Victorian Paediatric Cancer Consortium Ltd’s Post

10% of #breastcancer #patients >=65 yrs old have pathogenic variants w/ #germline #genetictesting, most frequently in #BRCA1, #BRCA2, #CHEK2, #ATM "The emphasis in testing guidelines on age at diagnosis as a predictor for carrying a PGV in a cancer-predisposing gene, is a barrier to the identification of actionable PGVs... Identification of PGVs can confer eligibility for #targetedtherapies and #clinicaltrials, enhanced screening and risk-reducing interventions, and cascade testing of at-risk relatives." "#Germline #GeneticTesting should not be overlooked in older #breastcancer #patients, as... > 10% of #patients have pathogenic variants, largely in potentially actionable genes." https://lnkd.in/gf29y5Ak #WorldJournalofOncology Hikmat Abdel-Razeq @ King Hussein Cancer Foundation and Center Invitae Labcorp #FarisTamimi Baha Sharaf Sarah Young (Nielsen) Brandie Leach Kathryn Browne, PhD Hira Ibrahim Bani Hani, MSc, GCSRT Khansa Al-Azzam #MaisAlkyam #RawanMustafa #AreejAlAtary #access #reducedisparities #universal #germlinetesting #precisionmedicine #precisiontherapy #clinicaltrials #precisionprevention #AI #precisioninterpretation

Colliding Genetic Processes Drive Tumor Growth and Open New Treatment Avenues for Aggressive Cancers Researchers have uncovered a key mechanism driving genetic instability in aggressive cancers: collisions between DNA replication and transcription processes. The findings, published in Nature Cancer, shed light on how these collisions cause large tandem duplications (TDs)—a specific type of genetic alteration strongly linked to cancer progression—and highlight potential biomarkers and treatment options for hard-to-treat cancers. Disrupting both processes and creating cellular stress known as transcription-replication collisions (TRCs). The role of TRCs in driving cancer-causing genetic instability has remained largely unexplored until now. Importantly, the findings have practical implications for treatment. The researchers discovered that cancers with large TDs are more sensitive to specific drugs, including WEE1, CHK1, and ATR inhibitors. These drugs target vulnerabilities in cells with high TRC levels, providing a potential pathway for developing treatments tailored to tumors with these genetic alterations. #opportunities #strategy #programming #design #team #research #data #health #development #collaboration #projects #testing #immunotherapy #cancer #technology #biotechnology #healthcare #medicine #oncology #precisionmedicine #liquidbiopsy #rna #dna #venturecapital #startup #immunooncology #tcells #innovation #growth #tech #lifesciences #biopharma #oncodxrx #genomics #NGS #CRISPR #gene #geneexpression #artificialintelligence #machinelearning #sequencing #NGS #cancerresearch #personalizedmedicine #targetedtherapy #PrecisionOncology #Therapy #earlydetection #MRD

🧬 The most exciting developments in the field of genomics in recent years have brought in the identification of thousands of high-risk gene variants which are associated with cancer. 🔎 Researchers assembled mutations in genes contributing to the risk of different cancers. This research, therefore, presents incredibly important guidelines for the future in personalized medicine and in preventing future diseases, including cancer. These findings will enable us to move closer to better risk-based assessments and result in appropriate treatments, making patient outcomes even more outstanding and saving lives. 🔬 Key Highlights: 🌱 The identification of thousands of genetic variants associated with an increased risk of certain cancers. 🌱 The potential to conduct more precise and personalized risk assessments. 🌱 Discovery in targeted therapies for the better treatment and prevention of cancer.   💊 In this way, this research will be the milestone of the field of genomics for health care opportunities. Every new secret in our DNA takes us closer to a future in which cancer might be better predicted, prevented, and treated. Stay tuned for more updates in the world of genomics and personalized medicine! 🌟 #Prevealth #Genomics #CancerResearch #PersonalizedMedicine #DNA #Healthtech #Cancer Source: https://lnkd.in/g3h6Sbs3

