteomics

The Annual Meeting of EATRIS Bulgaria brought together top researchers and experts to discuss groundbreaking advances in translational medicine, from stem cell therapies to innovative bio-printing and 3D models. With a dedicated conference on cutting-edge research, presentations from international and Bulgarian scientists, and collaborative sessions with BBMRI-ERIC Bulgaria, the event highlighted the future of biomedical innovation. Ethical, legal, and social aspects of biobanking and new EU regulations also took centre stage. Kudos to all participants for an inspiring event driving research and collaboration forward! 👉 Find out more here: https://lnkd.in/dJCfs6aY #EATRIS_BG

Big news: A $4.4M grant from Massachusetts Life Sciences Center will bring a cutting-edge NMR spectrometer to the UMass Institute for Applied Life Sciences! This state-of-the-art tool will accelerate breakthroughs in treating diseases like cancer and Alzheimer’s while training the next generation of biotech leaders. #AccelerateUMass Read more: https://bit.ly/41yPGWc