Vanathi Perumal, PhD’s Post

Researchers at the University of Rochester are developing a method to quickly diagnose cancer and monitor treatment progress. The technique uses ultrathin membranes to capture extracellular vesicles that provide insights into the cells they come from. As a result, extracellular vesicles are emerging as key targets for both cancer diagnosis and therapy. Read more: https://lnkd.in/eKREJuxh

*CAR-T cell therapy:* It's a cell therapy in which a part of the body's immune system, T cells, are primed to target and destroy cancer cells. Scientists focused on T cells because they are genetically programmed to attack foreign particles, and, with bioengineering, they can become more precise and potent warriors. CAR-T cells belong to a branch of oncology therapeutics called immunotherapy, which is now hailed as the fifth pillar of cancer therapy after surgery, chemotherapy, radiation and targeted therapy. Despite the success of CAR-T cell therapy in treating certain blood cancers such as B-celleukaemias and lymphomas, there are challenges such as side-effects, limited response against solid tumours and long-term survival of CAR-T cells in the body. Research is on to develop new CAR-T cell designs to address these shortcomings.(Courtesy Tata Memorial Centre) #cartcelltherapy #cancer #immunesystem #cancercells #bioengineering #Oncology #immunotherapy #chemotherapy #radiation #bloodcancer #leukaemia #lymphomas #solidtumours #Tatamemorialcentre

🔬 Research in the Spotlight 🔍 Researchers at MIT have developed innovative tiny gold nanoparticles designed for implantation at tumor sites. These particles deliver a dual therapy approach, combining heat and chemotherapy to target and treat the affected area effectively. This groundbreaking advancement holds promising potential in enhancing treatment outcomes for patients facing cancer. Link to manuscript: https://lnkd.in/eQfpbSpN #MITResearch #CancerTreatment #cancer #research #mit #nanoparticles #breastcancer #NIR #nearinfrared #photoactivated #cytotoxicity #machinelearning #ResearchInTheSpotlight #Innovation #Science #Technology

Tumor profiling in #BreastCancer . . . understanding the #genomics of a patient’s tumor can help guide treatment decisions. As a former histology tech, I deeply understand the information a pathologist can obtain from a breast core biopsy, but also know the limitations of what can be seen under the microscope. That’s why #GenomicTesting and the information it provides about the genes that are active or inactive in a patient’s cancer is important. This knowledge can help determine what medicine a patient’s cancer is most sensitive to and how it may respond to specific therapies. This was a wonderful conversation on Susan G. Komen Real Pink Podcast with Chief Medical Officer at Agendia, Dr. William Audeh, explaining what genomic testing can provide breast cancer patients beyond what pathologists see under the microscope. Key points: 1️⃣ Genomic testing improves treatment precision. When the genes within a tumor are examined, we better understand how a cancer behaves at the molecular level and gain insight into its aggressiveness. This can lead to some patients avoiding unnecessary treatments while also helping to select the best chemotherapy drug(s) when necessary. Furthermore, genomic testing can be used to identify patients who may benefit from immunotherapy. Genomics enables #PersonlaizedMedicine to identify the right treatments for the right patients at the right time. 2️⃣ Genomics can predict recurrence risk and avoid over-treatment. Women who are at low risk for recurrence, when cancer returns after initial treatment, can avoid aggressive treatment. Targeting treatment avoids over-treating patients with unnecessary therapy and reduces side effects while maintaining high cure rates. Some tumors may appear similar under the microscope, but one woman’s cancer may actually be less aggressive, as determined by tumor profiling, and would benefit from anti-estrogen pills as opposed to chemotherapy. 3️⃣ Results are used to guide timing of surgery and adjuvant (post-surgery) treatment. Genomic testing is being done more frequently before surgery to help determine whether a woman should receive chemotherapy BEFORE surgery (called neoadjuvant treatment) or go directly to surgery. The information learned from genomic testing can influence decisions for how long to continue hormone therapy as well. For example, whether a woman would benefit from extending anti-estrogen therapy beyond the standard five years because the cancer is very slow growing and has a high risk of recurrence. While genomic testing is used most frequently in early-stage hormone-positive breast cancer, it has also been beneficial in HER2+ and triple negative breast cancers. It’s exciting to see these types of advances transforming the treatment of breast cancer and reducing unnecessary side effects to provide more precise, individualized treatment options. #PrecisionMedicine https://lnkd.in/gQkw6cbB