🌟 Exciting News from NIBMG! 🌟 We are thrilled to invite Expression of Interest (EOI) for Joint Development and Commercialization of a Gene Panel/Diagnostic Kit for Early Oral Cancer Detection. This innovative gene panel is designed to detect early signs of oral cancer, offering a much-needed solution to one of India's major health concerns. 🔬 Why this is important: Oral cancer is a leading cause of cancer-related deaths in India, especially among males. Early detection can significantly improve outcomes, and our proposed gene panel will provide a fast, cost-effective, and accurate method for early diagnosis. 💡 Key Features: High sensitivity and specificity for detecting early oral cancer lesions. Fast turnaround times for results, making it perfect for clinical settings. Potential for large-scale screening programs, benefiting healthcare providers and patients 📅 Important Dates: Bid Submission Start Date: 4th October 2024 Submission Deadline: 23rd October 2024 We are looking for innovative partners to collaborate with us on this groundbreaking initiative. Together, we can make early oral cancer detection more accessible and affordable. To learn more visit https://bit.ly/3Yn8jua To participate email us at eoi.research@nibmg.ac.in #oralcancer #earlydetection #genomics #innovation #healthcare #CancerAwarenessMonth Department of Biotechnology

Standing Together Against Leukemia: DeepLife’s Dedication to Advancing the Cure 🌟 At #DeepLife, we are transforming medical research and treatment. In honor of #LeukemiaAwareness Day, we reaffirm our commitment to fighting leukemia alongside our valued collaborators. Leukemia poses significant challenges in treatment due to its complex nature, variability, and the tendency of cancer cells to develop resistance. This complexity calls for innovative, adaptive solutions that target specific cellular mechanisms. 🔬Our OmicStore provides access to 414 datasets and more than 36’000 experiments across species and single-cell technologies, all focused on leukemia. These meticulously curated datasets are designed for immediate use, helping researchers save time and resources while enabling swift biological exploration. Our capability to create on-demand organ or disease atlases from single-cell omics data elevates research precision, bringing new hope in overcoming leukemia’s treatment challenges. 🧬 Through the integration of cutting-edge omics data with our advanced #CellBlueprint cell type-specific interactome (https://lnkd.in/dQe7JTSc), we’re identifying the genes and molecular processes responsible for treatment resistance and disease progression. This work translates into real progress and hope for patients, their families, and the broader scientific community in the fight against leukemia. ✨ Be a Part of the Change: Contact us at partnerships@deeplife.co to get started. Together, we can make a difference and bring life-saving treatments to those who need them most. #CancerResearch #InnovativeResearch #OmicStore #DeepLife #CancerBreakthroughs #LeukemiaAwareness #CellBlueprint #LifeSciences #SingleCell #HealthcareInnovation #DataScience #Bioinformatics #Novartis #GileadSciences #BristolMyersSquibb #Roche #Amgen #Pfizer #AstraZeneca #AbbVie #Sanofi #Takeda

🚨 Breakthrough Study Links PM2.5 Exposure to Lung Cancer 🚨 Researchers have unveiled a significant molecular connection between fine particulate matter (PM2.5) and lung cancer, spotlighting the role of circular RNA, circDNA2, in malignant transformations. 🔍 Key Findings: - Chronic PM2.5 exposure accelerates the malignant transformation of human bronchial epithelial cells. - Elevated circDNA2 levels inhibit tumor suppressor gene GADD45A, promoting tumorigenesis through interactions with YTHDF2. - This discovery not only enhances our understanding of cancer mechanisms but also opens doors for targeted therapies to combat air pollution's harmful effects on lung health. As we delve deeper into the intricate relationship between environmental pollutants and genetic regulation, this research emphasizes the urgent need for comprehensive cancer prevention strategies and personalized medicine for at-risk populations. 🌱 Let's advocate for cleaner air and innovative health solutions! 👉 Click to learn more! #AirPollution #EnvironmentalHealth #HealthInnovation #LungCancer #Publications #RegulatoryAgencies #ResearchBreakthrough #MarketAccess #MarketAccessToday

