Xtalks’ Post

🚀 𝗨𝗽𝗰𝗼𝗺𝗶𝗻𝗴 𝗪𝗲𝗯𝗶𝗻𝗮𝗿: 𝗧𝗵𝗲 𝗣𝗼𝘄𝗲𝗿 𝗼𝗳 𝗗𝗡𝗔 𝗠𝘂𝘁𝗮𝗻𝘁 𝗟𝗶𝗯𝗿𝗮𝗿𝗶𝗲𝘀: 𝗔𝗰𝗰𝗲𝗹𝗲𝗿𝗮𝘁𝗶𝗻𝗴 𝗥𝗲𝘃𝗼𝗹𝘂𝘁𝗶𝗼𝗻 𝗶𝗻 𝗥𝗲𝘀𝗲𝗮𝗿𝗰𝗵 Join us and Dr. XING GAO in the conversation on the impact of DNA mutant libraries in biomedical research and development. Register here: https://bit.ly/3WGiqbn What you will learn from the webinar: 🔍 How DNA mutant libraries are revolutionizing biomedical research 🔍 The impact and application of DNA mutant libraries on gene and cell therapy (e.g., sgRNA library, CAR-/TCR-T libraries etc.), protein and antibody engineering and AI-driven drug design 🔍 Real-world case studies on applying DNA mutant libraries to enhance research and applications 🔍 The latest advancements and future possibilities in biomedical research #Biotech #DNA #Biomedical #ScienceNews #Webinar #DNAResearch

Exciting research update! Bristol Myers Squibb, Takeda, and BioTuring are utilizing Neuromics Human Primary Pancreatic Cancer-Associated Fibroblasts to delve into genetic variations between 2-D and 3-D "in vivo" like assays. Learn more. https://lnkd.in/eF523bW Image: Image: Gene expression profile of Neuromics Pancreatic CAFs and BxPC3 cells in 2D and 3D monocultures and cocultures. Different culture conditions lead to changing expression profiles. I wish all our valued customers, distributors, and collaborators a prosperous 2025!

Have you ever had one of your designed vectors rejected because it was too complex? It's happened to us way too many times in the past. But why accept that? So much research must still be done to test complex genes, or multiple genes in a single system - why accept being artificially limited by what can be synthesized or what's available in the same old catalogues? The #BirdOfPrey platform is our answer to the repeated & frustrating roadblocks getting in the way of new gene and cell therapy research. The first publicly available standardized modular DNA design & construction system is usable right now - just go to https://lnkd.in/ercp8yNq to learn more. The full DIY Handbook is finally available as well: https://lnkd.in/emuyvy2K Or, if you want us to help you build your vector of choice, take your gene of interest and make it fully usable with all of our other plasmids, contact us at clonecard@ospreybio.com

Excited to share BayesTS (https://shorturl.at/Z1wFi), a new tumor specificity index (measuring how safe a target is) we proposed for drug target discovery. It integrates RNA gene expression, protein staining, tissue essentiality, and many other modalities into a single score. The BayesTS score for all protein coding genes and the codes are freely availble at (https://lnkd.in/eHTpKbXy).

#AMPATH24 I am excited to present poster TT008: Cost-Reduction of T-Cell Receptor Rearrangement Diagnostic Testing Utilizing Low-Depth Sequencing Strategy. Summary: Next-generation sequencing (NGS)-based T cell receptor (TCR) gene rearrangement analysis is essential for diagnosing lymphoid malignancies but often involves over-sequencing to achieve sensitivity requirement. This study aimed to evaluate sequencing reduction while maintaining diagnostic performance. This approach preserves clonal architecture while reducing sequencing costs by 70%, offering an efficient solution for labs under financial constraints.

One week to go for #ESGCT! Many years ago I heard from a potential customer to services I was promoting saying: "I need an early success or an early failure: either one will tell me what to do next"...so WHAT ARE YOU WAITING FOR...? ...is your bioanalysis service provider taking too long to provide critical information regarding your precious clinical/pre-clinical samples? ...are you unsure about the selected method of sample preparation for your #biodistribution study...? ...have you been made aware how nucleic acid #extraction, the assay design, and #optimization process are can all have impact on the #quality of the results you have contracted to have...? ...do you need to have #answers sooner rather than later...? If any of these questions made you think, reach out or better: come to #Rome and meet the TATAA Biocenter team: we are at booth #A02! ...AND DON'T WAIT FOR THE REGULATORS TO CALL/EMAIL YOU, it will probably be too late ... #BETTERLATETHANNEVER #research #medicine #cancer #cro #glp #quality #lifesciences #drugdiscovery #pharma #biotech #biopharma

One of the annual conference highlights! You'll find me in the sessions, at the posters, at the morning run - and of course at the TATAA Biocenter booth. If you want to better plan your visit, simply e-mail to lukas.paul@tataa.com to schedule a meeting. Let's review how we can enable and accelerate your projects with expert #bioanalysis! #ESGCT2024

🔬 Elevating Your Single Cell Research with Evercode WT v3 Our latest tech note dives deep into a head-to-head evaluation of #singlecell RNA profiling technologies. Focusing on fixed nuclei from mouse lymph nodes, we compared droplet-based microfluidics (10x Genomics Chromium Flex) against combinatorial barcoding (Parse Biosciences Evercode WT v3). Key Findings: ➡️ Evercode WT v3 shows increased gene body coverage and sensitivity, detecting twice as many unique genes including diverse RNA biotypes compared to Chromium Flex. ➡️ The inconsistency of probe-based methods stands out against the comprehensive capture of RT-based methods. Dive into the full technical note for an insightful comparison and how these findings could impact your research. https://lnkd.in/gRdMMhMN

Discover the predictive value of HER2-positive CTCs! 🧬 The DETECT III trial shows improved survival in patients with HER2-positive CTCs treated with lapatinib. ANGLE’s advanced HER2 testing service offers precise longitudinal monitoring and optimized subject selection for research. For Research Use Only. Not for Use In Diagnostic Procedures.