Using novel machine learning tools developed by SCI member Everett Moding and team, the researchers have mapped three distinct cellular configurations corresponding to clinical outcomes for patients with a rare, difficult-to-treat cancer called soft tissue sarcoma. In particular, the technique identified a cellular neighborhood that correlated with a positive response to immunotherapy, which may help physicians make treatment decisions. #sarcoma #immunotherapy https://stan.md/4cD0F49

Cancer researchers, particularly those focusing on head and neck cancers, should consider reading this new Nature Portfolio article. This study presents intriguing findings on how targeting OGG1 and PARG can increase the sensitivity of head and neck cancer cells to high-LET protons. The #Gelcount was instrumental in this research, being used to generate data for Figures 1, 2, 3, 4, and 6, which helped determine the surviving fraction of colonies across what must have been hundreds upon hundreds of plates! #HeadAndNeckCancer #Oncology #CancerResearch #LabAutomation

Placental Circulating T Cells for Enhanced CAR-T Therapy Celularity Inc. researchers have developed and published a new method for CAR-T cell therapy, using placental circulating T cells as a source. This innovative strategy seeks to improve the effectiveness of CAR-T cell therapy. The published study highlights the significance of the quality and stemness of CAR-T cells sourced from the placenta, essential elements for the success of the therapy in terms of responsiveness, durability, and the formation of memory cells, vital for achieving long-term remission in cancer patients. CAR-T cells derived from placental circulating T cells exhibit enhanced and prolonged effectiveness and persistence in vivo compared to CAR-T cells derived from healthy adult peripheral blood mononuclear cells (PBMCs). This research points to the potential of placental circulating T cells as a strong, allogeneic CAR-T cell platform, providing a promising avenue for better cancer treatment outcomes. https://lnkd.in/gbJPfrSc Natalia Ruggeri Barbaro Theodore Drashansky Kristina Tess Mansour DJEDAINI Robert Hariri, MD, PhD Shawn He William van der Touw Kathy Karasiewicz #cartcells #cartcelltherapy #cancertherapy #celltherapy

#PaperoftheDay: "Utilizing cell line-derived organoids to evaluate the efficacy of a novel LIFR-inhibitor, EC359 in targeting pancreatic tumor stroma" DOI ⬇️ https://lnkd.in/dWiw_dKA #pancreaticcancer #cancer #research #openaccess #peerreview #publishing

#SpeakingofScience: In a recent breakthrough, Stanford University School of Medicine unveiled #AI-powered tools that offer new hope for treating soft tissue #sarcomas, a rare and challenging #cancer. The study mapped out distinct cellular configurations within these tumors, revealing insights into patient outcomes and #cancertreatment responses. One key finding is the identification of a cellular neighborhood linked to a positive response to #immunotherapy, potentially revolutionizing treatment approaches. Despite the cancer's complexity, #machinelearning techniques helped unravel crucial insights into the tumor microenvironment. This study challenges previous assumptions by suggesting that tumors with an intermediate level of immune cell infiltration may respond best to immunotherapy. Dr. Moding's team aims to validate these findings further, with the support of collaborative efforts and funding agencies. 🔬🚀 #CancerResearch #AI #Immunotherapy #PrecisionMedicine #StanfordMedicine #ClinicalResearch #Biotech #AIinhealthcare #MedTech #HealthcareInnovation #CancerDiscovery

Visit www.Oncotarget.org to read #blog synopses of new and #trending #research papers published by Oncotarget. #openaccess #peerreviewed #oncology #cancer #researchpapers #science #medicine #medEd #OA