Educational Content
"Ever wondered how cutting-edge lab technologies are transforming neuroscience research? Here’s a deep dive into three pivotal techniques:
1. Electrophysiology: By measuring electrical activity in neurons, electrophysiology helps us understand neural communication and brain function in real time.
2. MRI and fMRI: Magnetic Resonance Imaging (MRI) provides high-resolution images of brain structures, while functional MRI (fMRI) tracks brain activity by measuring changes in blood flow, offering insights into brain function and connectivity.
3. Optogenetics: This revolutionary technique involves using light to control neurons that have been genetically modified to express light-sensitive proteins. It's enabling precise manipulation of neural circuits, advancing our understanding of brain functions and behaviors.
These technologies are not just advancing our understanding of the brain but also paving the way for new treatments for neurological disorders. #Neuroscience#LabTech#Education"
Two is better than one!
We have developed a hybrid EEG+fNIRS system that integrates an EEG electrode with fNIRS emitters/detectors into a single pod.
Functional Near-Infrared Spectroscopy (fNIRS) is a non-invasive brain imaging technique that utilizes light to measure brain activity by observing changes in blood oxygenation. Leveraging fNIRS along with EEG empowers researchers with colocalized measurements of neural activity and blood flow. This combination significantly enhances research in neurovascular coupling, providing valuable insights into the interplay between neural activity and vascular functions, enabling a more comprehensive view of brain activity.
Our goal is to empower the neuroscience community with the most effective tools, therefore contributing to a deeper understanding of neural functioning. We hope this system will support researchers in their quest to uncover new knowledge about the brain 🧠
#EEG#fNIRS#Neurotech#NeurovascularCoupling#Neuroscience
I'm happy to announce that our latest research is now available on BioRxiv! In this study, we dive deep into the mechanisms underlying functional magnetic resonance imaging (fMRI) and challenge a longstanding assumption in neuroscience. Traditionally, fMRI signals have been attributed primarily to the activity of excitatory neurons, but recent findings suggest that inhibitory interneurons play a much more significant role.
Using a model-driven meta-analysis approach, we analyzed data across several different studies, revealing that:
- Less than 20% of the fMRI BOLD signal likely stems from excitatory neurons.
- A substantial 50-80% contribution comes from inhibitory interneurons.
Our model quantifies these contributions and explains the differences observed in fMRI responses across experimental conditions. This work offers a unified perspective on the complex interplay between different neuron types in shaping fMRI signals, bringing us closer to a new consensus on how we interpret these signals in brain mapping studies.
Check out the full study on bioRxiv to learn more about these exciting insights (https://lnkd.in/d6AuDfXt )! #Neuroscience#fMRI#Research#Neuroimaging#InhibitoryNeurons#Interneurons#BrainResearch#bioRxiv
New manuscript out on bioRxiv - one of the most important ones we have written, as of yet! :)
More specfically, we continue our journey of understanding the role of different cell types in generating the so-called BOLD response, which underlies fMRI-measurements of brain activity. Our results show that all of the new data that has come out recently on this topic are all pointing towards a new and quite revolutionary consensus: that it is not the most common cells - excitatory pyramidal cells - but the much less abundant interneurons, that dominate the control of the BOLD-response. So when we see changes in BOLD and fMRI, it may very well be the activity of interneurons we see.
This consensus could not have been reached without the modelling. Indeed, without the modelling it instead seems like there are different studies and experiments, which point in different directions. However, we explain how these differences are all consistent with one single mechanistic explanation. Our study is therefore an example of a model-based meta-analysis, which goes beyond the capabilities of a normal meta-analysis.
Since our results fundamentally challenges what it is you actually see when you measure brain activity with fMRI, which has been used in >10 000 papers, this paper is also an example of how modelling can help to create consensus on important topics for both fundamental biology and biomedical research, and for clinical examinations of brain activity.
Big thanks to Nicolas and Henrik Podéus, who led the work in this study!
STRATIF-AI
PhD, Post Doc at the Department of Biomedical Engineering, Linköping University
I'm happy to announce that our latest research is now available on BioRxiv! In this study, we dive deep into the mechanisms underlying functional magnetic resonance imaging (fMRI) and challenge a longstanding assumption in neuroscience. Traditionally, fMRI signals have been attributed primarily to the activity of excitatory neurons, but recent findings suggest that inhibitory interneurons play a much more significant role.
Using a model-driven meta-analysis approach, we analyzed data across several different studies, revealing that:
- Less than 20% of the fMRI BOLD signal likely stems from excitatory neurons.
- A substantial 50-80% contribution comes from inhibitory interneurons.
Our model quantifies these contributions and explains the differences observed in fMRI responses across experimental conditions. This work offers a unified perspective on the complex interplay between different neuron types in shaping fMRI signals, bringing us closer to a new consensus on how we interpret these signals in brain mapping studies.
Check out the full study on bioRxiv to learn more about these exciting insights (https://lnkd.in/d6AuDfXt )! #Neuroscience#fMRI#Research#Neuroimaging#InhibitoryNeurons#Interneurons#BrainResearch#bioRxiv
🚀 Exciting Breakthrough in Neuroscience Imaging! 🧠🔬
At MIT, a collaboration of engineers and neuroscientists has unveiled a groundbreaking microscopy system that tracks brain changes faster and with greater clarity than ever before. This new system allows researchers to observe the brain’s plasticity—the process by which neurons remodel synaptic connections—at high resolution across entire cells, a feat that was previously hindered by the slow pace of traditional microscopes and the light-scattering nature of brain tissue.