**🎗️Stronger Together: United for Lung Cancer Awareness🎗️**   🚀World Lung Cancer Day is coming. As a biotech company, we feel a great sense of responsibility at this special moment.   🔬 We focus on providing customers with advanced gene sequencing and gene transcription services, and are committed to contributing to the high-throughput gene sequencing of lung cancer. By deeply analyzing information at the genetic level, we can provide more accurate data support to medical professionals.   🦠However, fighting lung cancer cannot rely solely on the power of technology. We also strongly urge everyone to raise awareness of lung cancer prevention. Staying away from tobacco, maintaining a healthy lifestyle, and having regular physical examinations are all important measures to prevent lung cancer.   🌏Let's join hands to raise awareness and work towards a future where lung cancer is no longer a fearsome adversary. Together, we can make a difference.   #WorldLungCancerDay #Biotechnology #LungCancerResearch #PreventLungCancer #UnitedForLungCancer #StrongerTogether #BMKGENE

As the burden of cancer continues to grow globally, the complexity of the diseases demands more sophisticated solutions. Scientists are constantly striving to develop novel, more effective therapies and diagnostic tools to improve patient outcomes and resolve the biggest unmet needs in global healthcare. At the core of these efforts, there are two key technologies: PGA and OncoMRD. A cancer-free future starts with a transformative view of circulating cell-free mRNA — all from real-life patients. With patient-unique gene expression signature, you’ll never see cancer the same way again. Our end-to-end workflows provide a seamless option to answer cancer treatment/monitoring questions you didn't even know you had. #opportunities #strategy #programming #design #team #research #data #health #development #collaboration #projects #testing #immunotherapy #cancer #technology #biotechnology #healthcare #medicine #oncology #precisionmedicine #liquidbiopsy #rna #dna #venturecapital #startup #immunooncology #tcells #innovation #growth #tech #lifesciences #biopharma #oncodxrx #genomics #NGS #CRISPR #gene #geneexpression #artificialintelligence #machinelearning #sequencing #NGS #cancerresearch #personalizedmedicine #targetedtherapy #PrecisionOncology #Therapy #earlydetection #MRD 

What if a simple blood test at your annual physical could detect cancer in its earliest stages? 🩺🩸 Helmy Eltoukhy, CEO of Guardant Health, is turning this vision into reality. They’ve seen a spate of FDA approvals. With groundbreaking technologies like Guardant360 and Shield, they're revolutionizing cancer detection and treatment. By harnessing genomics and epigenomics, Guardant's tests can identify cancer signals in the blood, even before symptoms appear. 🧬💡 Ahead of Vital Signs, produced by Onyx and now available to read in Fortune magazine, I spoke with Helmy about their mission to make cancer screening accessible and effective. From reducing the cost of genome sequencing to developing tests that can detect multiple cancer types—and potentially other diseases—their work is a game-changer. 🌍🔬 Guardant Health is shaping the future of diagnostics, one blood test at a time: https://lnkd.in/e3qTHmSn

Did You Know?🧐 "A generation can skip Cancer, but can't skip Gene Mutations causing cancer." Gene Mutations: - Inherited Mutations: Gene mutations passed down from parents are embedded in DNA and carried by offspring, regardless of whether they lead to cancer or other diseases. - Non-Inherited Mutations: Some mutations, called somatic mutations, occur during a person’s lifetime due to factors like environment, aging, or random DNA replication errors, and these aren't passed on to the next generation. Cancer: - Skipping Cancer: Even if someone inherits a genetic mutation that increases cancer risk, they might never develop the disease due to lifestyle, environment, or just chance. This means a generation can "skip" cancer even if they carry the mutation. - Not Skipping the Mutation: However, the genetic mutation itself remains and can be passed down to the next generation, who might then be at risk of developing cancer. Insight: While cancer can skip a generation, the genetic mutation (predisposition) doesn't. It can still be passed from generation to generation, keeping the risk alive even if the disease doesn't manifest immediately.   Stay tuned for more insights on cancer! 🚀 #CancerAwareness #Oncology #HealthcareInnovation #Genetics #MedicalResearch #Biotechnology #TechMeetsHealth