📝 As detailed in their latest publication in Scientific Reports, this innovative technology overcomes these challenges, paving the way for deeper insights into brain function and learning. The team is already working on the next generation system, incorporating advanced detectors like hybrid photomultipliers and avalanche photodiode arrays to further enhance speed and sensitivity.
Join us in celebrating this leap forward in neuroscience research!
#Neuroscience#BrainResearch#Microscopy#Innovation#MIT#ScientificReports#Plasticity#Synapses#Neurotechnology#ScientificBreakthrough
How iPSCs are Advancing Neuroscience Research 🧠✨
Induced pluripotent stem cells (iPSCs) offer an invaluable method to model neural tissue development in vitro. One of their most exciting applications is in studying neurons, which are essential for human cognition and sensory processing. Neuron activity defects are linked to conditions like epilepsy, Alzheimer’s disease, and schizophrenia.
When culturing iPSCs, a well-designed matrix gel coating is crucial for supporting cell attachment and differentiation. At Nest, our NestGel Matrix provides the ideal environment for successful iPSC culture and differentiation.
Explore how our products can advance your research in neuroscience and beyond. #iPSC#Neuroscience#StemCells#Innovation#LifeSciences#NestGel
Each version is crafted to fit the tone and character limits of the respective platforms, while also promoting NestGel Matrix. Let me know if these work for you!
https://lnkd.in/equrtVGm
Scientists Control Mice Minds with Magnets – A Breakthrough in Neuroscience
South Korean researchers have developed Nano-MIND, an innovative technology that uses magnetic fields and nanoparticles to remotely control specific brain regions in mice. This groundbreaking approach allows for wireless manipulation of neural circuits, enabling modulation of behaviours such as appetite, social interactions, and maternal instincts.
Developed by the Institute for Basic Science and Yonsei University, Nano-MIND combines genetics, nanoparticles, and magnetic fields to achieve non-invasive control over specific neurons. This technology represents a significant advancement in understanding complex brain functions and has potential applications in treating neurological and psychiatric disorders.
The ability to precisely modulate brain circuits opens new avenues for research and therapeutic interventions, making Nano-MIND a promising tool for the future of neuroscience.
#Neuroscience#Innovation#Technology#Research#BrainHealth
Elevate your neuroscience research with our Neurite Outgrowth addition to the Gen5 cell imaging software for Agilent BioTek Cytation and Lionheart instruments. Designed for the curious minds in neuroscience, the new software generates neurite outgrowth metrics from fluorescently labeled, multichannel transmitted light & fluorescent images, and phase contrast images. The neurite outgrowth software empowers your research, from neuropathology to regenerative medicine.
Keep an eye out for further announcements as we continue to expand the capabilities of Agilent #CellImaging to support your research. https://bit.ly/3VrrCkG#Neuroscience#Innovation#ResearchExcellence#AgilentCellImaging
🧠Unveiling the Mouse Brain Cell-by-Cell ✨
Scientists from Allen Institute for Brain Science have achieved a groundbreaking milestone in neuroscience: a comprehensive, cell-by-cell map of the entire mouse brain! This vibrant mosaic not only highlights the diverse positions and roles of cells but also provides unprecedented insights into the functional complexities of the brain.
This intricate map is more than a scientific achievement; it's a window into understanding how various brain regions interact, communicate, and contribute to the behavior and health of mice. By deciphering this complex network, researchers are paving the way for advancements in treating neurological disorders and unlocking the mysteries of the human brain.
Why This Matters:
🔀 Offers a colorful, detailed view of the brain's cellular makeup
🧬 Enhances our understanding of brain function and complexity
🏥Opens new avenues for medical research and neurological therapies
Dive into the fascinating world of neuroscience and explore what this means for future research by reading more about it in this article from The Scientist - https://hubs.ly/Q02swH1s0#Neuroscience#MouseBrain#BrainResearch #ScientificDiscovery#MERFISH #MERSCOPE#Vizgen
The diverse applications of BESA products in #neurophysiology are highlighted by the wide range of research from our customers. A quick review of recent publications has revealed exciting new trends. Here are a few highlights:
▶ Neural Oscillations and Statistics: Pastötter et al. used beamforming to localize increased post-movement beta synchronization in functional movement disorders. Brain Communications 6:5, 2024, fcae301
▶ Connectivity and Visual Processing: Hu et al. studied brain responses to familiar vs. unfamiliar app icons, finding differences in the fusiform gyrus. NeuroReport 34:10, pp 521-525, 2023
▶ Effects of Cannabis: Schantell et al. observed a marked suppression of gamma activity in specific brain regions in regular cannabis users. Human Brain Mapping 45:11, 2024 (e26787)
▶ Clinical Population Analysis: Busboom et al. explored motor performance in individuals with cerebral palsy, revealing that cognitive interference impacts beta and gamma oscillations, which in turn affects reaction times. This suggests a role of top-down motor control influences in cerebral palsy. Neuroscience 536:9, pp 92-103, 2024
#neuroscience#science#medtech
Driven B.Sc. Medical Laboratory Technology Student | Future Innovator in Neuroscience & Lab Tech | Passionate About Advancing Scientific Discovery
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